특집 : 여성 성 기능 장애에 대한 동양 전통의 성 의학적 치료 ( Special Edition : Treatment of Oriental Medicine on Female Sexual Dysfunction )

장준복(Jun Bock Jang),송병기(Byung Key Song) 경희대학교 경희의료원 1996 慶熙醫學 Vol.12 No.1

少腹逐瘀湯의 效能에 關한 實驗的 硏究

金恩基,張峻福,李京燮,宋炳基 慶熙大學校 1995 論文集 Vol.24 No.-

This experiment was performed on analgesic, anti-pyretic, sedative, anti-swelling, anti-thrombotic, anti-tumor effect and response of isolated uterus by administrating high and low concentration of Sopokchukeotang's hot-water-extract to experimental animals. This administration purpose to investigate the efficacy of the Sopokchukeotang which is known as having effects on treating female genital diseases on basis of oriental medicine literature and its clinical use. The results obtained were as follows: 1. The writhing syndrome induced by acetic acid was decreased by administration of the Sopokchukeotang's hot-water-extract. However, there was no statistical significance between sample and control group. 2. The administration of the Sopokchukeotang's hot-water-extract elevated the pain threshold significantly by on hindpaw edema induced by 1% carrageenin in rat. 3. Abnormally elevated body temperature induced by thyphoid vaccine was decreased by the administration of the Sopokchukeotang's hot-water-extract. But, there was no statistical significance. 4. Sleeping time induced by Pentobarbital-sodium was prolonged by the administration of the Sopokchukeotang's hot-water-extract. However significant effect was recognized only in the treated by low concentration group(p<0.05). 5. The significant decrease of swelling induced by carrageenin was noted in the group treated by high concentration(p<0.05, p<0.01). 6. The group treated by low concentration showed significant anti-swelling effect on the swellings induced by yeast, but not in the group treated by high concentration didn't show it(p<0.05). 7. The serum FDP was decreased significantly by administrating the Sopokchukeotang's hot-water-extract to the experimental thrombosis(p<0.05, p<0.01). 8. The serum fibrinogen was increased significant by the administration of the Sopokchukeotang's hot-water-extract on the experimental thrombosis(p<0.01, p<0.001). 9. The prothrombin time was not influenced by the adminstration of the Sopokchukeotang's hot-water-extract on the experimental thrombosis. 10. The administration of the Sopokchukeotang's hot-water-extract did riot make a prolongation the survival in Saroma 180 ascitic tumor implanted Rats. 11. The administration of the Sopokchukeotang's hot-water-extract had no effect on the normal movement of the isolated uterus. However, it showed the relaxation effect on the oxytocin induced muscle contraction of the isolated uterus. According to the above results, it might be recognized that the Sopokchukeotang's hot-water-extract has the effect of analgesia, anti-pyrexia, sedation, anti-swelling, anti-thrombosis and relaxation effect on the oxytocin induced contraction of uterus muscle. However, anti-tumor effect of Sopokchukeotang's hot-water-extract was not appeared in the experiments. According to the above results. Sopokchukeotang's not-water-extract can be applied on the various inflammatory diseases in female genital organs.

한약이 임신중 태아에 미치는 영향(III) : 한약 및 한약 처방이 돌연변이원성과 염색체이상에 미치는 효과

김동현,이영경,김남재,장존복,송병기 경희대학교 동서의학연구소 2000 東西醫學硏究所 論文集 Vol.2000 No.-

Oriental herbal medicines were examined for mutagenicity in the reverse mutation test on Salmonella typimurium TA98/00 and chromosomal aberration test on cultured mammalina cells (Chinese hamster cell lines). The reverse mutation test was performed by a plate incorporation method with or without a metabolic activation system (S9 mix). Antaeeum, Aurantii Fructus and Kyoaekungkuetang significantly increased revertivle colonies on Salmonella typimurium TA 98 under the condition without S9 mix. Bojungikkitang significantly increased revertible colonies on Salmonella typimurium TA 100 under the condition with S9 mix than under the condition without S9 mix. The other tested herbal medicines did not significantly increased revertible colonies on any of the test strains under the condition with or without S9 mix. In the chromosomal aberration test. most tested herbal medicines did not significantly increased the number of aberrant cells under the conditions with S9 mix at concentrations of 1mg/ml, compared with the vehicle control. However, Gelatinum, Artemisiae Asiaticae Herba and Antaegumchultang, Kungsosan slightly increased revertivle colonies on any of the test strains under the conditions with S9 mix than under condition without S9 mix. These results indicate that most herbal medicines might be carefully used in obstetrics and gynecology, although they do not have the potent mutagenic potential under the present test conditions.

水蛭, 맹충, 斑猫가 姙娠에 미치는 影響

宋炳基,李京燮,金恩基 慶熙大學校韓醫科大學韓醫學硏究所 1996 慶熙韓醫大論文集 Vol.19 No.2

It is acknowledge that Hirudo, Tabanus and Mylabris are contraindicated drugs of pregnancy. The present work was done to investigate the influences of Hirudo, Tabanus, Mylabris on pregnancy. The extracted and condensed liquid of Hirudo, Tabanus and Mylabris were administered to experimental animals and the influences were evaluated on pregnant maintenance, corpus lutein functions and toxic action of kidney and liver during pregnancy. The result of this wors were summerized as follows: 1. The extracted and condensed liquid of Hirudo, Tabanus, and Mylabris was revealed action on the remarkable decrease of fertilized eggs, implantation in number. 2. When Hirudo, Tabanus, and Mylabris were administered the false-pregnant rabbit the decease of HCG was revealed. 3. The increase of GOT, GPT, BUN, ALP, creatinine, uric acid, urine protein was revealed, after Hirudo, Tabanus, Mylabris were administered to the false pregnant rabbit. According to the above results, it may be recognized that Hirudo, Tabanus, Mylabris obstruct pregnant maintenance and the functions of corpus lutein and give damage to kidney and liver during pregnancy.

養精種玉湯이 卵巢機能에 미치는 影響

宋炳基,李京燮,白承嬉 慶熙大學校韓醫科大學韓醫學硏究所 1996 慶熙韓醫大論文集 Vol.19 No.2

In order to study the effect of Yangjeongjongok-Tang applied to sterility a series of experiment was conducted on the ovulation in rats, as well as on the hyperprolactinemia in rats, and the follow results were obtained. 1. The Ovulation effect of the Drug was significantly increased in proportion to the amount administered. 2. The number of ovum during Ovulation was increased in Drug administered when combination treatment used PMSG with a HCG in comparison to only PMSG treatment. 3. The level of LH and Estradiol-17β in rat serum caused hyper prolactinemia was significantly increased after Drug administered and the Effect of Drug have a tendency to increased in proportion to the amount administered. 4. The level of FSH and Prolactin was not significantly increased in total group. According to the above results, it can be concluded that Yangjeongjongok-Tang take significant effect on the growth and maturity of ovary, therefore considered to improve Ovulation obstacle.

한약이 임신중 태아에 미치는 영향 (3) : 한약 및 한약 처방이 돌연변이원성과 염색체이상에 미치는 효과 Mutagenesis and chromosomal aberration of herbal medicines and their polyprescriptions

김동현,이영경,김남재,장준복,송병기 대한한의학회 부인과학회 2000 大韓韓方婦人科學會誌 Vol.13 No.2

Oriental herbal medicines were examined for mutagenicity in the reverse mutation test on Salmonella typimurium TA98/100 and chromosomal aberration test on cultured mammalina cells (Chinese hamster cell lines). The reverse mutation test was performed by a plate incorporation method with or without a metabolic activation system (S9 mix). Antaeeum, Aurantii Fructus and Kyoaekungkuetang significantly increased revertible colonies on Salmonella typimurium TA 98 under the condition without S9 mix. Bojungikkitang significantly increased revertible colonies on Salmonella typimurium TA 100 under the condition with S9 mix than under the condition without S9 mix. The other tested herbal medicines did not significantly increased revertible colonies on any of the test strains under the condition with or without S9 mix. In the chromosomal aberration test, most tested herbal medicines did not significantly increased the number of aberrant cells under the conditions with S9 mix at concentrations of 1㎎/ml, compared with the vehicle control. However, Gelatinum, Artemisiae Asiaticae Herba and Antaegumchultang, Kungsosan slightly increased revertible colonies on any of the test strains under the conditions with S9 mix than under condition without S9 mix. These results indicate that most herbal medicines might be carefully used in obstetrics and gynecology, although they do not have the potent mutagenic potential under the present test conditions.