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심소연,신세린,김진상,Shim, So-yeon,Shin, Se-rin,Kim, Jin-shang 대한수의학회 2001 大韓獸醫學會誌 Vol.41 No.4
Evidence from the last 10 years have been suggested that melatonin mainly produce a depressant effect on the cardiac system, but we found an activating effect of melatonin on heart rate in this research. To determine the hypothesis that melatonin has dual effects on physiological behaviour of cardiac system, we investigated the effects of melatonin on heart rate in isolated rat atria and anesthetized rats. Regardless of concentration, melatonin produced bradycardia in the 84 cases of 148 experiments (57 %) and tachycardia in the 64 cases of 148 experiments (43 %). And in atrium, melatonin produced a decrease automaticity in 52 cases of 86 experiments (60 %) and increase automaticity in 40 % (34/86 cases). Also, these effects are not significnat relationship with concetration of melatonin. The melatonin-induced bradycardia in vivo was inhibited by pretreatment of atropine or bilateral cervical vagotomy. Also, in isolated atrium the melatonin-induced decrease in automaticity was inhibited by pretreatment of atropine. These melatonin-induced responses were potenitated by pretreatment of propranolol. The melatonin-induced tachycardia in vivo was inhibited by pretreatment of propranolol, nifedipine or bilateral cervical vagotomy, but not by pretreatment of atropine. The melatonin-induced incease in automaticity in isolated atrium was converted to decrease in automaticity by pretreatment of propranolol. In addition, the change in heart rate caused by adrenoceptor agonists was inhibited by pretreatment of melatonin. These results indicate that melatonin-induced bradycardia may be related to a muscarinic receptor activation and melatonin-induced tachycardia may be related to a $\beta$-adrenoceptor stimulation.
Effect of Acute High-intensive Swimming Exercise on Blood Electrolytes and Metabolites
김상진,박혜민,신세린,전설희,김진상,강형섭 한국임상수의학회 2010 한국임상수의학회지 Vol.27 No.3
Magnesium (Mg2+) is an essential co-factor for over 325 physiological and biochemical processes so that plays a central role of neuronal activity, cardiac excitability, neuromuscular transmission, muscular contraction,vasomotor tone, and blood pressure significantly related to physical performance. However, only limited information on blood ionized Mg2+ (iMg2+) regarding to physical exercise is available and the data from blood total Mg2+ detection are inconsistent. This present study investigated the changes of blood iMg2+ correlated with metabolic demands during acute high-intensive exhaustive physical exercise in rats. After exhausted swimming (3-4 hours), blood pH, glucose,HCO3-, oxygen and ionized Ca2+ (iCa2+) were significantly decreased, whereas lactate, carbon dioxide, iMg2+, ionized Na+ and ionized K+ were significantly increased. During the exhausted swimming, the changes in iMg2+ showed a significant negative correlation with changes in pH, glucose, HCO3- and iCa2+, however a significant negative correlation with changes in lactate and anionic gap. It is concluded that the acute high-intensive exhaustive physical exercise could produced hypermagnesemia, an increase in blood iMg2+ via stimulation of iMg2+ efflux following increase in intracellular iMg2+ from muscle induced by metabolic and respiratory acidosis.