卵巢癌에 關한 東西醫學的 考察

金瞳一,李泰均 대한한의학회 부인과학회 1994 大韓韓方婦人科學會誌 Vol.7 No.1

三稜 및 봉술 藥鍼의 鎭痛, 抗血栓效能에 관한 硏究

許秀珍,李京燮,宋炳基 대한한의학회 부인과학회 2000 大韓韓方婦人科學會誌 Vol.13 No.2

Introduction Even though there are various causes of diseases in women whose physiological essence is blood, they can be divided into two sections such as deficiency of blood and stagnated blood. The latter is the important cause of most gynecologic diseases that accompany pain and is a kind of symptom representing the stagnation of blood-flow. In the western medicines, it can be compared to blood circulation disorders such as blood-shedding, thrombosis forming, partial deficiency of blood, edema and birth and growth or property change of partial organisms. The medicine that cures stagnated blood is blood-activating and stasis-removing drugs. Among them, Sparganii Rhizoma and Zedoariae Rhizoma hold drastic, strong effect. This study was designed to investigate the effects of Sparganii Rhizoma and Zedoariae Rhizoma aqua-acupuncture. Method & Materials Sparganii Rhizoma and Zedoariae Rhizoma aqua-acupuncture solutions manufactured by water-alcohol method were injected in the part of Kwanwon(CV4) in rats and mice. The experimental animals were divided into a normal, control and two experimental groups. Each of two experimental groups had 500㎎/㎏ and 1,000㎎/㎏ concentration groups. As the normal group was untreated, the control group was injected with normal saline(0.lml/10g) once a day for 5 days, and then injected with endotoxin(0.5㎎/㎏). One of the experimental groups(Sample I group) was injected with 500㎎/㎏ and 1,000㎎/㎏ concentration of Sparganii Rhizoma aqua-acupuncture solution (0. 1 ml/10g) once a day for 5 days, and then injected with endotoxin(0.5㎎/㎏). The other group(Sample Ⅱ group) was injected with 500㎎/㎏ and 1,000㎎/㎏ concentration of Zedoariae Rhizoma aqua-acupuncture solution (0.1mV10g) once a day for 5 days, and then injected with endotoxin(0.5㎎/㎏). The analgesic effect induced by acetic acid and hot plate was observed and the anticoagulation effect to endotoxin-induced Disseminated Intravascular Coagulation (DIC) was observed with indicators such as the number of blood platelet and white cell, fibrinogen content, prothrombin time(PT), and activated partial thromboplastin time(aPTT). Results The analgesic effects induced by acetic acid and hot plate could get in statistical acceptance in the concentration experiments of 1,000㎎/㎏ of Sparganii Rhizoma and Zedoariae Rhizoma aqua-acupuncture. The effects of Sparganii Rhizoma and Zedoariae Rhizoma aqua-acupuncture on the experimental disseminated intravascular coagulation(DIC) caused by endotoxin were that the blood platelet and white cell counts were significantly increased in all experimental groups, the blood fibrinogen content shows a meaningful growth only in 1,000㎎/㎏ concentration group. Activated Partial Thromboplastin Time(aPTT) showed meaningful decrease in all experimental groups and prothrombin time(PT) decreased only in the group of 1,000㎎/㎏ concentration. Conclusion According to the above results, Sparganii Rhizoma and Zedoariae Rhizoma aqua-acupuncture had analgesic and anticoagulative effects. In the future, it is considered that the study on the safety of aqua-acupuncture solution, the analysis of the adequate quantity and property and the adequate injection quantity should be made to utilize aqua-acupuncture in gynecologic diseases caused by blood stagnation.

艾葉 및 阿膠藥鍼이 止血效果에 미치는 影響

金봄님,李京燮,宋炳基 대한한의학회 부인과학회 2000 大韓韓方婦人科學會誌 Vol.13 No.2

This study was designed to study on the hemostatic effects of Artemisiae asiaticae Herba Aqua-acupuncture and Gelatin Aqua-acupuncture. For the first time I studied on the hemostatic effects in normal rats. I divided into control group and experimental group. Control group was administrated normal saline and experimental group was divided into Sample-A and Sample- B. Sample-A was injected with Artimisiae asiaticae Herba Aqua-acupuncture and Sample-B was injected with Gelatin Aqua-acupuncture. All administrations were injected to Shin-su acupoint once a day for 2 days s.c. For the second time, I studied on the hemostatic effects in hypoprothrombinemia rats by warfarin. I divided into normal group and experimental group. Normal group was done no treatment and experimental group was induced hypoprothrombinemia by warfarin I.0㎎/㎏ s.m. The experimental group was divided into control group, Sample-A and Sample-B. Control group was administrated normal saline. Sample-A was injected with Artimisiae asiaticae Herba Aqua-acupuncture and Sample-B was injected with Gelatin Aqua-acupuncture. All administrations were injected to Shin-su acupoint once a day for 3 days s.c. The results were following. 1. In normal rats, the blood coagulation time and APTT were significantly shortened in Sample-A 0.2㎖/100g group as compared with the control group. 2. In hypoprothrombinemia rats, the blood coagulation time was significantly shortened in Sample-A 0.2㎖/100g group as compared with the control group. 3. In hypoprothrombinemia rats, the prothrombin time was significantly shortened in Sample-A 0.2㎖/100g group as compared with the control group. 4. In hypoprothrombinemia rats, the APTT was significantly shortened in Sample-A 0.20/100g as compared with the control group. 5. In hypoprothrombinemia rats, the plasma recalcification time was significantly shortened in Sample-A 0.2㎖/100g group as compared with the control group. 6. In hypoprothrombinemia rats, the hematocrit value was significantly increased in Sample-A 0.2㎖/100g group and Sample-B 0.2㎖/100g group as compared with the control group.

十全濟陰丸이 排卵 및 初期胚發生에 미치는 影響

張美慶,李京燮,宋炳基 대한한의학회 부인과학회 2000 大韓韓方婦人科學會誌 Vol.13 No.2

In order to study the effect of Sibjunjeumhwan on the ovarian function, the ovulation rate and early embryonic developmental capacity were measured in adult and immature mice. The following results were obtained. 1. The ovulation rate was not statistically significant in Sibjunjeumhwan groups compared with control group, in adult and immature mice. 2. The early embryonic developmental capacity from zygote to blastocyst stage was higher in Sibjunjeumhwan groups than control group with stastistical significance in adult mice. 3. There was no significance between Sibjunjeumhwan groups and control group on the the early embryonic developmental capacity from zygote to blastocyst stage in immature mice.

MEDLINE에서 檢索된 不妊症에 關한 論文들의 最近 硏究性向에 對한 考察

朴鐘圭,金瞳一 대한한의학회 부인과학회 2000 大韓韓方婦人科學會誌 Vol.13 No.1

産後憂鬱症에 關한 文獻的 考察

李泰均,李智響 대한한의학회 부인과학회 2000 大韓韓方婦人科學會誌 Vol.13 No.1

四逆散 및 消遙散 連繫方들의 加減特性 및 臨床應用에 關한 硏究

李東寧,林垠美,梁源美,李泰均 대한한의학회 부인과학회 2000 大韓韓方婦人科學會誌 Vol.13 No.1

This study was performed to investigate the using of Sayuk-san(四逆散) and Soyo-san(逍遙散) in oriental medicine. In oriental medicine, Sayuk-san(四逆散) and Soyo-san(逍遙散) were useful herbal prescriptions on clinical medicine, especially on the gynecology. At early, Sayuk-san(四逆散) was used at cold of foot and hand, abdominal pain by JoLiGanBi(調理肝脾) and GanUlKiChe(肝鬱氣滯). But According to develop of oriental medical theory, this prescription was extended to a variety of symptom by adding herb-med. Also applications of a prescription were more and more extending. Soyo-san(逍遙散) was also came from Sayuk-san(四逆散), the prescription was released the stress by disorder of blood circulation. Applications of the prescription were also extended to very kind of disease, especially on the gynecology. Today, these prescriptions were based on treatment of disease that was occurred to stress, tension, psychosomatic disorders, neurosis, disorder of blood circulation, and so on.

乾漆散 煎湯液이 女性癌 細胞株에 미치는 影響

李俊成,柳同烈 대한한의학회 부인과학회 1997 大韓韓方婦人科學會誌 Vol.10 No.2

The purpose of this research was to investigate effect of water extract of Kun Chil San (KCSE) on the proliferation of human female tumor cells. The effects of KCSE on the proliferation of human female tumor cells, Balb/c 3T3 cells, mouse spleen cells and human lymphocytes were estimated by MTT colorimetric assay. KCSE inhibited the proliferation of MCF-7, HeLa and SK-OV3 cells, and stimulated the proliferation of Balb/c 3T3 cells. The cytotoxicity of mitomycin C and adriamycin on HeLa cells were increased by the combination of KCSE. The cytotoxicity of mitomycin C, cisplatin and adriamycin on Balb/c 3T3 cells were increased by the combination of KCSE did not affect the proliferation of mouse spleen cells, but activated the proliferation of human lymphocytes. KSCE recovered the number of leukocyte which was decreased by MMC. These results suggest that KCSE inhibit the growth of human female tumor cells without the cytotoxity on fibroblast cells and immune cells, and then increase the cytotoxicity of mitomycin on HeLa cells by the combination of KCSE.

獨活寄生湯이 卵巢嫡出로 骨多孔症이 誘發된 白鼠에 미치는 影響

이영석,김종환,조한백,최규섭 대한한의학회 부인과학회 2000 大韓韓方婦人科學會誌 Vol.13 No.2

Osteoporosis is a state of reduced bone mass per unit volume with a normal ratio of mineral to matrix. Postmenopausal osteoporosis is known to be related to estrogen deficiency and give rise to spine and hip fracture in old person. The purpose of this study is to examine what are the effects of the Dokhwalkisaengtang(DHKST) on the ovariectomized rat model of postmenopausal osteoporosis. The results were summarized as follows : 1. Body weight in control group showed significant increase in comparison with sham, but that in DHKST-treated showed no change in comparison with control. 2. The level of serum albumin in control group showed significant decrease in comparison with sham. That in DHKST-treated was slightly decreased in comparison with control, which showed no efficacy. 3. The level of serum ALP activity in control group showed significant increase in comparison with sham, but that in DHKST-treated was slightly decreased in comparison with control, which showed no efficacy. 4. The level of serum phosphorous in control group showed significant increase in comparison with sham, but that in DHKST-treated showed no change in comparison with control. 5. The level of serum calcium in control group showed no change in comparison with sham, but that in DHKST-treated was significantly decreased in comparison with control. 6. The level of serum T3 in control group showed no change in comparison with sham, but that DHKST-treated showed significant decrease in comparison with control. 7. The level of serum T4 in control group showed significant increase in comparison with sham, and that in DHKST-treated showed significant decrease in comparison with control. 8. Trabecular tibia strength in control group showed significant decrease in comparison with sham, but that in DHKST-treated was increased in comparison with control. According to the above these results, DHKST has shown to be capable of preventing and curing osteoporosis caused by postmenopause.

月經前症候群에 對한 硏究 (Ⅱ)

金哲源 대한한의학회 부인과학회 1997 大韓韓方婦人科學會誌 Vol.10 No.2

In this thesis, I have investigated on PAF(Premenstrual Assessment Form), differentiation of symptoms and signs, discriminant about the constitution of sixty-four females from 1997. 7. 10 to 1997. 7. 20. All objects work at Kwangju Wonkwang university oriental medicine hospital now. Through these researches, I have obtained several results as following. 1. In this study, the average age of objects was 28.14 years old. In terms of occupation, nurses and nurse's asides account for 56.3 percent, In view of blood type, B group amount to 40.6 percents. 2. It was most common that menstruation commenced at 14 years old, and that menstrual bleeding time consists for five days. Who complains dysmenorrhea account for 75 percent, and they commonly complain pain during menstrual period 1-2days ago and just before. 3. Frequencies of premenstrual syndromes appear as following. General discomfort syndrome appears in thirty-four persons(53.1%), major depressive syndrome appears in twenty-seven persons(42.2%), impaired social functioning appears in twenty-two persons(34.4%), impulsive syndrome appears in twenty persons(31.3%), water retention syndrome appears in nineteen persons(29.7%). 4. As a result of differentiation of symptoms and signs to premenstrual syndromes, the type of stagnation of the liver-qi appears in thirty-four persons(53.1%) the type of weakness of the spleen and the stomach appears in twenty-two persons(34.4%), deficiency of the kidney-yin appears in eight persons(12.5%). 5. As a result of discriminant about. the constitution, Soeum-in occupied form 25.0%, Taeeum-in occupied form 28,1%, Soyang-in occupied form 25.0%, Taeyang-in occupied form 3.1%. Out of consideration for above results, the greater number of cases of PAF, differentiation of symptoms and signs, discriminant about the constitution will be helpful to diagnosis of premenstrual syndromes.