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Cefotiam (Fontiam(R))에 의한 직업성 천식
류환철 ( Hwan Cheol Ryu ),박해심 ( Hae Sim Park ),이수미 ( Soo Mi Lee ),구태형 ( Tae Hyung Koo ),신봉철 ( Bong Chul Shin ),김보경 ( Bo Kyung Kim ),서효림 ( Hyo Rim Seo ),허정훈 ( Jeong Hun Heo ),양두경 ( Doo Kyung Yang ),이수걸 ( 대한천식알레르기학회 2008 천식 및 알레르기 Vol.28 No.2
Cephalosporins are well-known agents that may cause occupational asthma. There have been a few reports suggesting that its pathogenesis may be IgE-mediated. To the best of our knowledge, this is the first report of cefotiam-induced occupational asthma. A 36-year-old female, a nurse, visited our allergy department for the evaluation of occupational asthma. She had worked in the surgical inpatients`` ward and handled a few kinds of antibiotics for 4 years. At that time, she developed rhinorrhea, paroxysmal cough and chest tightness for 2 months. Her symptoms used to be aggravated during and shortly after her work and subsided several hours after work. However, her symptoms subsided spontaneously, because she was brought to the outpatients`` ward for recent 3 years. Therefore, she had only mild dyspnea on exercise. Methacholine bronchial challenge test revealed a negative response. The skin prick test with cefotiam (Fontaim(R)) showed a strong positive response and a specific bronchial provocation test with cefotiam demonstrated an early asthmatic response. A few days after bronchial provocation test with cefotiam, the methacholine bronchial challenge test showed a positive response. Further studies will be needed to evaluate the exact pathogenetic mechanism of cefotiam-induced occupational asthma. (Korean J Asthma Allergy Clin Immunol 2008;28:152-155)
두통을 주소로 내원한 베체트병 환자에서 상악동 내 발생한 림프종
홍현종 ( Hyun Jong Hong ),이상엽 ( Sang Yeob Lee ),김혜인 ( Hye In Kim ),황진연 ( Jin Yeon Hwang ),조용민 ( Yong Min Jo ),류환철 ( Hwan Cheol Ryu ),이성원 ( Sung Won Lee ),정원태 ( Won Tae Chung ),김대철 ( Dae Cheol Kim ) 대한류마티스학회 2008 대한류마티스학회지 Vol.15 No.1
Behcet`s disease is chronic and systemic inflammatory vasculitis, characterized by immunologically involving in variable size of arteries and veins. Clinically, principal manifestations are recurrent oral ulcer, genital ulcer, skin and eye lesions. Compared to other connective tissue disease, cancer is not accompanied commonly in Behcet`s disease. But, immunological confusion such as T cell depletion or B cell hyperplasia, or long-term of immunosuppressive treatment lead to occurrence of malignancy. Recently, we experienced a case of maxillary mass, induced to abrupt headache in Behcet`s disease, confirmed diffuse large B cell lymphoma by biopsy, and treated by rituximab-CHOP chemotherapy. Thus we report these with literature review.