Monitoring hyaluronidase activity using reducible hyaluronic acid nanogels

강윤영,목혜정 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1

Introduction. Indocyanine green (ICG), a near-infrared (NIR) fluorescent dye, has been clinically used as a superior and biocompatible probe for biopsy of sentinel lymph nodes. However, despite its great potential as a diagnostic probe, its application is still limited because of several innate limitations like poor physicochemical stability and low detection sensitivity. In this study, we present shell-crosslinked HA nanogels (sc-nanogels) generated via a reducible covalent linkage which incorporate ICG derivative for selective imaging of HAdases with appreciable signal-to-noise (S/N) ratios in serum and in vivo. Method. sc-nanogels with ICG were fabricated via both non-covalent interactions and cleavable chemical bonds for significantly increased specificity of probes as well as an enhanced physicochemical stability in serum conditions. Result. An ICG fluorescence signal of sc-nanogels was specifically switched on only in the presence of a hyaluronidase, an enzyme for the cleavage of HA. In addition, sc-nanogels exhibited long-term stability in aqueous solution at room temperature, compared to common ICG. Conclusion. Sc-nanogels might be facilitated for long-lasting and selective imaging and tracking for lymph nodes, cancer cells, and therapeutic cells in vivo.

온실가스 저감의무 부담과 경제에 미치는 영향

강윤영,Gang, Yun-Yeong 대한석유협회 2002 석유와 에너지 Vol.2002 No.3

Factors Influencing Management of Cognitive Impairment among Older Adults in Acute Care Settings: A Review of the Literature

강윤영 한국노인간호학회 2013 노인간호학회지 Vol.15 No.3

Purpose: This study was done to better understand factors affecting care management of older adults with cognitive impairments (CI) in acute care settings and to provide a discussion of the literature focusing on educational issues for nurses caring for older adults with CI in acute care settings. Method: Analysis was done of 26 articles related to management of acute or chronic confusion in older adults in acute care settings, which were published between 2000 and 2012. Results: The theoretical literature outlines nurse-related and organizational-related factors that influence management of dementia or delirium in older adults in acute care settings. These themes offer grounding for further research and the development of education that address the needs of older adults with CI undergoing management for co-morbidity in acute care settings. Conclusion: In the current studies, the emphasis was on the need for education, which has the potential to lead to a significantly positive improvement in RNs’ knowledge and attitudes, and the appropriate management and empowerment of family members to participate through the early detection of dementia or delirium in hospitalized older adults with CI. Consequently, facilitating care improvement for older adults with CI, particularly those with dementia, needs to be given attention in Korean acute care settings.

제2차 에너지기본계획

강윤영 한국자원공학회 2014 한국자원공학회지 Vol.51 No.2

This paper summarizes the main contents of the 2nd National Master Plan for Energy which was discussed and passed in the Cabinet Council on 14 January 2014. This plan presents the basic visions and directions of energy policies for decades to come through 2035. It proposes also principal objectives and tasks of six main policies. The six main policies are as follows: transition to energy policies focusing on demand management; establishment of the system for distributed power generation; enhancement of the sustainability of energy policies; reinforcement of energy security; stable framework for secure energy supplies; energy policies in tune with the people. This plan includes an energy demand forecast over the period to 2035, and sets a goal to reduce the final energy demand in 2035 by 13.3% compared to the reference case. In this plan, the share of nuclear power in 2035 is set at 29% in terms of power generation capacity, and that of renewable energy at 11% in terms of primary energy. 우리나라는 2014년 1월 14일 국무회의에서 제2차 에너지기본계획을 심의하고 확정하였다. 이에 본 고에서는 제2차 에너지기본계획의 주요 내용을 요약 및 정리하였다. 이 계획은 2035년까지의 에너지정책에 대한 비전과 기본방향을 제시하고, 6대 중점과제의 목표와 주요과제를 도출하였다. 6대 중점과제는 수요관리 중심의 에너지 정책전환, 분산형 발전시스템 구축, 에너지 정책의 지속가능성 제고, 에너지 안보 강화, 원별 안정적 공급체계 구축, 국민과 함께 하는 에너지 정책추진이다. 또한 2035년까지의 에너지 수요를 전망하였고, 2035년의 최종에너지의 목표수요를 기준수요 대비 13.3% 만큼 감축하는 것으로 설정하였다. 2035년의 원자력 비중목표를 전력발전설비 기준 29%로, 신재생에너지 보급 목표를 1차 에너지 기준 11%로 설정하였다.

Evaluation of Nursing Documentation of Delirium Care

강윤영 국제문화기술진흥원 2019 International Journal of Advanced Culture Technolo Vol.7 No.1

The purpose of the study was to determine whether a delirium educational program has a positive outcomeon nurses’ documentation in patient records of delirium care. A one group pre-post design was used. Aconvenient sample of 60 consecutive records that included documentation by participating nurses in fourmedical wards of one regional general hospital in South Korea was audited two months before and two monthsafter a delirium educational program. Although an educational program in this study positively changednurses’ knowledge and attitudes, these positive effects did not translate to improvement in the documentationsof delirium care. There was no significant increase in the frequency of nursing documentation of deliriumassessment following participation in the educational program. Furthermore, there was no significant increasein the frequency of nursing documentation of the use of non-pharmacological management following thedocumentation of keywords associated with delirium after participation in the educational program. Thefindings indicate the need to develop, implement and record a systematic risk assessment for delirium andassessment and management of existing delirium based on evidence-based guidelines in clinical practice inSouth Korea.

Nurse Educators’ Experience of Developing and Implementing a High-fidelity Simulation-based Interprofessional Education Module for Medical and Nursing Students

강윤영,김소명 국제문화기술진흥원 2023 International Journal of Advanced Culture Technolo Vol.11 No.4

Objective: Despite the recommendation of the use of high-fidelity simulation (HFS) in interprofessional education (IPE), there is little known about its work for nursing students. Thus, this study aimed to explore nurse educators’ perceptions and experiences in developing and implementing the HFS-based IPE for nursing and medical students. Methods: This study used a case study, using reflective filed notes. Results: Nursing educators perceived HFS as an effective educational approach to engaging nursing and medical students actively in interprofessional collaborative practice (ICP) experiences and in evaluating their actual performance on it. In terms of their perspectives on the elements necessary for effective HFS-based IPE, four themes were identified: collaborative learning, co-facilitating debriefing, leadership commitment and active faculty involvement.

Development of a Delirium Educational Program

강윤영 국제문화기술진흥원 2019 International Journal of Advanced Culture Technolo Vol.7 No.3

This paper outlines an intervention protocol used to educate nurses in a project that implemented and evaluated a delirium educational program in one general hospital. It outlines an evaluation of the content of the education and processes used to deliver the intervention through an analysis of reflective notes. The educational protocol was designed for adult learners and grounded in the six assumptions of Knowles’ learning theory. Results suggest the educational program positively impacted on participating nurses’ knowledge, attitudes and family caregiver involvement in delirium care of hospitalized older adults with and without dementia. This paper also acknowledges the challenges involved in sustaining a practice change through an educational intervention.

교토의정서 이후의 개도국 감축의무 분담방식 분석

강윤영 한국환경정책학회 2005 한국환경정책학회 학술대회논문집 Vol.2005 No.2

우리나라의 기후변화협약 대응정책 및 에너지절약시책

강윤영 한국자원공학회 2003 한국자원공학회지 Vol.40 No.4

1994년 3월 21일에 발효된 기후변화협약은 지구온난화에 따른 이상 기후현상을 예방하기 위한 목적으로 만들어졌다. 1997년 구체적인 실천방안이 교토의정서가 채택되어 선진국들이 먼저 의무부담을 지도록 하였으나 미국의 불참 및 당사국들의 이해관계 대립으로 비준 가능성은 아직 낮은 수준이다. 우리나라는 2002년 11월 국회에서 이를 비준하였으며, 감축의무부담에 대하여 제3차 공약기간부터 의무부담 검토를 천명한 바 있으나 우리나라를 둘러싼 여론은 제2차 의무이행기간으로 앞당기도록 요구하고 있다. 이렇게 될 경우 우리나라 경제에 미칠 악영향이 크게 확대될 것은 분명하기에 이에 대한 적극적인 대응 전략의 수립이 필요하다. 본 고에서는 따라서 기후변화협약 및 관련 에너지절약정책에 대하여 현재의 정부 정책을 검토하고 앞으로 준비하여야 할 방향에 대하여 분석하여보았다. 이를 통하여 기후변화대책 및 에너지절약정책을 총괄하는 종합기능을 가진 상시 행정 및 연구조직과 정책의 효과를 평가하기 위한 상시 평가조직의 설치를 제안한다.

온실가스 감축 이슈와 정책과제

강윤영 한국환경정책학회 2017 한국환경정책학회 학술대회논문집 Vol.2017 No.4