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김영상,박상민,이혜영,김영상 대한면역학회 2018 Immune Network Vol.18 No.1
IL-9 is a known T cell growth factor with pleiotropic immunological functions, especially in parasite infection and colitis. However, its role in tumor growth is controversial. In this study, we generated tumor clones expressing the membrane-bound form of IL-9 (MB-IL-9) and investigated their influences on immune system. MB-IL-9 tumor clones showed reduced tumorigenicity but shortened survival accompanied with severe body weight loss in mice. MB-IL-9 expression on tumor cells had no effect on cell proliferation or major histocompatibility complex class I expression in vitro. MB-IL-9 tumor clones were effective in amplifying CD4+ and CD8+ T cells and increasing cytotoxic activity against CT26 cells in vivo. We also observed a prominent reduction in body weights and survival period of mice injected intraperitoneally with MB-IL-9 clones compared with control groups. Ratios of IL-17 to interferon (IFN)-γ in serum level and tumor mass were higher in mice implanted with MB-IL-9 tumor clones than those observed in mice implanted with control cells. These results indicate that the ectopic expression of the MB-IL-9 on tumor cells exerts an immune-stimulatory effect with toxicity. To exploit its benefits as a tumor vaccine, a strategy to control the toxicity of MB-IL-9 tumor clones should be developed.
Effect of 3 - aminobenzamide on DNA Replication in CHO Cells Exposed to MMS
김영상,박상대 한국유전학회 1983 Genes & Genomics Vol.5 No.3
Effects of 3-aminobenzamide (3AB) on DNA replication was investigated in CHO cells treated with MMS by alkaline sucrose gradient sedimentation analysis. The inhibitor produced a dose-dependent decrease in the rate of DNA replication. The inhibitor did not seem to affect the specific step of DNA replication, but decreased the number of active replicon, which can accomplish DNA replication. Since 3-AB increased MMS-induced DNA strand breaks and significantly retarded the rejoining of strand breaks, we examined the possibility that single strand breaks enhanced by 3-AB may influence the pattern of DNA replication in the presence of MMS.
연악지반의 측방유동 평가를 위한 확률신경망 이론의 적용
김영상,주노아,이종재,이숙주 대한토목학회 2008 대한토목학회논문집 C Vol.28 No.1
Recently, there have been many construction projects on soft ground with growth of industry and economy. Therefore foundation piles of abutments and(or) buildings had been suffering from a lot of stability problems of inordinary displacement due to lateral flow of soft ground. Although many researches about lateral flow have been carried out, it is still difficult to assess the mechanism of lateral flow in soft ground quantitatively. And reasonable design method for judgement of lateral flow occurrence in soft ground is not established yet. In this study, six PNN (Probabilistic Neural Network) models were developed according to input variables and database compiled from Korea and Japan for the judgment of lateral flow occurrence. PNN models were compared with present empirical methods. It was found that the developed PNN models can give more precise and reliable judgment of lateral flow occurrence than empirical methods.