우황(牛黃).웅담약침액(熊膽藥鍼液)(BU)의 급성독성(急性毒性)에 관한 실험적(實驗的) 연구(硏究)

소경순,정찬길,이상운,박병모,김재형,강대인,조후리,김광호,Soh, Kyung-Sun,Jeong, Chang-Gil,Lee, Sang-Woon,Park, Pyung-Mo,Kim, Jae-Hyung,Kang, Dae-In,Jo, Hoo-Lee,Kim, Kwang-Ho 대한약침학회 2001 Journal of pharmacopuncture Vol.4 No.3

This experiment was carried out to study on the safety assessment of Bas tures . Ursus thibetanus extract solution(BU) for Herbal acupuncture. SD rats and ICR mice were used for acute toxicity test the results were summerized as follows; 1. In rats and mice, LD50 value could not be measured. 2. There were no abnormal finding in acute toxicity test treated BU for Herbal-acupuncture.

희첨이 Endotoxin으로 유발(誘發)된 흰쥐의 혈전(血栓)에 미치는 영향(影響)

소경순,Soh Kyung-Sun 대한예방한의학회 1998 대한예방한의학회지 Vol.2 No.1

In order to investigate the effect of the Herba Segesbeckiae on the thrombosis induced by endotoxin in rats. The rats were treated with solid extract of Herba Siegesbeckiae 41.9mg /200g(Sample) which were administered orally. And the thrombosis was induced by injecting endotoxin in the caudal vein rats. And then the number of platelets, concentration of fibrinogen, prothrombin time and FDP(fibrinogen degradation product) were measured. The results were as follows; 1. Platelet was increased significantly in sample group compared with control group. 2. Prothrombin time was shortened significantly in sample group compared with control group. 3. Fibrinogen was increased significantly in sample group compared with control group. 4. FDP was decreased significantly in sample group compared with control group. According to the above results, Herba Siegesbeckiae had significant effects on number of Platelets, Prothrombin time, Fibrinogen and FDP. therefore, it is considered that Herba Siegesbeckiae can be applied to diseases related to thrombosis.

보폐탕이 이산화황에 폭로된 흰쥐의 호흡기 손상에 미치는 영향( I )

소경순,Soh Kyung-Sun 대한예방한의학회 1998 대한예방한의학회지 Vol.2 No.1

Surfur dioxide, one of the air pollutants, has been related increasing morbidity rates due to respiratory damages. To investigate the effect of Bopaetang(補肺湯) on rats induced by exposur of $SO_2$, an experimental study was done the changes on white blood cell(W5C), the content of glycoprotein in treachea and the edema, congestion, inflammatory infiltrates of trachea. The experimental groups are the normal group, control group and sample group( administered Bopaetang to rats induced by exposur of $SO_2$). The results were as follows; 1. The change on WBC on rats induced by exposur of $SO_2$ were made significant differences in sample group compared with control group. 2. The content of Glycoprotein In trachea were made significant differences in sample group compared with control group. 3. The edema, congestion, inflammatory infiltrates of treachea were made significant differences in sample group compared with control group.

사향약침액(麝香藥鍼液)이 Triton WR-1339로 유발된 흰쥐의 고지혈증(高脂血症)에 대한 실험적(實驗的) 연구(硏究)

소경순,정찬길,김광호,이상운,강대인,Soh, Kyung-Sun,Jeong, Chan-Gil,Kim, Kwang-Ho,Lee, Sang-Woon,Kang, Dae-In 대한약침학회 2003 Journal of pharmacopuncture Vol.6 No.1

In order to study the effects of Moschus Herbal-acupuncture on hyperlipidemia, we divided the rats into three groups(Normal group, Control group & Sample group) and performed the experimental research. Hyperlipidemia rats were induced by Triton WR-1339(150mg/kg) for 3days. Sample group was injected Moschus Herbal-acupuncture 0.1 ml/200g for 3 days and control group was injected equal dose of saline. And then we measured the amount of serum total cholesterol, triglyceride, phospholipid and HDL-cholesterol. The results were as follows : 1.Moschus Herbal-acupuncture showed decreasing effects on total cholesterol, triglyceride and phospholipid levels in serum significantly(p<0.05). 2.Moschus Herbal-acupuncture showed increasing effects on HDL-cholesterol level in serum significantly(p<0.05). According to the above results, Moschus Herbal-acupuncture showed significant decreasing effects on hyperlipidemia and it is considered that it is appropriate to apply for hyperlipidemia.

송엽약침액(松葉藥鍼液)의 독성시험에 관한 실험적(實驗的) 연구(硏究)

김대현,소경순,Kim, Dae-Hyun,Soh, Kyung-Sun 대한예방한의학회 2006 대한예방한의학회지 Vol.10 No.1

This experiment was carried out to study on the safety assessment of Pinus densiflora Siebold et Zuccarini for Hebal-acupuncture. SD rats and ICR mice were used for acute toxicity test, the results were summerized as follows; 1. In rats and mice, $LD_{50}$ value could not be measured. 2. There were no abnormal finding in acute toxicity test treated Pinus densiflora Siebold et Zuccarini for Hebal-acupuncture.

정신양생(精神養生)에 관한 문헌적(文獻的) 고찰(考察)

금종철,소경순,김광호,Keum Jong-Chul,Soh Kyung-Sun,Kim Kwang-Ho 대한예방한의학회 1997 대한예방한의학회지 Vol.1 No.1

After examining the viewpoints of the mental cultivation of The yellow Emperor's Internal Bible(內徑), from the viewpoints of The yellow Emperor's Internal Bible, I studied the principles and methods of the mental cultivation(精神養生) which the Taoism School, the Confusian School and the past physicians proposed. And I studied the methods of mental cultivation of the child, the woman and the old by the differences of ages and sex. At the subject of health preservation(養生學) on the basis of concept of relevant adaptation of man to nature(天人相應思想), the mental cultivation(精神養生) was regard more important than the body cultivation(肉體養生) and it was considered that the success of health preservation depended on the state of mind. the basic principles of the mental cultivation is achivement of the mental internal keeping(精神內守) through the state of peace and tranquility without avarice and wild fancy(恬憺虛無). The ways of mental cultivation of the Taoism School, the Confusian School and the past physicians were in the category of The yellow Emperor's Internal Bible. 4. In the previous Jin dynasty(先秦時代), the important theoretical bases and practices to mental cultivation were made. In the Han dynasty(漢時代), the physicians attached importance to mental treaments. During the time from Sui dynasty to Tang Dynasty(隋唐時代), the mental cultivation was made perfect theoretically. During the Period from Song dynasty to Yuan Dynasty(宋元時代), Many methods of mental cultivation were newly created. During the Ming and the Qing Dynasties(明淸時代), the theory of health preservation and the methods of mental treaments were embodied. 5. Studying the mental cultivation by the differences of ages, the childhood(小兒期) is the spring of life. So the mental cultivation of this period put importance to the cultivation of Sh ng(養生). And the youth(靑年期) is the summer of life. So the mental cultivation of this period pill importance to the cultivation of Ch'ang(養長). And the middle age(中年期) is the autumn of life. So the mental cultivation of this period put imporance to the cultivation of Shou(養收). And the old age(老年期) is the winter of life. So the mental cultivation of this period put importance to the cultivation of Tsang(養藏). Studying the mental cultivation by the differences of sex, the man must do the mental cultivation through the dynamic nature(性情) of Yang(陽) and the woman must do the mental cultivation through the static nature of Yin(陰).

Glyceorl 투여에 따른 Rat의 혈액학 및 혈액생화학치에 관한 기초연구

윤왕수,소경순,최진용,강임성,정찬길,Yun, Wang-Su,Soh, Kyung-Sun,Choi, Jin-Yong,Kang, Im-Sung,Jeong, Chan-Gil 대한예방한의학회 2006 대한예방한의학회지 Vol.10 No.1

In order to study the changes in hematology and serum chemistry of rats injected with glycerol, Sprague-Dawley albino rats weighing 240 to 260 gm were injected intramuscularly with a 50% solution of glycerol(8ml/kg). We measured the values of hematology and serum chemistry, and compared the measured values of S1 group(passed for 1day after injection of glycerol), S2 group(passed for 2days after injection of glycerol), S3 group(passed for 3days after injection of glycerol), S4 group(passed for 3days after injection of glycerol) and S5 group(passed for 4days after injection of glycerol) with those of Normal group(non-treated group). The results are summarized as follows : 1. In body temperature, S1, S2, S4 groups showed significantly higher compared with Normal group, especially S2 group was higher than S1 group(p<0.05). But S5 group was lower than Normal group(p<0.05). 2. In RBC, S1 group was lower than Normal group(p<0.05). And in Hct, S1, S2, S3 groups were lower than Normal group(p<0.05), in Hb, S1 and S3 groups were lower than Normal group(p<0.05). 3. In WBC, S1, S2 groups were higher than Normal group(p<0.05). and in WBC differential count, S2, S3, S5 groups were higher than N, S1, S4 groups in monocyte(p<0.05). 4. In GOT, S1 group was higher than Normal group(p<0.05), and S2, S3, S4, S5 groups were lower than S1 group(p<0.05). In GPT, S1 group was higher than Normal group(p<0.05), and S2, S3 groups were lower than S1 group(p<0.05), S4, S5 groups were lower than N, S1, S2, S3 groups(p<0.05). 5. In total cholesterol and creatinine, S4 group was higher than Normal group(p<0.05). According to the above experimental results, we could find the anemia, inflamation, damage of renal function for 4 days by intramuscularly injection with a 50% solution of glycerol(8ml/kg) in rat.

사과락(絲瓜絡)이 Triton Wr 투여로 유발되는 고지혈증(高脂血證) 예방에 미치는 영향에 대한 실험적 연구

이정석,소경순,정찬길,Lee Jeong-Seok,Soh Kyung-Sun,Jeong Chan-Gil 대한예방한의학회 2002 대한예방한의학회지 Vol.6 No.2

In order to study the effect of Luffae fasciculus vascularis(絲瓜絡) on hyperlipidemia, experimental study was performed on Hyperlipidemia induced by Triton WR-1339. Also the level of Total cholesterol, Triglyceride, HDL-cholesterol, Phospholipid and LDL-cholesterol were measured. The results are summarized as follow: In the model of hyperlipidemia Rats induced by Triton WR-1339, luffae fasciculus vascularis(絲瓜絡) had significantly decreasing effects on total cholesterol, triglyceride, phospholipid, LDL-cholesterol in serum and increasing effects on HDL-cholesterol level in serum but were not significant. These results show that Luffae fasciculus vascularis(絲瓜絡) has significantly inhibitory effects on hyperlipidemia and that it could be clinically applied for hyperlipidemia.

도인(桃仁)이 Triton WR-1339로 유발(誘發)된 흰쥐의 고지혈증(高脂血症)에 미치는 영향(影響)

윤왕수,소경순,정찬길,Yun Wang-Su,Soh Kyung-Sun,Jeong Chan-Gil 대한예방한의학회 2002 대한예방한의학회지 Vol.6 No.2

In order to study effects of ${\ulcorner}Persicae\;Semen{\lrcorner}$ on the hyperlipidemia rats induced by Triton WR, we have made hyperlipidemia rats by administering Triton WR-1339 for 3 days, then have administered. The results were summerized as follows: 1. The total cholesterol, triglyceride and phospholipid by hypercholesteremic rats injected by Triton WR-1339 of the sample group were decreased as compared with those of the control group, 2. The HDL-cholesterol by hypercholesteremic rats injected by Trion WR -1339 were increased as compeared those of control group. According to the above results, Persicae Semen showed inhibition on increase of serum total cholesterol, triglyceride and phosholipid contents as well as inhibition on decrease of HDL-cholesterol contents in hyperlipidemia.

홍화(紅花) 투여량(投與量)에 따른 혈액(血液)의 변화(變化)에 대한 실험적(實驗的) 연구(硏究)

조후리,소경순,정찬길,Cho, Hoo-Lee,Soh, Kyung-Sun,Jeong, Chan-Gil 대한약침학회 2006 Journal of pharmacopuncture Vol.9 No.3

Objectives : The purpose of this study is to examine what are the effect of Carthami Flos on Blood according to the administered dosage. Methods : thrity Sprague-Dawleys rats of starved during 3 days were used and divided 3 groups ; Normal group ; Experimental group that were administered Carthmi Flos 117mg/200g(Sample1) ; Experimental group that were administered Carthmi Flos 936mg/200g(Sample2). and the observerd blood(RBC, Hct, Hb, MCV, MCH, MCHC, PLT, WBC NEUT, LYM, MONO, EOSIN). Result : the result were obtained as follows ; 1. RBC, Hb, MCHC were significantly increased, and MCV were decreased in Sample1.(p<0.05) 2. PLT, MCHC, LYM were significantly increased, and Hct, MCV were decreased in Sample2.(p<0.05) Conclusion : According in the above result, it was consided that a small quantity dosage of Carthami Flos was nourished the blood, and a large quantity of that was curative for thrombosis and elevated blood viscosity and it is suggested that more interest and study in the mechanism and clinical use were needed.