Recurrent Infantile Digital Fibroma

최현철(Hyun Chul Choi),계영철(Young Chul Kye),오칠환(Chil Whan Oh) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.5

Recurrent infantile digital fibroma is a peculiar fibrous tumiir that may be single or multiple on fingers and toes of infants and children. We report a 5-year-old gril with recurrent infantile digital fiber oma which was recurrent on the left 5th toe. The lesion had noted at the age of 6 months. and was excised surgically when the child was 3 year old. 2 years after operation, the lesion was recurred in operation site. Microscopically, nodular fibrous mass is attached to flattened,pidermis. The underlying nodule is composed of proliferating fibroblasts surrounded by derse collagenous tissue. We could find eosinophilic inclusion bodies in the cytoplasm of fibro ilast. It was stained pink with H&E, bright red with Massons trichrome and purple with PTAH. (Kor J Derrnatol 1992;30(5):743-746)

노인 인구군에서의 피부질환 분포 , 특성 및 피부관리에 대한 역학적 연구

최현철(Hyun Chul Choi),오칠환(Chil Hwan Oh) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.4

Background : With the development of medical science and technology, the proprotion of the aged has been significantly increasecl. Therefore it needs to be studied the fuadamental epidemiologic survey of dermatologic diseases and akin care in the elderly. Object : Our purpose was to provide clinically relevant data regaring both dermatologic diseases and skin care in the aged population. Methods : Total 172 volunteers aged 51 to 90 were enrolled in a study of 32-item questionnaire and total cutaneous examination. Results : The sex ratio of male to female of 172 elderly volunteers as 1:1.4 and population of 7th and 8th decades occupied 76.5% with their mean age 74.4. The dermatologic findings which showed higher incidence in this study were seborrheic keratosis, senile lentigines, xerosis, cherry angioma, and generalized pruritus. Through the interviews of 172 elderly, the mot fequent dermatologic complaint was generalized pruritus. As the mean age of the population increasec, the number of the population showing xerosis and complaing of pruritus was elevated(r=0.976. 0.917 respectively). And there was a significant stastical correlation between the finding of xerosis and the the presence of pruritus(P<0.005). Conclusion : This study suggests that dermatologic problems in the elilerly are very common ancl further dermatologic studies including substantial medical care will be needed. (Kor J Dermatol 1993;31(4):459-464)

영상분석법을 이용한 노화에 따른 피부주름의 변화에 대한 연구

최현철,오칠환 ( Hyun Chul Choi,Chil Hwan Oh ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.2

Background: The confgurations of the skin surface, as characterized by surface furrows and plateaux, are known to change with ageing. There are many parameters to analyze the effects of ageing processes on the surface configuration. However, there are contradictory results among the authors. Objective : The purpose of this study was to compare the sensitivity of various parameters being described in other reports with our new parameters used in evaluating the changes of the skin surface in the agein processes. Methods : 112 healthy Korean males in 4 age groups participated in this study. Silicon skin replicas were taken from medial and lateral aspects of the forearm. Images of the skin replicas were analyzed by means of a digital image processing system(AIC, GA). Most parameters were calculated and measured in the primary skin axis. Image analyses were porformed by 3 different processes i.e., morphometry, densitometry(optical profilometry), and histograms. Results.In Morphometry, the furrow count in the vertical section(VFC), the coefficient of the developed skin surface(CDSS) and mean width at maximal interception(MWMI) showed a tendencies to decrease with ageing.Irregularity of shadow shape(ISS) showed a tendency to increase with ageing. In Densitometry, the mean surface roughness(Ra) and mean depth of roughness(Rz) showed a tendency to increase with ageing. On histogram analysis, skewness was decreased with ageing but kurtosis did not show any significant changes. Conclusion :Ra, Rz, and ISS have shown a tendency to increase in the ageing processes(p<0. 05). VFC, CDSS, MWMI and skewness showed tendencies to decrease with ageing but the results were not statistically significant. The different results between morphometry and densitometry are likely to be due to increrr ent angles in the skin furrows with ageing. (Kor J Dermatol 1997;35(2): 292-302)

피부 병변이 동반된 파종성 칸디다증

조호연 ( Ho Youn Jo ),김동준 ( Dong Jun Kim ),최현철 ( Hyun Chul Choi ),오칠환 ( Chil Hwan Oh ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.4

Candidiasis is the most common fungal infection complicating the course of patients with hematologic malignant neoplasms. Although widespread organ involvement is characteristic of disseminated candidiasis, reports of skin are rare. Reports describing typical clinical and histopathological finding of cutaneous lesions are very important since it may enable a diagnosis of disseminated candidiasis to be made and thus antifungal therapy can be initiated earlier. A 50-year-old housewife was admitted with a 5-month history of fatigue and easy bruising. She was diagnosed as ha.ving acute myelocytic leukemia and treatment was begun with daunorubicin and cytosin, arabinoside. Eight days after the start of chemotherapy, she developed a fever and generalized tender well demacated erythematous to purplish papulonodular eruption. A biopsy specimen from the skin lesion showed perivascular mononuclear cell infiltration and spore and pseudohypae v,rere found within the dermis and subcutis in PAS stain. Cultures of one skin biopsy specimen and one of four blood sarnples grew Candida tropicalis. The patient was treated with intravenous amphotericin B for disseminated candidiasis. On the tenth day of antifun gal therapy, she developed cardiopulmonary arrest and died. (Kor J Dermatol 1995;33(4): 784-788)

고자장 14.1 T MRI/MRS 시스템에서 양성자 자기공명분광법을 이용한 생체 외 인체피부 보습효과에 대한 연구

최치봉,홍승탁,우동철,윤성익,윤문현,조지현,이철현,정재준,박상용,오칠환,최보영,Choi Chi-Bong,Hong Sung-Tak,Woo Dong-Chul,Yoon Seong-Ik,Yoon Moon-Hyun,Cho Ji-Hyun,Lee Chul-Hyun,Cheong Chae-Joon,Park Sang-Yong,Oh Chil-Hwan,Choe Bo-Young 한국의학물리학회 2006 의학물리 Vol.17 No.2

목적: 초고자장 MRI/MRS 장비를 이용하여 인체 피부조직의 고해상도 자기공명영상과 자기공명 스펙트럼을 얻고자 하였다. 또한 수분억제가 제외된 자기공명 스펙트럼을 이용하여 스킨로션(피부보습제)의 피부 보습효과가 측정가능한지 알아 보고자 하였다. 대상 및 방법: Bruker 14.1 T MRI/MRS 장비를 사용하였다. 자기공명영상을 얻기 위하여 Spin Echo 및 Fast Spin Echo 펄스시퀀스를 사용하였고 자기공명 스팩트럼을 얻기 위하여 PRESS 펄스시퀀스를 사용하였다. 결과: 초고자장 MRI/MRS 장비를 사용하여 인체 피부에 대한 고해상도의 자기공명영상과 자기공명 스펙트럼을 획득하였다. 수분 신호가 포함된 스펙트럼 분석을 통하여 스킨로션을 바르기 전에 비하여 스킨로션을 바른 후에 인체 피부조직의 수분 함유량이 상당히 증가함이 나타났다. 결론: 본 연구는 14.1 T 고자장 MRI/WRS 장비에서 얻은 피부 조직에 대한 고해상도 자기공명영상과 자기공명 스펙트럼이 보습효과를 측정하는 데 사용될 수 있음을 시사해 주고 있다. Purpose: We Investigated to achieve high resolution magnetic resonance (MR) Imaging and spectra of human skin in vitro with using a 14.1 T MRI/MRS system, and to evaluate the hydration effect of a moisturizer by measuring the skin's water concentration. Materials and Methods: We used the Brukrer 14.1 T MRI/MRS system with a vertical standard bore that was equipped with a DMX spectrometer gradient system (200 G/cm at a maximum 40 A), RF resonators (2, 5 and 10 mm) and Para Vision software. Spin echo and fast spin echo pulse sequences were employed for obtaining the high resolution MR images. The 3D-localized point resolved spectroscopy (PRESS) method was used to acquire the MR spectra. Results: The high resolution MR images and spectra of human skin in vitro were successfully obtained on a 14.IT system. The water concentration of human skin after applying a moisturizer was higher than that before applying a moisturizer. Conclusions: The present study demonstrated that the high-resolution MR images and spectra of human skin from a high field MRS instrument could be applicable to evaluating the hydration state of the stratum corneum.

연성 섬유종의 임상적 특징 및 연성 섬유종과 대장용종간의 연관성

조호연 ( Ho Youn Jo ),오용섭 ( Yong Sub Oh ),홍진호 ( Jin Ho Hong ),김재선 ( Jae Sun Kim ),최현철 ( Hyun Chul Choi ),송해준 ( Hae Jun Song ),오칠환 ( Chil Hwan Oh ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.6

Background : Skin tags are benign fleshy or darker colored papillomatous dermal tumors locatei mostly in the neck, axill or groin. Recent reports on a possible association between skin tags and colonic polyps, however, caused interest in these henign tumors of the dermis, especially wite regarding to their frequercy. Objective : The purpose rate this study was to explore the clinical profiles of skin tags, the effect of obesity on the frequeny of skin tags and the association between skin tags and obesity in the normal population. We also tried to evaluate the usefulness of skin tags as a general marker for the presence of colonic piyps. Methods : The first, 524 unselected patients were examined. The patient material comprised of 240 males and 284 females. Each patient was inspected with regard to skin tags by a clermatolgist. 334 patients were classified into obese groups and nonobese groups and then we evaluated the relationship between skin tags and the degree of obesity. The second, ninety consecutive patients referred for coloniscopic evaluation were examined to determine the association between skin tags and colonic polps. Results : We found 22.9% of the males and 22.5% of the females to be skin tag carriers in the general population. We also noticed a steady increase of the frequency according to age eccept for the third decads. Of the skin tags found 51% were in the axillar region, 40% around the neck and 8% in the inguinal region. In the study for the relationship between skin tags and obesity, 44.9% of the obise patients and 23% of the nonobese patients were skin tag carriers(relative risk=1.95, p<0.05). In the study for the association between skin tags and colonic polyps in patients undergoing colonoscopic examination, 18 of patients with skin tags(45%) hnd colonic polyps and 11 of patients without skin tags(22%) had colonic polyps(relative risk=2.05, p<0.05). Conclusion : This study identified an obese group that are at risk of the developing skin tags. Consideration of skin tags as a marker for colonic polyps is likely to prove helpful. (Kor J Dermatol 1995;33(6): 1075-1078)

안구 이상을 동반한 색소 혈관 모반증 1 예

최현철,오칠환,유동수,김진아 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.8

Phakomatosis pigmentovascularis is a neural crest disorder that is found almost exclusively in Asians. Type II is a syndrome in which extensive nevus flammeus is associated with persistent aberrant mongolian spots. We report a case of phakomatosis pigmentovascularis associated with congenital glaucoma in neonate.

몬도르씨 병 ( Mondors disease ) 1예

최현철,오칠환,윤흥석,유동수 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.12

Mondor's disease is an uncommon disorder characterized by superficial thrombophlebitis, classically of thoracoabdominal wall. In about 50%-60% of cases, the cause is not determined, whereas in others it is due to primary or secondary hypercoagulation requiring careful investigation. A 30-year-old woman presented a cord-like tender subcutaneous lesion on the left thoracoabdominal wall and histologic finding reveals thrombophlebitis. We found no evidence of primary and secondary hyper-coagulable states.