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인동등과 봉독약침이 Adjuvant 투여로 유발된 류마토이드 병태모델에 미치는 실험적 연구
배명현 ( Myung Hyun Bae ),염승룡 ( Seung Ryong Yeam ),김진희 ( Jin Hee Kim ),권영달 ( Young Dal Kwon ) 한방재활의학과학회 2015 한방재활의학과학회지 Vol.25 No.1
ObjectivesThis study was carried out to investigate the experimental effects of Lonicerae Caulis and Bee-venom Acupuncture in Yanglingquan (陽陵泉, GB34) that have clinical efficacy in the Rheumatoid Arthritis. MethodsMaterials of present study are Lonicerae Caulis Extracts (LCE), Bee-Venom Acupuncture (BVP), Sprague-dawley rats (250 g or so, ♂), and various kinds of needing experimental studies. We measured several experimental items of the rats with the arthritis induced by Freund``s complete adjuvant (0.2 ml/kg), such as body weight, rate of paw edema, analgesic effect by hot plate method, WBC, TNF-α cytokine and IL-10 cytokine. Rats were divided into four groups; Normal group that was treated with normal saline 1.0 ml (o.p) and 15 μl/kg (GB34) to normal rats, Control group that was treated with normal saline 1.0 ml (o.p) and 15 μl/kg (GB34) to pathologic model rats induced by Freund``s complete adjuvant 0.2 ml/kg, Experimental group A that was treated with LCE 1.0 ml (o.p) and normal saline 15 μl/kg (GB34) to pathologic model rats induced by Freund``s complete adjuvant 0.2 ml/kg and Experimental group B that was treated with LCE 1.0 ml (o.p) and BVP 15 μl/kg (GB34) to pathologic model rats induced by Freund``s complete adjuvant 0.2 ml/kg, and the experiment took over after 28 days. The results were analysed using SPSS for windows 12.0. ResultsExperimental group A showed the increase in body weight, paw licking times and IL-10 cytokine compared to Control group. Also it was decreased in rate of paw edema, WBC, and TNF-α cytokine compared with Control group. Experimental group B showed the increase in body weight, paw licking times, and IL-10 cytokine compared to Control group, and showed the decrease in rate of paw edema, WBC and TNF-α cytokine compared to Control group. Especially TNF-α cytokine and rate of paw edema were accepted statistical significance compared with Control group. ConclusionsIt is suggested that Lonicerae Caulis (o.p) and Bee-venom Acupuncture (GB34) can be used in the treatment of rheumatoid arthritis. (J Korean Med Rehab 2015;25(1):17-26)
연구논문 : 생명과학 ; 폴록사머 및 프로필렌글리콜을 이용한 클로트리마졸 고형 좌제의 물리화학적 특성
현경희 ( Jing Ji Xuan ),오유경 ( Yu Kyoung Oh ),김정애 ( Jung Ae Kim ),공경환 ( Kyung Hwan Gong ),김지현 ( Ji Hyun Kim ),양준호 ( Joon Ho Yang ),배명수 ( Myung Soo Bae ),김호동 ( Ho Dong Kim ),이종달 ( Jong Dal Rhee ),장현욱 ( Hye 영남대학교 약품개발연구소 2005 영남대학교 약품개발연구소 연구업적집 Vol.15 No.-
폴록사머 및 프로필렌글리콜을 이용한 클로트리마졸 고형 좌제의 물리화학적 특성
현경희,오유경,김정애,공경환,김지현,양준호,배명수,김호동,이종달,장현욱,용철순,최한곤 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.2
To develop a clotrimazole-loaded solid suppository with poloxamer and propylene glycol, the melting points of various formulations composed of poloxamer 188 (P 188) and propylene glycol were investigated. The dissolution study of clotrimazole delivered by the suppository composed of P 188 and propylene glycol was performed. The mixtures composed of P 188 and propylene glycol were homogeneous. Propylene glycol affected the melting points of poloxamer mixtures. In particular, the mixture [P 188/propylene glycol (70/30%)] with the melting point of about 32°C was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, propylene glycol affected greatly the dissolution rates of clotrimazole from the suppository. Dissolution mechanism analysis showed the dissolution of clotrimazole was proportional to the time. Our results indicated that the solid suppository with P 188 and propylene glycol would be a candidate of rectal dosage form for clotrimazole.