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부산지역 알레르기 클리닉을 내원한 환자들에서 점박이응애와 집먼지진드기의 감작률
서효림 ( Hyo Rim Seo ),이수미 ( Soo Mi Lee ),구태형 ( Tae Hyung Koo ),신봉철 ( Bong Chul Shin ),김보경 ( Bo Kyung Kim ),허정훈 ( Jeong Hun Heo ),양두경 ( Doo Kyung Yang ),이수걸 ( Soo Keol Lee ),손춘희 ( Choon Hee Son ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.4
Background: Recently, it has been demonstrated that the sensitization rate to two spotted mite (TSM, Tetranychus urticae) is as high as that to house dust mite (HDM) in respiratory allergy patients in the middle part of Korean peninsula. However, there are no published data on the sensitization rate to TSM in southern area of Korean peninsula. Objective: The aim of this study is to evaluate the sensitization rate to TSM in patients with allergic diseases in Busan area. Method: Skin prick tests were performed with 49 common inhalant allergens and TSM extracts on 519 patients with various allergic diseases between March 2005 and June 2007. We evaluated clinical characteristics and the sensitization rate to various inhalant allergens including TSM. Result: The sensitization rate to Dermatophagoides pteronyssinus (49.3%) was highest, followed by D. farinae (44.9%), TSM (32.9%), birch (17.0%) and mugwort (16.0%). Forty (7.7%) patients were sensitized to TSM only. Conclusion: TSM was the second most common sensitized allergen in patients visiting the allergy clinic in Busan area. These results suggest that TSM might be an important outdoor allergen in Korean peninsula. (Korean J Asthma Allergy Clin Immunol 2007;27:263-267)
침습선암의 조직소견이 동반된 혼합형 증식성 선종성 직장용종 1예
서효림 ( Hyo Rim Seo ),김지현 ( Ji Hyun Kim ),정수진 ( Soo Jin Jung ),최윤정 ( Yun Jung Choi ),류충헌 ( Choong Heon Ryu ),박관식 ( Kwan Sik Park ),하승인 ( Seoung In Ha ),정은욱 ( Eun Uk Jung ),이상헌 ( Sang Heon Lee ),박성재 ( Su 대한장연구학회 2012 Intestinal Research Vol.10 No.3
Epithelial colon polyps are largely divided into hyperplastic and adenomatous polyps. Adenomatous polyps are premalignant lesions, whereas hyperplastic polyps are regarded as benign lesions. However, this histological classification has been blurred, as cases of malignant changes in hyperplastic polyposis, mixed hyperplastic adenomatous polyps (MHAPs), and serrated adenomas in the colon have been reported. Rare cases of MHAP have been reported, and are mainly found at the proximal colon with a relatively large size. MHAPs seem to be an intermediate stage of the hyperplastic polyp-adenoma sequence or a collision tumor. Here, we report on a case of a single polyp in the rectum diagnosed with a MHAP combined with an invasive adenocarcinoma. (Intest Res 2012;10:295-299)
비장 혈관종과 직장 정맥류를 보인 Klippel-Trenaunay Syndrome
최윤정 ( Youn Jung Choi ),지삼룡 ( Sam Ryong Jee ),박관식 ( Kwan Sik Park ),류충헌 ( Choong Heon Ryu ),서효림 ( Hyo Rim Seo ),하승인 ( Seoung In Ha ),이상헌 ( Sang Heon Lee ),옥경선 ( Kyung Sun Ok ) 대한소화기학회 2011 대한소화기학회지 Vol.58 No.3
Klippel - Trenaunay syndrome (KTS) is characterized by a cutaneous vascular nevus of the involved extremity, bone and soft tissue hypertrophy of the extremity and venous malformations. We present a case of KTS with splenic hemangiomas and rectal varices. A 29-year-old woman was referred for intermittent hematochezia for several years. She had history with a number of operations for cutaneous and soft tissue hamangiomas since the age of one year old and for increased circumference of her left thigh during the last few months. Abdominal CT revealed multiple hemangiomas in the spleen, fusiform aneurismal dilatation of the deep veins and soft tissue hemangiomas. There was no evidence of hepatosplenomegaly or liver cirrhosis. Colonoscopy revealed hemangiomatous involvement in the rectum. There were rectal varices without evidence of active bleeding. Upon venography of the left leg, we also found infiltrative dilated superficial veins in the subcutaneous tissue and aneurismal dilatation of the deep veins. The patient was finally diagnosed with KTS, and treated with oral iron supplementation only, which has been tolerable to date. Intervention or surgery is not required. When gastrointestinal varices or hemangiomatous mucosal changes are detected in a young patient without definite underlying cause, KTS should be considered. (Korean J Gastroenterol 2011;58:157-161)
Cefotiam (Fontiam(R))에 의한 직업성 천식
류환철 ( Hwan Cheol Ryu ),박해심 ( Hae Sim Park ),이수미 ( Soo Mi Lee ),구태형 ( Tae Hyung Koo ),신봉철 ( Bong Chul Shin ),김보경 ( Bo Kyung Kim ),서효림 ( Hyo Rim Seo ),허정훈 ( Jeong Hun Heo ),양두경 ( Doo Kyung Yang ),이수걸 ( 대한천식알레르기학회 2008 천식 및 알레르기 Vol.28 No.2
Cephalosporins are well-known agents that may cause occupational asthma. There have been a few reports suggesting that its pathogenesis may be IgE-mediated. To the best of our knowledge, this is the first report of cefotiam-induced occupational asthma. A 36-year-old female, a nurse, visited our allergy department for the evaluation of occupational asthma. She had worked in the surgical inpatients`` ward and handled a few kinds of antibiotics for 4 years. At that time, she developed rhinorrhea, paroxysmal cough and chest tightness for 2 months. Her symptoms used to be aggravated during and shortly after her work and subsided several hours after work. However, her symptoms subsided spontaneously, because she was brought to the outpatients`` ward for recent 3 years. Therefore, she had only mild dyspnea on exercise. Methacholine bronchial challenge test revealed a negative response. The skin prick test with cefotiam (Fontaim(R)) showed a strong positive response and a specific bronchial provocation test with cefotiam demonstrated an early asthmatic response. A few days after bronchial provocation test with cefotiam, the methacholine bronchial challenge test showed a positive response. Further studies will be needed to evaluate the exact pathogenetic mechanism of cefotiam-induced occupational asthma. (Korean J Asthma Allergy Clin Immunol 2008;28:152-155)
페니토인에 의한 횡문근융해증이 동반된 항경련제 과민반응 증후군
김영훈 ( Young Hoon Kim ),이채욱 ( Chae Uk Lee ),김기호 ( Ki Ho Kim ),김상호 ( Sang Ho Kim ),신봉철 ( Bong Chul Shin ),서효림 ( Hyo Rim Seo ),김보경 ( Bo Kyung Kim ),허정훈 ( Jeong Hun Heo ),양두경 ( Doo Kyung Yang ),이수걸 ( Soo 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.1
Anticonvulsant hypersensitivity syndrome (AHS) is a multisystemic disorder with cutaneous changes and typical blood abnormalities that may be triggered by any of the aromatic anticonvulsant drugs. Hepatic involvement is most common among internal organ involvements. Rhabdomyolysis is a rare manifestation of AHS. We present the case of a woman who, following phenytoin treatment, developed AHS with rhabdomyolysis. A 21-year-old woman was consulted to Allergy Clinic due to fever, rash, myalgia, and marked periorbital and facial edema that developed 10 days after the start of phenytoin therapy for seizure. Her hospital course was remarkable with an increased serum creatine phosphokinase level of 8,576 IU/liter. Peripheral blood cell counts showed eosinophilia (1,100/μL) and thrombocytopenia (112,000/μL). Liver function tests revealed increased levels of liver enzymes (AST/ALT=1,0011/611 IU/L) and hyperbilirubinemia (total bilirubin/direct bilirubin=2.9/1.6 mg/dL). After the discontinuation of phenytoin and treatment with oral prednisolone for three weeks, her skin lesion and laboratory abnormalities improved. (Korean J Asthma Allergy Clin Immunol 2007;27:66-69)
진행성 비소세포폐암에서 Heme oxygenase-1 발현과 Cisplatin을 포함하는 항암화학요법의 치료반응과의 연관성
양두경 ( Doo Kyung Yang ),노미숙 ( Mee Sook Roh ),이경은 ( Kyung Eun Lee ),김기남 ( Ki Nam Kim ),이기남 ( Ki Nam Lee ),최필조 ( Pil Jo Choi ),방정희 ( Jung Hee Bang ),김보경 ( Bo Kyung Kim ),서효림 ( Hyo Rim Seo ),김민지 ( Min Ji 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.60 No.3