Roles of Periostin in Symptom Manifestation and Airway Remodeling in a Murine Model of Allergic Rhinitis

허동구,Roza Khalmuratova,안성기,하영술,민양기 대한천식알레르기학회 2012 Allergy, Asthma & Immunology Research Vol.4 No.4

Purpose: Periostin was originally identified as a secreted factor during screening of a mouse osteoblastic library. In a recent study, periostin was found to directly regulate eosinophil accumulation in allergic mucosal inflammation. Chronic eosinophilic inflammation is related to the development of remodeling. The present study examined the expression of periostin and evaluated its role in the inflammatory process and remodeling associated with allergic rhinitis. Methods: A murine model of allergic rhinitis was established in periostin knockout mice. We analyzed the expression of periostin, manifestation of nasal symptoms, eosinophilic inflammation, and subepithelial fibrosis as well as the expression of MMP-2, TIMP-1, and type 1 collagen in nasal tissue. Results: Periostin was mainly distributed in the subepithelial tissue of the nasal mucosa. The subepithelial tissue was thinner in the knockout group than in the control group. No differences in the expression of MMP-2 or TIMP-1 were found in the knockout group. However, after a month of allergen challenge, type I collagen in the nasal tissue was lower in the knockout group than in the control group. The number of eosinophils and the symptom score were also lower in the knockout group. Conclusions: Periostin is expressed in nasal tissues of murine models of allergic rhinitis. Periostin deficiency may affect the remodeling of nasal tissue with reduced subepithelial fibrosis, and lead to less eosinophilic inflammation.

체험현장-국내, 해외영업의 성공 및 실패담

허동구,Heo, Dong-Gu 한국전기산업진흥회 1997 電氣産業 Vol.8 No.1

무기체계 RAM 향상방안 연구

허동구,최석철 한국국방경영분석학회 2001 한국국방경영분석학회지 Vol.27 No.1

This research deals with the weapon system RAM which is the reliability, availability and maintainability for weapon systems. This weapon system RAM is one of very important factors because it is related to the life cycle cost and combat readiness of weapon systems. Therefore, in this research we introduce the weapon system RAM and analyze the problems of weapon system RAM management during system life cycle including acquisition period. Finally we suggest an alternative to improve the weapon system RAM in various agencies which are the department of defense and army headquarter level, etc., in the process of defense acquisition.

두부충동검사에서 양성을 보인 가성 전정신경염 2예

허동구,이은재,강흥수,안성기 대한평형의학회 2012 Research in Vestibular Science Vol.11 No.2

At emergency room, most patients who presented with abrupt isolated vertigo without neurologic deficits were diagnosed as common vestibular disorder including vestibular neuritis. However posterior circulation stroke also can be a cause of the isolated vestibular vertigo. This condition is called vestibular pseudoneuritis. It is very important to differentiate vestibular pseudoneuritis from common vestibular disorder because of requiring different management and avoiding severe complication. Previous studies reported that head impulse test is one of bedside tests which represents unilateral vestibular hypofunction. Most patients of the vestibular neuritis shows positive head impulse test. However the head impulse test can be positive in central origin vertigo. So it is necessary to interpret the results of the test with caution. We report 2 cases of vestibular pseudoneuritis which showed positive head impulse test with a review of the related literatures.

Cerebral Venous Sinus Thrombosis Presenting as Me´ nie` re’s Disease

허동구,류경화,안성기,이현진 대한이비인후과학회 2021 대한이비인후과학회지 두경부외과학 Vol.64 No.10

We report an unusual case of cerebral venous sinus thrombosis (CVST) with dizziness similarto Ménière’s disease. A 46-year-old male was initially suspected of having Ménière’s diseasebased on his clinical manifestations. His dizziness was characterized as spinning or whirlingvertigo, accompanied by aural fullness and tinnitus of the right ear. Vestibular examinationsshowed spontaneous nystagmus on the right, but the caloric and video head impulse tests werenormal. Electrocochleography revealed a right-side abnormality. On the third day of treatment,visual symptoms and papilledema, indicating increased intracranial pressure, were observed. The central lesion was explored using MRI, and a final diagnosis of CVST was made. Anticoagulation therapy improved the patient’s dizziness, aural symptoms, and papilledema. Based on our case, the diagnosis of Ménière’s disease requires a more careful approach, andneurological signs and clinical manifestations should be checked to rule out central lesionssuch as CVST.

설기저부에 발생한 악성 섬유조직구종 1예

허동구,김상욱,김광현 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.7

Although there are some reports of malignant fibrous histiocytoma arising from the head and neck region, there hasnt been any reports on cases originating from the tongue base. We experienced a case of 29-year old female patient who visited our hospital with complaints of dyspnea, swallowing difficulty and a tongue based mass. On physical examination, she showed a huge tongue base mass filling the hypopharynx. After a temporary tracheostomy, she underwent a mass excision via transhyoid pharyngotomy approach. Postoperatively, she received radiation therapy for adjuvant treatment. She has been followed up without any evidence of the disease for 20 months.

내시경적 뇌척수액비루 정복술 중 우연히 발견된외상성 내경동맥 가성동맥류 1예

허동구,심우섭,모지훈,이철희 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.12

Posttraumatic pseudoaneurysm of the internal carotid artery (ICA) is uncommon but potentially becomes a fatal cause of epistaxis. Because the onset of delayed bleeding from the time of injury is variable, a prompt diagnosis of cavernous ICA pseudoaneurysm is often a clinical challenge. Optimal management demands rapid recognition and prompt treatment to give the best functional outcome. Although there are many reports of posttraumatic pseudoaneurysm, most of those cases were presented with epistaxis. We experienced a case of 24-year old female who visited our hospital with complaints of rhinorrhea after traffic accident. During exploration of nasal cavity and sinuses for repairing cerebrospinal fluid (CSF) leakage, a huge pseudoaneurysm of left ICA was found in sphenoid sinus. She was successfully treated with endovascular embolization techniques that included detachable balloons. The clinical and radiologic findings in this case are presented.

Bilateral Benign Paroxysmal Positional Vertigo Occurred during Dancing Rehearsal

허동구,고준석,김진용,안성기 대한평형의학회 2015 Research in Vestibular Science Vol.14 No.3

Benign paroxysmal positional vertigo (BPPV) is the most common cause of recurrent vestibular vertigo. The etiology of BPPV is unidentified in 50%−70% of patients. However in secondary BPPV, the etiologies are well known a head injury as an example. And it has been reported that even minor head trauma can evoke BPPV. The authors experienced a case of bilateral BPPV occurred during a dancing rehearsal in a school thereby we report the case with a review of the related literatures.Res Vestib Sci 2015;14(3):93-96

A Comparison of Fifth-Edition and Sixth-Edition American Joint Committee Staging System for Sinonasal Squamous Cell Carcinoma

이재서,허동구,김인상,모지훈,이철희,민양기 대한비과학회 2004 Journal of rhinology Vol.11 No.1

The American Joint Committee on Cancer staging system has been widely used for sinonasal cancer. The sixth-edition stagingsystem suggests a new classification for staging sinonasal cancer. The purpose of this study was to evaluate the validity of 6thedition of AJCC (American Joint Committee on Cancer) staging system for predicting prognosis of sinonasal squamous cellcancer comparing with 5th edition. Sixty five sinonasal squamous cell cancer patients from 1981 through 2003 at SNUH wereevaluated. Survival rates of different stages were analyzed using Kaplan-Meier method to determine mean, median, and 5-yearsurvival statistics. The overall 5 year survival rate was 54%. The cases that changed stages from stage III (5th) to Iva (6th)showed a worse survival rate than the cases remained as stage III, although statistically insignificant. The survival rates of stageIva (6th) and Ivb (6th) showed a significant difference (p=0.01). The stage III group evaluated by 5th edition changed intostage III or stage IVA in 6th edition and they showed different 5-year survival rates, 58% in stage III (6th) and 34% in stage IVA(6th)(p=0.248), and different local recurrence rates, 33.3% in stage III (6th) and 46.7% in stage IVA (6th) which might haveresulted in a worse survival rate. The new 6th edition AJCC staging system seems to be better to predict the prognosis of sinonasalsquamous carcinoma.

외안근 전정유발근전위

안성기,허동구,안성용 대한평형의학회 2010 Research in Vestibular Science Vol.9 No.-