두개강 내압항진에 대한 실험적 연구 : The sequence of alterations in the vital signs during Acute experimental increased intracranial pressure

노순성,주정화 고려대학교 의과대학 1979 고려대 의대 잡지 Vol.16 No.1

Acute increased intracranial pressure in rabbits caused by inflation of an extradural balloon was associated with a sequential alteration in vital signs. As the balloon was infalted with small increments of saline, the intracranial pressur rose. The first few increments were not usually associated with a sustained rise in intracranial pressure. As the intracranial pressure was raised with additional increments, the vital signs altered in the following order. As the first increments were added, the respiratory rate decreased. Further inflation of the balloon was associated with a definite reduction of the pulse rate and marked slowing of the respiration. As the respirations became slower, with the increasing intracranial pressure their amphlitude increased. At this stage, later than the onset of respiratory change, further increment was sufficient to give a sudden parallel rise of the intracranial and arterial pressures. With this parallel rise of pressures the respiration became short and shallow associated with periods of apnea. Pulse rate usually decreased as the arterial dressure rose. A transient sudden rise of venous blood pressure was observed when the arteral pressure rose suddenly parallel to rise of intracranial pressure. If the balloon was not deflated the arterial pressure declined, the pulse rate increased significantly and periods of apnea occurred. Thereafter the intracranial and systemic arterial pressures gradually declined along with a reduction of the pulse rate. Respiration ceased and finally the heart stopped.

요부추간판탈출증을 동반한 Narrow Spinal Canal 수술 치험례

노순성,주정화,이기찬,이훈갑 대한신경외과학회 1978 Journal of Korean neurosurgical society Vol.7 No.1

A case of the narrow lumbar spinal canal was reported in which a lumbar disc herniation was coexisted at L3-L4 Interspace. The patient was a 58-year-old male whose chief complaint was pain in the low back and in both legs which was intermittent in occurence and alternative from side to side. The symtoms lated for about 7 years prior to this admission to hospital and it was initiated and aggravated by standing for minutes or walking and especially by extention of low back. No significant neurological deficits were detected in neurological examination except for signs of single nerve root compression from which L3-L4 disc herniation was 'suspected. Findings of simple lumbar spine radiograms and myelograms were compatible with those of narrowed spinal canal. Complete bilateral laminectomy of lumbar spine sparing articular facets were performed to get freedom of neural element or structure in the spinal canal from pressure. Hypertrophied ligamentum flavum, thickened laminae and protrusion of disc at L3-L4 interspace were the findings observed in the surgical operation. The patient became asymptomatic after the surgery.

두개강 내압항진에 대한 실험적 연구

노순성 고려대학교 의과대학 1979 고려대학교 의과대학 잡지 Vol.16 No.1

대뇌국소저온에 대한 실험적 연구

노순성,주정화 대한신경외과학회 1981 Journal of Korean neurosurgical society Vol.10 No.2

With the purpose of avoiding the usual complications of systemic hypothermia and particularly these secondary to the lower tolerance of temperature of the cardiac neuromuscular elements as compared with tissue of the central nervous system, extravascular local cooling of the brain in cat was designed for the experiment. The experimental technique was deviced to cool the brain with cold liquid (2-3℃) of physiological saline perfused or irrigated onto and with the salineice (-7℃) rested co the surface of the brain. Thermoccuples were introduced and placed at different depths of each 0.3cm in the brain, then the brain temperatures were measured at each depth before and during cooling every 10 minutes. Average temperature of brain surface before cooling was 35.7°±1.7℃ and mean of it recorded from surface to 1.5cm depth in the brain was 36.7°±1.1℃ in 20 cats. During cooling temperatures wes effectively and markedly droped at extent of 0.6cm thick in the subcortical tissue, and at 20 minutes, cooling the maximal drop of temperature was recorded. During cooling with saline solution, average temperature of normal brain surface was 22.3°±41.℃ and mean of it recorded at different depths in brain was 28.7°±2.5℃. During cooling with saline ice, average temperaure of normal brain surface was 12.2°±2.6℃, and mean of it recorded at different depths in brain was 22°±1.3℃. Temperature in the areas of brain injured by contusion or compression was relatively lower than in the normal brain. Temperature lowering in the injured brain during the cooling was more evident and marked in its degree than that in normal brain. Gross neurological examination failed to demonstrate any impairment of voluntary motor function after the cooling of brain for 50 minutes.

대뇌의 방사선조사후 괴사 1예

노순성,서중근,주정화,이훈갑,김인선 대한신경외과학회 1978 Journal of Korean neurosurgical society Vol.7 No.2

A case of postirradiation necrosis of the brain, clinically simulating neoplasm, is reported. A 29 years old male underwent a surgery with a partial removal of chromophobe adenoma of the pituitary gland postoperatively received deep radiation therapy with CO^(60). A total dose of 4,500 r. was given in 35 days. Approximately six months after the irradiation, the patient became confused and complained of frontal headache in association with signs of increased intracranial pressure and of intracranial dynamic mass lesion. Cerebral angiography and C-T scanning demonstrated findings of a large mass in the right temporal region. At operation done nine months after his initial craniotomy, tissue of the mass appeared to be a glioma and large blocks of tissue were resected. Histologically it was verified to be necrosis of the brain.

두개강 내압항진에 대한 실험적 연구 : The sequence of alterations in the vital signs during acute experimental incereased intracranial pressure

노순성,주정화 대한신경외과학회 1978 Journal of Korean neurosurgical society Vol.7 No.2

Acute increased intracranial pressure in rabbits caused by inflation of an extradural balloon was associated with a sequential alteration in vital signs. As the balloon was inflated with small increments of saline, the intracranial pressure rose. The first few increments were not usually associated with a sustained rise in intracranial pressure. As the intracranial pressure was raised with additional increments, the vital signs altered in the following order. As the first increments were added, the respiratory rate decreased. Further inflation of the balloon was associated with a definite reduction of the pulse rate and marked slowing of the respiration. As the respirations became slower, with the increasing intracranial pressure their amplitude increased. At this stage, later than the onset of respiratory change, further increment was sufficient to give a sudden parallel rise of the intracranial and arterial pressures. With this parallel rise of pressures the respiration became short and shallow associated with periods of apnea. Pulse rate usually increased as the arterial pressure rose. A transient sudden rise of venous blood pressure was observed when the arterial pressure rose suddenly parallel to rise of intracranial pressure. If the balloon was not deflated the arterial pressure declined, the pulse rate decreased significantly and periods of apnea occurred. Thereafter the intracranial and systemic arterial pressures gradually declined along with a reduction of the pulse rate. Respiration ceased and finally the heart stopped.

대뇌 국소저온에 대한 실험적 연구

노순성,주정화 고려대학교 의과대학 1982 고려대 의대 잡지 Vol.19 No.1

With the purpose of avoiding the usual complications of systemic hypothermia and particularly those secondary to the lower tolerance of temperature of the cardiac neuromuscular elements as compared with tissue of the central nervous system, extravascular local cooling of the brain in cat was designed for the experiment. The experimental technique was devised to cool the brain with cold liquid(2°-3℃) of physiological saline perfused or irrigated onto and with saline ice(-7℃) resting on the surface of the brain. Thermocouples were introduced into different depths of the cortex, to a depth of 1.5㎝, and measurements were made at 0.3㎝ intervals. Brain temperatures were measured at each depth before and during cooling every 10 minutes. In 20 cats, the average temperature of brain surface before cooling was 35.7±1.7℃ and the mean temperature recorded from the surface to a. 1.5㎝ depth in the brain was 36.7±101℃. During cooling, temperatures were effectively and markedly droped to the depth of 0.6㎝ in the subcortical tissue, and after 20 minutes cooling the maximal drop of temperature was recorded. During cooling with saline solution, the average normal brain surface temperature was 12.2±206℃, and the mean temperature recorded at different depths in brain was 22.0±1.3℃. Temperature in areas of brain injured by contusion or compression was relatively lower than in the normal brain. Temperature lowering in the injured brain during the cooling was more evident and marked in degree than that observed in normal brain. Gross neurological examination failed to demonstrate any imparment of neurological functions, particulary voluntary motor activities after the cooling of brain, thoracic spinal cord and sciatic nerver for 50 minutes. The results of this study confirmed the belief that the cold liquid (2℃-3℃) and ice (-7℃) of physiological saline can be used in clinical neurosurgery for an extravascular local cooling of the brain, the spinal cord or peripheral nerve and for irrigating or perfusing and operation fields.

Purple corn extract alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like phenotypes in BALB/c mice

노희원,남상현,서희원,서정현,박수현,김샛별,정준섭,박종열,최재근,이재용,서홍원,임순성,김진경 한국통합생물학회 2021 Animal cells and systems Vol.25 No.5

Zea mays L. (Poaceae), also known as purple corn, is an annual herbaceous plant that is grown as food for human consumption in a variety of forms, including cooking oils and sweeteners in processed food and beverage products. The purpose of this study was to determine whether a novel purple corn extract, FB801, might have an anti-atopic dermatitis (AD) effect on AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) in BALB/c mice. Topical sensitization (1%) and challenge (0.3%) by DNCB were performed on the dorsal skin and right ear of BALB/c mice to induce AD. Following FB801 and dexamethasone administered orally, the severity of skin lesions was examined macroscopically and histologically. Serum levels of immunoglobulin E (IgE) and various cytokines were determined by enzyme-linked immunosorbent assay. Oral administration of FB801 significantly reduced typical symptoms of AD (erythema/bleeding, swelling, molting/erosion and scaling/drying), scratching frequencies, and the recruitment of inflammatory and mast cells. In addition, FB801 suppressed serum levels of IgE and T helper (Th)2 type cytokines such as interleukin (IL)-4 and IL-10 in DNCB-treated BALB/c mice. Furthermore, FB801 reduced the degradation of inhibitor of nuclear factor-κB proteins (NF-κB) in tumor necrosis factor (TNF)-α-stimulated human keratinocyte (HaCaT) cells. These results suggest that FB801 inhibited the development of the AD-like skin symptoms by regulating Th1 and Th2 responses in the skin lesions in mice and suppressing TNF-α induced NF-κB activation in HaCaT cells, suggesting that FB801 has potential application as an effective alternative therapy for the prevention and management of AD.

레더씨 증후군

김창선,노순성,이훈갑,이기찬,주정화 대한신경외과학회 1979 Journal of Korean neurosurgical society Vol.8 No.2

The authors report two cases of paratrigeminal syndrome. They were male and involved in the left side, and had no known hypertension. The syndrome was produced and encountered in patients who had undergone a percutaneous carotid angiography and surgery with ligation of common carotid artery for, the treatment of carotidcavernous sinus fistulat. The clinical manifestations were unilateral, intense, throbbing supraorbital and periorbital pain recurring regularly, accompanied by drooping of the eye lid and miosis with normal sweating on the same side as the pain. The cases were treated conservatively with diphenylhydantion and antimigraine preparations with apparent success. It is probable that the underlying pathology of the syndrome in these cases may be compression of the internal carotid sympathetic fibers due to swelling of the internal carotid arterial wall. The clinical features and courses were compatible with those of group 2 of Raeder's syndrome.

거대세포 교아종 1례

이훈갑,노순성,이기찬,주정화 대한신경외과학회 1979 Journal of Korean neurosurgical society Vol.8 No.2

A rare case of a giant-celled glioblastoma arised from the intracranial portion of the right frontal base is presented. Clinical presentation was that of increased intracranial pressure with bilateral optic papilledema. Skull X-rays showed an erosion of the right orbital roof. Right carotid angiogram confirmed the presence of a tumor in the frontal base.