외이도에 발생한 관상선종 1예

김호엽,안성기,허동구,고경혁 대한이비인후과학회 2013 대한이비인후과학회지 두경부외과학 Vol.56 No.2

Tumors occurring in the external auditory canal (EAC) are rare. In particular, tubular adenoma (TA) is an extremely rare sweat gland neoplasm occurring in the EAC and is generally considered as benign. Up to now, less than one hundred cases of TA have been reported in the English literature. In fact, a comprehensive review of literature shows that TA in the EAC has seldom been reported. Herein, we report a case of a 35-year-old man with TA that occured in the EAC, together with characteristic histopathological findings.

Oseltamivir (TamifluⓇ) 투약 후 발생한 양측성 전정장애 1예

김호엽,안성기,허동구 대한평형의학회 2013 Research in Vestibular Science Vol.12 No.1

The threat of pandemic influenza has focused attention and resources on virus surveillance, prevention, and containment. The World Health Organization has strongly recommended the use of the antiviral drug, Oseltamivir (TamifluⓇ), to treat and prevent pandemic influenza infection. In recent years, there have been case reports of vestibulocochlear events during or after oseltamivir treatment,other countries. Oseltamivir is generally well-tolerated and its most frequent adverse effects include nausea and vomiting, diarrhea, and abdominal pain. Up to now, bilateral vestibular hypofunction after oseltamivir medication has not been reported. Herein, we report a very rare case of a 36-year-old female with bilateral vestibular hypofunction following oseltamivir medication

콧등에 발생한 피부혈관육종 1예

김호엽,이홍경,우승훈,김진평 대한이비인후과학회 2010 대한이비인후과학회지 두경부외과학 Vol.53 No.6

A cutaneous angiosarcoma is a rare, aggressive malignancy with a poor prognosis, with only a few cases of it in head and neck have been reported. In the present case, we reported a primary angiosarcoma of the nasal dorsum in a 70-year-old man without prior irradiation of head and neck region. The authors reviewed the literature and discussed treatment and prognosis of cutaneous angiosarcoma in nasal dorsum. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:383-5

갑상선 전 절제술 후 저칼슘혈증의 조기 예측인자

김호엽 ( Ho Youp Kim ),김진평 ( Jin Pyeong Kim ),박정제 ( Jung Je Park ),안성용 ( Seong Yong Ahn ),우승훈 ( Seung Hoon Woo ) 대한갑상선학회 2010 International Journal of Thyroidology Vol.3 No.2

Background and Objectives: Hypocalcemia is the most common complication after total thyroidectomy. The purpose of this study is to determine whether measurement of intact parathyroid hormone (i-PTH) concentrations in the early postoperative period accurately predicts patients at risk of developing hypocalcaemia and safely discharged on the first postoperative day. Materials and Methods: A prospective study of patients undergoing total thyroidectomy was carried out. Thirty eight patients were recruited into the study in the period May 2009 to March 2010. I-PTH concentrations, calcium, ionized calcium, P, Mg, were measured preoperatively and at 0 and 6 h, 12 h, 24 h, 72 h, 120 h postoperatively. Results: Papillary thyroid carcinoma was the most common indication for surgery (96%). In the correlation of all the results and the presence of symptom using the logistic regression test. In the statistically result, i-PTH is linearly relative to the change of the test time. In the P, Mg, albumin, Ca, and ionized Ca, there are not. We compared with the odds ratio of i-PTH. I-PTH of post OP 6 hours is most relative to symptomatic prevalence and timely significant. After ROC analysis using the significant hormonal level of the post OP 6 hours, they are stratified by four groups ≤4.2, ≤7.1, ≤10.6, and ≤13.6 mg/dl, and compared one another. Conclusion: An i-PTH measurement at 6 hours postoperatively allows for accurate prediction of patients at risk of hypocalcaemia. In the future patients with a normal postoperative i-PTH level can be safely discharged on the first postoperative day.

하악하 도서형 피판을 이용한 하구순 재건술

우승훈,김호엽,김준식,김진평 대한이비인후과학회 2011 대한이비인후과학회지 두경부외과학 Vol.54 No.4

Squamous cell carcinoma (SCC) of the lower lip is the most common malignant tumor, comprising 90% of all lip SCC. The typical picture of SCC of the lower lip is an ulcerated lesion with raised margins. Surgery is the treatment of choice for SCC of lower lip. After resection, reconstruction is important both aesthetically and functionally, because the lower lip is a prominent location in the face and it is where essential functions of the sphincter are carried out as in assisting mastication, swallowing, phonation, and expressing emotion. Depending on the location and size of the tumor, different types of flaps are used. We describe here a successful technique to reconstruct a large lower lip defect using a submental island flap and a mucosal flap for patients.

중소기업 정보시스템의 공격예방 및 탐지를 위한 대응 : 서베이

문형진,황윤철,김호엽 중소기업융합학회 2015 융합정보논문지 Vol.5 No.2

이뇨제를 처방한 재발성 전정장애의 임상적 특징과 경과

고준석,안성기,김호엽,허동구 대한평형의학회 2014 Research in Vestibular Science Vol.13 No.1

Background and Objectives: Recurrent vestibulopathy (RV) is a clinical syndromeof unknown etiology characterized by multiple episodic vertigo without auditoryor neurological signs or symptoms. The purpose of this study is to investigatethe clinical characteristics and the natural course of RV with diuretics medication. Materials and Methods: During the period January 2008 to December 2010, wereviewed the clinical records of 30 patients diagnosed with RV. All patients weregiven hydrochlorothiazide medication at least 3 months, approached by telephoneand using a questionnaire to make a long term follow-up. The analysis includedage, sex distribution, natural history, pure tone audiometry, caloric response, ageat onset, and the characteristics of vertigo. Results: Median follow-up was 29months (range, 27−37 months). Patients had a mean age at onset of 48.2 yearsand a mean duration of 2.75 years. An obvious female predilection was found,and unilateral caloric paresis (≥25%) was seen in 23.3%. Of the 30 patients,symptoms resolved in 80% but were unchanged in 20%. No patient with RVdeveloped a central nervous system disease or benign paroxysmal positionalvertigo during follow-up. Conclusion: The present study shows that in themajority of cases, vertigo resolved following diuretics medication. In cases of thepatients with severe or disabling recurrent vestibulopathy, the diuretics medicationmay be effective in reducing the frequency of vertigo attacks.

Immunohistochemical Study on β1- and β2-Adrenergic Receptors in Rat Vestibular Nuclei

안성기,Roza Khalmuratova,허동구,김호엽,박현우,주연희,강흥수 대한평형의학회 2012 Research in Vestibular Science Vol.11 No.2

Background and Objectives: The aim of this study was to examine the localizations of β1- and β2-adrenergic receptors (ARs) in rat vestibular nuclei by immunohistochemical staining procedure. Materials and Methods: Twelve male Sprague-Dawley rats were used in this study. Primary antibodies for the β1- and β2-ARs were used. The sections were treated with a biotinylated goat anti-rabbit antibody. The sections were then incubated in avidin-biotin-peroxidase reagent and processed with immunoperoxidase using 3.3’-diaminobenzidine tetrahydrochloride. Results: β1-AR and β2-AR immunopositive neurons were found to be distributed throughout the four major vestibular nuclei. Both receptors were primarily detected in neuronal somata and their proximal dendrites. β1-AR and β2-AR were moderately expressed in the superior vestibular nucleus, lateral vestibular nucleus, medial vestibular nucleus,and spinal vestibular nucleus. Conclusion: The present study demonstrates, for the first time, that β1-AR and β2-AR receptors are localized in rat vestibular nuclei. Furthermore, this study may provide additional speculation into the role of ARs during vestibular signal processing. Further studies are needed to clarify the roles played by β1-ARs and β2-ARs through physiologic and functional studies. Background and Objectives: The aim of this study was to examine the localizations of β1- and β2-adrenergic receptors (ARs) in rat vestibular nuclei by immunohistochemical staining procedure. Materials and Methods: Twelve male Sprague-Dawley rats were used in this study. Primary antibodies for the β1- and β2-ARs were used. The sections were treated with a biotinylated goat anti-rabbit antibody. The sections were then incubated in avidin-biotin-peroxidase reagent and processed with immunoperoxidase using 3.3’-diaminobenzidine tetrahydrochloride. Results: β1-AR and β2-AR immunopositive neurons were found to be distributed throughout the four major vestibular nuclei. Both receptors were primarily detected in neuronal somata and their proximal dendrites. β1-AR and β2-AR were moderately expressed in the superior vestibular nucleus, lateral vestibular nucleus, medial vestibular nucleus,and spinal vestibular nucleus. Conclusion: The present study demonstrates, for the first time, that β1-AR and β2-AR receptors are localized in rat vestibular nuclei. Furthermore, this study may provide additional speculation into the role of ARs during vestibular signal processing. Further studies are needed to clarify the roles played by β1-ARs and β2-ARs through physiologic and functional studies.

Effectiveness of an i-PTH Measurement in Predicting Post Thyroidectomy Hypocalcemia: Prospective Controlled Study

김진평,박정제,손희영,김록범,김호엽,우승훈 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.3

Purpose: Hypocalcemia is the most common complication after total thyroidectomy. The purpose of this study was to determine whether measurement of intact parathyroid hormone (i-PTH) level in thyroidectomy patients could predict hypocalcemia. Materials and Methods: We performed a prospective study of patients undergoing total thyroidectomy. Serum concentration of i-PTH, total calcium (Ca), ionized calcium (Ca2+), phosphate (P), magnesium (Mg), and albumin were measured preoperatively and at 0 hour, 6 hours, 12 hours, 24 hours, 48 hours, and 72 hours postoperatively. Results: 108 patients were recruited to the study. A total of 50 patients (46%) experienced hypocalcemia. The serum i-PTH concentration was linearly related to the time of measurement, while concentrations of P, Mg, albumin,Ca, and Ca2+ were not. We compared odds ratios, and found that the concentration of i-PTH at 6 hours post operation was the most closely related to the occurrence of hypocalcemic symptom. On ROC analysis using i-PTH level at 6 hours, an i-PTH level of 10.6 mg/dL was found to maximize both sensitivity and specificity at the same time point. Conclusion: We found that i-PTH was a predictor of hypocalcemia,and that the earliest predictor of hypocalcemic symptoms was an i-PTH concentration lower than 10.6 mg/dL obtained 6 hours after total thyroidectomy.

돌발성 난청을 주소로 내원한 전정내 지방종 1예

이은재,안성기,허동구,김호엽 대한이비인후과학회 2013 대한이비인후과학회지 두경부외과학 Vol.56 No.1

Intracranial lipomas are unfrequent tumors developed from mesenchymatous cells. The corpus callosum is the most frequent location (50%) in the intracranial regions, and these tumors are rarely present in the cerebellopontine angle, the internal acoustic meatus, or intravestibular lesions. With a review of literature, authors report a rare case of the left-sided intravestibular lipoma presented as sudden hearing loss in 17-year-old female. Furthermore, differential diagnostic magnetic resonance imaging characteristics of lipomas are discussed in detail.