산양산삼약침이 고지방식이에 의한 당뇨병 유발 흰쥐에 미치는 영향

박원필,이은,권기록,Park, Won-Pil,Lee, Eun,Kwon, Ki-Rok 대한약침학회 2005 Journal of pharmacopuncture Vol.8 No.2

Objectives : This study was to verify the effects of distilled cultivated wild ginseng herbal acupuncture(CWGHA) on diabetes by hematological analysis. Methods : Rats were fed with high fat diet for 8 weeks and the rats with hyperglycemia were selected for the experiment. Various treatments of distilled cultivated wild ginseng herbal acupuncture were administered intravenously and glucose, ${\beta}-lipoprotein,$ triglyceride, total-cholesterol, HDL-cholesterol, LDL-cholesterol, Free Fatty acid(FFA), TBARS, superoxide dismutase(SOD), catalase and glutathione peroxidase activities in the liver were analyzed. Results : 1. Experiment group 3(0.1 ml of CWGHA was injected intravenously 10 times) showed significant decrease in serum glucose, ${\beta}-lipoprotein,$ triglyceride, LDL-cholesterol levels and liver TBARS compared to the control group, whileas showed significant increase in liver glutathione peroxidase activity. 2. Experiment group 2 and 3 (treated with 0.5 ml, 1 ml, respectively), showed significant decrease in serum FFA, total cholesterol and TBARS levels compared to the control group, and showed significant increase in liver superoxide dismutase and catalase activities. 3. Serum HDL-cholesterol didn't show significant changes in both experiment and control groups. Conclusions : Above results indicate that distilled cultivated wild ginseng herbal acupuncture plays significant role as a hypoglycemic agent and in lipid metabolism. Increase in the number of administrations yielded more significant results.

약침용 불량 Needle의 미세 형태 관찰

박원필,김현도,권기록,Park, Won-Pil,Kim, Hyun-Do,Kwon, Ki-Rok 대한약침학회 2005 Journal of pharmacopuncture Vol.8 No.1

Objectives : This study was conducted to observe the tip of needles which induce poor needle sensation upon injection of herbal acupuncture. Methods : Among the syringes used for herbal acupuncture, needles which cause poor sensation were collected and evaluated by SEM (scanning electron microscope) for changes in structure, existence of impure matters, physical damage, and etc. Results : 1. Various forms contributed to poor needle sensation. Bent needle body, damaged or crooked needle tip, and blunted tip 2. Poor needles could be made during the manufacturing process, during insertion of the needle into the vial(except for the lubricants), and repeated procedures with one needle at different regions. Conclusion : Poor needles induce unnecessary pain and discomfort not only to the patients but also to administrators during injection. Herbal acupuncture is a treatment technique injecting herbal extract on the meridian points, and strict quality check must be enforced to prevent occurrence of poor needles.

유한차분법을 이용한 기능성 위장 장애 진단용 초음파 시스템의 개발

박원필(Won Pil Park),우대곤(Dae Gon Woo),고창용(Chang Yong Ko),이균정(Qyoun Jung Lee),이용흠(Yong Heum Lee),최서형(Seo Hyoung Choi),신태민(Tae Min Shin),김한성(Han Sung Kim),임도형(Dohyung Lim) Korean Society for Precision Engineering 2007 한국정밀공학회지 Vol.24 No.9

Sweet BV의 침감비교 연구

임청산,박원필,장성봉,최영곤,박도일,권기록,이희춘,Lim, Chung-San,Park, Won-Pil,Jang, Seong-Bong,Choi, Young-Chon,Park, Do-Il,Kwon, Ki-Rok,Lee, Hee-Choon 대한약침학회 2008 Journal of pharmacopuncture Vol.11 No.2

Objective Sweet bee venom is made by removing allergen from the bee venom through gel filtration chromatography and propionic acid/urea polyacrylamide gel electrophoresis. The aim of this study was to verify allergy inhibitory action in Sweet Bee Venom(SBV) and New Sweet Bee Venom(NSBV) removed enzymes and compounds of low molecular weight. Methods 84 healthy adult men and women were selected through a survey whom had never received the bee venom therapy in the past. The concentration of Normal Saline, SBV and NSBV pharmacopuncture was equally at 0.1mg/mL and the experiment was conducted as the double blind test. Results Participants of the study was comprised of 63 men and 21 women with the average age of 28.3 years. According to results of pain sense, SBV group showed significant higher score compared with NS group and NSBV group using VAS in treating time. And SBV and NSBV group showed significant higher score compared with NS group after 30 minutes. Other allergic responses were insignificant between the groups. Conclusions As a result of removed allergen and compounds of low molecular weight, NSBV significantly inhibits pain sense in treating time compared with SBV. This indicates wider and easier application of NSBV for the useful application in clinical treatment. Further comparative studies should be conducted to yield more objective verification.

저속 후방 추돌 자원자 실험을 통한 두부와 경부의 동작분석

홍성우,박원필,박성지,유재호,공세진,김한성,Hong, Seong Woo,Park, Won-Pil,Park, Sung-Ji,You, Jae-Ho,Kong, Sejin,Kim, Hansung 한국자동차안전학회 2012 자동차안전학회지 Vol.4 No.2

The purpose of this research is to obtain and analyze dynamic responses from human volunteers for the development of the human-like mechanical or mathematical model for Korean males in automotive rear collisions. This paper focused on the introduction to a low-speed rear impact sled test involving Korean male subjects, and the accumulation of the motion of head and neck. A total of 50 dynamic rear impact sled tests were performed with 50 human volunteers, who are 30-50 year-old males. Each subject can be involved in only one case to prevent any injury in which he was exposed to the impulse that was equivalent to a low-speed rear-end collision of cars at 5-8 km/h for change of velocity, so called, ${\Delta}V$. All subjects were examined by an orthopedist to qualify for the test through the medical check-up of their necks and low backs prior to the test. The impact device is the pendulum type, tuned to simulate the crash pulse of a real vehicle. All motions and impulses were captured and measured by motion capture systems and pressure sensors on the seat. Dynamic responses of head and T1 were analyzed in two cases(5 km/h, 8 km/h) to compare with the results in the previous studies. After the experiments, human subjects were examined to check up any change in the post medical analysis. As a result, there was no change in MRI and no injury reported. Six subjects experienced a minor stiffness on their back for no more than 2 days and got back to normal without any medical treatment.

Sweet BV가 복부비만에 미치는 영향

임청산,박원필,장성봉,최영곤,김관수,권기록,이희춘,Lim, Chung-San,Park, Won-Pil,Jang, Seong-Bong,Choi, Young-Chon,Kim, Kwan-Soo,Kwon, Ki-Rok,Lee, Hee-Choon 대한약침학회 2008 Journal of pharmacopuncture Vol.11 No.2

Objective The purpose of this study was to investigate the effects of Sweet Bee Venom to the abdominal fat accumulation clinically. Methods The 20 healthy women volunteers who showed the notice of this study by the home page of Sangji University were treated with Sweet Bee Venom(SBV) during twenty times. To investigate the effects of Sweet Bee Venom of the abdominal fat accumulation, abdominal CT, LFT, Thermography, BMI, Inbody 3.0 etc. were performed during clinical trials. And statistical analysis was carried out the data of 10 volunteers who performed all the schedule of this study. Results Following results were obtained from the clinical studies Sweet Bee Venom showed the effect of decreased the body weight, thickness of abdominal skin and fat layer, BMI, and increased abdominal heat, but they are not showed statistical significant. Conclusions These results suggest that treatment Sweet Bee Venom on the abdomen was effective to decrease fat tissue but for the treatment of obesity was performed with right diet program and exercise.

Anti-BV의 봉약침 항체 효능에 관한 실험적 연구

권기록,이광호,박원필,Kwon, Ki-Rok,Lee, Kwang-Ho,Park, Won-Pil 대한약침학회 2005 Journal of pharmacopuncture Vol.8 No.1

Objectives : To observe physiological anti-body effects of anti-BV, acute toxic response, measurement of $LD_{50}$, and the effects of anti-body were evaluated. Methods : $LD_{50}$ of Anti-Bee Venom were measured, and to analyze acute toxic responses, weight, and the anti-body effects various concentrations of Anti-BV were diluted and the survival rate was measured. Cell blood count (CBC), liver, spleen, and kidney pathologies were observed from the histological aspects. Results : Experiment was conducted to observe Anti-BV as the anti-body to the bee venom and the following results were obtained : 1.anti-BV was injected intraperitoneally and no toxic responses were witnessed. All of the experiment subjects stayed alive during the experiment, making $LD_{50}$ analysis impossible. 2.Anti-BV was injected intraperitoneally in mice and no significant weight changes were measured between the control group and the experiment groups. 3. Measuring the concentration dependent survival rate, the highest survival rate was at the concentration of $1.25{\times}10^2mg/kg$(1/2.000) for Anti-BV. 4. No particular results were shown in the CBC test. 5. Observation of changes in the organ tissues, Anti-BV was found to suppress blood stasis in the liver and inhibit necrosis of the cells. Conclusion : Above results suggest that Anti-BV doesn't cause any toxic responses in the body and works as an anti-body to the bee venom. Further studies must be followed to secure the findings.

초음파 응답특성 분석에 의한 위장 경화 진단시스템의 설계

임도형,김은근,이균정,박원필,김한성,신태민,최서형,이용흠,Lim, Do-Hyung,Kim, Eun-Geun,Lee, Gyoun-Jung,Park, Won-Pil,Kim, Han-Sung,Shin, Tae-Min,Choi, Seo-Hyung,Lee, Yong-Heum 대한의용생체공학회 2007 의공학회지 Vol.28 No.2

Functional gastrointestinal disorders affect millions of people of all age regardless of race and sex. There are, however, rare diagnostic methods for the functional gastrointestinal disorders because functional disorders show no evidence of organic and physical causes. Our research group identified recently that the gastrointestinal tract well in the patients with the functional gastrointestinal disorders becomes more rigid than healthy people when palpating the abdominal regions overlaying the gastrointestinal tract. The aim is, therefore, to develop a diagnostic method for the functional gastrointestinal disorders based on quantitative measurement of the rigidity of the gastrointestinal tract well using ultrasound technique. For this purpose, a preliminary ultrasound diagnostic system was developed and verified through phantom tests. The system consisted of transmitter, ultrasonic transducer, receiver, TGC, and CPLD, and verified via a phantom test. For the phantom test, ten soft-tissue specimens were harvested from porcine. Five of them were then treated chemically to mimic a rigid condition of gastrointestinal tract well, which was induced by functional gastrointestinal disorders. Additionally, the specimens were tested mechanically to identify if the mimic was reasonable. The customized ultrasound system was finally verified through application to human subjects with/without functional gastrointestinal disorders(Normal and Patient Groups). It was identified from the mechanical test that the chemically treated specimens were more rigid than normalspecimen. This finding was favorably compared with the result obtained from the phantom test. The phantom test also showed that ultrasound system well described the specimen geometric characteristics and detected an alteration in the specimens. The maximum amplitude of the ultrasonic reflective signal in the rigid specimens $(0.2{\pm}0.1Vp-p)$ at the interface between the fat and muscle layers was explicitly higher than that in the normal specimens $(0.1{\pm}0.0Vp-p)$ (p<0.05). Clinical tests using our customized ultrasound system for human subject showed that the maximum amplitudes of the ultrasonic reflective signals nea. to the gastrointestinal tract well for the patient group$(2.6{\pm}0.3Vp-p)$ were generally higher than those in normal group$(0.1{\pm}0.2Vp-p)$ (p<0.05). These results suggest that newly designed diagnostic system based on ultrasound technique may diagnose enough the functional gastrointestinal disorders.