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폐쇄성 정로장애로 인한 무정자증 환자에서 미세수술적 부고환 정자흡입술과 세포질내 정자주입술을 이용한 수정율 및 임신율 증진에 관한 연구
손일표,홍재엽,이유식,전진현,박용석,이호준,강인수,전종영,Son, I.P.,Hong, J.Y.,Lee, Y.S.,Jun, J.H.,Park, Y.S.,Lee, H.J.,Kang, I.S.,Jun, J.Y. 대한생식의학회 1994 Clinical and Experimental Reproductive Medicine Vol.21 No.3
We studied the role of assisted fertilization(subzonal insemination, intracytoplasmic sperm injection) in enhancing fertilization and pregnancy rate in obstructive azoospermia. MESA was performed in the patients with congenital absence of the vas deferens and unreconstructable obstructive azoospermia. Sperm were aspirated microsurgically from various sites along the epididymal stump. Sperm were then washed on a mini-PercoH gradient or swim-up method and treated by 2-deoxyadenosine and pentoxifylline. Conventional IVF(group I, 14 cycles), SUZI(group II, 13 cycles) and ICSI(gruop III, 28 cycles) were carried out in 55 treatment cycles. The clinical results are as follows: 1. Fertilization rates for group I, II and III were 16.1 %,31.4% and 48.6%, retrospectively (p<0.05). 2. Clinical pregnancy rates for group I, II and III were 7.1 %,7.7%, and 32.1 'Yo, retrospectively. 3. In 5 of MESA-ICSI cycles, epididymal sperm from alloplastic spermatocele were used and 2 clinical pregnancies (40%) were obtained. According to our results the combined MESA-ICSI procedure is highly effcient in improving fertilization and pregnancy rate in congenital absence of the vas deferens and unreconstructable obstructive azoospermia.
자궁내막증 또는 자궁선근증에 의한 불임환자에서 장기간 GnRH analogue ( Long - term Down DRegulation ) 사용 후 과배란 및 체외 수정 시술의 결과
양광문(K . M . Yang),유근재(K . J . Yoo),최범채(B . C . Choi),김계현(K . H. Kim),이홍복(H . B . Lee),이재훈(J . H . Lee),송인옥(I . O . Song),송지홍(J . H . Song),궁미경(M . K . Koong),전종영(J . Y . Jun),강인수(I . S . Kang) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10
목적 : 자궁내막증 또는 자궁선근증을 가진 불임 환자의 치료에 있어 GnRH analogue를 사용한 LTDR의 과배란 유도시 그 효과를 알아보았다. 방법 및 재료 : 복강경과 질식 초음파를 이용하여 자궁내막증 또는 자궁선근증을 진단 받은 불임 여성 43명의 47 LTDR cycles이 연구 대상이 되었다. GnRH analogue를 3개월 이상 장기간 사용하여 down regulation 시킨 후 gonadotropin을 이용하여 과배란 유도를 시행한 경우를 LTDR로 정의하였으며 임신을 위해 자궁강 내 정자 주입술 또는 체외 수정 및 배아 이식이 시행되었다. 결과 : 환자의 평균 연령(meanSD)은 33.83.8이었고 자궁선근증이 10cycles였으며 자궁내막증은 34cycles(1기:12cycles, 2기:9cycles, 3기 :5cycles, 4기:8cycles)이었다. 체외 수정 시 이식된 배아는 평균(meanSD) 3.70.3개였다. 자궁내막증을 가진 34cycles중 17.6%(6/34), 자궁선근증을 가진 10cycles중 40.0%(4/10)의 임신율을 보였다.결론 : 이 연구에서 LTDR은 자궁내막증과 자궁선근증에 의한 불임 환자의 치료에 효과적인 것으로 보이나 연구 대상군의 확대 조사가 필요하리라 사료된다. Objective : To assess the clinical efficacy of long term down regulation (LTDR) for in vitro fertilization (IVF) in infertile patients with endometriosis or adenomyosis.Materials and methods : Analysis were made from data collected from 45 paients who had endometriosis or adenomyosis diagnosed using pelvic laparoscopy and ultrasonography and had undergone intrauterine insemination or in vitro fertilization. LTDR was defined as long term, as long as three months down regulation of ovarian function followed by induction of ovulation using gonadotropins. Of these patients, 43 had undergone LTDR followed by IVF-ET, whereas 30patients in control group had undergone short or long protocol as an ovarian stimulation regimen.Results : The multiple independent parameters such as plasma basal estradiol (E2), plasma E2 level on day of hCG administration, number of oocytes retrived, number of good quality oocytes, number of embryo and number of transfered embryos were not significantly different between LTDR treated group and other control group. The clinical pregnancy rate in women treated with LTDR (17.6% in endometriosis, 40% in adenomysis, and 33.3% in endometriosis combined with adenomyosis) were comparable with those of control group (15.4% in endometriosis, 33.3% in adenomyosis and 40% in endometriosis combined with adenomyosis). Conclusions : In this study the LTDR as a ovarian stimulation regimen for IVF does not seems efficienct in infertile patients having endometriosis or adenomyosis than other protocols such as short or long, however further study with large number may be needed.
강인수,강태숙 濟州大學校 農科大學 動物科學硏究所 1995 動物科學論叢 Vol.10 No.1
This study was conducted to analyze the profitability of breeding cow farms in Cheju province. The total samples of 49 farms were included in this survey. 1. The sampled farms were divided into 3 groups, that is, less than 5,6-9 and 10-20 heads accord-ing to their raising sizes, and their number of households in each group were 16, 18 and 15, respectively. The average raising sizes in each group was 4.4, 7.3 and 11.2, respectively, and 8.8 in total. 2. The distributions of the rasing experience from 49 farms were 10.2, 20.4, 10.2, 14.3, and 44.9% for the groups of less than 5, 6-10, 11 - 15, 16-20, and over 21 years, respectively. 3. The utilization area of land per head were 80.2 (2,404 pyung), 101.2 (3,035 pyung) and 39.2a (1,176 pyung) for the group of less than 5 heads, 6 -9 heads and 10-20 heads, respectively. 4. The area of building (barn and attached building) per head were 12.3 (4 pyung), 8.6 (3 pyung), and 9.9㎡ (3 pyung) for the group of less than 5, 6-9, and 10-20 heads, respectively. The average area in total was 9.9㎡ (3 pyung) per head. 5. Only 42 farms possessed their own cutter while all the sampled farms possessed their own power tiller and sprayer. 6. The gross income per head were 1,038,357,985,439 and 1,026,317 won for the group of less than 5, 6-9 and 10-20 heads, respectively. The average gross income was 1.014,Oll won per head. 7. The production costs per head were 848,621, 751,312 and 769,303 won for the group of less than 5, 6-9, 10-20 head, respectively. The average production cost was 777,982 won per head. The opera-tion costs per head were 416,514, 359,753 and 380,280 won for the group of less than 5, 6-9 and 10-20 heads, respectively. The average operation was 379,813 won per head. 8. The net incomes per head were 189,000, 234,000 and 256.000 won for the group of less than 5, 6-9 and 10-20 heads respectively, and ther average were 236,000 won. The ratio of net incomes to gross income per head were 18, 23 and 25% for the group of less than 5, 6-9 and 10-20 heads, respectively, and their average as 23%.