인두주위간극으로 확장된 경부 하마종의 증례보고

신정현,박주용,지영민,송인석,방강미,최성원,Shin, Jung-Hyun,Park, Joo-Young,Ji, Young-Min,Song, In-Seok,Pang, Kang-Mi,Choi, Sung-Weon 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.6

Running title: A plunging ranula extended into parapharyngeal space Ranulas are lesion of sublingual gland origin, which occur in the floor of the mouth. Most ranulas, whether simple or plunging, are pseudocysts without and epithelial lining and ranulas have higher levels of salivary amylase and protein content. They can be classified into two types based on their extent: simple ranulas, confined to the sublingual space and plunging ranula which extend into adjacent spaces. Plunging ranula requires differential diagnosis with other lesions (neuroma, monomorphic adenoma, hemangioma, lipoma, dermoid cyst, lateral cervical cyst). The patient was diagnosed as plunging ranula. We experienced 17 years old male, visited to our department, who complain Rt. cervical swelling and in MRI view, this lesion involved sublingual, submadibular, parapharyngeal, skull base. We experienced a rare case of plunging ranula, extended into parapharyngeal space. We report the case.

방과 후 체육특기적성 활동참여가 학생들의 신체적 자기효능감과 학교생활만족도에 미치는 영향

신정현(Jung Hyun Shin),전선혜(Sun Hye Jun) 한국여성체육학회 2012 한국여성체육학회지 Vol.26 No.3

The aim of the study was to investigate the various effects of after-school physical activities on the degree of students` physical self-efficacy and of their satisfaction in school life. The effects were assessed through questionnaires from 600 students at four high and middle schools in Seoul. Data were analyzed using the independent t-test model, one-way analysis of variance (ANOVA), and the Duncan test was applied as a posteriori test. The following is a summary of the main findings. First, students who participated in after-school extracurricular activities reported higher levels of physical self efficacy (PSE) and school life satisfaction. Second, individual activities facilitated increases in students perceived levels of PSE, satisfaction with school life in class, and their relationships with peers than group activities. Third, positive reinforcements of the findings were evident through a prolonged participation in the after-school extracurricular activities, Fourth, it was observed that students felt more confident and satisfied with noted improvements in their ability of physical expression and their level of PSE, The results of this research indicate the importance of after-school extracurricular activities and highlight the benefits of physical activities on students lives.

韓國政治學의 課題

申正鉉(Jung Hyun Shin) 한국정치학회 1996 한국정치학회보 Vol.30 No.1

東北亞의 國際情勢와 日本-北韓關係의 變化

申正鉉(Jung Hyun Shin) 한국정치학회 1982 한국정치학회보 Vol.16 No.-

남북한 상호정책과 한반도 평화체제 모색 - `99 통일문제학술세미나 한반도 평화체제구축의 과제 - 신뢰구축 문제와 관련해서 -

신정현(Jung Hyun Shin) 조선대학교 동북아연구소 2000 동북아연구 Vol.13 No.-

N/A

남북한(南北韓) 대화(對話)의 국내외적(國內外的) 환경(環境)

신정현 ( Jung Hyun Shin ) 평화문제연구소 1989 統一問題硏究 Vol.1 No.1

The purpose of this paper is to investigate some environmental factors that facilitate contacts and dialogue between South and North Korea. Since the conclusion of the armistice agreement in 1953, the two Koreas have maintained a highly tension-ridden relationship, which has become a major element causing the instability and insecurity within and without the Korean peninsula. Those factors are divided into three catagories : They are psycological, operational and international ones. First, the psycological category refers to the perceptions and attitudes of Koreans toward each of the two divided parts. Second, the operational category includes socio-political and economic factors of South and North Korea, which have contributed to the sustaining of different ideas, systems and policies in each part. Third, the international category mainly concerns the global and regional situations which have something particular to do with the Korean peninsula. In this category, diplo-strategic interests and the power configuration among the four major powers, the United States, the Soviet Union, China(PRC) and Japan are deeply examined with the assumption that those factors exert important influence on the development of South - North Korean dialogue. Despite the July 4 the cornmorn communique in 1972, which both sides agreed that Korean unification must be attempted peacefully as well as indepentently, one`` s perceptions and attitudes toward the other are still conflicting and even antagonistic. The people of both Koreas considerably share enemy-images toward each other. These psycological and perceptual factors have been formed through the Korean War and subsequent development of confrontation and conflicts along the de-militarized zone between the two Koreas, It is certain that these factors are highly disfunctional to the improvement of South and North Korean relations. Meanwhile, some operational factors, demonstrating certain changes in political structures and processes, are expected to have positive influences on the opening of dialogue between the two Koreas. Most important are the over-all processes of democratization which is under way in South Korea, and the generational changes in ruling circles and the adoption of open -door policy in North Korea. But these changes will gradually take place, and have some influences on the improvement of inter- Korean relations. Lastly, current international environments surrounding the Korean peninsula prove to be favorable to the maintenance of a stable relationship and to the conduct of negotiations between the two Koreas. The growing mood of detente among the four major powers and their respective relations with the two Koreas will be certainly conducive to the creation of a stable peace structure in the Korean peninsula, which may in turn contribute to the regional stability in Northeast Asia. Although psycological and perceptual factors remain unchanged, it is assumed that they are also affected by the change in operational and international environments. To sum up, the inter-Korean relations are surely entering into a new era that may facilitate the peaceful solution of the unification problem through contacts and dialogue between both`` sides, What is most necessary is that both Koreas increace their capabilities to adopt themselves to the changing environments, which keeping self-restrained interactions between themselves.

흡연에 의해 유발된 급성 호산구성 폐렴 2예

신정현 ( Jung Hyun Shin ),권용은 ( Yong Eun Kwon ),윤성호 ( Sung Ho Yoon ),이승일 ( Seung Il Lee ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.4

Acute eosinophilic pneumonia (AEP) is characterized by idiopathic febrile illness with short duration, severe hypoxemia, diffuse pulmonary infiltration, and eosinophilia in bronchoalveolar lavage fluid. We experienced two cases of AEP following smoking. They started smoking cigarette 3 weeks prior to admission and presented typical clinical and radiological characteristics of AEP. No cause of AEP was identifiable apart from smoking. One patient had never smoked, and the other was an ex-smoker who started small amount smoking 2 years ago but quitted 1 year ago. Pneumonia-like respiratory symptoms were improved after high-dose systemic steroid applied. After an 8-week cessation of cigarette smoking, one of them has resumed smoking 10∼20 pieces per day again. He did not experience any symptom except flu-like symptoms on the seventh day. Chest radiographs showed no infiltration, and flu-like symptoms subsided without any specific therapy. This suggests that cigarette smoking led to AEP in this patient and tolerance might develop against chronic repeated resumption of smoking cigarettes. We should pay attention to awareness of cigarette smoking-induced AEP, especially among the younger generation who started smoking recently. (Korean J Asthma Allergy Clin Immunol 2007;27:277-282)

World War 1 and the Bolshevik Revolution

신정현 ( Jung Hyun Shin ) 慶熙大學校 社會科學硏究院 1982 社會科學硏究 Vol.8 No.-

폐암세포주에서 저용량 시스플라틴에 의해 유도된 자가포식

신정현 ( Jeong Hyun Shin ),장혜연 ( Hye Yeon Jang ),정진수 ( Jin Soo Chung ),조경화 ( Kyung Hwa Cho ),황기은 ( Ki Eun Hwang ),김소영 ( So Young Kim ),김휘정 ( Hui Jung Kim ),이삼윤 ( Sam Youn Lee ),이미경 ( Mi Kung Lee ),박순아 ( 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.69 No.1

Background: Most lung cancer patients receive systemic chemotherapy at an advanced stage disease. Cisplatin-based chemotherapy is the main regimen for treating advanced lung cancer. Recently, autophagy has become an important mechanism of cellular adaptation under starvation or cell oxidative stress. The purpose of this study was to determine whether or not autophagy can occurred in cisplatin-treated lung cancer cells. Methods: H460 cells were incubated with RPMI 1640 and treated in 5 μM or 20 μM cisplatin concentrations at specific time intervals. Cells surviving cisplatin treatment were measured and compared using an MTT cell viability assay to cells that underwent apoptosis with autophagy by nuclear staining, apoptotic or autophagic related proteins, and autophagic vacuoles. The development of acidic vascular organelles was using acridine orange staining and fluorescent expression of GFP-LC3 protein in its transfected cells was observed to evaluate autophagy. Results: Lung cancer cells treated with 5 μM cisplatin-treated were less sensitive to cell death than 20 μM cisplatin-treated cells in a time-dependent manner. Nuclear fragmentation at 5 μM was not detected, even though it was discovered at 20 μM. Poly (ADP-ribose) polymerase cleavages were not detected in 5 μM within 24 hours. Massive vacuolization in the cytoplasm of 5 μM treated cells were observed. Acridine orange stain-positive cells was increased according in time-dependence manner. The autophagosome-incorporated LC3 II protein expression was increased in 5 μM treated cells, but was not detected in 20 μM treated cells. The expression of GFP-LC3 were increased in 5 μM treated cells in a time-dependent manner. Conclusion: The induction of autophagy occurred in 5 μM dose of cisplatin-treated lung cancer cells.

원발성 폐암에서 혈장 과립구 자극인자의 암표지자로서의 역할과 의의

송정섭 ( Jung Sub Song ),김소영 ( So Young Kim ),조향정 ( Hyang Jeong Jo ),이강규 ( Kang Kyoo Lee ),신정현 ( Jeong Hyun Shin ),신성남 ( Seong Nam Shin ),김동 ( Dong Kim ),박성훈 ( Seong Hoon Park ),이영진 ( Young Jin Lee ),고창보 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.66 No.6

연구배경: 폐암은 진단 당시에 완치할 수 있는 확률이 적어 예후가 불량한 종양으로 알려져 있어, 폐암 진행을 예측할 수 있는 암 표지자(tumor marker)의 발굴이 필요한 실정이다. 그러나 폐암에서 아직까지 특이적인 항원이 없고 현재까지 알려진 많은 종양관련 항원들의 민감도가 떨어지기 때문에 보편화되지 못하고 있다. 본 연구에서는 원발성 폐암 환자에서 혈장 G-CSF를 측정하고 암의 진행 및 예후와 관련이 있는지 알아보고자 하였다. 방법: 원발성 폐암으로 진단된 100명 환자와 건강 검진에서 이상 소견이 없는 127명 정상인을 대상으로 하였다. 결과: 정상인에서 혈장 G-CSF 농도는 12.2±3.6 pg/mL (mean±SD), 폐암환자에서는 46.0±38.0 pg/mL였다(p<0.001). 비소세포폐암에서 G-CSF 농도는 유의하게 소세포폐암보다 높았으며(p<0.05), 비소세포 폐암중 대세포 폐암이 가장 높았고, 편평세포암, 선암, 세기관지폐포암 순이었다. G-CSF 농도는 국소형보다는 진행형 비소세포폐암에서 증가하는 경향을 보였다. 또한 타 장기로의 전이가 있을 때 유의하게 증가하였으며(p<0.05), 다발성 전이에서는 뇌, 부신, 골 전이 순으로 혈청 G-CSF 농도가 증가하는 경향이었다. 결론: 혈장 G-CSF 농도는 폐암이 진행한 경우, 특히 타 장기로의 전이가 있을 때 유의하게 증가하였다. 그러므로 진행형 폐암의 추적관찰에 이용할 수 있으리라 사료된다. Background: Biomarkers for cancer have several potential clinical uses, including the following: early cancer detection, monitoring for recurrence prognostication, and risk stratification. However, no biomarker has been shown to have adequate sensitivity and specificity. Many investigators have tried to validate biomarkers for the early detection and recurrence of lung cancer. To evaluate plasma G-CSF as such a biomarker, protein levels were measured and were found to correlate with the clinicopathological features of primary lung tumors. Methods: Between December 2006 and May 2008, 100 patients with histologically-validated primary lung cancer were enrolled into this study. To serve as controls, 127 healthy volunteers were enrolled into this study. Plasma G-CSF levels were measured in lung cancer patients using the sandwich ELISA system (R & D inc.) prior to treatment. Results: The mean plasma G-CSF levels were 12.2±0.3 pg/mL and 46.0±3.8 pg/mL (mean±SE) in the normal and in the cancer groups, respectively. In addition, plasma G-CSF levels were higher in patients with early lung cancer than in healthy volunteers (p<.001). Plasma G-CSF levels were higher in patients who were under 65 years old or smokers. Within the cancer group, plasma G-CSF levels were higher in patients with non small cell lung cancer than in patients with small cell lung cancer (p<.05). Overall, plasma G-CSF levels were shown to increase dependent upon the type of lung cancer diagnsosed. In the order from highest to lowest, the levels of plasma G-CSF tended to decrease in the following order: large cell carcinoma, squamous cell carcinoma, adenocarcinoma, and bronchioloalveolar carcinoma. Plasma G-CSF levels tended to be higher in patients with advanced TNM stage than in localized TNM stage (I, II<III, IV). Increased levels were also seen in patients with distant metastasis in the order of bone, adrenal gland involvement. Conclusion: Plasma G-CSF level were significantly increased in patients with lung cancer, and in especially advanced TNM stage. These results suggest that plasma G-CSF can be used to support the diagnostic process of lung cancer staging and as an indicator of metastasis.