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Bang, Sookhee,Jang, Sung Ill,Lee, Su Yeon,Baek, Yi-Yong,Yun, Jieun,Oh, Soo Jin,Lee, Chang Woo,Jo, Eun Ae,Na, Kun,Yang, Sugeun,Lee, Don Haeng,Lee, Dong Ki Hindawi Publishing Corporation 2015 Gastroenterology Research and Practice Vol.2015 No.-
<P>Implantation of self-expanding metal stents (SEMS) is palliation for patients suffering from inoperable malignant obstructions associated with biliary and pancreatic cancers. Chemotherapeutic agent-eluting stents have been developed because SEMS are susceptible to occlusion by tumor in-growth. We reported recently that paclitaxel-eluting SEMS provide enhanced local drug delivery in an animal model. However, little is known about the molecular mechanisms by which paclitaxel-eluting stents attenuate tumor growth. We investigated the signal transduction pathways underlying the antiproliferative effects of a paclitaxel-eluting membrane (PEM) implanted in pancreatic/cholangiocarcinoma tumor bearing nude mice. Molecular and cellular alterations were analyzed in the PEM-implanted pancreatic/cholangiocarcinoma xenograft tumors by Western blot, immunoprecipitation, and immunofluorescence. The quantities of paclitaxel released into the tumor and plasma were determined by liquid chromatography-tandem mass spectroscopy. Paclitaxel from the PEM and its diffusion into the tumor inhibited angiogenesis, which involved suppression of mammalian target of rapamycin (mTOR) through regulation of hypoxia inducible factor (HIF-1) and increased apoptosis. Moreover, implantation of the PEM inhibited tumor-stromal interaction-related expression of proteins such as CD44, SPARC, matrix metalloproteinase-2, and vimentin. Local delivery of paclitaxel from a PEM inhibited growth of pancreatic/cholangiocarcinoma tumors in nude mice by suppressing angiogenesis via the mTOR and inducing apoptosis signal pathway.</P>
( Sang Yu Oh ),( Bo Ryung Park ),( Byung Uk Lee ),( Jae Ho Park ),( Byung Gyu Kim ),( Seok Won Jung ),( In Du Jeong ),( Sung-jo Bang ),( Jung Woo Shin ),( Neung Hwa Park ),( Yun Im Lee ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Either entecavir (ETV) or tenofovir disoproxil fumarate (TDF) are recommended to use as the first-line nucleoside analogues (NAs) in patients with chronic hepatitis B (CHB) due to their potent viral suppression with a lower risk of drug resistance and excellent preventive effect for hepatocellular carcinoma (HCC) development. However, the effects of ETV and TDF on HCC development in CHB patients have not been fully examined. Methods: The aims of the current study were therefore to compare the effects of ETV and TDF therapy on HCC development in CHB patients in clinical practice. A total of 1,412 ETV-naïve patients and 1,318 TDF-naı¨ve patients were enrolled into the study. Results: The baseline characteristics of both groups were no significant difference. Virological and biochemical responses were similar between the two therapy groups over time. During a median 26 months of follow-up (range 1.0-60 months), 126 patients (4.6%) developed HCC. The 1-, 2-, 3- and 5-year cumulative HCC incidence rates in all cases were 2.2%, 3.8%, 5.1% and 9.9%, respectively. There was no significant difference in cumulative rates of HCC carcinoma (HCC) development (log-rank P = 0.357) between the two therapy groups. Multivariate analysis showed that male, older age, cirrhosis, lower albumin levels and HBeAg-positve status were independently associated with HCC development. Conclusions: HCC incidence and virological response were similar between ETV and TDF therapy groups in CHB patients in clinical practice. Therefore, either ETV or TDF are recommended to use as the first-line nucleoside analogues in patients with CHB due to their potent viral suppression and similar effect for HCC development.
CDN interconnection service trial: implementation and analysis
Bang, Yonghwan,Rhee, June-Koo Kevin,Park, Kyungsoo,Lim, Kyongchun,Nam, Giyoung,Shinn, John D.,Lee, Jongmin,Jo, Sungmin,Koo, Ja-Ryeong,Sung, Jonggyu,Seo, Young-il,Choi, Taesang,Kim, Hong-Ik,Park, Junyo Institute of Electrical and Electronics Engineers 2016 IEEE communications magazine Vol.54 No.6
<P>Content delivery service has become a major traffic load on today's Internet, and this has triggered the interest of ISPs in operating their own content delivery networks (CDNs) to optimize Internet traffic considering both content delivery caching and user-network proximity. ISPs, however, are typically regionally bound or network-domain-wise isolated; hence, their CDN gain is somewhat limited. In order to enhance the gain of ISP CDN services to the level of incumbent global CDNs, a CDN interconnection (CDNI) model is introduced by IETF, where local ISP CDN services can be extended among heterogeneous CDNs across network domains. However, despite the multiple benefits of a CDNI system, it is difficult to apply a CDNI service to the current CDN market due to the platform independence. Hence, we introduced a CDNI gateway model that is standard-capable and platform-independent. With the CDNI gateway model, we design and implement a complete CDNI system and conduct a CDNI service trial with three major ISPs in South Korea. To the best of our knowledge, this is the first CDNI service trial complying with the IETF standard achieved by a multi-ISP collaboration. According to the analysis of experimental results from the service trial, we observe that CDNI can reduce content traffic by about 40 percent at the Internet exchange link compared to a legacy CDN system.</P>
Sung-Min Jeong,In-Won Lee,Yu-Jin Jo,Jeong-Kyu Bang,Suk Namgoong,Nam-Hyung Kim 한국동물생명공학회(구 한국동물번식학회) 2017 Reproductive & Developmental Biology(Supplement) Vol.41 No.2
Polo-like kinase 1 (Plk1) plays crucial roles in various stages of oocyte maturation. Recently, we demonstrated that synthesized peptidomimetics AB103-8, targeting the polo- box domain (PBD) of Plk1 disrupted oocyte meiotic maturation and meiosis resumption. However, as a peptidic character of AB103-8 appeared to be defective due to poor membrane permeability and protease stability. To overcome the drawbacks, we designed and synthesized a series of pyrrole-based small-molecule inhibitors and screened against porcine oocyte maturation rates. Among the synthesized compounds, the macrocyclic inhibitor compound 4 displayed the highest inhibition potential against the oocyte meiotic maturation and embryos blastocyst formation. Furthermore, the addition of this compound to culture medium efficiently blocked the maturation of porcine and mouse oocytes, indicating that the lead compound could penetrate zona pellucida and cell membrane. We also investigated the Plk1 inhibiting ability of this compound. Treated mouse oocytes confirmed the Plk1 inhibition by showing abnormal spindle formation. Collectively, these results suggest that the novel Pyrrole-based compounds could be used for the basis of developing contraceptive agents.
Bang, Ye-Ji,Lee, Zee-Won,Kim, Dukyun,Jo, Inseong,Ha, Nam-Chul,Choi, Sang Ho American Society for Biochemistry and Molecular Bi 2016 The Journal of biological chemistry Vol.291 No.31
<P>The bacterial transcriptional regulator OxyR is known to function as a two-state redox switch. OxyR senses cellular levels of H2O2 via a 'sensing cysteine' that switches from the reduced to a disulfide state upon H2O2 exposure, inducing the expression of antioxidant genes. The reduced and disulfide states of OxyR, respectively, bind to extended and compact regions of DNA, where the reduced state blocks and the oxidized state allows transcription and further induces target gene expression by interacting with RNA polymerase. Vibrio vulnificus OxyR2 senses H2O2 with high sensitivity and induces the gene encoding the antioxidant Prx2. In this study, we used mass spectrometry to identify a third redox state of OxyR2, in which the sensing cysteine was overoxidized to S-sulfonated cysteine (Cys-SO3H) by high H2O2 in vitro and in vivo, where the modification deterred the transcription of prx2. The DNA binding preferences of OxyR2(5CA)-C206D, which mimics overoxidized OxyR2, suggested that overoxidized OxyR2 binds to the extended DNA site, masking the -35 region of the prx2 promoter. These combined results demonstrate that OxyR2 functions as a three-state redox switch to tightly regulate the expression of prx2, preventing futile production of Prx2 in cells exposed to high levels of H2O2 sufficient to inactivate Prx2. We further provide evidence that another OxyR homolog, OxyR1, displays similar three-state behavior, inviting further exploration of this phenomenon as a potentially general regulatory mechanism.</P>
Sung-Yoon Jo,Kyung-Sook Bang 한국아동간호학회 2023 Child Health Nursing Research Vol.29 No.3
Purpose: This study aimed to identify clinical characteristics of South Korean pediatric inflammatory bowel disease (IBD) in a children's hospital over the past 5 years, with a specific focus on comparing the features observed between Crohn's disease (CD) and ulcerative colitis (UC). Additionally, it aimed to examine the nursing diagnoses given to patients. Methods: This retrospective study analyzed the medical records of Korean pediatric patients under 18 years of age who were diagnosed with IBD and hospitalized at a children's hospital in Seoul, South Korea, from January 2017 to December 2021. Results: The number of pediatric patients diagnosed with IBD steadily increased. This finding was particularly prominent for CD patients, the majority of whom were male. Pediatric patients with CD had significantly higher rates of abdominal pain and perianal lesions, while pediatric patients with UC had a higher rate of bloody stool. Laboratory findings indicated that CD patients had higher levels of inflammatory markers and lower albumin levels than UC patients. The nursing diagnoses given during hospitalization mostly related to safety and protection, physical comfort, and gastrointestinal function. Conclusion: This study provides insights into Korean pediatric IBD patients, enabling early detection and the development of nursing intervention strategies. From a comprehensive perspective, nursing care should not only address patients' physical needs but also their psychosocial needs.
Bang, Hyeon-Jo,Park, Shin Young,Kim, Seh Eun,Md Furkanur Rahaman, Mizan,Ha, Sang-Do Elsevier 2017 FOOD SCIENCE AND TECHNOLOGY -ZURICH- Vol.84 No.-
<P>This study investigated the synergistic effects of combined ultrasound (US; 37 kHz, 380 W for 10-60 min) and peroxyacetic acid (PAA; 50-200 ppm) on reducing Cronobacter sakazakii biofilms on cucumbers. US was not sufficient to eliminate C. sakazakii biofilms (0.04-0.60 log-reduction), whereas PM (200 ppm) significantly (p < 0.05) reduced biofilm formation on cucumber (0.89-1.88 log reduction). Furthermore, the combination of 60 min US and 200 ppm PM resulted in an additional 1.63 log-reduction of C sakazakii biofilms (3.51 log-reduction = 1.88 + 1.63 log). Synergistic reduction of C sakazakii biofilms was observed in most combined treatment, although the most synergistic reduction values were <1.0 log(10) CFU/cm(2). The highest synergistic value of reduction in cucumber was 1.03-1.08 log(10) CFU/cm2 when treated with a combination of 60 min US and 150-200 ppm PM. In addition, the Hunter color('L', 'a', and 'b'), moisture contents(%), and texture(hardness and chewiness) after combined treatment with 60 min US and 200 ppm PM did not differ significantly from those of cucumbers exposed to a single treatment. These results indicate that combined treatment with 60 min US and 150-200 ppm PM could be a useful approach to reduce C. sakazakii biofilms on fresh-produce and could help enhance their shelf-life during transportation and storage. (C) 2017 Elsevier Ltd. All rights reserved.</P>