Quality Characteristics of Soy Sauce for Marinated Abalone Using Sea Tangle Extract and Coriander

Yu Ri Choe,Yu Jin Son,Na Kyeong,So Ra Jin,Gyeon Jin Juong,Seo Lim Hwang,Man-Kwon Baek,Khawaja Muhammad Imran Bashir,Jae-Suk Choi,Jae Hak Sohn 한국수산해양기술학회(구 한국어업기술학회) 2017 한국수산해양기술학회 학술발표대회 Vol.2017 No.11

Elevated Prx1 Provides Resistance to Docetaxel, But Is Not Associated with Predictive Significance in Lung Cancer

Hwang, Ki Eun,Park, Chul,Seol, Chang Hwan,Hwang, Yu Ri,Hwang, June Seong,Jung, Jae Wan,Choi, Keum Ha,Jeong, Eun Taik,Kim, Hak Ryul The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.75 No.2

Background: This study was conducted in order to elucidate the effects of docetaxel on the growth of peroxiredoxin 1 (Prx1) knockdown A549 xenograft tumors and further tested the role of Prx1 as a predictor for how a patient would respond to docetaxel treatment. Methods: Effects of docetaxel on the growth of scrambled- and shPrx1-infected A549 xenograft tumors in nude mice were measured. Moreover, immunohistochemical expression of Prx1 was evaluated in paraffin-embedded tissues from 24 non-small cell lung cancer patients who had received docetaxel-cisplatin regimens as a first-line treatment. Results: Docetaxel treatment in Prx1 knockdown xenograft tumor resulted in reduced tumors growth compared with other groups. Prx1 knockdown increased the production of cleaved caspases-8 and -9 in the control itself compared to scramble tumors. Moreover, docetaxel treatment in Prx1 knockdown tissue led to an increased protein band. Phosphorylated Akt was found in Prx1 scramble tissues. Phosphorylated FOXO1 was detected in the docetaxel treatment group. On the other hand, Prx1 knockdown completely suppressed the Akt-FOXO1 axis. The median progression-free survival (PFS) of patients with low Prx1 expression was 7 months (95% confidence interval [CI], 6.0-7.7), whereas the median progression-free survival of patients with high Prx1 expression was 4 months (95% CI, 4.0-5.0). However, high Prx1 expression was not associated with decreased PFS (p=0.114). Conclusion: Our findings suggest that elevated Prx1 provides resistance to docetaxel treatment through suppression of FOXO1-induced apoptosis in A549 xenograft tumors, but may not be related with the predictive significance for response to docetaxel treatment.

S-278 : A case of solitary bronchial papilloma mimicking lung cancer

( Yu Ri Hwang ),( Chul Park ),( Chang Hwan Seol ),( Ki Eun Hwang ),( Hak Ryul Kim ),( Eun Taik Jeong ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Solitary bronchial papillomas are rare benign tumors in adult derived from the bronchial epithelium. Adult bronchial papilllomas can be classified by their cell types into three groups: squamous cell papilloma, glandular papilloma, and mixed squamous cell and glandular papilloma. Among them mixed squamous cell and glandular papilloma is extremely rare. Here we report a case of solitary bronchial mixed squamous cell and glandular papilloma mimicking lung cancer. The patient was a 58-year-old smoking male patient, presenting with cough, purulent sputum and fever. A bronchoscopy on this admission revealed a grape like polypoid lesion in the inferior lobar bronchus. We performed bronchoscopic biopsy and squamous dysplasia showing mild atypia was suspected on histopathological findings. FDP-PET scan showed a moderately hypermetabolic lesion in the left lower lobe. The patient was undertaken the left lower lobectomy. Histopathological diagnosis confirmed a mixed squamous and glandular papilloma.

스마트교육을 위한 스마트기기 및 콘텐츠 효과성 연구

황유리 ( Yu Ri Hwang ),강신천 ( Shin Cheon Kang ) 한국컴퓨터교육학회 2013 한국컴퓨터교육학회 학술발표대회논문집 Vol.17 No.2

스마트교육은 정보기술(IT)의 발전에 따라 과거 획일적이고 표준화된 교육방식에서 선택적, 맞춤형 교육방식으로 전환하여 개개인의 교육수준에 맞게 성장시킬 수 있는 교육환경의 조성이 가능하며, 학생들이 인터넷을 통해 생산한 지식을 공유하고 새로운 지식을 생산하는 순환구조가 발현되어 정보기술을 활용한 창의적 학습사회로의 가속화를 이룰 수 있다. 본 연구에서는 우리나라 스마트교육을 위한 스마트 기기와 콘텐츠 효과성을 연구하기 위해 현장에서 스마트교육을 적용하고 있는 관련 학교 교사 및 학생들에게 설문 조사를 실시하여 스마트기기 사용의 장점 및 단점, 스마트기기의 활용과 선호도를 알아본다. 또한 교사와 학생들이 주로 사용하는 콘텐츠를 조사하여 콘텐츠 개발 및 개선점을 찾아 효율적인 스마트교육을 실현할 방안을 모색한다.

SSDT를 이용한 웜 탐지 시스템 설계 및 구현

황유동(Yu-dong Hwang),이유리(You-ri Lee),박동규(Dong-gue Park),임황빈(Hwang-bin Yim),오진태(Jin-tae Oh),장종수(Jong-soo Jang) 한국통신학회 2007 韓國通信學會論文誌 Vol.32 No.12D

네트워크 침해 유형이 특정 호스트나 서버를 목표로 하여 개별 시스템이나 해당 시스템이 제공하는 서비스에 대한 공격에서 광역 네트워크 서비스 제공에 대한 공격으로 변화 하고 있다. 또한 네트워크 인프라의 속도가 증가되고 서버들의 성능이 개선됨에 따라서 공격 피해의 전파 속도 또한 빨라지고 있다. 야에 따라서 웜은 그 특성상 빠른 공격이 예상된다. 따라서 본 논문에서는 웜을 통한 공격으로부터 네트워크 인프라를 보호하기 위해서 SSDT(System Service Dispatch Table)를 이용한 웜 탐지 시스템을 설계 및 구현한다. The specific host or the server is appointed as a goal and the server has the network breach type in an attack to the individual system or the service which the corresponding system provides to the attack about the wide area network service providing with a change. Moreover, as the speed of the network infrastructure is increased and the performance of the servers is improved, the speed moreover gets raged with the propagation velocity of the attack damage. Accordingly, as to the worm, the fast attack of the on characteristic real-time is predicted. Therefore, in this paper looked, it tries to design and implementation of the worm detection system for protecting the network infrastructure from the attack through the worm.

품종과 건조방법에 따른 고춧가루의 집단 특성

강유리(Yu Ri Kang),이상훈(Sang Hoon Lee),김현영(Hyun Young Kim),우관식(Koan Sik Woo),황인국(In Guk Hwang),황영(Young Hwang),유선미(Seon Mi Yoo),김행란(Haeng Ran Kim),김혜영(Hae Young Kim),이준수(Junsoo Lee),정헌상(Heon Sang Jeong) 한국식품영양과학회 2012 한국식품영양과학회지 Vol.41 No.9

건조방법에 따른 품종별 고춧가루의 물리적 특성을 알아보기 위하여 집단밀도, 압축특성, 쌓임각, 비회복성 일 및 응력이완 특성을 살펴보았다. 이완집단밀도는 0.4197~0.4274g/cm3 범위로 열풍건조 한반도품종이 큰 밀도를, 청양품종 열풍건조가 작은 밀도를 나타내었다. 충격집단밀도는 0.523~0.586 g/cm3 범위로 원적외선건조 한반도 품종이 큰 밀도를 나타내었고 한반도품종 천일건조가 0.523 g/cm3로 작았다. 하우스너 비는 1.225~1.370의 범위를 보였으며, 두 품종 모두 원적외선 건조에서 큰 값을 나타내었다. 압축성은 0.00157~0.00225 범위로 한반도품종 원적외선건조가 큰 압축성을 나타내었다. 압축비는 0.971~1.032의 범위로 열풍건조가 크게 나타났으며, 품종에 따라서는 한반도품종이 큰 값을 나타내었다. 안식각은 37.47~42.38o 범위로 열풍건조가 큰 값을 나타내었으며, 비회복성 일은 76.0~81.7%의 범위로 건조방법에 따른 차이는 작았지만 한반도품종이 청양품종에 비해 큰 값을 보였다. k2값은 1.20~1.24 범위로 건조방법 및 품종 간 차이는 작았으며, 이완성은 13.41~24.31%범위로 원적외선 건조가 큰 값을 보였고 건조방법별로 청양 품종이 큰 값을 나타내었다. This study investigated the bulk properties of red pepper powders according to drying method and variety. Bulk density, compressive characteristics, irrecoverable work, dynamic angle, and stress relaxation were investigated. Loose bulk density ranged between 0.420 g/cm3 for Cheongyang cultivar and 0.427 g/cm3 for Hanbando cultivar by hot-air drying. The highest tapped bulk density was 0.586 g/cm3 for Hanbando cultivar by far-infrared drying and the lowest value was 0.523 g/cm3 for Hanbando cultivar by sun drying. Hausner ratio reached a maximum value of 1.370 for Hanbando cultivar by far-infrared drying. Compressibility ranged between 0.0016 for Cheongyang cultivar by sun drying and 0.0023 for Hanbando cultivar by far-infrared drying. Compression ratio reached a maximum value of 1.032 for Hanbando cultivar by hot-air drying. Dynamic angle of repose ranged between 37.47 and 42.97o. Irrecoverable work ranged between 76.0 and 81.7%. Relaxation reached a maximum value of 24.31% for Cheongyang cultivar by far-infrared drying.

Elevated Prx1 Provides Resistance to Docetaxel, But Is Not Associated with Predictive Significance in Lung Cancer

( Ki Eun Hwang ),( Chul Park ),( Chang Hwan Seol ),( Yu Ri Hwang ),( June Seong Hwang ),( Jae Wan Jung ),( Keum Ha Choi ),( Eun Taik Jeong ),( Hak Ryul Kim ) 대한결핵 및 호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.75 No.2

Background: This study was conducted in order to elucidate the effects of docetaxel on the growth of peroxiredoxin 1 (Prx1) knockdown A549 xenograft tumors and further tested the role of Prx1 as a predictor for how a patient would respond to docetaxel treatment. Methods: Effects of docetaxel on the growth of scrambled- and shPrx1-infected A549 xenograft tumors in nude mice were measured. Moreover, immunohistochemical expression of Prx1 was evaluated in paraffin-embedded tissues from 24 non-small cell lung cancer patients who had received docetaxel-cisplatin regimens as a first-line treatment. Results: Docetaxel treatment in Prx1 knockdown xenograft tumor resulted in reduced tumors growth compared with other groups. Prx1 knockdown increased the production of cleaved caspases-8 and -9 in the control itself compared to scramble tumors. Moreover, docetaxel treatment in Prx1 knockdown tissue led to an increased protein band. Phosphorylated Akt was found in Prx1 scramble tissues. Phosphorylated FOXO1 was detected in the docetaxel treatment group. On the other hand, Prx1 knockdown completely suppressed the Akt-FOXO1 axis. The median progression free survival (PFS) of patients with low Prx1 expression was 7 months (95% confidence interval [CI], 6.0?7.7), whereas the median progression-free survival of patients with high Prx1 expression was 4 months (95% CI, 4.0?5.0). However, high Prx1 expression was not associated with decreased PFS (p=0.114). Conclusion: Our findings suggest that elevated Prx1 provides resistance to docetaxel treatment through suppression of FOXO1-induced apoptosis in A549 xenograft tumors, but may not be related with the predictive significance for response to docetaxel treatment.

Cutaneous extramedullary plasmacytomas in Korean patients with multiple myeloma

( Yu Ri Woo ),( Jong Sic Kim ),( Ji Hong Lim ),( Sewon Hwang ),( Miri Kim ),( Jung Min Bae ),( Hyun Jeong Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Multiple myeloma (MM) is a plasma cell dyscrasia characterized by the presence of a clonal proliferation of tumor cells. Cutaneous extramedullary plasmacytomas in patients with MM is very rare and remains poorly understood. Objectives: The aim of this study was to examine the clinical and histopathological characteristics of cutaneous extramedullary plasmacytomas in patients with MM and identify factors associated with overall survival of MM with cutaneous involvement. Methods: Medical records of 1,228 patients with MM were retrieved and analyzed. Among them, 14 patients (1.14%) with cutaneous extramedullary plasmacytomas were further evaluated for their clinical and histopathological findings. Results: Patients with cutaneous extramedullary plasmacytomas showed significantly reduced overall survival compared with those without cutaneous involvement (median: 28 months vs. 57 months; hazard ratio: 1.929; 95% confidence interval: 1.030-3.613). In subgroup analyses of patients with MM with cutaneous extramedullary plasmacytomas, erythematous nodules (P = 0.004), multiple cutaneous lesions (P = 0.002), and absence of a grenz zone (P = 0.004) were clinicopathologic features associated with reduced overall survival after Bonferroni correction. Conclusion: Cutaneous extramedullary plasmacytomas accounted for about 1.14% of patients with MM and was associated with reduced overall survival.

P060 Upregulation of erythroid differentiation regulator 1 after treatment with ingenol mebutate gel in actinic keratosis

( Yu Ri Woo ),( Jong Sic Kim ),( Ji Hong Lim ),( Sae Won Hwang ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Actinic keratosis (AK) is a most common premalignant lesion that may progress into the invasive squamous cell carcinoma (SCC). Ingenol mebutate gel has been shown to be effective and safe for treatment of AK. Erythroid differentiation regulator 1 (Erdr1), which functions as stress-related factor, was recently reported to play a crucial role in malignant skin cancers like malignant melanoma. Objectives: The purpose of this study is to investigate whether expression of Erdr1, p53, and bcl-2 was affected by treatment of ingenol mebutate gel in actinic keratosis. Methods: Nine patients with AK received the skin biopsy at baseline and 2 months after the treatment with ingenol mebutate gel for histological and immunological evaluation. In addition, skin samples from five control subjects were retrieved. Immunohistochemical staining with Erdr1, p53, and bcl-2 was performed. Results: Upregulation of Erdr1 was observed after treatment with ingenol mebutate gel. In addition, a significant decrease in p53 and bcl-2 expression was observed after the treatment. Conclusion: The expression of Erdr1 was upregulated after treatment with ingenol mebutate gel, suggesting that Erdr1 may be involved in the pathogenesis of AK. Furthermore, p53 and bcl-2 can be used as a biomarker for evaluating the treatment outcome in AK after treatment with ingenol mebutate gel.

P145 Erythroid differentiation regulator 1 expression in various types of alopecias

( Yu Ri Woo ),( Jong Sic Kim ),( Ji Hong Lim ),( Sae Won Hwang ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Erythroid differentiation regulator 1 (Erdr1) is known to involved in the inflammatory process via regulating immune system in various cutaneous disorders, psoriasis, rosacea. However, the role of Erdr1 in alopecia has not been studied. Objectives: The aim of this study is to investigate the expression patterns of Erdr1 in various types of alopecias. Methods: In all, twenty patients with alopecia were included. Skin samples from nine patients with alopecia areata, eight patients with scarring alopecia, three patients with traumatic alopecia, and five control subjects were retrieved for evaluation of Erdr1 expression. Results: Downregulation of Erdr1 was observed in alopecia than control groups. The expression density of Erdr1 was weaker in hair follicle than epidermis. In particular, a significant decrease in expression density of Erdr1 was observed in 44% of patients with alopecia areata, who were recalcitrant to the treatment. Conclusion: The expression of Erdr1 was downregulated in alopecia, which suggest that Erdr1 may be involved in the pathogenesis. Especially for alopecia areata, the expression of Erdr1 could be used as a prognostic factor for disease progression and treatment outcome.