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Optimal Design of Direct-Driven PM Wind Generator for Maximum Annual Energy Production
Sang-Yong Jung,Hochang Jung,Sung-Chin Hahn,Hyun-Kyo Jung,Cheol-Gyun Lee IEEE 2008 IEEE transactions on magnetics Vol.44 No.6
<P>Optimal design of the direct-driven PM wind generator, coupled with finite element analysis and genetic algorithm, has been performed to maximize the annual energy production over the whole wind speed characterized by the statistical model of wind speed distribution. Particularly, the parallel computing via internet web service has been applied to loose excessive computing times for optimization.</P>
a case of severe coronary spasm associated with 5-Fluorouracil Chemotherapy
( Sang Min Kim ),( Cheol Hoon Kwak ),( Bora Lee ),( Seong Beom Kim ),( Jung Ju Sir ),( Wook Hyun Cho ),( Suk Koo Choi ) 대한내과학회 2012 The Korean Journal of Internal Medicine Vol.27 No.3
Cardiotoxicity associated with 5-fluorouracil (FU) is an uncommon, but potentially lethal, condition. The case of an 83-year-old man with colon cancer who developed chest pain during 5-FU infusion is presented. The electrocardiogram (ECG) showed pronounced ST elevation in the lateral leads, and the chest pain was resolved after infusion of nitroglycerin. A coronary angiogram (CAG) revealed that the patient had significant atherosclerosis in the proximal left circumflex artery. Coronary artery spasm with fixed stenosis was considered, and a drug-eluting stent was implanted. After 8 hours, the patient complained of recurring chest pain, paralleled by ST elevation on the ECG. The chest pain subsided after administration of intravenous nitroglycerin followed by sublingual nifedipine. Repeated CAG showed patency of the previous stent. This case supports the vasospastic hypothesis of 5-FU cardiac toxicity, indicating that a calcium channel blocker may be effective in the prevention or treatment of 5-FU cardiotoxicity.
Jung Eun Hwang,Sun-Hee Kim,Sun-Goo Hwang,Cheol Seong Jang,Jin-Baek Kim,Sang Hoon Kim,Bo-Keun Ha,Si-Yong Kang,Dong Sub Kim 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Ionizing radiation is known to cause chromosomal alterations such as inversions and deletions and affects gene expression within the plant genome. To monitor the genome-wide transcriptome changes by ionizing radiation, we used rice Affimetrix GeneChip microarray to identify genes that are up- or down regulated by gamma-ray (200 Gy, 60Co source), cosmic-ray and ion beam (40 Gy, 220 MeV carbon ion). The overall expression patterns between gamma-ray and ion beam were similar but cosmic-ray was regulated differently. Combined results from all 3 radiations identified 27 up-regulated genes and 188 down regulated genes. These results mean the induction of similar mechanism changes in treatments of gamma ray and ion beam. However the different expression in treatment of cosmic-ray might be due to the other environmental conditions. Among the commonly up- or down- regulated genes, we chose highly up- or down- regulated several genes and confirmed its regulation in response to ionizing radiation exposure by RT-PCR analysis. Moreover, we showed that specific co-expression networks of candidate radio marker genes by ARACNE algorithm. Our results present profiles of gene expression related to different ionizing radiation and marker gene to predict sensitivity to ionizing radiation, such as GS (glutelin subunit) and FBX322.
Sang Sun Lee,Won Yu Kang,Dong In Nam,Il Hyung Jung,Chung Kang,Hong Ju An,Ho Yeong Song,Hoon Kang,Sang Cheol Cho,Sun Ho Hwang,Wan Kim 조선대학교 의학연구소 2014 The Medical Journal of Chosun University Vol.39 No.2
May-Thurner syndrome is associated with deep vein thrombosis resulting from chronic compression of the iliac vein against the lumbar vertebrae caused by the overlying common iliac artery. Stent insertion into the compressed lesion is used in treatment of May-Thurner syndrome. Various complications can occur during angioplasty while using a stent. Among these complications, shrinkage of the vein below the stent, a rare complication, was observed in our hospital during treatment of a patient with May-Thurner syndrome. Different complications can occur when venous angioplasty is performed, unlike that when arterial angioplasty is performed.
( Sang Cheol Bae ),( Jinseok Kim ),( Jung Yoon Choe ),( Won Park ),( So Ra Lee ),( Yong Ho Ahn ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Etanercept is a recombinant fusion protein that blocks TNF. HD203 is a biosimilar of etanercept with demonstrated comparability across pharmacokinetics, safety and tolerability. The objectives of this study were to evaluate equivalence in effi cacy and compare safety of HD203 with reference etanercept, in combination with MTX in patients with RA. (ClinicalTrials. gov NCT01270997). Methods: Korean patients (male or female aged =20 years) with active RA were randomized (1:1) to 25 mg HD203 or reference etanercept, administered subcutaneously twice weekly with MTX for 48 weeks. The primary endpoint was the proportion of patients achieving ACR20 at week 24. Secondary endpoints included ACRn, DAS28, andEULAR response at week 24 and 48, safety and immunogenicity. Results: In total, 294 patients were randomized: HD203, n=147; reference etanercept, n=147. The proportion of patients achieving ACR20 at week 24 was not signifi cantly different between HD203 and reference etanercept. Equivalent effi cacy was demonstrated within predefined margins. There were no significant differences between proportions achieving ACR20 at week 12 and 48. ACR50 and ACR70 displayed similar trends. There were no signifi cant differences between groups for ACRn, DAS28, and EULAR response. Safety set analysis (HD203, n=147; reference etanercept, n=146) revealed no signifi cant difference for treatment-emergent (all-causality) adverse events (AEs): HD203 76. 87% vs. reference etanercept 78. 08% (p=0. 8040). No significant differences between HD203 and reference etanercept were observed for adverse drug reactions, serious AEs, or discontinuations due to AEs. Few patients tested positive for anti-drug antibodies. Conclusions: The study met the primary endpoint of demonstrating equivalent effi cacy of HD203 compared to reference etanercept. HD203 was well tolerated, with a safety profi le comparable to reference etanercept in this population of patients with RA.
( Cheol Kyu Park ),( Yong Soo Kwon ),( Hong Joon Shin ),( Boram Lee ),( Hee Jung Ban ),( Injae Oh ),( Kyu Sik Kim ),( Yuil Kim ),( Sung Chul Lim ),( Young Chul Kim ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Understanding of the bacteriology is critical in treatment of pleural infection. However, there are few studies about pathogens of pleural infection in Korea. This study aimed to determine microbiologic characteristics of pleural infection and identify predictive factors associated with mortality. Methods: We performed a retrospective study analyzing 114 cases of parapneumonic effusion with 134 micro-organisms. We examined pleural fluid cultures using two culture systems, BACTEC blood culture and conventional method. Results: Of all isolated organisms, the most frequent pathogen was streptococcal species (35.8%) followed by staphylococci (19.4%), anaerobes (15.7%) and gram negatives (9.0%). In 73 specimens using both culture systems, BACTEC blood culture showed higher culture-positive rate (94.5%) than conventional method (35.6%). Streptococci were main organisms in conventional culture (48.4%), community-acquired infection (58.7%) and all susceptible, whereas staphylococci were major isolates in BACTEC blood culture (28.0%), hospital-acquired infection (33.8%) and drug-resistant organisms (58.8%). Smoking, interventions (pigtail, tube thoracostomy, intrapleural fibrinolytics, surgery), and severity score (CURB-65) were significantly associated with 30-day mortality in univariate analysis. In multivariate analysis, tube thoracostomy (aOR 0.158, 95% CI 0.051 - 0.489, p=0.001), smoking (aOR 6.958, 95% CI 1.882 - 25.720, p=0.004) and CURB-65 =2 (aOR 4.204, 95% CI 1.345 - 13.136, p=0.014) were significant predictive factors for mortality. Conclusions: Common pathogens of pleural infection in Korea were streptococcal species, staphylococci, and anaerobes. Tube thoracostomy, smoking, and CURB-65 =2 could be predictive factors for death in pleural infection.