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약용식물의 Peroxynitrite와 Hydroxyl radical 소거 활성
민오진,김민석,곽병희,류동영 한국자원식물학회 2008 한국자원식물학회지 Vol.21 No.4
The radical scavenging activities of 9 medicinal plants on peroxynitrite (ONOO-) and hydroxyl (∙OH) radical were investigated using in vitro system. The water extracts of 9 medicinal plants showed the protective effect against ONOO- and∙OH radical. In particular, Akebia quinata, Aster scaber, Cudrania tricuspidata, Diospyros kaki, Eriobotrya japonica, Lycium chinense, Parthenocissus tricuspidata and Polygonum aviculare exhibited ONOO-- scavenging activity by about 50% at the concentration of 10μg/ml. Although those ONOO--scavenging activities were lower than that of penicillamine (94.08±3.04%) as a positive control, Eriobotrya japonica (89.87±4.57%) was the most potent scavenger of ONOO- at the concentration of 10μg/ml. Also, Diospyros kaki and Urtica angustifolia showed the strong∙OH-scavenging activity than thiourea, positive control, at the concentration of lmg/ml. Our results indicate that 9medicinal plants may act as free radical scavengers and reduce damages caused by oxidative stress associated with ONOO- and∙OH radical.
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민오진,오진,김현아,백흠영,김용재,류동영 한국생약학회 2010 생약학회지 Vol.41 No.4
Obesity is caused from an imbalance between energy intake and expenditure, which may lead to pathologic growth of adipocytes and accumulation of fat in tissue. We examined the inhibitory effects of Eriobotrya japonica leaf and seed extracts on lipid absorption in vitro and fat accumulation during the differentiation of 3T3-L1 to adipocytes. 3T3-L1 preadipocytes were stimulated with DMEM media containing 10% FBS, 0.5 mM 3-isobuthyl-1-methyxanthine (IBMX), 5 µg/ml insulin, and 1 µM dexamethasone for differentiation to adipocytes. E. japonica leaf extract at concentration of 0.5 or 1 mg/ml inhibited pancreatic lipase activity. The cell viability of 3T3-L1 adipocytes slightly reduced about 3% by treatment of E. Japonica leaf and seed extracts. The leaf and seed extracts of E. japonica effectively inhibited the accumulations of lipid droplet and expression of C/EBPα promoting adipogenesis. Thus, this data suggest that E. japonica leaf and seed extracts inhibit fat accumulation through regulation of C/EBPα, and leaf extract is more effective in lipid absorption and adipogenesis than seed extract.
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3T3-L1 지방세포와 db/db 마우스에서 옥수수수염 물 추출물의 지방생성 억제 및 혈당 저하효과
류동영,민오진,샤르마베스라지,박철민 한국생약학회 2011 생약학회지 Vol.42 No.2
Obesity occur from the imbalance between energy intake and energy expenditure. Obesity is a complex chronic disease that is suggested to cause other metabolic disorders such as type 2 diabetes, hyperlipidemia, hypertension, and arteriosclerosis. In this study, our purpose is to investigate the anti-hyperglycemic and anti-obesitic effects of Maydis stigma water extract in 3T3-L1 adipocytes and db/db mice. Maydis stigma water extract at dose of 100 and 500 μg/ml slowly inhibited cell viability as compared to that of control in mature adipocytes. Also, the additions of 50 and 250 μg/ml of Maydis stigma water extract significantly inhibited the lipid accumulations and CCAAT/enhancer-binding protein(C/EBP) α and peroxisome proliferator-activated receptor(PPAR) γ expressions with dose-dependent manner in 3T3-L1 adipocytes. Maydis stigma water extract at 250, 500, and 1000 μg/ml only showed the increasing pattern on lipolysis activity. The oral treatment of Maydis stigma water extract (100 or 400 mg/kg body weight) in db/db mice only showed tendency to decrease body weight, food efficiency ratio (FER), HbA1c, blood glucose, total cholesterol, triglyceride, and the adipocyte size of in db/db mice. However, Maydis stigma water extract increased the insulin level in a dose dependent manner. Thus these results indicate that Maydis stigma water extracxt inhibits adipogenesis through regulation of C/EBPα and PPARγ expressions in 3T3-L1 adipocytes and shows anti-hyperglycemic effect through increase of insulin secretion in db/db mice.
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류동영,김민석,민오진,김동욱 한국자원식물학회 2008 한국자원식물학회지 Vol.21 No.1
Reactive oxygen species (ROS) or free radical-mediated oxidative stress plays an important role in the pathophysiologic process of disease state. This study investigated antioxidative effects of Phellinus linteus extract on the generation of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, superoxide anion radical (O2-), hydroxyl radical (·OH), nitric oxide (NO), and peroxynitrite (ONOO-) radical and free radical-mediated protein oxidation under in vitro assay systems. This results showed that Phellinus linteus extract effectively inhibited the generation of free radicals in the all assay system with dose-dependent manner and also significantly reduced the protein oxidative level. Thus, the present study indicates that Phellinus linteus extract possesses a potent antioxidant activity and plays a beneficial role against free radical-induced oxidative injury.
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김은 ( Eun Kim ),김민숙 ( Min Sook Kim ),류동영 ( Dong Young Rhyu ),민오진 ( Oh Jin Min ),백흠영 ( Hum Young Baek ),김용재 ( Yung Jae Kim ),김현아 ( Hyeon A Kim ) 韓國食品營養學會 2009 韓國食品營養學會誌 Vol.22 No.2
E. japonica is a well-known medicinal plant in Japan. The leaves of E. japonica were reported to have a hypoglycemic action. However, seeds of E. japonica are discarded and not used. To elucidate for anti-diabetic effects of E. japonica, Type 2 diabetic mice were allocated to control group, E. japonica leaf, and seed extract group. Animals were fed a 2018S Teklad global 18% protein rodent diet. Animals were received daily oral injections of E. japonica leaf or seed extract at a dose of 200 ㎎/㎏ body weight for 6 weeks. Body weight, food intake and water intake, and total adipose tissue weight of animals were significantly reduced by feeding of E. japonica leaf extract. All E. japonica extract groups significantly decreased fasting blood glucose, glycosylated hemoglobin levels, size of adipocytes and serum adiponectins. However, they did not have a beneficial effect on the serum triglyceride and cholesterol in the diabetic animals. These results suggest that E. japonica seed and leaf extracts have a antidiabetic effect by controlling of blood glucose and decrease of size of adipocytes in db/db mice and seed extract is more effective in hypoglycemic action than leaf extract.
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