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본태성 고혈압 환자 적혈구막의 Na+ - Li+ Countertransport 에 관한 연구
신영우(Yung Uoo Shin),신영기(Yeong Kee Shin),손성표(Seong Puo Son),이동일(Dong Il Lee),김용근(Yong Kun Kim) 대한내과학회 1991 대한내과학회지 Vol.41 No.4
N/A In order to investigate the changes of Na+ transport system of the red blood cells in patients with essential hypertension, N+-Li+ countertransport was measured in 30 cases of essential hypertension and 20healthy normal controls. Furthermore, these measurements were analyzed in terms of some important clinical parameters in patients with essential hypertension, i.r., body mass index (BMI), status of hypertension, and plasma lipids. Na+-Li+ countertransport in the patient group significantly increased compared with the control group (62.2±4.5 and 46.8±3.0㎛ol/L cells.hr). In the analysis regarding the relationship between the Na+-Li+ countertransport system and some important clinical parameters of the patients with essential hypertension, Na+-Li+ countertransport was related to BMI, and the level of triglycerides did not show any significant relationship with the level of blood pressure, WHO class, and the level of cholesterol. These results suggest that Na+-Li+ countertransport systems in essential hypertensive patients were significantly altered compared with normal healthy controls but overlapped considerably between the 2groups.
정원태(Won Tae Chung),신영기(Yeong Kee Shin),배상균(Sang Kyun Bae),이민기(Min Ki Lee),이동일(Dong Il Lee),문창형(Chang Hyung Moon) 대한내과학회 1994 대한내과학회지 Vol.47 No.5
N/A Objectives: The study was designed to establish normal serum lipid levels in the Korean adult population and to identify the effect of sex, age, blood pressure, body mass index (BMI), smoking, alcohol consumption, exercise, economic status, occupation and location on the serum lipid levels. Methods: The serum total cholesterol and triglyceride distribution in the normal Korean adult population were studied in 5,342 cases (males 2,834 and females 2,508) in the age groups of 3rd to 8th decades. Data were collected from 33 institutes and hospitals throughout the country during the period of June 1989 to December 1990. The serum lipid level were examined in the state of fasting of at least 12 hours and by the enzymatic method, Results: The mean level of serum total cholesterol was 183.6 mg/dl. Males had 181.9 mg/dl and females had 185.5 mg/dl without statistical significance between gender, but levels were significantly higher in the 4th decade in males and in the 6th, 7th and 8th decades in females. The mean level of serum triglyceride was 131.9 mg/dl. Males had 140.5 mg/dl and females had 122.2 mg/dl without statistical significance between gender, but levels were significantly higher in the 4th and 5th decades in males and in the 7th decade in females. The lipid levels rose gradually with the increase of age. The peak of serum total cholesterol and triglyceride level for the males was in the 6th decade and that for the females was in the 7th decade. The incidence of hypercholesterolemia with the standard of 240 mg/dl or more was 8.7% Males had 7.2% and females had 10.4% with the significantly higher incidence in females. The incidence of more than 220 mg/dl was 17.5% Males had 15.1% and females had 19.2% with higher incidence in females having statisticai significance. But there was no significant difference between big cities (cities controlled by central government) and smaller cities & towns in the incidence with either standard of levels. The incidence of hypertriglyceridemia of more than 200 mg/dl was 15%. Males had 18.0% and females had 11.5% with the significantly higher incidence in males. The incidence of more than 150 mg/dl was 29.1%. Males had 33.2% and females had 24.3% with higher incidence in males being significance. There was no significant difference between big cities and smaller cities & towns, The incidence of low serum total cholesterol less than 140 mg/dl was 12.4%, Males had 13.0%, and females had 11.7% without significant difference between gender. The incidence of less than 120 mg/dl was 3.7%. Males had 4.2% and females had 3.2%. It was significantly higher in males, and in the comparison between big cities and smaller cities & towns the incidence was significantly higher in smaller cities k towns compared with big cities in the standard of 140 mg/dl but not in the standard of 120 mg/dl. The significantly related factors for the serum total cholesterol level were age, sex, BMI, systolic blood pressure, occupation, location and family history. For the triglyceride level age, sex, BMI, diastolic blood pressure and smoking were the significantly related factors. Conclusion: The results of this research indicates that present lipid level profile in the adult Koreans is not a serious health situation. Additional research and on- going studies should be made to update this study. In addition an educational campaign to inform the medical profession and citizens of the danger of this health problem should be undertaken to avoid the health problems faced by other advanced countries.
연속파형 Doppler 법에 의한 폐동맥압의 비관혈적 계측
차광수(Kwang Soo Cha),전국진(Kook Jin Chun),신지애(Ji Ae Shin),이동일(Dong Il Lee),이정유(Jung Yoo Lee),이종수(Jong Soo Lee),신영우(Yung Woo Shin),신영기(Yeong Kee Shin),양만석(Man Seok Yang),권형각(Hyong Gak Kwon) 대한내과학회 1991 대한내과학회지 Vol.41 No.5
N/A In order to assess the possibility of noninvasive estimation of pulmonary artery pressure by Doppler echocardiography, pulmonary artery pressures estimated by continuous wave Doppler echocardiography were compared with those measured by cardiac cath-eterization in 10 patients with tricuspid and pulmonary regurgitation. Doppler-determined pressure gradients were estimated from the tricuspid and pulmonary regurgitant flow velocity(V) by means of the simplified Bernoulli equation(ΔP =4v²). The results were as follows: Pressure gradients (PGs) between right ventricle and right atrium at systole measured by Doppler method and catheterization were 58.05±11.67, 59.12±13.78 mmHg, respectively, and correlated well with each other (r=0.95, p<0.01). As for pulmonary arterial systolic pressure (PASP), PGs added by assumed (5 mmHg) right atrial pressure (RAP) and by actual RAP, and catheter-measured PASP were 63.05±11.67, 63.93±11.59, 66.30±12.26mmHg, respectively, and PGs added by assumed RAP and by actual RAP correlated well with catheter-measured PASP, respectively (r=0.97, p<0.01; r=0.98, p<0.01). The PGs between pulmonary artery and right ventricle at end-diastole measured by Doppler method and catheterization were 20.48±4.35, 20.90±4.87, respectively, and correlated well with each other (r=0.97, p<0.01). As for pulmonary arterial diastolic pressure (PADP), the PGs added by assumed (5 mmHg) right ventricular end-diastolic pressure (RVEDP) and by actual RVEDP, and catheter-measured PADP were 25. 48±4.35, 26.38±4.04, 26.80±4.40mmHg, respectively, and PGs added by assumed RVEDP and by actual RVEDP correlated well with catheter-measured PADP, respectively (r=0.96, p<0.01; r=0.96, p<0.01). Doppler-determined PG between the pulmonary artery and right ventricle at early diastole and catheter-measured mean pulmonary arterial pressure were 37.30±6.31, 40.30±5.53mmHg, and correlated well with each other (r=0.81, p<0.01). In conclusion, pulmonary arterial systolic, diastolic pressure and mean pulmonary arterial pressure could be well predicted noninvasively by continuous wave Doppler echocardiography in patients with tricuspid and pulmonary regurgitation,
이정유(Jung Yoo Lee),차광수(Kwang Su Cha),이종수(Jong Su Lee),김진도(Jin Do Kim),이형유(Hyung Yoo Lee),송철수(Chul Soo Song),신영우(Yung Uoo Shin),신영기(Yeong Kee Shin) 대한내과학회 1991 대한내과학회지 Vol.41 No.3
N/A The Authors investigated the serial change of serum lipids in the early period of acute myocardial infarction and its relation to several clinical parameters. The level of serum total cholesterol was lowest in the period of 2 to 5days after an attack of acute myocardial infarction, especially on the fourth day and thereafter increased gradually until 2 to 3weeks of the observation period. On the other hand the serum triglyceride level was lowest in the first 2days, especially the first day, and thereafter increased gradually until 2 to 3weeks of the observation period. The extent of the cholesterol change was very small compared with that of the triglyceride. The level of change in the serum cholesterol was not related to the ejection fraction, the frequency of ventricular arrhythmia, Killip class or fatality rate. On the otherhand the level of change in the serum triglyceride had a significant adverse influence on the ejection fraction, the frequency of ventricular arrhythmia, Killip class and fatality rate, respectively. Thus it seems that the initial change of serum triglyceride is somewhat helpful in foreseeing the outcome of acute myocardial infarction.
하태정(Tae Jung Ha),이선희(Sun Hee Lee),정영태(Young Tae Jung),박병규(Peong Kew Park),김용기(Yong Ki Kim),박순규(Soon Kew Park),신영기(Yeong Kee Shin) 대한내과학회 1996 대한내과학회지 Vol.50 No.3
N/A Objectives: Diabetes mellitus was known to cause a variety of complications, and was highly sensitive to the infections. Based on this fact, the studies which suggested the relationship between diabetes and pulmonary tuberculosis have been reported for a long time. With some exceptions, the prevalence of pulmonary tuberculosis was significantly higher in diabetic patients compared with non-diabetics and, especially, occurrence of tuberculosis in the lower lung field was strongly emphasized in diabetic patients. Author analyzed the clinical characteristics of patients with pulmonary tuberculosis complicated with diabetes mellitus and control group who were pulmonary tuberculosis without diabetes. Methods: The medical records of 582 patients who admitted with diabetes mellitus at Pusan National University Hospital from January 1, 1993 to July 30, 1994 were reviewed. Among them, 50 patients with pulmonary tuberculosis complicated with diabetes were investigated. As a control groups, 50 nondiabetic patients with pulmonary tuberculosis who were admitted to this hospital during the same period and were matched according to age and sex were evaluated. In addition, to examine the relationship between patients with pulmonary tuberculosis complicated with diabetes and control group, author partly used the Report on the Sixth tuberculosis Prevalence Survey as a another control group. Lower lung field tuberculosis was defined as tuberculosis involving the right middle lobe, left lingula segments, and one or both lower lobes without upper lobe lesions. Results: 1) Among 582 diabetic patients, 50 cases(8.6%) had pulmonary tuberculosis on chest X-ray and 40 cases(6.9%) were positive acid fast bacilli on sputum smear, it was much higher incidence compared with control group, 2.3% and 0.35% respectively. 2) Thirty six(12.5%) of 287 male and 14(4.7%) of 295 female diabetic patients had pulmonary tuberculosis, the overall sex ratio was 2.7 versus l. 3) According to the radiological classification of pulmonary tuberculosis in 50 diabetic patients, minimal tuberculosis cases were 16(32%), moderate advanced cases were 20(40%), and far advanced cases were 14(28%). The ratio of the moderate advanced and the far advanced pulmonary tuberculosis in diabetics was higher than the control group. 4) Ten of 50 patients with diabetes were noted to have only lower lung field involvement in both lung fields, however no lower lung field disease was observed in nondiabetic group. Among 10 diabetic patients with lower lung field tuberculosis, 9 cases(90%) were bacteriologically confirmed, of the 50 patients with pulmonary tuberculosis complicated with diabetes occurred in the right upper lobe with 33(66%), in the right middle lobe with 9(18%) and in the right lower lobe with 16(32%). On the other hand in the left lung, the frequency was 25(50%) in the left upper lobe, 9(18%) in the lingula segments and 13(26% in the left lower lobe. 5) The incidence of hemoptysis was higher in the patients with pulmonary, tuberculosis complicated diabetes(28%, 14 of 50) than in the control group(12%, 6 of 50)(p<0.05). Conclusion: By the above results, it could be concluded that the diabetic patients had much more incidence of prevalence, hemoptysis and moderated and far advanced pulmonary tuberculosis compared with controul group, and had a high possibillity of pulmonary tuberculosis in the lower lung field.