종양괴사인자 알파 억제제의 피부과적 부작용

문성훈 ( Seong Hun Moon ),고주연 ( Joo Yeon Ko ) 대한류마티스학회 2014 대한류마티스학회지 Vol.21 No.1

As anti-tumor necrosis factor alpha (anti-TNFα) agents are progressively being used in various medical conditions, dermatological adverse events have been encountered more frequently. To understand such dermatological conditions that have been documented while undergoing anti-TNF therapy, we reviewed relevant literature, including case reports and case series. Reported dermatological conditions included infusion and injection site reaction, cutaneous infection, psoriasiform eruption, dermatitis, allergic rash, lupus-like lesion, vasculitis, lichenoid reaction, granulomatous reaction, hair loss, cutaneous infection, and cutaneous neoplasm. These events had varying strengths of causal association and severity therefore, drug discontinuation may or may not be required.

자가면역 물집 피부질환 환자의 삶의 질

문성훈 ( Seong Hun Moon ),권형일 ( Hyoung Il Kwon ),박현철 ( Hyun Chul Park ),김정은 ( Jeong Eun Kim ),고주연 ( Joo Yeon Ko ),노영석 ( Young Suck Ro ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.6

Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea Background: Autoimmune blistering skin diseases such as pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid and epidermolysis bullosa acquisita substantially affect patients. daily life and psychosocial well-being. Objective: The aim of this study was to evaluate the quality of life (QOL) in patients with autoimmune blistering diseases and to identify the factors that can influence their QOL by comparing them to healthy controls. Methods: Forty patients with autoimmune blistering skin diseases and 40 healthy controls were interviewed using the Korean version of Skindex-29. The study assessed the clinical severity of the disease. Results: The total, symptom, function, and emotion scores of Skindex-29 were significantly higher in patients with autoimmune blistering skin diseases (35.28, 40.78, 30.57, and 36.67, respectively) than in the healthy controls (6.90, 9.38, 5.47, and 6.60, respectively) (p<0.001). Higher disease severity had a negative correlation with QOL in patients with blistering skin diseases, and QOL was lower when patients had low levels of satisfaction with treatment. Conclusion: The results show that autoimmune blistering skin diseases can affect patients’ QOL. In addition, disease severity and low satisfaction with treatment are important factors that reduce QOL. Development of new treatments should improve treatment efficacy and the QOL of patients with autoimmune blistering diseases. (Korean J Dermatol 2014;52(6):402∼409)

성인남성의 저항성 운동프로그램에 따른 슬관절 근기능 비교연구

문성훈 ( Moon Seong-hun ),권봉안 ( Kwon Bong-an ) 한국체육대학교 체육과학연구소 2017 스포츠사이언스 Vol.34 No.2

본 연구는 성인남성에게 8주간 근 수축 유형별 운동프로그램을 실시하여 슬관절 등속성 근력, 근파워, 근지구력을 전·후 비교하여 알아봄으로써 등장성 운동과 등척성 운동의 특이점을 확인하고 운동프로그램에 있어서 성인남성에게 보다 효과적인 운동방법을 검증하는데 목적이 있다. 연구 대상자는 서울시 N구에 거주하며 휘트니스 센터에 등록되어 있는 회원 중 1개월 미만으로 운동을 하고 있는 20~25세의 성인남성 14명을 대상으로 하였으며, 등장성 운동프로그램에 참여하는 집단 7명과 등척성 운동프로그램에 참여하는 집단 7명을 나누어 실시하였다. 등속성 측정기기를 사용하여 슬관절을 중심으로 대퇴사두근과 햄스트링근의 Peak Torque(%BW)의 근력, 근파워, 근지구력을 사전·사후로 측정하였다. 본 연구를 위하여 저항성 트레이닝 운동프로그램을 구성하였으며 현재 ○○○트레이닝 센터에서 사용되는 GX(Group Exercise)프로그램 중 하체 강화 프로그램의 일부를 사용하였다. 준비운동과 본 운동, 정리운동으로 구성하여 주 3회, 회당 30분씩 총 8주를 실시하였다. 운동 강도는 1RM의 60%의 중강도로 실시하였으며 Isotonic집단은 set당 30초간 등장성반복운동을 실시하였으며, Isometric집단에게는 set당 30초간 등척성 반복운동 및 동작 당 근 수축 시 6초간 유지하는 운동으로 분류하여 종목 당 3set 반복훈련을 실시하였다. 자료처리는 SPSS V22.0Window 통계프로그램을 이용하여 각 변인들의 기초통계량인 평균(mean) 및 표준편차(SD)를 산출하였다. 슬관절 근기능에 따른 두 집단 간의 체중 당 Peak torque 평균 차이의 유성을 비교하기 위해서 반복측정 분산분석(Repeated measure ANOVA)을 이용하여 검증하였다. 운동 시기와 집단 간의 상호작용에서 유의한 차이(p<.05)가 있을 경우 Paired t-test를 사용하여 변화에 대한 차이를 검증하였으며 연구 결과는 다음과 같다. 첫째, 성인남성의 집단 간 근수축 유형별 운동프로그램으로 성인남성의 슬관절 등속성 근기능(%BW)을 반복측정 분산분석 한 결과 양측 굴곡·신전 근력, 양측 굴곡·신전근파워, 양측 굴곡·신전근지구력에서 유의한 차이가 나타나지 않았다. 둘째, 성인남성의 운동시기 간 근 수축 유형별 운동프로그램으로 성인남성의 슬관절 등속성 근기능(%BW)을 반복측정 분산분석 한 결과 좌측 신전 근력, 양측 굴곡 근력, 좌측 신전 근력의 파워에서 유의한 차이를 나타냈다(p<.05). 셋째, 성인남성의 집단* 운동 시기 간 근 수축 유형별 운동프로그램으로 성인남성의 슬관절 등속성 근기능(%BW)을 반복측정 분산분석 한결과 우측 굴곡 근력, 우측 굴곡 근력의 파워, 양측 굴곡 근력의 지구력에서 유의한 차이를 나타냈다(p<.01). 또한 상호작용에 따른 추가적인 Paired T-test 차이분석에서는 Isotonic(A)집단의 굴곡 근력의 지구력에 대한 유의한 차이(p<.05)가 나타났으며, Isometric(B)집단의 굴곡 근력과 굴곡 근력의 지구력에 대한 유의한 차이(p<.05)가 나타났다. 굴곡 근력 운동과 굴근 지구력 운동에서의 등척성 운동이 등장성 운동보다 우수한 효과를 나타내었다. The purpose of this study is to check special points of isotonic exercise and isometric exercise and verify more effective exercise method for adult male in exercise program by comparatively examining isokinetic muscle strength, muscular power and muscular endurance in knee joint before·after the program following the implementation of exercise program according to muscle contraction type for 8 weeks in adult male. Study participants were 14 adult men aged 20 years ~ 25 years, who had exercised for less than 1 month among members who resided in N district, Seoul city, and who registered for fitness center. It was implemented after they were classified into one group of 7 persons participating in isotonic exercise program and the other group of 7 persons participating in isometric exercise program. The pre-·post-measurement of muscular strength of Peak Torque(%BW), muscular power and muscular endurance in quadriceps femoris muscle and hamstring muscle around knee joint was taken by using an isokinetic dynamometer. For this study, a resistance training exercise program was made. And among GX(Group Exercise) programs currently used in ○○○ training center, a part of lower body workout program was used. It was composed of warm-up, main activity and cool-down, and was carried out for a total of 8 weeks (3 sessions per week, 30 minutes per session). With regard to exercise intensity, exercises were done at moderate intensity, i.e., 60% of 1RM. And isotonic group repeated isotonic exercises for 30 seconds per set. And isometric group did 3 sets of repeated exercises per exercise type after being classified into repeated isometric exercise for 30 seconds per set and exercise where a stance was maintained for 6 seconds per stance when muscle contracted. With regard to data processing, this study calculated mean and standard deviation (SD), basic statistics of respective variables by using statistical program SPSS V22.0 Window. In order to compare significance of difference in the mean of Peak torque per body weight between two groups according to knee joint muscle function, a test was carried out by using the repeated measure ANOVA. In case there was significant difference in interaction between exercise time and group (p<.05), a difference of change was tested by using the paired t-test. And the results of study are as follows. First, in the results of repeated measure ANOVA of knee joint isokinetic muscle function (%BW) for adult men with exercise program according to muscle contraction type between adult male groups, an insignificant difference was shown in bilateral flexor·extensor muscle strength, bilateral flexor·extensor muscle power and bilateral flexor· extensor muscle endurance. Second, in the results of repeated measure ANOVA of knee joint isokinetic muscle function (%BW) for adult men with exercise program according to muscle contraction type between exercise times in adult men, a significant difference was shown in left extensor muscle strength, bilateral flexor muscle strength and left extensor muscle power (p<.05). However, an insignificant difference was shown in right extensor muscle strength, right extensor muscle power, bilateral flexor muscle power and bilateral flexor·extensor muscle endurance. Third, in the results of repeated measure ANOVA of knee joint isokinetic muscle function (%BW) for adult men with exercise program according to muscle contraction type between adult male group * exercise time, a significant difference was shown in right flexor muscle strength, right flexor muscle power and bilateral flexor muscle endurance (p<.01). However, an insignificant difference was shown in left flexor muscle strength, bilateral extensor muscle strength, left flexor muscle power and bilateral flexor·extensor muscle power and bilateral extensor muscle endurance. Besides, in an additional analysis of difference using the paired T-test according to interaction, a significant difference (p<.05) was shown in significance probability regarding flexor muscle endurance in isotonic (A) group. A significant difference (p<.05) was shown in significance probability regarding flexor muscle strength and flexor muscle endurance in isometric (B) group. In flexor muscle strength exercises and flexor muscle endurance exercises, isometric exercises produced better effect than isotonic exercises.

건선 환자에서 경구 Cyclosporine 치료 후 재발인자에 대한 연구

문성훈 ( Seong Hun Moon ),김정은 ( Jeong Eun Kim ),고주연 ( Joo Yeon Ko ),노영석 ( Young Suck Ro ) 대한피부과학회 2015 대한피부과학회지 Vol.53 No.4

Background: Cyclosporine, which is one of the effective systemic treatments for psoriasis, has a rapid therapeutic effect. However, despite the efficacy of cyclosporine, the recurrence of psoriasis may still occur if treatment with this drug is discontinued. Several studies on the efficacy and safety of cyclosporine for psoriasis have already been conducted. However, studies on the factors causing psoriasis recurrence after cyclosporine treatment are rare. Objective: The aim of this study was to identify the factors that cause recurrence of psoriasis in patients treated with cyclosporine. Methods: We performed a retrospective study of the medical records obtained between January 2007 and March 2014 of 174 patients diagnosed with psoriasis and followed up for at least 6 months after treatment. We analyzed the differences in the demographic characteristics, body surface area, psoriasis area and severity index (PASI) score, psoriasis type, accompanying psoriatic nail, involvement of exposed areas, and several treatment-related factors (starting dose, last dose, maximal dose, cumulative dose, mean daily dose, and treatment duration) between the group that experienced a recurrence and the group that did not. Additionally, we analyzed the effects of these factors on the recurrence and the time to recurrence. Results: Of the 174 patients, 57 (32.8%) reported a recurrence of the disease. There were statistically significant differences between the two groups in terms of their PASI score (p=0.031) and mean daily dose (p=0.014). In the multiple logistic regression analysis, the PASI score (p=0.017, odds ratio=1.057) and treatment duration (p=0.035, odds ratio=0.984) showed a significant relation with relapse. Conclusion: This study suggests that long-term treatment with cyclosporine is necessary for high-severity psoriasis in patients to prevent recurrence. However, as this study is retrospective, further prospective and large-scale studies are necessary to confirm this fact. (Korean J Dermatol 2015;53(4):277∼283)

스마트 전기차 자동 화재 진압 시스템

문성훈(Seong-Hun Moon),김경모(Gyeong-Mo Kim),정한용(Han-Yong Jeong),주승민(Seung-Min Ju),최원근(Won-Geun Choi),최지원(Ji-Won Choi),박성원(Sung-Won Park) 대한전기학회 2023 대한전기학회 학술대회 논문집 Vol.2023 No.11

경피증양 만성 피부 이식편 대 숙주질환에서 광범위하게 발생한 근막염

문성훈 ( Seong Hun Moon ),김현우 ( Hyun Woo Kim ),박현철 ( Hyun Chul Park ),김정은 ( Jeong Eun Kim ),고주연 ( Joo Yeon Ko ),노영석 ( Young Suck Ro ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.7

Fasciitis can occur very rarely with sclerotic-type chronic cutaneous graft-versus-host disease (GVHD). A 54-year-old woman presented with painful skin tightness on upper and lower limb with limited range of movement. She was diagnosed with chronic myelocytic leukemia 5 years ago and underwent allogeneic bone marrow transplantation. Histopathologically, the interlobular septum of subcutis and fascia were remarkably thickened with fibrosis and moderate inflammatory infiltrates accompanying the dilated lymphatic channels with considerable leakage of lymph fluids. Herein, we report a case of extensive fasciitis as a manifestation of chronic GVHD associated with poor prognosis. (Korean J Dermatol 2013;51(7):544∼547)

뾰족 콘딜로마(Condyloma Acuminatum)와 유사한 양상을 보인 전정 유두종증

문성훈 ( Seong Hun Moon ),이민원 ( Min Won Lee ),백준오 ( Jun Oh Paek ),강명승 ( Myung Seung Kang ),김정수 ( Joung Soo Kim ),유희준 ( Hee Joon Yu ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.4

Vestibular papillomatosis is an uncommon benign condition that can occur on labia minora and is considered as a normal anatomical variant of the vulva, as the female equivalent of pearly penile papules in men. Because vestibular papillomatosis resemble condyloma, it can be misdiagnosed as condyloma acuminatum and can lead to unnecessary treatment. We herein report a case of a 27-year-old women with multiple skin-colored soft papules on labia minora. The lesion was distributed symmetrically on the inner of labia minora and showed a separate base of individual projection. To the best of our knowledge, this is a unique case reported in the Korean dermatological literature. (Korean J Dermatol 2013;51(4):258∼260).

신장병변을 동반한 결절성 경화증 2 예

문성훈(Sung Hun Moon),최해종(Hae Jong Choi),윤욱돈(Uk Don Yun),양두경(Doo Kyoung Yang),우영석(Young Seok Woo),장광열(Kwang Yul Chang),지삼룡(Sam Ryong Jee),오일환(Il Hwan Oh),김성은(Seong Eun Kim),김기현(Ki Hyun Kim) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.1

Tuberous sclerosis is a rare disease, which occurs sporadically or hereditarily and is recognized by its neurological and dermatological manifestations and may be accompanied with renal anomalies. The cla- ssical triad is composed of seizure, mental retardation and adenoma sebaceum on face. We experienced two cases of tuberous sclerosis in sporadic forms by mutation without any familial history which suggests the diseases were occurred by mutation rather than by autosomal dominant inheritance. In the first case, a 24-year-female patient with hypertension and abnormal renal function tests which were noted on the routine prenatal check at 32 weeks of gestation delivered normally at 37 weeks. The daughter of patient had seizure when she was 6 years old and was diagnosed as polycystic kidney disease by abdorninal computed tomography. This case developed sporadic form of disease without familial history but, the daughter of patient might inherited by autosomal dominant form. The patient's clinical feature was characterized by history of epilepsy, painless abdominal mass due to polycystic kidney disease, abnormal renal function, skin abnormalites including angiofibroma and shagreen patch. Abdominal computed tomography demonstrated numerous variable sized cysts throughout both kidney. In second case, the patient was a 32-year-female patient complaining of 5kg weight gain, abdominal distension due to palpable masses. Her clinical feature was characterized by bilateral huge renal angiomyolipoma with normal renal function and skin abnormality such as erythematous papule on the face. Abd CT and MRI revealed huge angiomyolipoma of about 15cm×18.5cm×30cm and 14.5cm×18cm×30cm res- pectively. We presented the two cases with brief review of the literatures.

건선 및 건선관절염에서 손톱 병변에 대한 임상적 고찰

오수진 ( Su Jin Oh ),고원선 ( Won Seon Koh ),권형일 ( Hyoung Il Kwon ),문성훈 ( Seong Hun Moon ),김정은 ( Jeong Eun Kim ),고주연 ( Joo Yeon Ko ),노영석 ( Young Suck Ro ) 대한피부과학회 2016 대한피부과학회지 Vol.54 No.3

Background: It has been reported that nail psoriasis is common in psoriatic arthritis (PsA) patients, however, studies on the prevalence of PsA with nail psoriasis and the relationship between the severity of the diseases has not previously been reported in Korea. Objective: The aim of this study was to investigate nail psoriasis and its relation to psoriasis and PsA. Methods: After researching past medical records, 48 patients with nail psoriasis and 247 patients without nail psoriasis were enrolled in this study. Nail psoriasis was classified according to the morphologic types of nails and severity was evaluated using the modified nail psoriasis severity score index (mNAPSI). We assessed the severity of psoriasis and PsA by psoriasis area and severity index (PASI), and swollen and tender joint counts (STJC), respectively. Finally, we analyzed the relationship between mNAPSI, PASI, and STJC. Results: Nail involvement was observed in 48 (16.3%) of 295 patients. Prevalence of PsA was higher in nail psoriasis (31.3%) than in uncomplicated psoriasis (9.3%, p<0.001). mNAPSI showed a positive correlation with STJC (p=0.002, Pearson correlation=0.427), but not with PASI (p=0.094, Pearson correlation=0.202). Conclusion: The results show that PsA is more common and severe in psoriatic patients with nail involvement than in uncomplicated psoriasis. Clinicians should be alert to nail involvement in psoriatic patients, as it could be related to the disease course and prognosis of PsA. (Korean J Dermatol 2016;54(3):178~183)

Nocardia farcinica에 의한 일차성 피부 노카르디아증

최현석 ( Hyun Seok Choi ),신재민 ( Jae Min Shin ),문성훈 ( Seong Hun Moon ),김정은 ( Jeong Eun Kim ),노영석 ( Young Suck Ro ),고주연 ( Joo Yeon Ko ) 대한피부과학회 2016 대한피부과학회지 Vol.54 No.3

The Nocardia species are aerobic Gram-positive filamentous bacteria found worldwide in soil and decaying organic plant matter. Primary cutaneous nocardiosis is a rare entity and most commonly caused by Nocardia brasiliensis (N. brasiliensis). However, it can rarely be caused by N. farcinica, which is recognized as a human pathogen. Here we report a case of a 54-year-old female patient who presented with erythematous nodules on her abdomen for 1 week. She had been treated with methotrexate and prednisolone due to systemic lupus erythematosus and rheumatoid arthritis. By bacterial culture and 16S ribosomal RNA gene sequencing, the patient was diagnosed with a primary cutaneous nocardiosis caused by N. farcinica, which has not previously been reported in the Korean dermatological literature. (Korean J Dermatol 2016;54(3):194~198)