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가미지황탕(加味地黃湯)이 고지혈증(高脂血症) 관련(關聯) 인자(因子)에 미치는 영향
박소애,조현경,유호룡,김윤식,설인찬,안정조,Park, So-Ae,Jo, Hyun-Kyung,Yoo, Ho-Ryong,Kim, Yoon-Sik,Seol, In-Chan,An, Jung-Jo 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.2
Objective : Gamijihwang-tang(GJT) has been used as a therapeutic agent for hyperlipidemia in oriental medicine for several years. This study was performed to investigate the effects of GJT on hyperlipidemia in rats using diverse biological methods. Method : Hyperlipidemia was induced by a hyper-lipidemic diet fed for 4 weeks. Total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, and glucose were measured in the serum after an oral administration of GJT. Lipid peroxidase, SOD, catalase, ACAT, and HMG-CoA were measured in liver after oral administration of GJT. Result: 1. GJT showed safety against cytotoxicity and toxicity in liver. 2. GJT significantly decreased rat's body and liver weight. 3. GJT significantly decreased serum total cholesterol and LDL-cholesterol, but increased serum HDL-cholesterol. 4. GJT significantly decreased serum triglyceride and glucose. 5. GJT significantly decreased lipid peroxidation and increased SOD and catalase in liver. 6. GJT significantly decreased ACAT and HMG-CoA reductase of cholesterol manifestation in liver. Conclusions : These results suggest that GJT might be effective in treatment and prevention of hyperlipidemia.
중풍환자에서 장기간의 한약과 양약의 병용투여가 간장 및 신장에 미치는 영향
안정조,박소애,문승희,An, Joung-jo,Park, So-ae,Moon, Seung-hee 대한중풍순환신경학회 2009 대한중풍.순환신경학회지 Vol.10 No.1
Object : The purpose of this study was to evaluate whether herbal medication may injure the liver function and kidney function in stroke patients. Method : We observed the serum AST, ALT, r-GTP, Creatinine, BUN of 78 patient from May 1. 2008 to June 30. 2009 admitted in Oriental Hospital of Daejeon University. Liver function and Kidney function tests were done on admission and before discharge. And all patients take herbal medicine with Western medicine. Result : AST, ALT, r-GTP, Creatinine, BUN decreased on discharge compared with the value on admission. The liver function and kidney function test score(AST, ALT, r-GTP, Creatinine, BUN) by administration period of herbal medication was not significantly changed. Conclusion : This study suggests that general herbal medication does not injure liver function and kidney function of human.
청간플러스(가미청간탕(加味淸肝湯))로 호전된 뇌경색을 동반한 C형간염 환자 1례 및 알코올성 간염 환자 1례
최성환,장문원,박소애,임승민,안정조,조현경,유호룡,설인찬,김윤식,Choi, Seong-Hwan,Chang, Mun-Won,Park, So-Ae,Lim, Seong-Min,An, Joung-Jo,Jo, Hyun-Kyung,Yoo, Ho-Rhyong,Seol, In-Chan,Kim, Yoon-Sik 대한한의학방제학회 2008 大韓韓醫學方劑學會誌 Vol.16 No.2
This study is a clinical report for hepatitic C patient and alcoholic hepatitis patient who were improved by treatment of a herbal viscous extracts(Chunggan plus). We checked up Aspartate-aminotransferase(AST), Alamine-aminotransferase(ALT) and ${\gamma}$-Glutamyl transpeptidase (${\gamma}$-GTP) and compared the level of AST, ALT, ${\gamma}$-GTP after treatment. After medication the level of AST, ALT, ${\gamma}$-GTP was significantly normalized. So we suggested that herbal viscous extracts(Chunggan plus) has effects on hepatitis.
가미진해탕(加味鎭咳湯)과 소청룡탕가석고(小靑龍湯加石膏)가 PMA로 유발된 기도뮤신의 생성 및 MUC5AC gene 발현에 미치는 영향
변준섭,박양춘,양수영,안정조,박소애,Byun, Jun-Seop,Park, Yang-Chun,Yang, Su-Young,An, Joung-Jo,Park, So-Ae 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.3
Objectives : In this study, the author tried to examine whether Gamijinhae-tang and Socheongryong-tang-ga-seokgo significantly affect both PMA-induced mucin production and MUC5AC gene expression from airway epithelial cells. Materials and Methods : Confluent NCI-H292 cells were pretreated for 30 min in the presence of JHT and STS and treated with PMA (10ng/ml), to assess the effects of the agents on PMA-induced mucin production by enzyme-linked immunosorbent assay (ELISA). Also, the effects of the agents on PMA-induced MUC5AC gene expression from the same cells were investigated. Possible cytotoxicities of the agent were assessed by examining the rate of survival and proliferation of NCI-H292 cells after treatment of agents during 48 hrs. Results : (1) JHT and STS did not show significant cytotoxicity to NCI-H292 cells. (2) JHT significantly decreased PMA-induced mucin production from NCI-H292 cells. However. STS did not affect mucin production. (3) JHT significantly inhibit the expression levels of PMA-induced MUC5AC gene in NCI-H292 cells. STS slightly decreased the expression levels of PMA-induced MUC5AC gene. Conclusion : These results suggest that JHT can not only affect the production of mucin but also affect the expression of the mucin gene, and this explains the traditional use of JHT in oriental medicine. The effects of JHT and STS with their components should be further investigated using animal experimental models that simulate pathophysiology of airway diseases through future studies.