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도플러 제대동맥 혈류속도 파형치의 측정 부위에 따른 비획일성
박용원 ( Y. W. Park ),정인배 ( I. B. Chung ),이성기 ( S. K. Lee ),송찬호 ( C. H. Song ) 대한주산의학회 1990 大韓周産醫學會雜誌 Vol.1 No.1
Fetal umbilical arterial systolic/diastolic(S/D) ratios are said to be uniform throughout the umbilical cord except for the fetal abdominal portion due to entrance region phenomenon. This study was undertaken at YUMC in order to evaluated this uniformity by duplex Doppler on 46 fetuses at three sites: near the placenta, at the free-floating midportion, and near the fetal abdomen. Nine of 46 fetuses examined(20%) demonstrated pronounced nonuniformity of the S/D ratio with a discrepancy of 1 or greater at two different sites of S/D measurements. Studies demonstrated the highest S/D ratio and RI (resistance index) at fetal abdominal wall and lowest values were observed at the placental origin. These results suggest that S/D ratio and RI of the umbilical arterial flow velocity waveforms are not uniform throughout the cord. This site-dependent difference in S/D ratio,RI could be clinically important. Therefore one could not achieve an accurate information for fetal well-being by measuring S/D ratio and RI at only one site of the umbilical cord.
김영태 ( Y. T. Kim ),박용원 ( Y. W. Park ),김세광 ( S. K. Kim ),양영호 ( Y. H. Yang ),송찬호 ( C. H. Song ) 대한주산의학회 1990 Perinatology Vol.1 No.1
Down syndrome is by far the most common and best known of the chromosome disorders. Down syndrome can usually be diagnosed at birth or shortly thereafter by its phenotypic features. Recently direct access to fetal blood during the second and third trimesters of pregnancy opens new fields of prenatal diagnosis and in utero fetal treatment. Cordocentesis (percutaneous umbilical blood sampling), a method that involves ultrasonographically guided needle insertion into the umbilical vein, appeares to have an acceptable clinical trial. A case of Down syndrome diagnosed by cordcentesis is presented with brief review of literature.
이성만,박용원,이종국,오상준,이홍섭,김창호 인제대학교 1993 仁濟醫學 Vol.14 No.3
600mOsm/kg의 저삼투질 농도를 가진 ioxaglate(Hexabrix 320)의 신독성 여부를 관찰한 결과 탈수 상태에서 2.0 ml/kg 이상을 사용하게 되면 신세뇨관 손상이 야기되는 것을 관찰할 수 있다. This study was aimed at checking whether tri-iodinated compounds with greater solubility and low osmolality, Na or meglumine ioxaglate(Hexabrix 320, Guerbet Lab., France) has nephrotoxicity. Subjects were 21 children admitted to our hospital for the evaluation of their congenital heart diseases. None of them had any evidence of renal dysfunction before the study. They were deviled into 2 groups, one was low-dose group(Hexabrix given, < 2.0ml/kg) and the other one was high-dose group(≥ 2.0ml/kg). Renal function studios including serum creatinine(Scr), fractional excretion of sodium(FENa) and urinary β2-microglobulin excretion(UBME, mg of β2-microglobulin per gm creatinine) were done before and after Hexabrix administration. Statistical analyses were done using paired t-test and Wilcoxon signed rank test. Results were as follows ; 1.There were no significant differences of Scr and FENa between before-and after-Hexabrix study. 2.There were significant differences of UBME before - and after- Hexabrix study. 3.Comparing 2 groups, high-dose and low-dose group, with regard to UBME, there was significant increase of UBM in high-dose group after Hexabrix study but not in low-dose group. 4.Uric acid and/or calcium oxalate crystaluria appeared after Hexabrix administration. In conclusion, we confirmed that Hexabrix 320 could induce renal injury, particularly proximal tubular dysfunction, in recommended dosages for cardiac evaluations and that was dose dependent.