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백민원,석승혁,이희영,김동재,이병희,Young-Tae Ahn,Kwang-Sei Lim,허철성,박재학 대한수의학회 2008 JOURNAL OF VETERINARY SCIENCE Vol.9 No.1
An herbal extract mixture and yogurt added to the herbal extract mixture were tested for their protective and therapeutic effects on ethanol-induced liver injury. The herbal extract mixture, yogurt and commercial drugs were used for treatment for two weeks prior to administering a single oral dose of ethanol (3 g/kg body weight). The herbal extract mixture and yogurt added to the herbal extract mixture were found to provide protection against ethanolinduced toxicity comparable to the commercial drug treatment, according to the serum and histopathological analysis. It was also shown that co-treatment with herbal extract mixture and yogurt against a triple oral dose of ethanol (2 g/kg body weight, over one week) provided protection against ethanol toxicity. After the initial set of experiments, the herbal extract mixture and yogurt treatments were extended for three more weeks. When compared to the positive control, further treatment with both the herbal extract and yogurt significantly reduced liver injury and resulted in a lower grade of lipid deposition.
석승혁 ( Seung Hyeok Seok ),백민원 ( Min Won Baek ),김동재 ( Dong Jae Kim ),나이랑 ( Yi Rang Na ),한주희 ( Ju Hee Han ),고애선 ( Ae Sun Koh ),박재학 ( Jae Hak Park ) 한국동물실험대체법학회 2008 동물실험대체법학회지 Vol.2 No.2
Zebrafish is proposed as an ideal vertebrate cancer model. Because zebrafish is easy to maintain and breed, and her fecundity is high enough (200~300 eggs per fish). Powerful genetics and cellular biology tools are also available in zebrafish. Even, histologically many organs are very similar with humans. We have raised over 1,000 fish for the transgenesis study through injections of various genes in a closed recirculating water system. In the end of the study, before euthanasia, we biopsied the negative control fish at 24 months of age. The histological analysis of one case of zebrafish tumorous change revealed biliary carcinoma, based upon the H&E staining. The local invasion, fibrosis, and increased mitotic index were observed in Laboratory maintained wild type zebrafish. This is the first documentation of the spontaneous biliary carcinoma in wild type zebrafish in Korea.
제브라피쉬 장내에서 Vancomycin-resistant enterococci 분리
석승혁 ( Seung Hyeok Seok ),백민원 ( Min Won Baek ),김동재 ( Dong Jae Kim ),나이랑 ( Yi Rang Na ),한주희 ( Ju Hee Han ),고애선 ( Ae Sun Kohv ),정우경 ( Woo Kyung Jung ),박재학 ( Jae Hak Park ) 한국동물실험대체법학회 2008 동물실험대체법학회지 Vol.2 No.2
The use of zebrafish embryos is not regulated by current Animal Protection law (full amendment, January 26, 2007) in Korea and therefore considered as a refinement, if not replacement of animal experiments because the complicated physiological environment is absent in vitro system. The skin ulcers and abdominal swelling were observed in Laboratory maintained zebrafish. Contents of abdominal swelling found at necropsy are peritoneal exudates. Vancomycin resistant enterococci (VRE) were detected for VanC-1 (Enterococcus gallinarum) by PCR on cultured colonies from the affected fish gut, exudates. In addition, unhatched eggs were observed in the abdominal exudates, based upon the H&E staining. This is the first documentation of the precise identification of VRE with VanC-1 gene in laboratory-maintained zebrafish. The pathogenesis to VRE infection in zebrafish was required in the following study.