鹿蔘地黃湯이 抗老衰에 미치는 影響

蘇敬順,金光湖 慶熙大學校韓醫科大學韓醫學硏究所 1995 慶熙韓醫大論文集 Vol.18 No.2

It is a natural desire of a human being who lives through the life cycle of birth, growth, maturity, aging and death to retard and delay the aging process, and to live a long heathy life. For the purpose of longevity, in Korean Medicine, it is considered to be imported to augmentation of the spleen(補脾) and reinforcement of the kidney(益腎). In this research, we made the formula of Noksamjiwhangtang(鹿蔘地黃湯) that has the augmentation of the spleen and reinforcement of the kidney(補脾, 益腎). In experiment, Age-related changes were measured such as body weight, organ weight, RBC, MCV, total cholesterol of serum, IgG, and in 50 weeks of age, body weight, organ weight, RBC, MCV, total cholesterol of serum, IgG, BaSO₄ transport, oxigen consumption, PSP test, amount of exercise and state of fur. I found a correlation between organ weight and body weight ratio for RBC, MCV, total cholesterol of serum, IgG. The results were as follows; 1. In age-related changes, through 40 weeks and 50 weeks body weight, organ weight, RBC were decreased in the group C(not fed Noksamjiwhangtang)but group S-1 (fed Noksamjiwhangtang) continuously increased. And MCV, total cholesterol of serum, IgG increased in the group C but group S-1 was decreased. 2. In the check of body weigh, RBC, BaSO₄transport, PSP test, amount of exercise group S-1, S-2 were significantly increased in comparison with group C and in the time of oxigen consumption group S-1, S-2 were significantly decreased in comparison with group C and in the state of fur group S-1, 5-2 and group C were made differences. 3. In the check of body weight, RBC, BaSO₄transport, PSP test, amount of exercise group S-1, S-2 were made significant differences. 4. Correlation between counts of RBC, MCV, BaSO₄transport and PSP test was less related and total cholesterol of serum, IgG were not related and counts of RBC, MCV, total cholesterol of serum, IgG in comparison with body weight and between the organ weights were highly related. In conclusion, Noksamjiwhangtang(鹿蔘地黃湯) is considered to have the effect of delaying the ageing process and retarding senile. And it is considered that body weight ratio for counts of RBC, total cholesterol of serum, IgG and relation between organ weight are will be used for experiment or as an indicator of aging process.

담관암 발생과정중 관찰되는 small cell과 oval cell의 면역조직화학

서일복,소경순 世明大學校 1998 世明論叢 Vol.7 No.-

This study was carried out to examine the immunohistochemical characteristic of the small cells and oval cellsin experimentally induced cholangiocarcinoma. Forty two female Syrian goldern hamsters were divided into two groups. Group I was served as experimentally induced cholangiocarcinoma group, which was infected orally with C. sinensis and given dimethylnitrosamine(15ppm) in drinking water. Group Ⅱ was served as contro. Five or six heads of hamsters in each group were sacrificed at 4, 7, 11 and 15 weeks after the begining of the experiment. The livers were examined grossly, histopathologically and immunohistochemically. The results obtained were as follows ; 1. Cholangiocarcinomas were occurred in 1 of 6 animals at 11 weeks and in 4 of 6 animals at 15 weeks. 2. Small cells and oval cells were proliferated around the portal triads from 4 weeks and peaked at 7 weeks and 11 weeks respectively, and decreased after then. 3. Any of the small cells not expressed cytokeratin. 4. Small cells divided into α-fetoprotein positive population and α-fetoprotein negeative population 5. Oval cells divided into α-fetoprotein positive population, α-fetoprotein negative population and cytokeratin positive population

魚腥草가 實驗的 高脂血症의 豫防效果에 미치는 影響

金光湖,蘇敬順,李晸源 慶熙大學校韓醫科大學韓醫學硏究所 1995 慶熙韓醫大論文集 Vol.18 No.2

In order to investigate the preventive effects of Houttuyniae Herba experimental studies were performed in rats fed 1%-cholesterol + Houttuyniae Herba Ex.. The results were summarized as that : Houttuyniae Herba showed significant inhibition on increase of serum total cholesterol, triglyceride and phospholipid contents as well as remarkable inhibition on decrease of HDL-cholesterol contents in hyperlipidemia-induced rats fed 1%-cholesterol + Houttuyniae Herba Ex. Judging from above results, it is proved that Houttuyniae Herba is applicable to hyper-lipidemia such as hyper-cholesterolemia, hyper-triglyceridemia and so on, causing ischemic heart diease, hypertension, artero-sclerosis and cerebro-vascular accidents.

청소년기 문제행동과 부모 양육행동에 관한 연구

손석한,노경선,허묘연,정현옥,이소희,김세주 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 일반 청소년의 문제행동(내재화 문제, 외현화 문제)을 평가하고, 그들을 정상 집단과 문제행동 집단으로 나누어 집단간에 부모 각각의 양육행동이 어떠한 차이를 보이는지 알아보고자 한다. 방 법 : 서울 소재의 일반 고등학교 학생 792명을 대상으로 부모 양육행동 척도와 K-YSR을 실시하여 청소년이 지각하는 부모의 양육행동과 청소년의 문제행동을 평가하였다. 부모의 양육행동과 청소년의 문제행동과의 상관관계를 분석하였다. 학생들이 보고한 각 문제행동을 상/하위 25% tile을 기준으로 정상 집단과 문제행동 집단으로 나누어 부모의 양육행도의 차이를 분석하였다. 결 과 : 다음과 같다. 1) 부모의 애정, 합리적 설명, 감독의 긍정적인 양육행동은 대부분의 청소년 문제행동들과 유의한 부적 상관을 보였다. 반면에 학대, 과잉간섭, 과잉기대, 방임, 비일관성이 부정적인 양육행동은 문제행동들과 유의한 정적 상관이 있었다. 2)내재화 문제를 보이는 청소년들은 정상 집단에 비해 부모로부터 학대, 과잉간섭, 과잉기대, 방임, 비일관성의 양육행동을 유의하게 더 많이 받았고, 반면에 애정을 유의하게 더 적게 받았다고 지각하고 있었다. 외현화문제를 보이는 청소년들은 정상집단의 청소년들에 비해 부모로부터 학대, 과잉간섭, 과잉기대, 방임, 비일관성의 양육행동을 유의하게 더 많이 받았고, 반면에 감독을 유의하게 더 적게 받았다고 지각하고 있었다. 3) 내재화 및 외현화 문제를 모두 보이는 집단이 내재화 문제만 보이는 집단과 외현화 문제만 보이는 집단에 비해서 양쪽 부모로부터 유의하게 더 많은 과잉간섭을 받을 것으로 지각하고 있었다. 또한, 내재화-외현화 집단과 내재화 집단은 외현화 집단에 비해서 어머니로부터 유의하게 더 적은 애정과 더 많은 방임을 받고 있고, 아버지로부터 유의하게 더 많은 학대를 받은 것으로 지각하고 있었다. 결 론 : 이상의 결과로 미루어 볼 때, 청소녕이 지각한 부모의 학대, 과잉간섭, 과잉기대, 방임, 비일관성의 양육행동은 청소년의 내재화 및 외현화 문제 모두와 유의한 연관이 있고, 반면에 부모의 애정, 감독, 합리적 설명의 양육행동은 다양한 청소년기 문제행동을 줄일 수 있음을 시사하고 있다. Objectives : The purpose of this study is to evaluate the problem behaviors of adolescents and to discriminate between parenting behaviors of problem behavior groups and those of non-problem behavior group. Methods : The subjects of this study were 792 high school students in Seoul. We administered 'parenting behavior Inventory' and Korean version of Youth Self-Report(K-YSR) to the subjects in order to evaluate the parenting behaviors perceived by adolescents and the problem behaviors of adolescents. We analzed the relationship between parenting behaviors and problem behaviors. We classified the subjects into problem behavior groups(internalizing group, externalizing group, internalizing-externalizing group) and a non-problem behavior(normal) group. We studied the differences of parenting behaviors among the groups. Results : The results are as follows. 1) There were significant negative correlations between the positive parenting behaviors such as affection, reasoning, and monitoring and the problem behaviors of adolescents. By contrast, there were significant positive correlations between the negative parenting behaviors such as physical abuse, intrusiveness, over-expectation, neglect, and inconsistency and the problem behaviors of adolescents. 2) Adolescents of the internalizing group perceived significantly more parental abuse, intrusiveness, over-expectation, neglect, and inconsistency than those of normal group. Meanwhile, they perceived significantly less affection than normal adolescents. Adolescents of the externalizing group also perceived significantly more parental abuse, intrusiveness, over-expectation, neglect, and inconsistency than those of normal group. Also, they perceived significantly less monitoring than normal adolescents. 3) Adolescents of the internalizing-externalizing group perceived significantly more intrusiveness from both parents than those of either the internalizing or the externalizing groups. Adolescents of the internalizing-externalizing group perceived significantly less affection and more neglect from their mothers than those of the internalizing of the externalizing groups. In addition, adolescents of the internalizing-externalizing group perceived significantly more physical abuse from their fathers than those of the internalizing or the externalizing groups. Conclusion : Parenting behaviors such as abuse, intrusiveness, over-expectation, neglect, and inconsistency are associated with both internalizing and externalizing problems. In contrast, our results suggest that parenting behaviors such as affection, monitoring, and reasoning might decrease the various problem behaviors of adolescents.

性別 및 年齡에 따른 體格과 體力의 特性과 變化에 關한 縱斷的 硏究 Ⅰ : 體育專攻 大學生을 中心으로 Emphasised on College Men of Physical Education

金尙國,姜東洹,金昇一,徐再均,金耕知,孫斗玉,鮮于攝,崔榮烈,尹宇相,金亨燉,方永鎭,李錫元 慶熙大學校 體育科學大學 1988 體育科學論叢 Vol.- No.1

The purpose of this study was to compare the characterists and change in physique and physical function by college student of physical education major(287males and 40 females of age groups ranging from 18 to 26). The results were as following; 1) The characteristics of physique and physical function by sex and age. ① The male group of 18yrs old showed higher values in Height, Weight, Upper Limb Length, Strength, Flexibility, and Vital Capacity than any other groups, but female group showed lower values in Height, Weight, Chest Girth, Lower Limb Length, Thigh, Girth, Calf Girth and all of the Physical function. ② The male group of 19yrs old showed high values in power and Agility, then female group showed in Strength and Flexibility. ③ The male group of 20yrs old showed the lower values in Weight, Waist Girth, Upper Limb Length, Fore Arm Girth, Thigh Girh.Calf Girth, Vital Capacity, and female group are very lowed in Upper Arm Lenght, Fore Arm Length, Skin Fold Thickness and 5 minute Run. ④ The male group of 23yrs old showed the high values in Upper Arm Girth, Fore Arm Girth and Balance, and then female group higher in Weight, Chest Girth, Waist Girth, Upper Arm Girth, Fore Arm Girth, Thigh Girth, Power, Shuttle Run, Balance and vital capacity than any other age Groups. ⑤ In male group, Chest Girth, and Blood Pressure were significantly related, and Side Step and Trunk Extension were nagatively related to the age at 0.1% level, and then in female group, Sargent Jump, Standing Long Jump and Vital Capacity were showed a significantly related at 0.5% level. 2) The difference of physique and physical function between male and female by age. ① Everage difference in whole physique items except skinfold thickness was 9.8%, and that 21.1% in all of physical function except Trunk Flextion between male and female group subjects. ② About the ages, the 18yrs old male group showed the 22.8% higher values of 26 items, but 22yrs old male group were about 12.2% in 23 items, thus it is very lower than any other groups. 3) The difference of physique and physical function between General group and physical education group in age-matched. ① In the physique male physical education groups showed about 7% higher in Weight, Chest Girth, Upper Limb Length, Upper Arm Girth, Thigh Girth, and female group showed about 7% higher in Weight and Upper Limb Length. ② In the physical function, Trunk Flextion, 5 minute Run, and Blood Pressure(Diastolic) were about 8% high values in whole group, and female group showed about 8% higher in Standing Long Jump, Shuttle Run, and Trunk Extension. ③ In 22yrs old male and female physical education group were very dominated in physique and physical function than the other age group against the general group.

Morphology of Carrot Somatic Embryos Formed in Medium with Abscisic Acid

Soh, Woong Young,Cho, Duck Yee,Kim, Kyung Sik,Sun, Byung Yun 한국식물학회 1997 Journal of Plant Biology Vol.40 No.1

Somatic embryogenesis was induced from embryogenic cells derived from cotyledon explants cultured on MS medium supplemented with 1 ㎎/L 2,4-D. In order to clarify the effect of abscisic acid (ABA) on the morphology of somatic embryos, embryogenic cell clumps or developing somatic embryos were treated continuously, or briefly, with ABA during culture. When embryogenic cells in MS medium without 2,4-D were treated with 0.04 ㎎/L ABA for the first week, normal embryos with two cotyledons increased slightly and embryos with anomalous cotyledons decreased. However when cell clumps in 2,4-D-free medium were treated with ABA in the second week normal embryos with two cotyledons decreased prominently and this decrease of normal embryos also occurred in the continuous ABA treatment during culture. Thus the morphological abnormalities in somatic embryogenesis occurred by exogenous ABA treatment beyond globular stage or by continuous treatment. The length of somatic embryos with anomalous cotyledons was larger than that of normal embryos with two cotyledons in control but both the normal and anomalous somatic embryos treated with ABA were almost similar in length. Somatic embryos formed in medium with ABA were larger in size than those in control due mainly to enlarged cotyledons. The enlarged cotyledons were composed of a greater number of cells than those of control. Therefore the enlargement of cotyledon by exogenous ABA seems to be not due to the enlargement of cells in cotyledons.

L-Carnitine을 함유한 전해질 혼합 음료가 단련한 흰쥐의 지구력 운동능력 및 글리코겐 절약 효과에 미치는 영향

소동문,원은경,최건식,박정선,김남익,김영일,이진주,연동수 대한스포츠의학회 2000 대한스포츠의학회지 Vol.18 No.2

It has been hypothesized that the increased fatty acid oxidation and carnitine trunover associated with endurance training could produce a relative carnitine deficiency in rats and for free fatty acid(FFA) oxidation and turnover during submaximal exercise. Thus, the present study was undertaken to investigate the influence of carnitine containing electrolyte beverages on endurance performance and muscle and liver glycogen sparing effects of endurance trained rats. Rats were trained on the treadmill for 4 weeks and seperated into control, electrolyte, carnitine and carnitine-electrolyte groups that they were supplied with water, electrolyte balanced beverage, carnitine(70mg/kg) in the water and carnitine in electrolyte balanced beverage for 4 weeks trained period, respectively. The exercise test for maximal running time(MRT) were measured on treadmill at 1.8 kilometer per hour (KPH) and 14% grade. The exercise test for measuring glycogen sparing effect of carnitine is consisted of running up 14%grade at 1.8 KPH for 0, 15, 30, 60 or 90 min. At the end of run, rats were sacrificed for the measurement of plasma FFA and glycerol, blood glucose and lactate concentration, and muscle of liver glycogen contents. The results are summarized as follows. 1. MRT of carnitine and carnitine electrolyte groups were significantly higher compared to the control. But there was no significant difference in MRT between control and electrolyte groups. 2. In carnitine and carintine electrolyte groups, the slow muscle glycogen contents after 30, 60, 90 min exercises, the fast muscle glycogen content after 90 min exercise were significantly higher compared to the control. 3. In carnitine and carnitine electrolyte groups, the liver glycogen contents after 60 and 90 min exercises were significantly higher compared to the control. 4. The plasma FFA and glycogen concentrations presented a nonsignificant trend toward higher values in carnitime and carnitine electrolyte groups than in the control. 5. There were no significant differences in blood glucose and lactate concentrations between carnitine of carnitine electrolyte group and the control. These results suggest that carnitine increase endurance performance of trained rats and increment of endurance performance was attributed to enhanced fat utilization and muscle and liver glycogen sparing effects of carnitine.

은행나무(Ginkgo biloba L.)유식물의 자엽절에서 유관속형성층의 초기발생

蘇雄永,姜京德,崔弼善 全北大學校 基礎科學硏究所 1994 基礎科學 Vol.16 No.-

은행나무 유식물에서 유관속형성층은 성숙한 잎을 포함하여 5장의 잎이 자라고 있을 때 제일 먼저 자엽절에서 발생되고, 이어서 지하기관인 배축-뿌리로 그리고 지상부의 줄기로 즉, 양쪽 방향으로 분화되었다. 접선면 관찰에서 자엽절의 유관속형성층 발생유형은 줄기와 같고 뿌리와는 다르다. 자엽절에서 초기의 전형성층은 동일형의 세포로 구성된 균일구조를 이루고, 발생이 진행됨에 따라 신장생장을 하는 일부세포와 횡단분열을 하는 나머지 세포의 두종류 세포로 된 비균일 구조로 전환된다. 신장을 하는 긴 세포로부터 유관속형성층의 방추형 시원세포가 그리고 횡단분열을 하는 짧은 세포로부터 방사조직 시원세포가 기원된다. 그러므로 방추형 시원세포가 심한 관입생장을 거쳐서 발생된다. The vascular cambium in Ginkgo biloba seedling began to differentiate in the cotyledonary node, and then the differentiation proceeded bidirectionally from the cotyledonary node toward the stem and root. In tangential view, procambium at the early developmental stage was a homogeneous structure consisted of almost similar cells in shape, and at later stage the procambium became a heterogeneous one consisted of long cells and short cells. Such a differentiation pattern in the cotyledonary node was similar to that in the stem. However, it was diffferent from that in the root. Fusiform initials and ray initials consisting the vascular cambium were originated from the long cells and the short cells, respectively. The long cells and the fusiform initials in the cotyledonary node were shorter and wider than those in the first internode.

급성 심근경색 : Gd-DTPA 조영증강 자기공명영상 Gd-DTPA Enhanced Magnetic Resonance Imaging

정경일,김제현,이창호,이영주,김한수,소동문,이영돈,박경주,왕희정,탁승제,이철주,김선용,김옥화,임태환,문창현,최병일,서정호 아주대학교 의과학연구소 1996 아주의학 Vol.1 No.1

This study was undertaken to determine the value of gadolinium dimeglumine (Gd-DTPA) enhanced MRI in the diagnosis of acute myocardial infarction. Seven cats were subjected to 2 hours of left anterior descending coronary arteryocclusion (group 1) and 8 cats to 1 hour of occlusion (group 2). Reperfusion was followed by taking Tl-weighted MR images at 5, 15, 30, 45, 60 minutes after Gd-DTPA (0.2 mmol/kg) injection. Myocardial enhancement patterns were categorized into three zones (central ischemic, peripheral ischemic, and normal) or two zones (ischemic and normal) and the presence of injured myocardium in each zone was confirmed by 2,3,5-triphenyltetrazolium chloride (TTC) staining. Signal intensity (SI) of each zone was evaluated relative to back muscle in regard to its chronological changes and difference among the zones. Group 1 displayed three zones of enhancement in 6 cats whereas 1 cat in group 1 and all in group 2 showed two zones of enhancement. Intermediate SI central zone was compatible but smaller than TTC nonstained area, and determined to be a persistently occlusive injury. High SI peripheral zone in group 1 and high SI ischemic zone in group 2 were stained and determined as reperfused injury although reversibility was not definite. The peak SI, occurring 15 minutes after Gd-DTPA injection, of 2.47±0.48 at peripheral zone was greater than that of 1.66±0.36 at central zone in group 1 and of 1.81±0.41 at ischemic zone in group 2 (p < 0.05). SI of injured myocardium increased more rapidly and decreased more gradually than that of normal myocardium. That the features of SI change with time in injured myocardium was compatible with the results of other studies using different contrast agents. Gd-DTPA enhanced MRI differentiated persistently occlusive injury as central intermediate SI, and reperfused injury as homogenous high SI, with the maximal contrast between the two at 15 minutes after contrast injection, thus indicating the value of Gd-DTPA enhanced MRI in the diagnosis of acute myocardial infarction.

보폐탕이 이산화황에 폭로된 흰쥐의 호흡기 손상에 미치는 영향( I )

소경순,Soh Kyung-Sun 대한예방한의학회 1998 대한예방한의학회지 Vol.2 No.1

Surfur dioxide, one of the air pollutants, has been related increasing morbidity rates due to respiratory damages. To investigate the effect of Bopaetang(補肺湯) on rats induced by exposur of $SO_2$, an experimental study was done the changes on white blood cell(W5C), the content of glycoprotein in treachea and the edema, congestion, inflammatory infiltrates of trachea. The experimental groups are the normal group, control group and sample group( administered Bopaetang to rats induced by exposur of $SO_2$). The results were as follows; 1. The change on WBC on rats induced by exposur of $SO_2$ were made significant differences in sample group compared with control group. 2. The content of Glycoprotein In trachea were made significant differences in sample group compared with control group. 3. The edema, congestion, inflammatory infiltrates of treachea were made significant differences in sample group compared with control group.