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Vibrio vulnificus의 혈청형 : Vibrio vulnificus균의 신속한 동정 방법으로서의 이용과 예후적 가치
고명옥(Myoung Ok Koh),박석돈(Seok Don Park) 대한피부과학회 1992 大韓皮膚科學會誌 Vol.30 No.6
Vibrio vulnificus is a halophilic gram-negative, marine bacterium which causes fulminating and potentially fatal human disease. A new sensitive and specific serogrouping procedure was developed for identifying V. vulnificus. Reference antis:ra(01-014) to V. vulnificus were prepared by vaccinated rabbits with heat-killed bacteria, and the antisera were examined whether erogrouping test will be available for rapid and sensitive identification method of V. vulnifiius or not. All of thirty-seven clinical strains tested were agglutinated with 5 kinds of aritisera such as 04A, 01, 013, 03, and 014. Of these serovar 04A was predominant(75.7%). The author investigated the correlation among certain serovars, consumed seafoods, and nortality rate to verify whether the serovar is of pognostic value. There was no significant orrelation among them. These results suggest theart serogrouping procedure could be of value in rapidly identifying V. vulnificus. (Kor J Derrnatol 1992;30(6):787-793)
고명옥(Myoung Ok Koh),전봉길(Bong Kil Jeon),박석돈(Seok Don Park),이재승(Jae Sung Lee) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.1
Ewing's sarcoma is a highly malignant, small, round cell tumor that usually affects long bones. The acral part of the extremities is a very rare primary site for this neo plasm. A fifteen-year-old girl was seen for a lobulated, dome-shaped, 2.7cm diameter, denuded mass on the distal phalanx of the right middle finger which had increased in size over a 14-month period. The radiological featuies of the hand showed a cortical brick of distal phalanx and surrounding soft tissue mass. Histologically, the biopsy specimen showed sheets of small round to oval cells with scanty cytoplasm, that were closely packed and separated into lobules by trands of fibrous tissue. A periodic acid-Schiff stain demonsirated glycogen in the cytoplasm of the tumor cells. Electron microscopy showed large aggregates of glycogen in the cytoplasm of the neoaplastic cells. Immunohistochemical stains revealed positive staining for vimentin, glial fibrillary acid potein, and neuron specific enolase, stains for S-100, Factor VIII, and cytokeratin were negative. (Kor J Dermatol 1993; 31(1): 143-148)
고명옥(Myoung Ok Koh),전봉길(Bong Kil Jeon),박석돈(Seok Don Park) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.2
Focal dermal hypoplasia (Goltz syndrome) is a rare genetic mesoectodermal disorder characterized by variable multisystem defects, including anomalies of the skin, skeleton, teeth and eyes. A 22-year-old female patient presented with confluent and disciete, yellowish nodules on the calves, white linear atrophic lesions, hypoand hyper!igmented patches, and telangiectasia scattered over the trunk, neck and extremities. In addition to the skin lesions, this patient showed hypertrophy of the left leg, anomalies of the left foot, fingers and nails, and maloccluded teeth. Histopathological findings of a yellow nodule revealed accumulations of adipose tissue very near to the epidermis that largely replaced the upper dermis. (Kor J Dermatol 1992;30(2): 262-266)
Paraquat ( GramaxoneR ) 에 의한 원발성 접촉 피부염 3예
전봉길(Bong Kil Jeon),고명옥(Myoung Ok Koh),박석돈(Seok Don Park) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.6
Paraquat(Gramoxone) is the most commonly used herbicide in Korea. But serious paraquat poisoning in human beings has occurred following ingestion or exposure to the skin. Exposure to paraquat through the skin has resulted in local irritation or inflammation of varyiig degree, sometimes severe. We report three cases of primary irritant dermatitis due to paraquat. Two patients developed generalized vesicobullae and necrotirulcer in the scrotum, respectively. The other patient developed painful whitish patch and erosion in ttie tongue after accidental exposure. (Kor J Dermatol 1993;31(6):953-956)
개구리자리 (石龍芮) 에 의한 원발성 접촉 피부염 3예
전봉길(Bong Kil Jeon),고명옥(Myoung Ok Koh),박석돈(Seok Don Park) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.6
The buttercup is an inportant irritant plant which contairs an unsaturated lactone, protoanemonin, formed by the breakdown of a glucoside in injured plants. We report the three cases of irritant contact dermatitis due to buttercup(Ranunculus sceleratus). These patient developed erythematous and edematous patches with tense vesicles or bullae on t,he application site of pounded buttercup for the treatment of diabetes mellitus, arthralgia, and neuralgia, respectively. (Kor J Dermatol .992;30(S):886-891)
Aeromonas hydrophila에 의해 생산되는 세포외 효소와 백서 복강내 비만세포의 histamine 유리
박석돈,고정운,전병득,오선희,송창호,고명옥 ( Seok Don Park,Jung Woon Ko,Byung Deuk Jeon,Seon Hee Oh,Chang Ho Song,Myoung Ok Koh ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.6
N/A Aeromonas hydrophila is a facultatively anaerobic, gram-negative rod which has been often regarded as an opportunistic pathogen in hosts with compromised defense mechanisms. A. hydrophila can produce septicemia with skin lesions such as necrosis, edema, and blisters. Therefore, it is necessary to investigate what kinds of exocellular ?oxic or pathogenic factors are produced by A. hydrophila for elucidation of pathogenesis and effective treatment. This study was designed to determine the extracellular enzymes produced by two strains of A. hydrophila which were isolated from the blood and wound of patients with septicemia and osteomyelitis, respectively. Histamine release from rat peritoneal mast cells evoked by A. hydrophila culture supernatant was assayed. The morphologica changes of rat peritoneal mast cells treated with A. hydrophila culture supernatant were observed by electron microscopy. A. hydrophila produced elastease, protease DNase, hemolysin(alpha and beta), lipase, lecithinase, and gelatinase but it did not produce coagulase, hyaluron dase, chondroitin sulfatase or mucinase. The culture supernatant fluid of A. hydrophila induced aistamine release from rat peritoneal mast cells. Transmission electron microscopic studies of mast cells treated with the culture supernatant revealed microvesicles of various size in the cytoplasm and around the cell membrane. These findings suggest that A. hydrophila culture supernatant induces histamine release from rat peritoneal mast cells by a process that may involve a resicular transport mechanism, namely, piecemeal secretion.