Absence of dysplasia in the excised cervix by a loop electrosurgical excision procedure in the treatment of cervical intraepithelial neoplasia

류애리,남계현,정수호,김정식,이해혁,고은석,배동한 대한부인종양학회 2010 Journal of Gynecologic Oncology Vol.21 No.2

Objective: Absence of dysplasia in the excised specimen following loop electrosurgical excision procedure (LEEP) for treatment of cervical intraepithelial neoplasia (CIN) 2/3 is an occasional finding of uncertain clinical significance. We evaluated several factors including age, liquid-based Pap (LBP) test, human papillomavirus (HPV) load before treatment, and HPV typing as predictors for absence of dysplasia. Absence of dysplasia in LEEP specimens was analyzed in terms of factors for recurrent disease after LEEP conization. Methods: In total, 192 women (mean age, 39.3±8.4 years; range, 24 to 70 years) with biopsy-proven CIN 2/3 were treated by LEEP conization. Age, LBP test, histological grade, HPV load, and HPV DNA typing were evaluated as possible predictors of the absence of residual dysplasia or recurrent disease. Results: Of the LEEP specimens, 34 (17.7%) showed no dysplasia in preoperative biopsies from patients with proven CIN 2/3. Low HPV load (<100 relative light units [RLU]) was significantly related to the absence of dysplasia in LEEP specimens, using logistic regression. Margin involvement and high HPV load (≥400 RLU) were significant factors for recurrence. Conclusion: Absence of dysplasia in LEEP specimens occurred in 17.7% of our specimens. Prediction of the absence of dysplasia in LEEP specimens was associated with low HPV load. Residual/recurrent disease after LEEP was associated with a positive resection margin and high viral load, and was not associated with absence of dysplasia in LEEP specimens. Even if there is no dysplasia in conization specimens, close follow-up for residual/recurrent disease is needed.

마른 이상적 체형의 내면화 및 신체비교가 이상섭식행동에 미치는 영향에 있어서 신체 수치심의 매개효과 검증

류애리,송원영 한국건강심리학회 2013 한국심리학회지 건강 Vol.18 No.2

The aim of this research is to verify the mediated effects of body shame when thin-ideal internalization and physical comparison affect disordered eating behavior. For this research, a survey was conducted targeting female undergraduates of K-university in Chung-Nam and Dae-Jeon, South Korea. Data of 280 undergraduates were analyzed. In order to sort out female undergraduates who have a possibility of disordered eating behavior, the Korean Eating Attitude Test-26 (KEAT-26) was used which have been standardized what Garner and Garfinkel developed and amended. To measure the internalization of thin-ideal internalization, Sociocultural Attitudes toward Appearance Scale (SATAS) was used, which was a test that Jung-Shin Moon has adapted from what Cusumano and Thompson developed. To measure the physical comparison, Physical Appearance Comparison Scale(PACS), which was a test that Eun-Jung Son has adapted what Tantleff developed, and Specific Attributes Comparison Scale(SACS), which was a test that Eun-Jung Son adapted what Tiggermann and Mcgill developed, were used. To measure body shame, eight questions regarding body shame from the Objectified Body Consciousness Scale, developed by Mickinley and Hyde, were used, which were a test that Eun-Jung Son has adapted. A correlation analysis and a multiple regression analysis were conducted by the PASW 18.0 program using collected data. The consequences of this research are follows: First, thin-ideal internalization and physical comparison had a significantly positive correlation with disordered eating behavior, as well as with body shame. Body shame, also, had a significantly positive correlation with disordered eating behavior. These consequences show that disordered eating behaviors of female undergraduates could increase due to body shame particularly when they have a high level of thin-ideal internalization and physical comparison. Second, the body shame was partially mediated between the thin-ideal internalization and physical comparison and the disordered eating behavior. Consequently, it is crucial to decrease the level of thin-ideal internalization and physical comparison, however first step is to educate females about their physical appearance so that they can decrease the level of body shame, which implies that eating disorder caused by disordered eating behavior can finally decrease. Likewise, further discussion and proposals for following researches are proposed. 본 연구는 마른 이상적 체형의 내면화 및 신체비교가 이상섭식행동에 미치는 영향에 있어서 신체 수치심의 매개효과 검증을 목적으로 하였다. 이를 위해 대전․충남 지역의 여대생들을 대상으로 설문조사를 실시하여, 최종적으로 280부의 자료를 분석하였다. 평가도구로는 한국판 식사태도검사(KEAT-26), 마른 이상적 체형의 내면화척도(Sociocultural Attitudes toward Appearance Scale; SATAS), 신체비교 척도(Physical Appearance Comparison Scale; PACS, Specific Attributes Comparison Scale; SACS), 신체 수치심 척도(The Objectified Body Consciousness Scale)를 사용하였다. 수집된 자료는 PASW 18.0 프로그램을 활용하여 분석의 목적에 따라 상관분석과 중다회귀분석을 실시하였다. 연구결과 첫째, 마른 이상적 체형의 내면화 및 신체비교는 이상섭식행동 및 신체 수치심과 유의한 정적인 상관을 보였으며, 신체 수치심과 이상섭식행동에서도 유의한 정적인 상관을 보였다. 둘째, 마른 이상적 체형의 내면화 및 신체비교가 이상섭식행동에 미치는 영향을 신체 수치심이 부분 매개하는 것으로 나타났다. 이 결과는 일상생활에서 발생되는 이상섭식요인들뿐 아니라 올바른 신체상과 자신에게 맞는 적절한 체중에 대한 기대가 섭식장애나 비만자들을 위한 프로그램에 활용될 수 있음을 시사한다. 관련 논의와 향후 연구에 대한 제안점 등을 논의하였다.

태아성장지연의 진단 및 관리

류애리 순천향대학교 순천향의학연구소 2017 Journal of Soonchunhyang Medical Science Vol.23 No.1

Fetal growth restriction (FGR) occurs due to various reasons and is associated with increased fetal and neonatal mortality and morbidity. FGR has been defined as having birth weight less than the 10th centile. The first clinically relevant step is the detection of true FGR, pathological small fetuses, associated with signs of abnormal placental insufficiency and poorer perinatal outcome. The role of obstetric management is to identify growth restricted fetuses at risk of chronic hypoxia in uterus, to monitor their wellbeing, and to deliver when the adverse outcome is imminent. The purpose of this document is to review the FGR with diagnosis, antenatal surveillance tools, and guidance for management and timing of delivery.

한국인의 베타지중해성 빈혈 임신부

류애리 순천향대학교 순천향의학연구소 2017 Journal of Soonchunhyang Medical Science Vol.23 No.2

Thalassemia is hereditary disease characterized by impaired production of the normal globin peptide. Beta-thalassemia, a common disorder in Central Africa, the Middle East, and Southeast Asia, has been rarely reported in Korea. It should be considered in the differential diagnosis of hypochromic, microcytic anemia. The genetic subtypes among the different ethnic groups vary; this may pose challenges in prenatal diagnosis or genetic counselling. During pregnancy, women with thalassemia will often show more significant anemia. Recently we have experienced Korean pregnant woman with beta-thalassemia associated with anemia. We describe this case with a brief review of the literature.

포상기태 이후 발생한 지속성 융모질환 1예

류애리,장시형 순천향대학교 순천향의학연구소 2016 Journal of Soonchunhyang Medical Science Vol.22 No.2

Gestational trophoblastic disease is an abnormal proliferations of trophoblastic tissue during pregnancy. Persistent gestational trophoblastic t umor develops in about 20% after evacuation of complete mole. Following evacuation of hydatidiform mole, the interpretation of serial serum human chorionic gonadotropin (hCG) regression patterns is important in monitoring the course of the disease. Because it is the most reliable and sensitive method for the early detection of gestational trophoblastic disease. We describe an uncommon case of complete hydatidiform mole in a 48-year-old woman, who has presented to us with complaints of bleeding. She experienced after the evacuation of a complete mole and no decreased in hCG levels over four consecutive serum hCG measurements. The patient underwent hysterectomy due to leiomyoma. Finally, pathologic diagnosis was confirmed persistent gestational trophoblastic disease.

초기 자궁경부암 환자에서 복강경하 근치적 자궁목절제술 및 복식자궁경부 봉합술 후 성공적인 자연임신 1예

류애리,전섭,전혜지,조미옥 순천향대학교 순천향의학연구소 2019 Journal of Soonchunhyang Medical Science Vol.25 No.1

Women in the reproductive age group diagnosed with cervical cancer can receive radical trachelectomy for fertility preservation. Extremely short cervix following radical trachelectomy could result in cervical incompetence. Although prophylactic cervicoisthmic cerclage is placed at the time of radical trachelectomy, it might not be sufficient to prolong pregnancy. We present a successful term pregnancy after laparoscopic radical trachelectomy and concurrent cervicoisthmic cerclage for early stage cervical cancer.

Early human papillomavirus testing predicts residual/recurrent disease after LEEP

류애리,남계헌,곽정자,김정식,전섭 대한부인종양학회 2012 Journal of Gynecologic Oncology Vol.23 No.4

Objective: The purpose of this study was to determine the predictive factors for residual/recurrent disease and to analyze the timing for Pap smears and human papillomavirus (HPV) testing during follow-up after loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia (CIN) 2 or worse. Methods: We retrospectively analyzed 183 patients (mean age, 39.3 years) with CIN 2/3 who were treated with LEEP. Post-LEEP follow-up was performed by Pap smear and HPV hybrid capture2 (HC2) testing. The definition of persistent/recurrent disease was biopsy-proven CIN 2 or worse. Results: Among 183 patients, punch biopsies were CIN 2 in 31 (16.9%) and CIN 3 in 152 (83.1%). HPV HC2 tests before LEEP were positive in 170 (95.5%) of 178 patients. During follow-up, 12 patients (6.6%) had residual/recurrent CIN 2+. LEEP margin status was a significant predictive factor for persistent/recurrent disease. Other factors such as age, HPV HC2 viral load (≥100 relative light units), and HPV typing (type 16/18 vs. other types) did not predict recurrence. Early HPV HC2 testing at 3 months after LEEP detected all cases of residual/recurrent disease. The sensitivity and negative predictive value of the HPV HC2 test for residual/recurrent disease were both 100% at 3 and 6 months. Conclusion: Margin involvement in conization specimens was a significant factor predicting residual/recurrent disease after LEEP. HPV test results at 3 and 6 months after treatment were comparable. Early 3-month follow-up testing after LEEP can offer timely information about residual/recurrent disease and alleviate patient anxiety early about treatment failure.

난소갑상선종 1예

류애리,문성택,문가을,장시형 순천향대학교 순천향의학연구소 2014 Journal of Soonchunhyang Medical Science Vol.20 No.2

Struma ovarii is a rare, monodermal and highly specialized teratoma, composed entirely or predominantly (>50%) of thyroid tissue. Presenting symptoms are not specific. Despite containing thyroid tissue, only 5% of struma ovarii have features of hyperthyroidism. Therefore, preoperative diagnosis of struma ovarii is difficult. Recently, the authors experienced a case of struma ovarii found in a young woman who presented with known pelvic mass and dysmenorrhea. A transabdominal ultrasonography and computed tomography detected a 16-cm sized multiloculated mass in pelvic cavity. She underwent laparoscopic unilateral ovarian wedge resection. The final histopathologic diagnosis was struma ovarii of the mature cystic teratoma. Therefore, we report this rare case with a brief review of the literature.

임신 중기에 발생한 원인불명 급성간염 1예

전혜지,류애리 순천향대학교 순천향의학연구소 2016 Journal of Soonchunhyang Medical Science Vol.22 No.2

Although liver diseases in pregnancy are rare, they can seriously affect mother and fetus. Although any type of liver disease can develop during pregnancy, it is difficult to identify features of liver disease in pregnant women because of physiological changes. Physiologic changes of pregnancy can be confounding with the symptoms of liver diseases. It can not only complicate mother’s life but also burden life of fetus to growth restriction. We describe an uncommon case of acute hepatitis with disseminated intravascular coagulation and clinical chorioamnionitis coincidentally in mid-trimester pregnancy. She experienced the development of acute hepatitis of unknown causes. She presented with fever, maternal tachycardia, and fetal tachycardia. We decided termination of pregnancy because of 16 weeks’ gestation. After termination, she was managed about acute hepatitis. So we report our case with a brief reviews of the literature.

후복막하 혈종을 동반한 자궁외임신 1예

문성택,류애리 순천향대학교 순천향의학연구소 2017 Journal of Soonchunhyang Medical Science Vol.23 No.1

Ectopic pregnancy is an implantation of the fertilized ovum on a place except the endometrium. Most of the ectopic pregnancies are located at the fallopian tube. Few cases of retroperitoneal hematoma associated with ectopic pregnancy have been reported on previously; in each the retroperitoneal space had been the site of implantation. In contrast, we treated a patient with an ectopic pregnancy that implanted in the tube and then perforated through into the retroperitoneal space. To our knowledge this is very rare case of retroperitoneal hematoma caused by a ruptured tubal pregnancy.