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朴順一,徐舜圭 우석대학교 의과대학 1971 우석의대잡지 Vol.8 No.1
Although the hyponatremia in pulmonary tuberculosis has been described, the pathogenesis is still controversial. Since no study on hyponatremia in pulmonary tuberculosis has been reported in Korea, anthers studied 201 cases of pulmonary tuberculosis. The serum sodium level and the incidence of hyponatremia in pulmonay tuberculosis were analyzed. The urinary sodium excretion test by Sub's method and the study of renal water excretion were carried out by water test, alcohol test and cortisone test. The following results were obtained. I. The serum sodium of pulmonary tuberculosis was 134.5 mEg/L in average, which was significantly lower than those of normal Koreans. There were 36 cases(17.9%) of hyponatremia (less than 130 mEq/L) among 201 cases of pulmonary tuberculosis and the hyponatremia was not related to the extent of pulmonary tuberculosis or nutritional state but to the red cell sedimentation rate. 2. The urinary basal sodium excretion was lower than normal and the sodium loading and deprivation test showed exaggerated excretion of sodium. These data suggested an impaired renal sodium preservation in pulmonary tuberculosis. 3. The renal water test was abnormal in only 5 of 14 cases of hyponatremia. In 3 cases, the renal water excretion was increased by alcohol and in 1 case by alcohol and cortisone. These data suggested that the hyponatremia in pulmonary tuberculosis is due only in part to inappropriate secretion of antidiuretic hormone but in many cases may be due to other mechanisms.
시호(柴胡)가 뇌허혈유발 노령(老齡) 흰쥐의 해마 c-Fos 및 c-Jun 발현에 미치는 영향
박순일,오경환,유도균,한창호,정승현,신길조,이원철,황주원,Park, Soon-Il,Oh, Kyung-Hwan,Ryu, Do-Kyun,Han, Chang-Ho,Chung, Sung-Hyun,Shin, Gil-Cho,Lee, Won-Chul,Hwang, Joo-Won 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.3
Objectives : In this study, aged BCAO rats were used to observe the effect of Bupleuri Radix on brain ischemic injury because aging is an important factor in storke. Methods : The brain ischemic injury was induced by temporary closing carotids on both sides in a low blood pressure state, and Bupleuri Radix was orally administered to 18 month-old BCAO rats. The ischemic damaged hippocampus and c-Fos and c-Jun expression were analyzed by the immunohistochemical staining. Result and Conclusions : Results are summarized as fellows; 1. The c-Fos expression after inducing a brain ischemic injury in the hippocampus was more inhibited in the experimental group than in the control group. 2. The normalized optical density of c-Fos expression was more reduced in cornu ammonis(CA)1, dentate gyrus(DG) areas in the experimental group than in the control group. 3. The c-Jun expression after inducing a brain ischemic injury in the hippocampus was more inhibited in the experimental group than in the control group. 4. The normalized optical density of c-Jun expression was more reduced in CA1 and DG areas in the experimental group than in the control group.