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염을균,Ok-Kyung Yang,Ji-Eun Kim,박희정 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.9
We have developed a one-step synthesis of benzofurans from o-iodophenol and various terminal alkynes, by using Pd catalyst supported on nano-sized carbon balls (NCB) under copper- and ligand free conditions. This recyclable catalyst could be reused more than 5 times in the same heteroannulation reaction. The results have demonstrated that diverse 2-substituted benzofurans with tolerant functional groups can be prepared simply and conveniently under these conditions.
Microwave-assisted Transition Metal-catalyzed Coupling Approach to Indazole Diversity
오유진,염을균 대한화학회 2019 Bulletin of the Korean Chemical Society Vol.40 No.5
Diverse mono or biaryl substituents were introduced to indazole moieties under microwave-assisted palladium-catalyzed coupling reactions with isomeric bromoindazoles and aryl boronic acids. 1,3-Disubstituted indazoles were also obtained by C?C or C?N coupling of monosubstituted indazoles with functionalized terminal alkenes and arylhalides. Facile introduction of diverse substituents to indazoles showed useful synthetic approach for creating indazole compound library to discover biologically active small molecules.
박아름,염을균 대한화학회 2018 Bulletin of the Korean Chemical Society Vol.39 No.11
Diverse functional groups were introduced in isoquinolines under microwave-assisted palladium- or copper-catalyzed coupling reactions, which include functional groups to isoquinoline were achieved with 1-substituted 4- and 7-bromoisoquinolines, arylboronic acids, terminal alkenes, terminal alkynes, and azaheterocycles. 1,4- or 1,7-Disubstituted isoquinolines were obtained in moderate to excellent yields within 1 h under microwave irradiation. The facile functional group modification of isoquinoline core could establish isoquinoline compound library for drug discovery.
마이크로파와 금속 촉매를 이용한 Pyrrolo[3,2-d]-pyrimidine 유도체의 다양화
변정섭,염을균,김영준 대한화학회 2022 대한화학회지 Vol.66 No.6
Diverse pyrrolo[3,2-d]pyrimidines that are expected to exhibit bioactivity were synthesized through O-aryla- tion and Suzuki coupling reactions. Microwave-assisted O-arylation was successfully performed using a Cu metal catalyst, so that 4 position of pyrrolo[3,2-d]pyrimidine could be substituted with phenol group. In addition, 4-aryl substituted pyrrolo[3,2- d]pyrimidines were synthesized with good to excellent yields by microwave-assisted Suzuki coupling reaction using a Pd metal catalyst. By using microwaves as reaction conditions for diversification of derivatives, it was possible to dramatically overcome the disadvantages of traditional heat reactions of long reaction times and heat transfer efficiency problems. The result of this study can be used to be diversify pyrrolo[3,2-d]pyrimidine derivatives, which are expected to play an important role in the drug discovery research. 생리학적 활성을 보일 것으로 기대되는 다양한 pyrrolopyrimidine 유도체를 O-arylation과 Suzuki 짝지움 반응을 통해 합성하였다 . 금속 촉매 Cu를 사용하고 마이크로파 조사 조건에서 O-arylation을 성공적으로 진행하여 pyrrolo[3,2-d]pyrimidine의 4번위치에 phenol기를 도입할 수 있었다 . 또한 , 금속촉매 Pd를 사용하는 Suzuki짝지움 반응도 마이크로파를 사용하여 pyrrolo[3,2- d]pyrimidine의 4번 위치에 aryl 기를 도입할 수 있었다 . 유도체의 다양화를 위한 반응 조건으로 마이크로파를 사용함으로써 긴 반응 시간과 열전달 효율성 문제를 가지고 있는 전통적인 열 반응의 단점을 획기적으로 극복할 수 있었다 . 본 연구 결과는 신약개발 연구에 중요한 역할을 할 것으로 기대되는 pyrrolo[3,2-d]pyrimidine 유도체를 다양화하는데 사용할 수 있다.
박희정,김지은,염을균,김영훈,한창우 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.1
Three types of isomeric 2-substituted furo[3,2-b]pyridine, furo[2,3-b]pyridine and furo[3,2-c]pyridine were prepared using Pd/C-catalyzed heteroannulation of o-halopyridinols and terminal alkynes under copperand ligand-free conditions. We also demonstrated that double functionalization yielding 2,3-disubstituted furopyridines could be achieved through heteroannulation followed by bromination and Suzuki/Heck reactions. In addition, the use of recoverable Pd/C in the absence of a cocatalyst and ligand can aid in the development of greener chemical processes.
Fluorescence Chemosensor for Zn(2+) with Indene-1,3-dione Derivative
오유진,안경룡,염을균,전근 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.0
A fluorescent sensor based on Indene-1,3-dione derivative (sensor 1) for Zn(2+) was synthesized through the reaction of salicylaldehyde and 1,3-Indandione . The sensor 1 showed a high selectivity and sensitivity toward Zn(2+) in DMSO/H2O (v/v = 7:3, pH = 8.04) . It showed a 50 nm Blue-shift of fluorescence emission band upon addition of Zn(2+). And the fluorescence emission intensity increased upon addition of Zn(2+). The 1:1 stoichiometry of sensor complex 1+Zn(2+) was confirmed by Job`s plots based on fluorescence emission titration.
박아름,최성민,김태성,염을균 대한화학회 2019 Bulletin of the Korean Chemical Society Vol.40 No.11
Microwave-assisted synthesis of 5,6,7-trisubstitutedpyrrolo[2,3-d] pyrimidines viapalladium-catalyzed heteroannulation with internal alkynes AreumPark, Sung Min Choi, Tae Sung Kim, and Eul Kgun Yum.