침구(鍼灸) 치료와 활락탕(活絡湯) 투여가 급성요통 및 간기능에 미치는 영향에 관한 임상적 고찰

임정은,송호섭,권순정,이성노,강미숙,변임정,황현서,김기현,Lim, Jeoung-Eun,Song, Ho-Sueb,Kwon, Soon-Jung,Lee, Seong-No,Kang, Mi-suk,Byun, Im-Jung,Hwang, Hyeon-Seo,Kim, Kee-Hyun 대한침구의학회 2001 대한침구의학회지 Vol.18 No.5

Objective : The purpose of this study was to investigate the effect of acupuncture, moxibustion and whuallak-tang on acute back pain and liver function. Methods : We investigated 34 acute back pain patients. We treated them with acupuncture, moxibustion and bed rest, herbal medicine (Whuallak-tang, Huoluo-tang, 活絡湯) and physical therapy and we observed clinical effects and checked the changes of AST,ALT,ALP on admission and 1week later. Results : The result obtained is as follows. The patients were 58.8% male and 41.2% female ranging in age from 29 to 76 years. after treatment, of the 34 cases, 10(29.4%) were obtained excellent results and 23(67.7%) were good, and 1(2.9%) case was obtained fair result, with the total effective rate being 97.1%. AST,ALT,ALP was within normal range on admission and 1week later. and AST and ALP were decreased but had no statically significance.(P>0.05) Conclusion : This study suggests that acupuncture, moxibustion and Whuallak-tang are effective on acute back pain and should not induce hepatotoxicity. even though there are few toxic herbs in Oriental medicine, acupuncture and general herbal medication by a oriental doctor should not injure liver function of human.

현호색의 Acetylcholinesterase 활성 저해 성분 및 그 작용기전

황세영,장영표,변순정,전미희,김영중,Hwang, Se-Young,Chang, Young-Pyo,Byun, Soon-Jung,Jeon, Mee-Hee,Kim, Young-Choong 한국생약학회 1996 생약학회지 Vol.27 No.2

In the course of searching for acetylcholinesterase inhibitors from crude drugs, it was found that total MeOH extract of Corydalis Tuber showed significant inhibitory effect on acetylcholinesterase. To isolate acetylcholinesterase inhibitors from Corydalis Tuber, total MeOH extract of the the crude drug was subjected to activity guided fractionation. The MeOH extract was suspended in water and fractionated with methylene chloride and subjected to acid-base fractionation. Silica gel column chromatography of the basic fraction which showed significant inhibitory effect on acetylcholinesterase was carried out and 5 subfractions (1-5) were obtained. From subtraction 4, compound I was isolated. The structure of isolated compound I was identified by spectroscopic parameters of $^1H-NMR$, $^{13}C-NMR$, EI-MS and FAB-MS. The compound I was identified as berberine. It was found from the Lineweaver-Burk plot that berberine was a reversible and specific inhibitor of acetylcholinesterase having 90% inhibitory effect at the concentration of $2.5{\mu}M$.

시호의 메탄올 추출물이 일차배양한 뇌, DRG 및 간세포에 미치는 영향

김영중(Young Choong Kim),박미정(Mi Jung Park),변순정(Soon Jung Byun),송진호(Jin Ho Song) 한국생약학회 1990 생약학회지 Vol.21 No.1

Effects of the methanol extract of Bupleuri Radix on primary cultured. chicken embryonic brain cells, dorsal root ganglia (DRG) and rat hepatocytes were studied. The methanol extract of Bupleuri Radix at the concentration ranging from 10 ㎍/㎖ to 100 ㎍/㎖ significantly recovered the cytotoxicity of rat hepatocytes induced by the treatment of galactosamine; at the concentration of 100 ㎍/㎖, values of GOT and GPT in the culture medium were reduced by the 60% and 75%, respectively of those in the absence of the methanol extract of Bupleuri Radix. The addition of the methanol extract of Bupleuri Radix, into chicken embryonic brain cells which were cultured with a deficient medium significantly increased the number of cells promoting the neurite outgrowth. However, the methanol extract of Bupleuri Radix showed no effect on the activities of PDHC and acetylcholinesterase in primary cultured brain cells.

수종 생약 수침 엑기스의 면역증강 작용에 관한 연구

김미숙(Mi Sook Kim),이나경(Na Gyong Lee),이재현(Jae Hyun Lee),변순정(Soon Jung Byun),김영중(Young Choong Kim) 한국생약학회 1988 생약학회지 Vol.19 No.3

Immunopotentiating activity of water extract of Lycii Fructus, Rubus Fructus, Torilis Fructus, Schizandrae Fructus and Cuscutae Semen were investigated using mouse fed with normal diet and protein deficient diet. Body weight, ratio of spleen or thymus to body weight, number of total peritoneal exudate cell, content of total serum protein and albumin content were decreased in the mouse fed with protein deficient diet as compared to the mouse fed with normal diet. Regardless of the nutritional condition, the supplement of the water extract of Lycii, Rubus, Torilis, Schizandrae Fructus or Cuscutae Semen increased the ratio of spleen to body weight. The increment of this ratio was significant by the supplement of water extracts of Lycii and Torilis Fructus in mouse fed with protein deficient diet. The supplement of water extracts of Torilis Fructus to the mouse fed with protein deficient diet increased the content of total serum protein and albumin content significantly. Similar results were obtained with Lycii, Rubus, Schizandrae Fructus and Cuscutae Semen. The electrophorogram shows the difference in the concentration of some serum protein constituents between the mouse fed with normal diet and protein deficient diet.

인삼 사포닌이 간세포 독성에 미치는 영향

김선여(Sun Yeou Kim),김영중(Young Choong Kim),변순정(Soon Jung Byun),김은(Eun Kim) 한국생약학회 1992 생약학회지 Vol.22 No.4

Liver protective effects of ginsenosides as well as fractions of dammarane glycosides of Panax ginseng were studied using galactosamine (Ga1N)-induced cytotoxicity in primary cultured rat hepatocytes. Preventing effects on Ga1N-induced hepatotoxicity were found both microscopic observation and determination of GPT level with total dammarane glycosides fraction and 20(S)-ginsenoside-Rb₁ as well as 20(S)-ginsenoside-Rg₁ at the concentration of 50 ㎍/㎖. The syntheses of both protein and RNA were significantly increased by the treatment of 50 ㎍/㎖ of total dammarane glycoside fraction, 20(S)-ginsenoside-Rb₁, -Rc, -Re and -Rg₁, respectively in both normal and Ga1N-induced cytotoxic hepatocytes.

배초향지하부의 Diterpene 성분에 관한 연구

한대석(Dae Suk Han),김영중(Young Choong Kim),김세은(Se Eun Kim),주혜수(Hye Soo Ju),변순정(Soon Jung Byun) 한국생약학회 1987 생약학회지 Vol.18 No.2

A new diterpene, mp 178∼180°, C_(21)H_(28)O_5, was isolated from the root of Agastache rugosa O. Kuntze in the family of Labiatae. The structure of this compound was postulated as 19(4→3)-abeo-12,14,15-trihydroxy-11-methoxy-abiet-4(18), 8,11,13-tetraen-7-one by spectroscopic methods.

요부 경근의 급성 염좌에 경근자침 및 경근이완요법이 미치는 영향

강미숙,변임정,송호섭,권순정,김기현,강미정,이성노,임정은,황현서 대한침구학회 2001 대한침구의학회지 Vol.18 No.6

Objective : To broaden understanding about relationship between Meridian Tendino-musculature and muscles in a lumbar area and to evaluate the effect of Meridian Tendino-musculature acupuncture and release therapy on acute lumbar sprain. Materials and Methods : From Oct. 1st, 2000 to Mar. 31th, 2001, 692 outpatient's chart of Kyung Won University Hospital were reviewed. Out of them, 39 outpatients were selected. they had low back pain, were diagnosed with acute lumbar sprain, showed only straightened curvature on lateral view of lumbar spine X-ray and get the Tendino-musculature acupuncture and release therapy. Results : 1. On patients' first visit, 72% had GrM and Gr.IV predominantly. 2. Major muscles related with low back pain were divided into two groups. One was Quadratus lumborum group and the other was Rectus abdominis group. In the correlation with Meridian Tendino-musculature, the former was mainly related with Chok-taeyang(B) and slightly related with Chok-soyang(G), Chok-taeum(SP), the latter was mainly related with Chok-taeyum(SP), Chok-yangmyong(S) and slightly related with Chok-taeyang(B), Chok-soyang(G). 3. In the evaluation of treatment effect, Exellent was 27(69%), Good was 10(6%), Fair was 2(5%) and Bad was 0(0%). Fair rate reached 100% eventually. 4. Most of Gr.Ⅲ, Gr.Ⅳ patients who had severe conditions that almost every R.O.M. was limited and Milgram test positive was shown on the physical examination, were fully recovered and lived normal daily life without admission by Meridian Tendino-musculature acupuncture and release therapy within 3 to 5, 4 to 7 days, respectively, since they had started to get their outpatient treatment. 5. Two patients was troubled with pain induced, by twitching response and acupuncure stimuli, which lasted around acupunctured muscle for about a day after treatment, so they coudn't endure the pain and quitted treatment in spite of Fair condition. conclusion : Meridian Tendino-musculature acupuncture and release therapy was found to be helpful to patients who wish to recover from their back pain induced by acute lumbar sprain as - soon as possible, but the treatment actually had some problems to be overcome such as pain during or after the treatment. therefor, in order to make this treatment method more available, we should pay more attention to improving treatment appliance and acupuncture technique.

침구 치료와 활락탕 투여가 급성요통 및 간기능에 미치는 영향에 관한 임상적 고찰

강미숙,송호섭,권순정,김기현,변임정,황현서,이성노,임정은 대한침구학회 2001 대한침구의학회지 Vol.18 No.5

Objective : The purpose of this study was to investigate the effect of acupuncture, moxibustion and whuallak-tang on acute back pain and liver function. Methods : We investigated 34 acute back pain patients. We treated them with acupuncture, moxibustion and bed rest, herbal medicine (Whuallak-tang, Huoluo-tang, 活絡湯) and physical therapy and we observed clinical effects and checked the changes of AST,ALT,ALP on admission and ]week later. Results : The result obtained is as follows. The patients were 58.8% male and 41.2% female ranging in age from 29 to 76 years. after treatment, of the 34 cases, 10(29.4%) were obtained excellent results and 23(67.7%) were good, and 1(2.9%) case was obtained fair result, with the total effective rate being 97.1%. AST,ALT,ALP was within normal range on admission and ]week later. and AST and ALP were decreased but had no statically significance.(P>0.05) Conclusion : This study suggests that acupuncture, moxibustion and Whuallak-tang are effective on acute back pain and should not induce hepatotoxicity. even though there are few toxic herbs in Oriental medicine, acupuncture and general herbal medication by a oriental doctor should not injure liver function of human.