특이한 지지부를 가진 접형 인공수정체를 이용한 공막봉합고정술의 임상성적

류은혜,이정희,이수영,Eun Hye Ryu,Jeong-Hee Lee,Soo Young Lee 대한안과학회 2008 대한안과학회지 Vol.49 No.7

Purpose: To report the surgical results of transscleral fixation of foldable acrylic intraocular lens with a unique haptic shape (CORNEALⓇ, ACR6D, France). Methods: We analyzed the medical records of 18 patients (19 eyes) who had transscleral fixation of posterior chamber intraocular lens implantation from July 2004 to July 2006. Results: According to the cause of operation, there were five eyes with complicated cataract, eight with trauma, and six with aphakia associated with a previous operation. The mean age of the patients was 55.9±21.2 years. The mean preoperative best-corrected visual acuity was 0.31±0.35, and the postoperative value was 0.63±0.29 (p<0.05). The mean preoperative spherical refractive equivalent was 6.58±5.33 diopter, and the postoperative value was -1.77±1.59 diopter. The mean refractive error was -1.13±1.57 diopter. This showed a myopic shift (p<0.05). The mean astigmatism decreased with time, and it stabilized two months after the operation. The trend was toward mild against-the-rule astigmatism. The mean follow-up duration was 11.0±7.6 months. Conclusions: In eyes with inadequate capsular support, transscleral fixation of posterior chamber intraocular lens implantation with CORNEALⓇ lenses is a safe and effective procedure for visual correction. J Korean Ophthalmol Soc 49(7):1071-1077, 2008

Lactobacillus plantarum GBL17 균주를 이용한 복분자 유산발효 특성

류은혜,윤해훈,정지혜,Ryu, Eun-Hye,Yoon, Hae-Hoon,Jung, Ji-Hye 한국식품조리과학회 2015 한국식품조리과학회지 Vol.31 No.6

Lactic acid fermentation of black raspberry (Rubus occidentalis) juice was carried out by using the Lactobacillus plantarum GBL17 strain. The sterilized black raspberry juice was fermented using the L. plantarum GBL17 strain at $30^{\circ}C$ for 72 hours after which the total acidity increased and the pH value decreased. In addition, the highest total acidity content (2.38%) was reached, the lowest pH value (3.22) was observed, and the sugar content decreased by $9.8^{\circ}Brix$ after the 72 hour fermentation. The number of viable cells rapidly increased up until 24 hours, after which it gradually decreased. HPLC analysis of the organic acids showed 14.51 mg/g of lactic acid content in the fermented black raspberry juice, which was not detected in the non-fermented black raspberry juice (control). The content of fructose and glucose slightly decreased after fermentation. The total polyphenol and flavonoid contents of the fermented black raspberry juice increased significantly after fermentation. The DPPH radical scavenging activity of fermented black raspberry juice (70.92%) was higher than that of the control (62.96%). After lactic acid fermentation, there was no significant increase in ABTS radical scavenging activity. These results confirm that lactic acid bacteria, such as L. plantarum GBL17, showed generally higher activities with a potential as a functional beverage.

코로나19(COVID-19) 유행 전후 서울의 생활인구 패턴변화 및 지역환경이 생활인구 변화에 미치는 영향

류은혜 ( Eun Hye Ryu ),김은정 ( Eun Jung Kim ) 한국도시지리학회 2021 한국도시지리학회지 Vol.24 No.3

본 연구는 코로나 유행 전후 행정동별 생활인구 변화율 분포가 유사한 지역을 유형화한 후, 유형별 지역특성을 살펴보고 지역특성이 생활인구 변화에 미치는 영향을 분석하였다. 이에 코로나19가 집중적으로 확산된 2020년의 1·2·3차 유행시기를 대상으로 전년대비 생활인구 변화율을 군집분석을 통해 증가·감소·변화없음 지역으로 유형화하였다. 군집된 지역의 특징을 파악하고자 지역특성 변수를 이용해 일원배치 분산분석을 실시하였고, 다중회귀분석을 통해 지역특성이 생활인구 변화에 미치는 영향을 분석하였다. 분석 결과, 코로나19 발생 후 생활인구 분포가 도심지에서 동네생활권 지역으로 이동했음을 알 수 있었다. 분산분석 결과 생활인구 증가지역에서 생계형 사업 밀도와 공원 비율이 가장 높았고 생활인구 감소지역에서 상업지역 비율이 가장 높았다. 다중회귀분석 결과, 전체 유행시기에서 식품접객업, 숙박업 밀도가 높은 행정동의 생활인구가 감소한 것으로 나타났다. This study categorized regions with similar distributions of de facto population change rates by dong before and after COVID-19, examined regional characteristics by type and analyzed the effect of regional characteristics on de facto population change. So, the rate change in the de facto population compared to the previous year was categorized as area with increase·decrease·no change through cluster analysis for 1st, 2nd, and 3rd periods of 2020 when COVID-19 spread intensively. In order to understand the characteristics of the clustered area, a One-way ANOVA was conducted using regional characteristic variables, and the effect of regional characteristics change in the de facto population was analyzed through multiple regression analysis. As a result of the analysis, it was found that the distribution of the de facto population moved from the city center to the neighborhood area after the outbreak of COVID-19. As a result of ANOVA, the ratio of livelihood business and parks was the highest in de facto population increased area, and the ratio of commercial areas was the highest in de facto population decreased area. As a result of multiple regression analysis, it was found that de facto population of dongs with high density in the food service and lodging industries decreased during the entire epidemic.

토종효모 Saccharomyces cerevisiae GBY5를 이용한 오디발효주의 발효 특성 및 항산화 활성

류은혜(Eun-Hye Ryu),채규서(Kyu-Seo Chae),권지웅(Ji-Wung Kwon) 동아시아식생활학회 2019 동아시아식생활학회지 Vol.29 No.3

복분자 착즙박을 이용한 식초의 이화학적 특성 및 항산화 활성

류은혜(Eun-Hye Ryu),채규서(Kyu-Seo Chae),김성웅(Sung-Woong Gim),김용석(Yong-Suk Kim),김기덕(Ki-Deok Kim),권지웅(Ji-Wung Kwon) 한국식품과학회 2021 한국식품과학회지 Vol.53 No.1

본 연구에서는 복분자 가공 후 버려지는 부산물의 활용성을 높이기 위하여 착즙박의 발효를 통해 식초를 제조한 후, 전통 발효식초의 소재로서의 이용 가능성을 살펴보고자 발효 특성 및 항산화 활성을 포함한 이화학적 특성을 분석하였다. 알코올 발효후 이화학적 특성 분석 결과, 총 산도와 알코올 함량은 착즙액보다 착즙박에서 각각 0.49, 1.32% 만큼 낮게 나타났으며, 초산발효 후에는 알코올 함량과 당도가 착즙액에서 각각 0.72, 0.6 °Brix 만큼 높게 나타났다. 착즙박에서 pH는 0.32 낮았고 총 산도가 0.38% 높게 나타났다. 이러한 결과에 비추어 볼 때 착즙박 또한 원활한 발효가 진행됨이 확인되었다. 유기산 분석 결과 착즙박에서는 acetic acid가 착즙액에서는 citric acid가 더 높게 나타났다. 복분자 착즙박을 이용한 식초의 총 폴리페놀, 총 플라보노이드, 총 안토시아닌 함량을 측정한 결과 각각 51.58 TAE mg/mL, 9.55RUE mg/mL, 6.05 CYE mg/mL로 대조구인 복분자 착즙액 식초보다 높은 함량을 보였다. 복분자 착즙박 식초의 산화 방지 활성측정을 위해 DPPH 및 ABTS 라디칼 소거능의 IC<SUB>50</SUB> 값을 측정한 결과 각각 10.23, 18.30 μL/mL로 착즙액 식초보다 높은 활성을 나타내었으며, 환원력 및 FRAP 또한 착즙박을 이용한 식초에서 높게 나타났다. 이러한 결과를 종합해볼 때 복분자 가공 부산물로 버려지는 착즙박은 초산발효 결과가 우수하고, 높은 산화 방지 활성을 나타내어 기능성 발효식초로 활용이 가능할 것으로 판단된다. In this study, vinegar was prepared using black raspberry pomace to increase its utilization capacity. As a result of alcohol fermentation, the final alcohol content was 8.90% and the sugar content was 7.03°Brix. The total acid content after acetic acid fermentation was 4.44%, which was 0.38% higher than that of the juice. Among the organic acid content, the acetic acid content was higher in the pomace than in the juice. The total polyphenol (51.58 TAE mg/mL), total flavonoid (9.55 RUE mg/mL), and total anthocyanin (6.05 CYE mg/mL) contents of vinegar produced using black raspberry residue were higher than those of the juice. In addition, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical scavenging activity, reducing power, and ferric reducing antioxidant power (FRAP) activity were higher than those of the juice, indicating strong antioxidant properties. Thus, black raspberry pomace has excellent acetic acid fermentation ability and high antioxidant activity, indicating that it can be used as a functional fermented vinegar.

미숙과와 완숙과 복분자 추출물의 항산화 및 항균 활성 비교

류은혜 ( Eun-hye Ryu ),김성웅 ( Sung-woong Gim ),이수정 ( Su-jung Lee ),김용석 ( Yong-suk Kim ),권지웅 ( Ji-wung Kwon ) 한국식품조리과학회 2021 한국식품조리과학회지 Vol.37 No.5

Purpose: This study compared and analyzed the antioxidant and antimicrobial activities of unripened and ripened black raspberry (Rubus occidentalis) extracts. Methods: Unripened and ripened extracts were prepared with water, 25%, 50%, and 75% ethanol. To estimate in vitro antioxidant activity, total polyphenol, total flavonoid, and total anthocyanin contents were measured and DPPH and ABTS radical and nitric oxide (NO) scavenging activity were analyzed. In addition, antimicrobial activity against pathogenic microorganisms and bronchus disease-inducing bacteria was measured. Results: Total polyphenol and total flavonoid content were higher in unripened than in ripened black raspberry extracts, and total anthocyanin content was higher in ripened extracts. The DPPH and ABTS radical scavenging activity of ripened extracts was also found to be superior to that of the unripened extracts. The NO scavenging activity was found only in unripened extracts. Further, it was confirmed that the unripened extract had a relatively high antimicrobial activity except against K. pneumoniae KCTC 2245 compared to the ripened extract. Conclusion: These results suggest that unripened black raspberry (Rubus occidentalis) extracts have better antioxidant and antimicrobial activity than ripened extract. Thus, unripened black raspberry extracts have a higher potential for development as antimicrobial material such as a natural antioxidant and preservatives.

한국과 호주여성의 모발관리행동 비교

류은혜(Ryu Eun-Hye),박숙현(Pakr Sook-Hyun),권미정(Kwon Mi-Jeong) 한국생활과학회 2005 한국생활과학회지 Vol.14 No.2

전방깊이와 안축장에 따른 인공수정체 삽입 후 굴절 오차의 경향

맹효성,류은혜,정태영,정의상.Hyo-Sung Maeng. MD. Eun Hye Ryu. MD. Tae-Young Chung. MD. PhD. Eui-Sang Chung. MD. PhD 대한안과학회 2010 대한안과학회지 Vol.51 No.2

Purpose: To investigate the error tendency between preoperative expected refraction and postoperative manifest refraction based on anterior chamber depth (ACD) and axial length (AXL) in cataract surgery cases and to report how ACD and AXL affect determination of intraocular lens (IOL) power. Methods: We retrospectively studied 82 eyes of 62 patients who underwent cataract surgery in our hospital between August 2008 and January 2009. Anterior chamber depth and AXL were measured using IOL MasterⓇ, and IOL power was calculated using the SRK II and SRK/T formulae. Patients were divided into three groups based on ACD and into another three based on AXL. Refractive error (RE) was analyzed one month after surgery. Results: Though the RE of each group showed a tendency for hyperopic shifts, only those obtained with the SRK/T formula showed statistically significant differences between groups (p<0.05). Using the SRK/T formula, we found that an increasing AXL was associated with an increased hyperopic shift. This was more pronounced in those with shallow ACD (<2.5 mm), though the difference was not statistically significant. Similarly, an increase in ACD was associated with an increased hyperopic shift, and this difference was more pronounced in those with short AXL (<22.5 mm), and this time the difference was statistically significant. Conclusions: As ACD and AXL significantly affect RE, both should be considered when investigating postoperative RE tendency and when determining IOL power. Postoperative RE will be greatly affected by a short AXL or a shallow ACD, and therefore these factors should be considered in IOL power determination. J Korean Ophthalmol Soc 2010;51(2):195-202

실험적 피부포도알균 안내염에서 가티플록사신의 유리체강내 주사의 효과

이수영,류은혜,문선경,김현진,우소연,조민선,고형준,Soo Young Lee,Eun Hye Ryu,Sun Kyung Moon,Hyun Jin Kim,So-Youn Woo,Min-Sun Cho,Hyoung Jun Koh 대한안과학회 2008 대한안과학회지 Vol.49 No.4

Purpose: To compare the efficacy of intravitreal gatifloxacin with intravitreal vancomycin in the treatment of Staphylococcus epidermidis endophthalmitis in a rabbit model. Methods: Albino rabbits (n=30), infected with an intravitreal inoculum of S. epidermidis (105 colony forming unit/0.1 mL), were divided into 6 groups (n=5). Groups I and IV received 200 μg/0.1 mL of intravitreal gatifloxacin, and groups II and V were injected 1000 μg/0.1 mL of vancomycin intravitreally. Intravitreal balanced salt solutions (untreated control) were given to Groups III and VI. Intravitreal antibiotic therapy commenced 24 hours after bacterial inoculation. The bactericidal efficacy was determined by electroretinography (ERG), clinical grading, bacterial culture of vitreous aspirates and histopathologic grading. ERGs and clinical gradings were performed only for groups I, II, and III and bacterial cultures were done only for groups IV, V, and VI. Results: Eyes in the gatifloxacin groups showed similar appearance to those in the vancomycin treated groups clinically, histologically, and functionally as proved with ERG. All aspirates from the gatifloxacin and vancomycin groups were culture‐negative at 5 days after bacterial inoculation, whereas all eyes in the untreated control group were culture‐positive. Conclusions: This study demonstrated that intravitreal injection of 200 μg /0.1mL gatifloxacin appeared to be equally effective compared to intravitreal 1000 μg /0.1 mL vancomycin in the treatment of S. epidermidis endophthalmitis. If proven safe and efficacious after further study in humans, intravitreal injection of gatifloxacin could be considered an effective alternative to vancomycin for the treatment of S. epidermidis endophthalmitis.

토종효모를 이용한 복분자 발효주의 바이오제닉아민 함량 및 향기성분 분석

윤해훈,손락호,류은혜,정지혜,Yoon, Hae-Hoon,Son, Rak-Ho,Ryu, Eun-Hye,Jung, Ji-Hye 한국식품조리과학회 2015 한국식품조리과학회지 Vol.31 No.3

We investigate black raspberry (Rubus occidentalis) wine made using traditional yeast (Saccharomyces cerevisiae A8, B6, GBY2, GBY3) and S. cerevisiae Fermivin (FM), which is widely used in wine manufacturing, and analyze the biogenic amine content and the volatile flavor compounds. Black raspberries were separately inoculated with yeast up to $1{\times}10^9CFU/kg$, followed by incubation at $25^{\circ}C$ for 7 days. FM produced the highest alcohol content, however the final fermentation characteristics of the wine made using four different yeasts were similar. S. cerevisiae A8 had a large biogenic amine (BA) content, specifically tryptamine, thus we excluded this yeast from fermentation. S. cerevisiae GBY3 was selected for black raspberry wine fermentation as a result of sensory evaluation. The volatile flavor compounds of two wines (S. cerevisiae GBY3 and FM) were analyzed by gas chromatography and mass spectrometry. 37 compounds in the samples were separated, and several ester compounds were identified in greater amounts in the wine made with S. cerevisiae GBY3 than in the wine made with FM. A greater amount of the major compound, ethyl benzoate, giving the sweet and fruity flavor, was identified in wine made with S. cerevisiae GBY3 than in the wine made with FM. In conclusion, S. cerevisiae GBY3 was confirmed to produce no major BAs and a better flavored wine. These results give new leads in the production of high quality wine.