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자궁경부의 Adenoid basal carcinoma 1례
박동춘(Dong Choon Park),김재훈(Jae Hoon Kim),이형근(Hyung Gun Lee),정대영(Dae Young Chung),김진우(Jin Woo Kim),유영옥(Young Ok Lew),김대훈(Dae Hoon Kim),남궁성은(Sung Eun NamKoong) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.8
We report a rare case of adenoid basal carcinoma in uterine cervix. The patient was a 43-year-old Korean female. She received neoadjuvant chemotherapy with Quick Cis-VP16 (cisplatin and VP16 with 7-10 days interval), three times and radical hysterectomy with pelvic lymph nodes dissection under the diagnosis of cervical cancer stage IIa. After the neoadjuvant chemotherapy, the mass size was 3 x 2.5 Cm and which was protruded in exocervical region. Microscopically, scattered small nests of uniformed small cells with dark nuclei and scant cytoplasm were observed. Peripheral palisading as well as the formation of gland-like or acinar structures were noted. There were also foci of squamous differentiation in same portion of the small nests. The epithelial surface in other portions showed squamous cell carcinoma, large cell non-keratinizing cell type. Distribution between adenoid basal carcinoma of the cervix and other disease, such as adenoid cystic carcinoma and squamous cell carcinoma with basaloid features, is important for clinical management because the clinical behavior of adenoid basal carcinoma is less malignant than adenoid cystic carcinoma.
박동춘(Dong Choon Park),최양규(Yang Kyu Choi),김진우(Jin Woo Kim),박종섭(Jong Sup Park),김대훈(Dae Hoon Kim),남궁성은(Sung Eun Namkoong),이준모(Joon Mo Lee) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.3
N/A Object: The effect of low dose estradiol used for respect of hormone replacement therapy on the proliferation of epithelial ovarian cancer was investigated in vitro and in vitro. Method: In Vitro, 6 epithelial ovarian cancer cell lines containing different estrogen receptors were used: OVCAR-3, MDAH2774, PA-1, SK-OV-3 SNU-8, and ES-2 for XTT assay. The difference in the proliferation was compared among the group treated with FSH and LH (FL group),the group with FSH, LH and additionally estradiol (FLE group)and control group. Using flow cytometry, the changes in the cell cycle of the ephithelial ovarian cancer cell lines between the FL group and FLE group were analyzed. in vitro, OVCAR-3 was xenografted in female NOD-SCID mice, which had both ovaries removed, to compare the extent of proliferation of the xenograft tumor between the FL group and FLE group. The difference in proliferation was confirmed in the xenograft tumor tissues through the immunohistochemical staining for PCNA and p53. The expressions of the proteins-Rb, p16, cyclin D1,which controls cell cycle progression from G1 to S phase were examined by Western blot to investigate the mechanism behind the arrest at the G0/G1 phase. Results: in vitro, the difference of proliferation in FLE group compared to the FL group was not statistically significant (P>0.05). In flow cytometric assay, FL group showed a tendency to distribute the cell cycle to the S phase, compared to the control group, and the addition of estradiol tended to arrest the cell cycle at the G0/G1 phase, compared with FL group. in vitro, the proliferation of xenograft tumor was suppressed in FLE group, compared with the FL group (P<0.05).The immunohistochemical staining for PCNA, was more frequently and strongly expressed in FL group than in FLE group. But for p53,it was too weakly expressed to compared. In addition, the expression of Rb protein was stronger in FLE group than in FL group. On the other hand, cyclin D1 expression was significantly evident in FL group, while the expression of p16 was too weak to be compared. Conclusion: The results of this study show that estradiol does not promote the proliferation of epithelial ovarian cancer but rather decrease the proliferation that was promoted by FSH and LH during menopause; this may be due to the arrest of cell cycle at G0/G1 phase by estradiol.
알레르기 비염 및 부비동염에 의한 아데노이드의 국소 면역에 대한 고찰
여승근,박동춘,홍창기,심주섭,차창일,Yeo, Seung-Geun,Park, Dong-Choon,Hong, Chang-Kee,Sim, Ju-Sup,Cha, Chang-Il 대한면역학회 2007 Immune Network Vol.7 No.2
Background: Chronic rhino-sinusitis and persistent allergic rhinitis is often cited as risk factor for developing adenoid hypertrophy or adenoiditis, but this relationship has not been studied extensively. In this study, we evaluated the mucosal barrier, squamous changes of ciliated epithelium, IgA secretion and BCL-6 expression in adenoids, and adenoid size. Methods: Six children with allergic rhinitis and sinusitis, nine children with only allergic rhinitis, nine children with only sinusitis and six children without any history of allergic rhinitis and sinusitis were enrolled. H-E stain of adenoid for squamous metaplasia, immunohistochemical study of adenoid for IgA and BCL-6, cytokeratin stain for evaluation of mucosal barrier and lateral view X-ray for adenoid size were performed. ANOVA test was used in the analysis and data showing p value of less than 0.05 were considered significant. Results: The number of ciliated cells had tendency to be decreased and squamous metaplasia had tendency to be increased in three experimental groups (p>0.05). Deterioration of mucosal barrier had tendency to be detected in three experimental groups than control group (p>0.05). BCL-6 had tendency to be increased and IgA secretion had tendency to be decreased in three experimental groups (p>0.05). There is no difference in adenoid size between three experimental groups and control group. Conclusion: Despite the expectation that adenoid would be affectecd by allergic rhinitis and rhino-sinusitis, we found no evidence for influence of adenoid immunity.