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Multidimensional Frictional Coupling Effect in the Photoisomerization of trans-Stilbene
곽기정,이상엽,신국조,Gwak, Gi Jeong,Lee, Sang Yeop,Sin, Guk Jo Korean Chemical Society 1995 Bulletin of the Korean Chemical Society Vol.16 No.5
A model based on two coupled generalized Langevin equations is proposed to investigate the trans-stilbene photoisomerization dynamics. In this model, a system which has two independent coordinates is considered and these two system coordinates are coupled to the same harmonic bath. The direct coupling between the system coordinates is assumed negligible and these two coordinates influence each other through the frictional coupling mediated by solvent molecules. From the Hamiltonian which is equivalent to the coupled generalized Langevin equations, we obtain the transition state theory rate constants of the stilbene photoisomerization. The rates obtained from this model are compared to experimental results in n-alkane solvents.
강윤영,송지현,정희선,곽기정,유경희,안중훈,김선화,목혜정 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.60 No.-
To examine proper multivalency and type of aptamers in linear nucleic acid-based structures for efficient intracellular uptakes, we designed linear DNA structures with single and dual aptamers targeting guanosine-rich oligonucleotide 100 (AS1411) and mucin 1 (MUC-1). Multivalent linear DNA structures containing dual types of aptamers showed significantly superior cellular internalization. In addition, multivalent aptamer-immobilized DNA–RNA hybrid structures showed excellent tumor accumulation in vivo without liver toxicity and very low nonspecific cytokine induction. Thus, these multivalent nucleic acid based structures with dual types of aptamers can be specifically applied as carriers of therapeutic nucleic acids without inducing noticeable systemic toxicity.