Effects of C2-ceramide on the Malme-3M Melanoma Cell Line

유종엽 ( Jong Yeop Yoo ),박경찬 ( Kyoung Chan Park ),한원석 ( Won Suk Han ),윤상웅 ( Sang Woong Youn ),김동석 ( Dong Seok Kim ),김숙영 ( Sook Young Kim ),김규한 ( Kyu Han Kim ) 대한피부과학회 2002 초록집 Vol.40 No.20

The use of radiofrequency for skin tightening, is it really effective treatment?

유종엽 ( Jong Yeop Yoo ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Nonablative skin rejuvenation encompasses a wide spectrum of noninvasive techniques using laser, noncoherent light, or radiofrequency to improve the appearance of aging skin RF application has recently been used for facial tissue tightening. Although RF devices have their own rationales and reports of their effectiveness, there is some controversy about their effectiveness among physicians Among RF devices, I will deal with monopolar RF treatment, Themage Because thermage is the best studied and has been developed into 3rd generation form, CPT(Comfort Pulse Technology) Radiofrequency tissue tightening was first cleared in 2002 for the treatment of periorbital wrinkles and rhytids. The first device to use monopolar RF energy for skin tightening was the ThermaCool device(Thermage) by FDA. Monopolar RF treatment has generated considerable interest among physicians and patients seeking nonsurgical skin tightening procedures. Several recent studies have reported improvements in facial tissue tightening using subjective clinical grading systems to assess improvements in facial features after RF treatment. But no measurable objective quantification of improvements in the face have been reported. Many doctors still have doubt about the effectiveness of thermage. Although the efficacy of RF tightening has been established by some studies, widespread adoption of the technology has been limited by seemingly inconsistent results Now I will review the articles about thermage and evaluate the evolution of thermage(CPT, total tip) Continued refinement of techniques, including the use of multiple treatments, multiple passes, and adjusted energy levels, may carry results to a level that will satisfy patients and physicians alike. As physicians better understand the efficacy of RF skin tightening, an interesting concept is being developed to consider using monopolar RF as a laxity prevention tool.

재발한 원발성 피부 CD30 양성 대형세포 림프종 2 예

유종엽(Jong Yeop Yoo),최원우(Won Woo Choi),조광현(Kwang Hyun Cho) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.10

The clinical characteristics of primary cutaneous CD3O-positive large cell lymphoma are solitary or localized skin lesions, frequent relapses, spontaneous regression and a favorable prognosis. These relapses and spontaneous regressions occur frequently in borderline cases between CD30-positive large cell lymphoma and lymphomatoid papulosis. Regression and relapse, which occurs in both cutaneous CD30 positive large cell lymphoma and lymphomatoid papulosis, dose not help distinguish one from the other. We report two cases diagnosed as clinically and histologically primary cutaneous CD30-positive large cell lymphoma, recurred respectively on the same anatomic site and on the different anatomic site.

보툴리눔 독소(보톡스(R))로 치료한 얼굴 주름의 임상적 고찰

윤상웅 ( Sang Woong Youn ),서구일 ( Koo Il Seo ),유종엽 ( Jong Yeop Yoo ),박경찬 ( Kyoung Chan Park ),은희철 ( Hee Chul Eun ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.4

N/A Background : Botulinum toxin type A is being widely used for the treatment of facial wrinkles sheeted by facial expression muscles. Due to the sudden and exponential surge in popularity of its use for facial wrinkles, there are scanty reports of facial wrinkles treated with botulinum toxin type A especially in Asians. Objective : This study was performed to investigate the clinical features of facial wrinkles affected by facial expression muscles and the effects of botulinum toxin A on the treatment of wrinkles. Methods : Medical records of 61 patients with facial wrinkles treated with botulinum toxin type A were reviewed. Demographic profiles of the patients, the age of onset of facial wrinkle, the distributions of facial wrinkles, treatment dose of botulinum toxin type A. side effects, and follow up data went analyzed. Results : Female patients were predominant(93.4%) than male patients(6.6%). The m . e of the patients was 41.3 years. Crow, s feet were the mast frequently treated site of facial wrinkles. Average number of treated sites were 2.38. Side effect profiles were similar as previous reports in Cents,tons. The number of patients who took the regular retreatment was less than expected. Conclusion : The clinical profiles of wrinkle patients in Koreans treated with botulinum toxin A were assessed. We think it is one a of the effective treatment modalities for antiwrinkling.

신생아 홍반성 루푸스 2예

권인호,유종엽,이종희,조광현 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.7

Neonatal lupus erytematosus is characterized by cutaneous findings showing the morphology of subacute cutaneous lupus erythematosus, congenital heart block, and anti-Ro/SSA and/or anti-La/SSB autoantibodies which result from the transplacental passage of maternal autoantibodies. We report two cases of a 25-day-old female infant and a 30-day-old male infant who presented with characteristic clinical features of cutaneous neonatal lupus erythematosus but without evidence of congenital heart block. The serological studies in both infants revealed the presence of anti-SSA/Ro antibodies and antinuclear antibodies. We diagnosed their mothers as systemic lupus erythematosus with the clinical and laboratory findings. (Korean J Dermatol 2003;41(7) : 956~959)

폴리프로필렌 공정의 첨가제와 직업성 피부영향

전승호,이경민,윤간우,백도명,유종엽,은희철 大韓産業醫學會 2003 대한직업환경의학회지 Vol.15 No.3

목적: 정유공장의 폴리프로필렌(polypropylene) 부서와 복합수지 부서에서 사용되는 첨가제들중 피부첩포검사를 통하여 피부독성을 야기할 수 있는 물질들을 알아보기 위해서 본 조사를 수행하였다. 방법: 일개 정유공장에서 총 44명의 근로자를 대상으로 폴리프로필렌공정에서 첨가제를 취급한 노출군과 그런 작업을 하지 않은 비노출군으로 나누어 피부첩포검사를 했다. 노출군은 27명으로 과거 노출자 10명, 현노출자 17명이었다. 비노출군은 17명이었다. 10개의 첨가물 중 Microstat 16은 0.25%, Amoslip-CP는 0.1%의 농도로 첩포검사를 하고, 나머지 8종은 1%의 농도에서 검사 후 48시간 후 피부에 양성반응을 보이면 0.1%로다시 피부첩포검사를 했으며 음성방응을 보이면 10%로 검사를 시행했다. 결과: 각 물질별 결과로는 Ultranox-626과 Millad 3988이 가장 많은 피부양성반응을 보였다. 피부의 발진을 많이 보이는 (양성 및 의양성) 빈도는 Ultranox-626, Millad 3988, Armoslip-E, Songstab Sc-100 순이었다. 피부에 발진을 보이는 (양성 및 의양성) 대상자는 18명(41%)이었고, 그중 노출군이 14명(51.9%)이고 비노출군이 4명(23.5%)으로누출군에서 더 많은 발진을 야기하였다. 피부첩포검사에서 반응을 보이는 18명 중 자극가증서응로 작용하는 대상자는 7명(38.9%)이었고, 알레으기 가능성으로 작용하는 대상자는 6명(33.3%)이었으며 여러 물질에 강한 반응을 보이는 다중 반응 대상자는 5명(27.8%)이었다. 알레르기 가능성 반응 대상자는 현재의 노출자가 과거노출자와 비노출자 보다 통계적으로 유의하게 많았다(p=0.04). 자극가능성 반응 대상자들 중 현재 노출자, 과거노출자, 비노출자 사이의 통계적 차이는 없었다. 다중 반응 대상자는 과거노출자가 통계적으로 유의하게 많았고(p=0.05), 현재의 노출자는 없었다. 결론: 자극성 반응과 알레르기성 반응을 포함하여 첨가제에 노출된 집단이 비노출군보다 높은 과민상태를 보였다. 결과적으로 이들 물질에 노출되는 경우 잠재적 알레으기 가능성 반응이 유발 될 수 있능 것으로 보인다. 피부첩포검사에서 반응을 보이는 원인물질로 빈도가 높은 Ultranox-626 Millad 3988 Armoslip-E Songstab Sc-100의 4가지 물질에 대한 노출을 우선적으로 관리하는 것이 필요하다고 판단된다. 첨가물의 알레으기 여부를 정확히 판정하는 작업과 피부병 유발 가능성을 향후 좀더 구명할 필요가 있을 것으로 보인다. Objects: To investigate the causative agents for the dermatological problems associated with the polypropylene manufacturing process. Methods: The study subjects consisted of 44 male workers involved in the polypropylene manufacturing process. Twenty-seven of them had been exposed to additives, and the remaining 17 had not. Among the 27 exposed, 10 had been exposed previously, and 17 are currently being exposed through their duties. Patch test were performed with three different concentrations, 0.1%, 1% and 10% of 10 different additives that was diluted with Vaseline. Results: 18 subjects (41%) had positive reactions to the patch tests. Exposed group had a higher reaction rate (51.9%) than the control group (23.5%). When the positive reactions were further classified, 7, 6 and 5 were compatible with probablu irritant, probably allergic, and multiple hypersensitivity reactions respectively. The most frequent reactions were from Ultranox-626 followed by Millad 3988, Armoslip-E and Songstab Sc-100. Conclusions: When considering the significantly higher probability of an allergic reaction rate among the currently exposed group compared to non- or previously-exposed groups, the nature of dermatological problems in a polypropylene plant is probably allergic. Ultranox-626, Millad3988, Armoslip-E and Songstab Sc-100 were the main causatives agents found in the process.