RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      검색결과 좁혀 보기

      선택해제
      • 좁혀본 항목 보기순서

        • 원문유무
        • 원문제공처
        • 등재정보
        • 학술지명
          펼치기
        • 주제분류
        • 발행연도
          펼치기
        • 작성언어
        • 저자
          펼치기

      오늘 본 자료

      • 오늘 본 자료가 없습니다.
      더보기
      • 무료
      • 기관 내 무료
      • 유료
      • KCI등재
      • KCI등재
      • KCI등재
      • KCI등재
      • KCI등재

        담배 흡연이 생쥐의 흉선 및 비장의 면역 기능에 미치는 영향

        홍성실(Sung-Sil Hong),박윤아(Yun-A Park),이진우(Jin-Woo Lee),김미자(Mi-Ja Kim),남궁승(Seung Namkoong),구현정(Hyun-Jung Koo),손은화(Eun-Hwa Sohn) 한국산학기술학회 2021 한국산학기술학회논문지 Vol.22 No.9

        본 연구에서는 담배필터를 통해 호흡기로 노출되는 주류연 흡연 장치를 구현하여 직접 흡연에 의한 주류연의 노출이 면역시스템에 미치는 영향을 생쥐모델을 이용하여 규명하고자 하였다. 실험동물(n = 15)은 대조군(sham군)과 담배 2개비/일 노출군 및 4개비/일 노출군으로 각각 나누고, 7일 동안 주류연을 노출시킨 후 체중변화와 면역기관 지수를 측정하였다. 주류연 노출이 면역세포의 기능에 미치는 영향을 확인하기 위해, lipopolysaccharide(LPS) 또는 concanavalinA(ConA) 자극에 대한 비장세포와 흉선세포의 증식력과 nitric oxide(NO) 분비량을 측정하였다. 실험결과, 4개비/일 고용량 노출군의 흉선, 비장, 간 무게가 대조군에 비해 각각 0.3, 0.2 및 0.2배 유의적으로 감소하였고(P<0.05), 흉선세포 생존율과 B세포 및 T세포 증식력이 감소하였다. 또한, LPS에 의한 비장세포의 NO 분비능도 감소하였다. 본 연구는 주류연 노출이 흉선과 비장에 직접적인 손상을 주며, 자극원에 대한 면역세포의 증식력과 NO 분비 등 방어능력을 유의적으로 약화시킨다는 것을 보여주었다. 이는 흡연과 관련된 면역질환 발생이 주류연의 노출에 대한 직접적인 면역기관의 손상과 자극에 대한 방어 기능의 약화가 관련되어 있음을 제시한다. This study investigated the effect of exposure to mainstream smoke (MS) through cigarette filters on the immune system in mice. Fifteen mice were divided into 3 groups; control (sham), 2 cigarettes smoked/day (CS), 4 CS. Changes in body weight and organ index were measured after exposure to MS for 7 days. The effects of exposure to MS on nitric oxide (NO) production and cell proliferation induced by lipopolysaccharide (LPS) or concanavalin A (ConA) in murine lymphocytes were also determined. Exposure to 4 CS reduced the organ indices of the thymus, spleen, and liver by 0.3-, 0.2-, and 0.2-fold (P<0.05), respectively. Exposure to MS also inhibited the lymphocyte proliferation by LPS or ConA and the NO production by LPS. This study confirmed that the immune organs were directly damaged as well as weakened in their cell function by exposure to MS. It provides direct evidence that the occurrence of various immune diseases caused by smoking is closely related to the impairment of immune functions by exposure to MS.

      • KCI등재

        저위전방절제술에서 문합부 누출률을 줄이기 위한 피브린글루 사용의 효용성

        성기완(Gi Wan Seong),조용범(Yong Beom Cho),윤정아(Jung-A Yun),박윤아(Yoon Ah Park),윤성현(Seong Hyeon Yun),김희철(Hee Cheol Kim),이우용(Woo Yong Lee),전호경(Ho-Kyung Chun) 대한종양외과학회 2014 Korean Journal of Clinical Oncology Vol.10 No.1

        Purpose: Anastomotic leakage (AL) is a major complication occurring after low anterior resection (LAR). Several methods for anastomotic protection have been tried. However, the effectiveness of these methods at preventing AL is questioned. The present study examined whether direct application of fibrin glue to an anastomotic site could be an effective method for reducing aspects of AL, such as leakage rate. Methods: This study targeted patients who had undergone LAR between March and September 2012 for primary rectal cancer or rectosigmoid cancer which curative resection was possible. Anastomosis was performed with end to end anastomosis in all patients. Fibrin glue was used in 99 patients and conventional methods in the controls (130 patients). The research was conducted as a prospective non-randomized study. Results: AL occurred in seven cases (7.1%) in the fibrin glue group and seven cases (5.4%) in the control group; this difference wasn’t statistically significant. No significant differences were found between the two groups in terms of clinical stage of primary cancer, operation time, and length of hospital stay after surgery or in the severity of leakage or the treatment policy decisions for patients with AL. An analysis of risk factors showed that the occurrence of AL was significantly higher in male patients. Conclusion: Fibrin glue applied to an anastomotic site to prevent AL during LAR did not reduce the rate of AL. No differences were noted in other aspects of AL that would favor the use of fibrin glue over conventional methods.

      • KCI등재

        Poloxamer-407로 유도한 이상지질혈증 생쥐에서 홍삼의 예방 효과

        홍성실(Sung-Sil Hong),이진우(Jin-Woo Lee),박윤아(Yun-A Park),김성혁(Sung-Hyeok Kim),장소희(So-Hee Jang),하창우(Chang-Woo Ha),김미자(Mi-Ja Kim),남궁승(Seung Namkoong),구현정(Hyun-Jung Koo),손은화(Eun-Hwa Sohn) 한국산학기술학회 2021 한국산학기술학회논문지 Vol.22 No.10

        본 연구에서는 홍삼의 이상지질혈증 개선 효능과 안전성을 조사하고자 하였다. Poloxamer-407(P407)에 의한 이상지질혈증을 유발한 동물모델에 홍삼추출물과 지질강하제 simvastatin을 2주간 복강 투여한 후 지질프로파일과 간독성의 조절효과를 확인하였다. 실험동물은 8주령 수컷 ICR 마우스(n = 30)를 6개 그룹(무처치군, P407 유도군과 홍삼추출물 10, 50, 100 mg/kg 투여군 및 simvastatin 투여군)으로 나누어 각 그룹 당 5마리씩 무작위로 배치하였다. 실험종료 후 각 그룹의 마우스에서 간, 부고환 지방, 흉선 및 비장을 적출 하여 중량을 측정하였다. 또한 혈액에서 총콜레스테롤, 중성지방, 저밀도지단백질, 고밀도지단백질을 포함한 지질프로파일의 변화와 glutamate oxaloacetate transaminase(GOT) 및 glutamate pyruvate transaminase(GPT)를 측정하였다. 실험결과 홍삼추출물 10 mg/kg 투여군에서 P407로 증가된 혈중 총콜레스테롤, 중성지방, 저밀도지단백질을 모두 유의적으로 감소시켰으며(p <0.05), 그 효과는 simvastatin 10 mg/kg 투여군과 유사한 수준으로 나타났다. 또한, 홍삼추출물은 혈중 GPT와 GOT 수치에 영향을 미치지 않았으며 주요면역기관인 흉선의 무게를 증가시켰다. 이러한 결과는 홍삼이 이상지질혈증에 예방 효과가 있고 지질관련질환에 대한 statin계열 약물의 보조물질로서 활용 가능성을 제시한다. This study aimed at investigating the efficacy and safety of red ginseng (RG) for improving dyslipidemia. After 2 weeks of intraperitoneal administration of RG and simvastatin (lipid-lowering medication) to an animal model with dyslipidemia induced by poloxamer-407 (P407), the regulatory effects on the lipid profile and hepatotoxicity were confirmed. 8-week-old male ICR mice (n = 30) were divided into 6 groups (control, P407-induced dyslipidemia group, RG 10, 50, 100 mg/kg group, simvastatin group). 5 mice were randomly placed in each group. At the end of the experiment, the weight of the liver, epididymal fat, thymus, and spleen was measured in each group. We also identified changes in the lipid profile, including total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL), high-density lipoproteins (HDL), and determined the levels of the glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) in the blood. The results show that 10 mg/kg RG significantly reduced the increase of P407-induced levels of TC, TG, and LDL (p <0.05), similar to the simvastatin group. Moreover, RG did not affect the levels of GPT and GOT, and increased the weight of the thymus, a major immune organ. These results suggested that RG may be able to prevent dyslipidemia and has therapeutic potential as an adjuvant to statins for the management of lipid disorders.

      • KCI등재

        원발 직장암 절제 후 조기 재입원의 요인분석

        김봉균(Bong Kyun Kim),이우용(Woo Yong Lee),윤정아(Jung-A Yun),윤성현(Seong Hyeon Yun),김희철(Hee Cheol Kim),조용범(Yong Beom Cho),박윤아(Yoon Ah Park) 대한종양외과학회 2013 Korean Journal of Clinical Oncology Vol.9 No.1

        Purpose: Early readmission of patients who underwent resection for primary rectal cancer will raise social costs and resources for treatment and will affect the patients’ prognosis. Thus, analysis of the characteristics of readmitted patients should be done to find a way to reduce the readmission rate. Methods: The study enrolled 521 patients who were admitted and underwent low anterior resection for primary rectal cancer at Samsung Medical Center during the period from January 1st to December 31st, 2010. The data of these patients regarding the related factors of readmission were collected retrospectively. For these related factors of readmission, we used univariate analysis by the chi-square test and multivariate analysis by the logistic regression test to find the odds ratio of the readmission rate. Results: Of 457 patients who meet inclusion criteria in the 521 patients, 22 patients (4.8%) were early readmitted within 30 days after discharge. Ten of these patients (45.5%) were readmitted due to adhesive ileus. Univariate and multivariate analyses for early readmitted patients showed that the readmission rate is significantly higher in the group of less than 65 years of age, had a history of smoking, had education less than elementary school, had an albumin level of less than 3.2 g/dL before discharge, and had complications during hospitalization. Conclusion: After surgery for rectal cancer, patients should be managed more carefully during hospitalization, and for the patients who have readmission risk factors, we should reinforce discharge criteria and education, curtail the period until the following outpatient clinic after discharge so that we may reduce the readmission rate after surgery.

      • KCI등재

        A Study on Human Sensitivity in Design of Men's suit

        이연순,박윤아,정은영 한국의류학회 2002 한국의류학회지 Vol.26 No.12

        신사복 정장은 일상의 관습으로 착용되는 가장 중요한 항목으로서, 사무직, 관리직, 전문직 등의 정신 노동자들에게 폭넓게 수용되는 매우 중요한 의복항목이다. 따라서 소비자의 감성에 부합되는 신사복 개발을 위해 신사복 디자인에 대한 감성연구가 필요하다. 이에 본 연구에서는 신사복 상의 디자인 개발을 위해서 소비자의 감성에 적합한 신사복 상의를 적절하게 표현해 줄 수 있는 감성어휘를 추출하고 그 인자를 분석하였다. 요인분석결과, 7개의 요인과 67개의 감성어휘가 채택되었다. 선택된 감성어휘는 인자별로 대별하여 7개의 요인으로 묶어서 대표적인 요인명을 붙인 결과, 요인 1은 품위성 요인, 요인 2는 매력성 요인, 요인 3은 실용성 요인, 요인 4는 체형성 요인, 요인 5는 외관성 요인, 요인 6은 남성미 요인, 요인 7은 활동성 요인이라고 하였다.

      • 의류 매장 디스플레이에 관한 소비자의 견해에 대한 조사 연구

        이연순,박성혜,박윤아 영남대학교 자원문제연구소 1993 資源問題硏究 Vol.12 No.-

        For investgating the consummer's opinion about the display of clothing- store, this research was carried out in reference to 800 females students whose major is clothing & textiles, from March 1. 1991 to April 30. 1991. The result was as Fellows : 1. Consumers preferred clothing specialty store which sells National brands and Desigiers' brands the most due to variety of merchandise. They considered design as the most important factor when purchasing clothes. They also used newspaper, magazines, TV advertisings for fashion information. 2. Consumers were conscious of the necessity and effect of display highly. They perceived the purpose of display looking merchandise prominent. The way of display and selling space organization were shown to affect the purchase of clothes. Lack of orginality and jammed merchandise in display area were indicated to have to be improved. 3. Consumers were impressed by interior and general atmosphere of the store. They indicated that moving distance in the store according to merchandise layout was short for the most part. However, they criticizd lack forest area in the store and too much merchandise in display area. 4. Consumers preferred mannequin as display fixture for women's wear. They perceived display props as actualization of merchandise image. And they usually used analogous color scheme. They also used lighting to help general atmosphere in the store.

      연관 검색어 추천

      이 검색어로 많이 본 자료

      활용도 높은 자료

      해외이동버튼