Trimethyltin 유도성 인지기능 저하 동물 모델에 대한 들기름의 개선효과

강진용(Jin Yong Kang),박보경(Bo Kyeong Park),승태완(Tae Wan Seung),박창현(Chang Hyeon Park),박선경(Seon Kyeong Park),진동은(Dong Eun Jin),강성원(Sung Won Kang),최성길(Sung-Gil Choi),허호진(Ho Jin Heo) 한국식품과학회 2015 한국식품과학회지 Vol.47 No.3

본 연구에서는 들기름의 TMT 유도성 인지 기능 상실에 대한 개선 효과와 함께 가정에서 식용유로서 사용량이 많은 대두유와 그 효과를 비교·연구하였다. 실험에서 들기름과 대두유를 섭취한 마우스를 TMT로 인지 기능 손상을 유발하여 Y-maze test와 Morris water maze test 한 결과, 공간 인지 기능 및 학습능력 개선에 대해 대두유는 효과가 미비하였으나 들기름은 대조군과 유의적인 차이가 없는 정도의 유의적 개선 효과를 보였다. 동물 실험 후 mouse로부터 적출된 뇌 조직을 대상으로 AChE 활성, MDA 함량, SOD 활성 측정 및 산화된 glutathione 측정한 결과, 대두유는 TMT 단독 처리군의 경우와 유사한 반면 들기름은 TMT에 의해 손상을 입은 mice의 뇌 조직에서 AChE의 활성과 MDA 생성 및 GSH의 산화를 억제시킬 뿐만 아니라 SOD 활성을 유의성 있게 증가시킨 것으로 나타났다. 이러한 결과는 들기름에 존재하는 풍부한 생리 활성 물질로서 ω-3계 지방산, 페놀화합물 그리고 비타민 E 등에 의한 것으로 사료된다. 결국 들기름은 상대적으로 우수한 인지 기능 개선 효과를 나타냈고, 이는 건강기능식품으로서 고부가가치 소재로 활용될 수 있는 산업적 활용 가능성을 나타내는 것으로 판단된다. This study aimed to investigate the anti-amnesic effect of perilla oil against trimethyltin (TMT)-induced learning and memory impairment in ICR mice. Perilla oil (2.5 mL/㎏ of body weight) and soybean oil (2.5 mL/㎏ of body weight) were administered orally to mice for 3 weeks, and at the end of the experimental period, cognitive behavior was examined by Y-maze and Morris water maze (MWM) tests. Behavioral tests showed that the mice treated with perilla oil had improved cognitive function compared to that in mice administered soybean oil. Analysis of brain tissue showed that perilla oil significantly lowered acetylcholinesterase activity and malondialdehyde (MDA) levels. Oxidized glutathione (GSH)-to-total GSH ratio also decreased from 10.4% to 5.3% in perilla oil-treated mice, but superoxide dismutase (SOD) activity increased from 11.7 to 14.2 U/㎎ protein. Therefore, these results suggest that the perilla oil could be a potential functional substance for improving cognitive function.

피지선 모반에서 발생한 편평상피세포암

강진문(Jin Moon Kang),김홍석(Hong Sik Kim),정섬(Seum Chung),이민걸(Min Geol Lee) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.9

N/A

임산부에 발생한 전신탈모증

강진문 ( Jin Moon Kang ),이호정 ( Ho Jung Lee ),이종서 ( Jong Seo Lee ),정기양 ( Kee Yang Chung ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.4

안면부에 재발되는 환상 홍반을 보인 Sjogren 증후군

강진문 ( Jin Moon Kang ),윤경한 ( Kyeong Han Yoon ),한승경 ( Seung Kyung Hann ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.5

Sjogren's syndrome has been considered to be an autoimmune disease affecting various organs including salivary and lacrimal glands. It occurs most commonly in middle-aged women, and less than 20 cases with primary Sjogren's syndrome have been reported in children. An 11-yim-old boy presented with recurrent annular erythema on the face that had been present for 2 years. A schirmers test showed a positive result. ANA was detected at a dilution of 1:640. Anti-Ro/SSA and anti-La/SSB antibodies were also detected. On histological examination, lymphocytes were infiltrated in the periappendegeal areas as well as the papillary and reticular dernis. The skin findimg is uncommon in children, but has become a characteristic feature of childhood Sjogrens syndrome with anti-Ro and/or anti-La antibodies. (Korean J Dermatol 1998;36(S): 910-913)

석회화 건막 섬유종

강진수(Jin Soo Kang),김태흥(Tea Heung Kim),박기범(Ki Beom Park) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.2

Calcifying aponeurotic fibroma is a rare benign tumor found primarily on the hands or wrists of children and adolescents. It has a tendency of local invasion, and a high recurrence rate after excision. An 11-year-old boy had a hard indurated. 3 x 3cm-sized, nodule on the right sole for 3 years. A biopsy specimen showed heavy focal calcification within areas of densely paked stromal fibroblastic cells. Some fields contained multinucleatec giant cells and chondroid metaplasia. There were infiltrative growth patterns of fibroblastic cells extending into the adjacent adipose tisse and blood vessels. There was no evidence of reccurence at 3 months after the operat on. (Kor J Dermatol 1992;30(2): 253-257)

재피닝 가공한 SM45C강의 피로특성

강진식(Jin-Shik Kang),서유원(Yu-Won Seo),김태형(Tae-Hyung Kim),정성균(Seong-Kyun Cheong),신용승(Yong-Seung Shin) 대한기계학회 2002 대한기계학회 춘추학술대회 Vol.2002 No.5

The fatigue characteristics of re-peened SM45C steel are investigated in this paper. Re-peening<br/> process is applied to the specimen after the shot peened specimen undergoes the fatigue damage.<br/> Surface hardness, surface roughness, surface compressive residual stress, and fatigue life are also<br/> examined. The experimental results shows that the compressive residual stress of shot-peened specimen<br/> decreases under the fatigue loading and then increases again by re-peening process. Re-peening process<br/> increases the fatigue life of shot-peened and fatigue damaged specimen. The increase of fatigue life<br/> under high stress level is much higher than that under low stress level.

가속수명시험법을 이용한 쇼트피닝가공 금속의 피로수명예측

강진석(Jin-Shik Kang),남지헌(Ji-Hun Nam),이재헌(Jae-Heon Lee),정성균(Seong-Kyun Cheong) 대한기계학회 2004 대한기계학회 춘추학술대회 Vol.2004 No.11

Shot peening process is used as one of the various kinds of techniques to improve the fatigue properties. However, to obtain fatigue properties of metal materials, many efforts and time are needed. Because the fatigue life of shot peened metals increases highly. In this paper, fatigue properties of shot peened Al 7075-T6 are estimated using the fundamental of accelerated life test to reduce the experimental. Experimental results show that the estimated life data almost agree with actual rotary bending fatigue test data within 7% error.

담관내압측정검사 ( Biliary Manometry ) 로 진단된 Biliary Dyskinesia 2예

강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),박인서(In Suh Park),정재복(Jae Bock Chung),이상인(Sang In Lee),김원호(Won Ho Kim),송시영(Si Young Song) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.2

Biliary dyskinesia is a rare disease and is defined as a primary disorder of sphincter of Oddi (SO) tonic/phasic motor activity without evidence of a structural narrowing of part or all of the SO segment. It is suspected when a patient, usually a woman, presents with biliary-type pain in the absence of a structural cause for such pain. Some authors classified SO motor disturbances into two broad categories. papillary stenosis: defined as a structural narrowing of the SO segment, and biliary dyskinesia. But because of the difficulty in clearly separating these two clinical entities, this syndrome is sometimes referred to such as SO dysfunction. Even though various tools to diagnose biliary dyskinesia have been developed, such as simple ultrasonography and ultrasonography after a fatty meal or cholecystokin administration, cineradio-graphy, ERCP, nuclear scintigraphy and biliary manometry, ERCP and biliary manometry are still considered as the gold standards. In Western countries, the number of reports of biliary dyskinesia confirmed by manometry have tended to increase recently, but it was known to be absent up to now in Korea. We report two cases of biliary dyskinesia confirmed by manometry who had suffered from recurrent biliary colic and showing normal findings on ERCP and ultrasonography without evidence of structural lesions. On biliary manometry, the basal and peak pressures of SO phasic contractions were markedly elevated and the frequencies of the phasic wave also increased (tachyoddia). After endoscopic sphincterotomy was performed for the purpose of treatment, a remarkable decrease in basal and peak pressure of SO phasic contraction was noted and the subjective symptoms were disappeared campletely.

독립 인증 서버를 이용한 Eddystone-EID 검증 시스템 구현

강진수 ( Jin Su Kang ),서정훈 ( Jeong Hun Seo ),송호종 ( Ho Jong Song ),원유재 ( Yoo Jae Won ) 한국정보처리학회 2017 한국정보처리학회 학술대회논문집 Vol.24 No.2

최근 비콘을 이용하여 근거리에 있는 사용자를 찾아 다양한 혜택을 지원해주는 서비스가 제공되고 있다. 2016년에 Google은 보안성 강화를 위해 비콘의 고유 ID를 사용하는 것이 아닌, 주기적으로 변경되는 임시 ID를 사용하여 이를 암호화하고 Broadcasting 하는 Eddystone-EID(Ephemeral Identity)를 공개하였다. EID를 사용하기 위해서는 Google에 비콘의 정보를 등록하는 과정과 EID를 수신 후 Google을 통해 검증하는 과정이 필요하다. 이러한 이유로 외부 업체들도 EID를 사용하기 위해서는 Google에 비콘을 등록해야 하는 문제점이 발생한다. 이러한 문제점을 해결하기 위해 본 논문에서는 Eddystone-EID를 Google을 이용하지 않고 자체적으로 검증하는 방법을 제시한다.

IP 네트워크 기반 고품질 오디오 협업 시스템

강진아(Jin Ah Kang),김홍국(Hong Kook Kim) 한국HCI학회 2008 한국HCI학회 학술대회 Vol.2008 No.2

본 논문에서는 IP 네트워크에서 동작하는 오디오 협업 시스템의 성능을 향상시키는 방법들을 구현하고 구현된 방법들의 성능을 검증한다. IP 네트워크가 갖는 지연(jitter) 및 패킷 손실 등의 특성은 음성 및 오디오의 품질을 저하시킨다. 이러한 품질 저하를 줄이기 위해, 패킷 손실률은 패킷 크기를 줄임으로써 감소시킬 수 있다는 점에 착안하여 MPEG-2 AAC 오디오 코덱을 이용한 저전송률 오디오 전송 방법을 제안한다. 또한, 음성 전송 시 패킷손실에 따른 음성 품질을 향상시키기 위해 패킷 손실에 견고한 iLBC (Internet Low-Bitrate Codec) 음성 코덱 및 ITU-T G.711 패킷 손실 은닉 알고리즘을 오디오 협업 시스템에 적용한다. 제안한 방법들을 RAT (Robust-Audio Tool)[7]를 기반으로 구성된 오디오 협업 시스템에 구현하였다. 구현한 결과, 256 kbit/s에서 동작하는 MPEG-2 AAC 오디오 코덱은 압축하지 않고 전송된 오디오와 유사한 품질을 제공하는 것을, iLBC와 G.711 패킷 손실 은닉 알고리즘은 2~10% 패킷 손실 환경에서 음질을 개선하는 것을 확인할 수 있었다. In this paper, we implement several methods to improve an audio collaboration system over IP networks, and then evaluate the performance of the implemented methods. In general, speech and audio quality degrades depending on the characteristics of IP networks such as jitter and packet loss. In order to reduce this quality degradation, we propose a lower bit rate audio delivery scheme using the MPEG-2 AAC (Advanced Audio Coding) audio codec in a viewpoint that a packet loss rate could be reduced by a smaller packet size. In addition, iLBC (Internet Low-Bitrate Codec) and the G.711 packet loss concealment algorithm defined by IEFT and ITU-T, respectively, are applied to a audio collaboration system. RAT (Robust-Audio Tool)[7] is used as a baseline platform for the implementation of the proposed methods. It is shown from the implementation that the implemented MPEG-2 AAC audio codec with a bitrate of 256 kbit/s performs as similar as the uncompressed audio quality with a bitrate of 512 kbit/s, and that iLBC and the G.711 packet loss concealment algorithm can improve speech quality when a packet loss rate is 2~10%.