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애완동물로부터 감염된 환자 및 애완동물에서 분리된 T. mentagrophytes 의 internal transcribed spacer 1 ( ITS1 ) 염기서열 분석
김정애(Jeong Aee Kim),임종현(Jong Hyun Rim),문상은(Sang Eun Moon),김규한(Kyu Han Kim),조광현(Kwang Hyun Cho) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.10
N/A Background: Trichophyton mentagrophytes is a complex species and 3 perfect states, Arthroderma benhamiae, A. vanbreuseghemii, and A. simii have been described. In Korea and Japan, all of the isolates of T. mentagrophytes of which the perfect states determined were known as A. vanbreuseghemii till recently. However, in Japan, one isolate from a monkey was reported as A. simii and several strains from rabbits or patients were A. benhamiae. Therefore, it is necessary to confirm the existence of A. simii or A. benhamiae in Korea. Objectives: We performed this study to determine the teleomorphs of 19 strains of T. mentagrophytes isolated from Korean patients infected from pets and 4 from the skin lesions of rabbits. Metbods: DNA sequences of internal transcribed spacer 1 (ITS1) area of the 23 isolates and 3 reference strains were determined and matched with the data registered in GenBank nucleotide sequence database. Results: The sequencing data of 22 isolates were very similar to those of A. vanbreuseghemii and 1 to T, mentagrophytes var. interdigitale respectively. Conclusion '. Although all of the clinical isolates were related with A. vanbreuseghemii in this study, the possibility of the existence of A. simii and A. benhamiae in Korea is still high and further study is needed. (Korean J Dermatol 2001;39(8): 1086-1093)
Trichophyton verrucosum에 의한 두부독창 2예
윤춘식,문승현,김정애,김규한,조광현,강성하 대한의진균학회 2000 대한의진균학회지 Vol.5 No.2
In Korea, kerion celsi caused by Trichophyton(T.) verrucosum was first reported in the Honam area in 1986. Since then, more cases have been reported in the Youngnam and Chungcheong areas but there has been no report in Seoul and Kyonggido until now. Recently, two patients with kerion celsi visited Seoul National University Hospital and T. verrucosum was isolated from the scalp lesions of these patients. Case 1 was a 52 year-old female living in Kapyoung, Kyonggido and she showed l0×10 cm and 5×3 cm sized, indurated alopecic masses on the scalp which were developed 2 months ago. Case 2 was a 50 year-old female living in Youngju, Kyongsangbukdo and a 10×7 cm sized, purulent alopecic plaque was developed on the scalp 1 month ago. They were farmers raising cows with gray or whitish plaques on their skins. These patients were successfully treated with terbinafine 250 mg per day for 7 weeks and 8 weeks, respectively. We report these cases to call more attention to detect this species even in urban areas such as in Seoul. Therapeutic effect of terbinafine on kerion celsi has not been reported in Korea so far and our cases demonstrated the excellent therapeutic effect of terbinafine on kerion celsi cause by T. verrucosum. [Kor J Med Mycol 5(2): 60-65]