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후천성 면역부전증에 병발한 원발성 중추신경계 림프종 1예
이은봉,유경훈,유창달,김남중,오명돈,신형식,백한주,지제근,허대석,최강원 대한감염학회 1996 감염 Vol.28 No.4
저자들은 인간면역부전바이러스 검사 양성, cryptosporidiosis로 후천성면역부전증을 진단받은 환자에서 나타난 원발성 중추신경계 림프종을 경험하였기에 이를 보고한다. A 43-year old man with acquired immunodeficiency syndrome was admitted to this hospital because of cognition defect. The patient with a history of homosexual behaviour developed acquired immunodeficiency syndrome seven months before this admission, when he was positive for HIV test, had cryptosporidiosis and suspicious pulmonary tuberculosis. One week before admission, fever, cognition defect, including inappropriate response and memory disturbance, and ptosis of the left eye developed. Brain MRI showed an ill-defined, rim enhancing lesion in the left mid brain and both thalami. Stereotaxic brain biopsy showed malignant lymphoma with monoclonal T cell phenotype on nested PCR and immunohistochemistry. Brain radiotherapy of 6120 rad was delivered, which resulted in stable disease. We report the first case with acquired immunodeficiency syndrome and primary central nervous system lymphoma in Korea.
이은봉,허대석,송영욱,백한주,임용성,유창달 대한내과학회 1998 대한내과학회지 Vol.54 No.2
Rheumatic manifestations in non-Hodgkin's lymphoma (NHL) are common but actual arthritis as a presenting feature appears to he very rare. We experienced a case of NIK, presenting as polyarthritis in a 24-year-old woman. Eight months ago she was admitted to the hospital due to polyarthritis and skin rash. She had pleural and pericardial effusion. Antinuclear antibody was positive and rheumatoid factor was negative. Joint X-ray showed periarticular osteopenia at both knees, wrists, hands and feet. Prednisolone, salsalate and anti-tuberculosis drugs were administered under the impression of either probable lupus or rheumatoid arthritis and pleural tuberculosis. After then pleuropericardial effusion and skin rash improved. But polyarthralgia persisted and she developed right cervical lymphadenopathy. On her second admission she was found to have a round mass in left lower lung field and multiple mediastinal lymph node enlargement. Cervical lymph node biopsy revealed non-Hodgkin's lymphoma. She received 8 cycles of systemic chemotherapy until 1996 July. NHL was remitted completely and polyarthralgia disappeared. We report a case of non-Hodgkin's lymphoma presenting as polyarthritis and literatures are reviewed.