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랫트에 있어서 DWH-01(Ranitidine : Bismuth subcitrate : Sucralfate)의 아급성독성에 관한 연구
박선미(Sun Mee Park),김형식(Hyung Sik Kim),김용기(Yong Kee Kim),변수현(Soo Hyun Byung),연제덕(Je Deuk Yeon),유영효(Young Hyo Yu),이병무(Byung Mu Lee),이향우(Hyang Woo Lee) 대한약학회 1993 약학회지 Vol.37 No.4
Subacute toxicities of DWH-01(Ranitidine : Bismuth : Sucralfate = 1.5 : 2 : 6) were inverstigated in Sprague-Dawley rats. After oral administration of DWH-01 with different dosages of 5g/kg, lg/kg, and 0.2g/kg, we examined the number of deaths, general signs, food intake, water intake, body weight and histopatholgical changes for both sexes of rats. During the adminstration period, urinalysis and opthalmological examination were also performed in the treated animals. 1) Animals were all survived for 4 weeks. 2) There were no significant differences in pathological and opthalmological findings between the control and treated animals. 3) There were no significant changes in body weight, food intake and water intake compared with control group. 4) In hematological examination and blood chemical analysis, there was no significant change compared with control group. 5) In histopathological examinations of organs and tissues, there was some hemorrhage in a lung tissue of low dose group, but it was thought to be caused by environmental factor. These data suggest that DWH-01 is not subacutely toxic in Sprague-Dawley rats.
남석우(Suk Woo Nam),박승희(Seung Hee Park),유세근(Se Geun Yu),서동완(Dong Wan Seo),김형식(Hyung Sik Kim),이병무(Byung Mu Lee),심점순(Jeon Soon Shim),유영효(Young Hyo Yu),박명환(Myung Hwan Park),이향우(Hyang Woo Lee) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.3
The acute toxicity of DWP305 (Ursodeoxycholic acid : Silymarin : Fursulthiamine : Riboflavin tetrabutyrate=1 : 1 : 0.1 : 0.05) was evaluated in both sexes of Sprague-Dawley rats, 6 weeks old by the oral route of administration. DWP305 was not considered to induce any toxic effect on the rats in mortalities, clinical findings, body weights and gross findings. It is suggested that LD_(50) value in rats would be above 5 g/㎏ in the oral administration. Subacute toxicity of DWP305 was examined in Sprague-Dawley rats. Four groups of rats were administered orally at doses of 0, 0.32, 0.8, and 2.0 g/㎏/day of DWP305 for one month. Any significant toxic clinical symptom was not observed in the treated rats during the experimental period. Macroscopic examination on the organs of tested animals showed no abnormal findings. On autopsy, no significant changes were found in organs examined. Maximum tolerated dose of DWP305 for the rat was estimated to be above 2 g/㎏ in this study.
과채류 및 식기류에 있어서 합성세제와 계면활성 성분의 잔류성과 안전성에 관한 연구
김형식,남석우,이향우,홍사욱 한국환경독성학회 1994 환경독성보건학회지 Vol.9 No.2
Synthetic detergents and commercial surfactants have been widely used as household and industrial detergents. The purposes of this study was to investigated the residual amounts and its safety of synthetic and commercial surfactants on the surfaces of fruits, vagetables and tablewares. The tested solutions were four kinds of raw materials of detergents such as LAS (Linear alkyl benzene sulfonate), AOS (α-Oleffine sulfonate), SLS (Sodium lauryl sulfonate) and SLES (Sodium lauryl ester sulfonate) and two kinds of commercial surfactants for kitchen. Cabbage and grapes were dipped in the each solution of the synthetic or commercial surfactants and washed 5 times in static or flow state. For the other experiments, stainless bowl was dipped in the each solution and washed also 5 times with cold and hot water in static or flow state. The residual amounts of the detergents were measured and also safety assessment was determined. The results of this study were summarized as follows. 1. The residual amounts of the detergents on the tested cabbage and grapes after 5 times washing were detected with the range from 0.105 to 3.009ppm in static state and from 0.104 to 2.963ppm in flow state. 2. The residual amounts of the detergents on the tested stainless bowl after 5 times washing were detected with the range from 0.012 to 1.243ppm in static state and from 0.014 to 1.4232ppm in flow state. 3. The safety ratio has been used as an evaluation of human health effects on the exposure of synthetic and commercial detergents. In this study, the estimated safety ratio was 2,459 and it is higher than recommended safety ratio on the food additives in WHO.
랫트에 있어서 DWH-01 (Ranitidine:Bismuth subcitrate:Sucralfate) 의 급성독성에 관한 연구
김용기,이향우,김형식,유영효,이병무,이제원,변수현,박선미 한국응용약물학회 1993 Biomolecules & Therapeutics(구 응용약물학회지) Vol.1 No.2
Acute toxicities of DWH-O1 (Ranitidine : Bismuth : Sucralfate=1.5 : 2 : 6) were investigated in Sprague-Dawley rats. Seven days after oral administration of DWH-O1 with different doses (10 g/kg, 5 g/kg, 2.5 g/kg, 1.25 g/kg, 0.625 g/kg), we examined numbers of deaths, general signs, weight measurement and histopathological examination for both sexes of rats. Summaried results are: 1) No deaths were occurred, 2) There were no pathological and clinical differences compared with control group, 3) No significant changes of body weights were observed, and 4) In histopathological examinations of organs and tissues, there was some hemorrhage in a lung tissue of low dose group for male and female respectively, but it was thought to be caused by environmental factor. The results suggest that toxicity of DWH-Ol is low and its LD_(50), is over 10 g/kg in Sprague-Dawley rats.