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柳在賢 東亞大學校 大學院 1988 大學院論文集 Vol.13 No.-
The purpose of this study is to understand many aspects of the civil service reform in Britain, considering at each periods as the establishment of civil service based on the merits system, the First,Second World War and civil service, the Fulton Report and civil service, and analysing especially the recommendations of Northcote-Trevelyan Commission and Fulton Committedd. The civil service in Britain based upon the merits system was firmly established by the Order in Council of 1855, 1870, the Superannuation Act of 1859, gbeing based on the Northcote-Trevelyan Report. Entered upon thetwenty contry, the civil service reform in Britain also was continuing by the Northcote-Trevelyan principle. Through the administrative reform to meet the changes of administrative demands and the periodic requirements by the First, Second World War, government enlarged increasingly the social services and economic affairs which meant a governmental charge of the functions of welfare and regulatory. Set in the 1960s, the demands of the whole administrative reform rose strongly in Britain. And many commissions or committees to inquire in various fields were established and acted, which lec to considerable administrative reforms in the latter 1960s and the early 1970s. Notably, the civil service reform based upon the activities and the report to the civil service of Fulton Committee was implemented in the most big and basic change since the Northcote-Trevelyan Report, and made a contemporary civil service in Britain. In conclusion, some characteristics of the civil service reform in Britain can be summarized as follows: 1)The civil service reform seemed to be the establishing merits system and its unfolding process. 2)The discussion of civil service reform was involved as follows; ⓐthe recruitment of civil service relating closely to the educational system, ⓑthe British idea on the responsibility of a Cabinet minister in civil service, and ⓒthe importance of planning in the contemporary State. 3)The civil service reform in Britain is an incremental reform; it is not a reform, but an amendment within the category of the basic value in the past or a series of a set of value. 4)The British always southt the economic rationalism of civil service based upon the their own philosophy of empiricism and pragmatism. 5)Many activities and recommendations of commission or committee to inquire gave much influnce to the policy-making of civil service refrom; commission or committee had an analytic and catalytic role for government to begin the actitities of reform through the recommendation of report.
한국인 조현병 환자에서 ST8SIA2 유전자 다형성의 연합 연구
유재현,류승형,조은영,허익수,박태성,이유상,권준수,홍경수,Yoo, Jae-Hyun,Ryu, Seung-Hyong,Cho, Eun-Young,Huh, Ik-Soo,Park, Tae-Sung,Lee, Yu-Sang,Kwon, Jun-Soo,Hong, Kyung-Sue 대한생물정신의학회 2012 생물정신의학 Vol.19 No.3
Objectives : ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sialyltransferase 2 gene) is located at 15q26, a susceptibility locus for schizophrenia. Some previous research had indicated that single-nucleotide polymorphisms (SNPs) in the promoter region of ST8SIA2 were associated with schizophrenia in Japanese and Chinese populations. We investigated the association between SNPs in the promoter region of ST8SIA2 and schizophrenia in the Korean population. Methods : The study subjects were 190 Korean patients with schizophrenia and 190 healthy controls. We performed allelic, genotypic, and haplotypic association analyses for rs3759916, rs3759915 and rs3759914 of ST8SIA2. All genotypes were determined by direct sequencing. Results : In the genotype-based analysis, rs3759914 showed a nominally significant association with schizophrenia under recessive genotypic model (p = 0.047). However, this association did not remain statistically significant after correction for multiple testing. Both allelic and haplotype analyses did not show any significant association. Conclusions : These findings suggest that ST8SIA2 does not play a major role in the susceptibility to schizophrenia in the Korean population. Further studies with a larger number of subjects are required to definitively rule out minor effects of this gene on schizophrenia vulnerability.