복합유기용제 장기 노출자들의 골수충실도 평가를 위한 자기공명영상의 계량적 활용

정해관,최대섭,박건욱,윤환중,김정란,하경임,양승오,김양호 大韓産業醫學會 2002 대한직업환경의학회지 Vol.14 No.2

목 적 : 자기공명영상은 골수의 지방세포와 조혈세포간의 분퐁 차이를 신호강도 차이로 구분할 수 있어 골수 충성도에 대한 평가가 가능하다. 저자들은 유기용제에 장기간 노출된 조선업체 도장공 및 대조군을 대상으로 비참습적인 방법으로 골수 충실도를 평가하는 도구를 개발하기위하여 본 연구를 시행하였다. 방 법 : 1998녀 8월부터 2000년 1월까지 조선소 도장공 중 1개 대학병원에서 유기용제 장기간 사용으로 인한 골수검사 결과 저세포성 골수로 진단 받은 환자 6명(남자 5명, 여자 1명; 평균연령 환자군 46.5세)을 대상으로 말초혈액이 혈액학적 검사, 골수검사 및 요추부 자기공명영상을 실시하였다. 대조군으로는 동일 병원에서 요추부 자기공명영상을 촬영한 환자 132명(남 67명, 여자 65명, 연령 평균 42.5세, 범위 30-59세)을 선정하였다. 요추부 자기공명영상은 T1 및 T2 강조영상의 시상 단면에서 제 12 흉추부터 제 1 천추사이의 추체에서 각반드시 신호강도를 기록하였다. 기준 부위로는 동일 단면의 척추주위근 및 지방조직의 산호강도를 이용하여 각 부위에서 측정한 신호강도를 나누어 골수 신호강도지표를 구하였다. 결 과 : 환자군의 골수 충실도는 20.33-33.6 %이었고 혈액검사상 백혈구수는 2,100-7,600/㎣이었다. 환자군과 대조군 모두에서 각 지표는 제 12흉추에서 아래로 내려갈수록 점차 감소하였다가 제 4 요추 이후 다시 증가하는 양상을 보였다. 환자군과 대조군간의 골수 신호강도지표를 비교하였을 때 T1 강조영상에서 척추주위근을 기준으로 한 골수 신호강도지표가 환자군과 대조군간의 차이를 가장 잘 반영하였으며 환자군이 모든 추체에서 유의하게 높았다. (p<0.05, p<0.01). 대조군의 골수 신호강도지표는 T1 강조영상이 척추주위근을 기준으로 측정하였을 때 여성에서 연령 증가에 따라 모든 측정점에서 골수 신호강도지표는 증가하는 양상을 보였으며 30대와 50대간의 차이는 유의하였다. (p<0.05, p<0.01). 성별에 따른 골수 신호강도지표는 근육을 기준으로 한 골수 신호강도지표에서는 보이지 않았으나 비장을 기준으로 한 골수 신호강도지표는 남녀간에 유의한 차이를 보였다. (p<0.05). 다변량 선형회귀분석에서 연령 및 성별을 보정하였을 때 T1 강조영상의 근육을 기준으로 한 골수 신호강도지표는 환자군에서 대조군에 비하여 제 1 천추에서 0.364 더 높았다. 제 1 천추의 T1 근육을 기준으로 한 골수 신호강도지표의 연령 성별 평균+1 표준편차를 기준으로 하였을 때 6명 중 5명이 그 이상이 분포를 보여 두 군간의 차이가 가장 뚜렷하였다. 결 론 : 저자들은 자기공명영상을 이용하여 골수 충실도를 평가하기 위한 지표를 개발하였고 정상 참고치를 제시하였다. 골수 신호강도지표는 지방조직 함량, 골밀도함께 칼슘 등의 영향을 동시에 반영하지만 이러한 영향을 적절히 보정할 경우 고위험집단에서 골수 충실도를 평가하는데 활용할 수 있음을 확인하였다. 보다 좋은 지표의 개발을 위하여 충분한 표본수를 가진 저세포성 골수 환자집단을 대상으로 후속연구를 수행할 필요가 있다. Objectives : To develop a quantitative and noninvasive method of bone marrow cellularity evaluation in solvent exposed painters. Methods : Six painters (mean 46.5 years, 5 males and one female with hypocellular marrow, and 132 controls were examined using magnetic resonance imaging (MRI). A full examination of the peripheral blood and a bone marrow biopsy was done on each patient. Signal intensities were measured at the vertebral bodies from T12 to S1 on both the T1 and the T2-weighted image (T1WI and T2WI). Signal indices were calculated by dividing the signal indeces of the vertebral bodies by that of the paraspinal muscle and the subcutaneous fat in the same view. Results : The Bone marrow cellularities of the cases painters were between 20.3 % and 33.6 %. Signal indices based on the muscle at T1WI were greater in the cases of the painters compared to those of the controls (p<0.05, p<0.01). Signal indices based on the muscle at T1WI were significantly higher in older women compared with men (p<0.05). After adjusting for age and gender, the signal index of cases at S1 based on muscle of T1WI was higher than that of the controls by 0.364. Five of the six cases had a muscle signal index at S1 of T1WI higher than the mean + 1 standard deviation for the same age group and gender. Conclusions : MR signal indices are influenced by constitutional factors such as fat content. bone density, and the presence of other pathology. However, after adequate adjustment, it can be used as a useful indicator of bone marrow cellularity in a high-risk population.

후복막 선 섬유종의 1 예

오연희,윤혜원,이현경,배한의,홍승호,임문환 東國大學校醫學硏究所 1994 東國醫學 Vol.2 No.-

혼합성Mullerian 선 종양(mixed Mullerian tumor)의 양성대조물로 여겨지는 선 섬유종은 상피 세포의 증식을 동반하는 부인과에서 매우 드문 종양으로 더욱이 자궁이외에서 발견되는 경우는 극히 드물었다. 난소 및 자궁이외에서 발생하는 경우 복막의 subcelomic mesenchyme으로부터 기원되었을 것이라는 설과 coelomic epithelium의 metaplasa에 의하여 또는 자궁내막으로부터 기원되었을 것이라는 가설이 있으나 아직 정확히 알려져 있지 않다. 저자들은 난소종양을 의심하여 수술하던 중 적출한 후복막종야이 부인과에서 매우 드문 선 섬유종으로 확인되어 보고하는 바이다. Mixed Mullerian tumor, composed of both epithelial and stromal components, are very rare. Because of biphasic nature of these tumors, these histologic classification is controversial until now. Adenofibroma is regarded as the benign counterpart of Mullerian adenosarcoma. We have experienced a case of adenofibroma in retroperitoneum and this is presented in this report with brief review.

[ I - 123 ] IPT SPECT를 이용한 도파민 재섭취부위의 영상화 : 반정성적 분석방법을 이용한 정상인과 파킨슨병 환자의 차이

양승오(Seoung Oh Yang),최윤영(Yun Young Choi),이희경(Hee Kyung Lee),김희중(Hee Joung Kim),류진숙(Jin Sook Ryu),임주혁(Joo Hyuck Im),이명종(Myung Chong Lee) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.1

N/A Dopamine transporter concentrations have been known to decrease in Parkinson's disease (PD) or increase in Tourette's disorder. The purpose of this study was to evaluate the effectiveness of [I-123]N-(3-iodopropene-2-yl)-2β-carbomethoxy-3β-(4-chlorophenyl) tropane (IPT) as an imaging agent for measuring changes in transporter concentrations with PD. IPT labelled with 6.69+/-0.64 mCi (247.53+/-23.68 MBq) of I-123 was intravenously injected into ten patients(age: 55+/-11) with PD, and six normal controls(NC)(age: 46+/-14) as a bolus. Dynamic SPECT scans of the brain were then performed for 5 minutes each over 120 minutes on a triple headed camera. Time activity curves were generated for the left basal ganglia(LBG), right basal ganglia(RBG), and occipital cortex(OCC). The statistical parameters included the time to peak activity, the contrast ratio of LEG and RBG to OCC at several time points, and the accumulated specific binding counts/mCi/pixel (ASBC) from 0 to 115 minutes. The uptake of IPT in the brains of PD and NC peaked within 10 minutes of injection in all subjects. The maximum target to background ratio in the basal ganglia of PD and NC occurred at 85+/-20 min and 110-+/-6 min of injection, respectively. The BG/OCC ratios at 115 minutes for PD and NC were 2.15+/-0.54 and 4.26+/-0.73, respectively. The ASBC at 115 minutes for PD and NC were 152.91+/-50.09 and 289.51+/-49.00, respectively. The ratio of BG/OCC for the NC was significantly higher than the ratio for PD. SPECT data matched with clinical diagnosis for PDs. The ratio between BG and OCC and the ASBC for PD were clearly separated from NC and may be useful outcome measures for clinical diagnosis. The findings suggest that IPT may be a very useful tracer for early diagnosis of PD and study of dopamine reuptake site.

파킨슨씨 병과 골다공증

박준용,임주혁,양승오,하상배 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.1

SPECT IMAGING OF DOPAMINE REUPTAKE TRANSPORTER WITH [I - 123] IPT IN NORMAL CONTROLS AND EARLY PARKINSON ` S DISEASE .

Kim, Hee Joung,Lee, Hee Kyung,Yang, Seoung Oh,Ryu, Jin Sook,Im, Joo Hyuk,Cheon, Jun Hong,Nam, Ki Pyo,Lee, Myoung Chong 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.3

[ I - 123 ] IPT SPECt를 이용한 정상인과 파킨슨환자의 도파민 운반체의 영상화 및 단순화된 정량분석 방법들의 비교연구

문대혁(Dae Hyuk Moon),양승오(Seoung Oh Yang),이희경(Hee Kyung Lee),김희중(Hee Joung Kim),류진숙(Jin Sook Ryu),천준홍(Jun Hong Cheon),임주혁(Joo Hyuck Im),봉정균(Jung Kyun Bong),남기표(Ki Pyo Nam),권수일(Soo Il Kwon) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.3

N/A The purpose of this study was to compare the specific binding ratio method with model based methods in estimating the transporter parameter k3/k4 in normal controls and Parkinson's patients with [I-123]IPT SPECT and to evaluate the usefulness of [I-123]IPT SPECT. 6.5±1.1 mCi (239.0±40.3 MBq) of [123]IPT was intravenouly injected as a bolus into six normal controls(age:45±13) and seventeen patients(age:55±8) with Pakinson's disease(PD). The transporter parameter k3/k4 was derived using the Ichise's graphical method(Rv) and Lassen's area ratio method(RA) for the dynamic IPT SPECT data without blood samples. Then, the relationships between the transporter parameter Rv, RA and the ratio of (BG-OCC)/OCC at 115 minutes were evaluated by linear regression analysis. Rvs by Ichise's graphical method for NC and PD were 2.08±0.29 and 0.78±0.31, respectively. RAs by Lassen's area ratio method for NC and PD were 1.48±0.16 and 0.65±0.24, respectively. The correlation coefficients between (BG-OCC)/OCC and Rv, (BG-OCC)/OCC and RA, and RV, and RA were 0.93, 0.90, 0.99 and their corresponding slopes were 0.54, 0.34, and 0.65,respectively. The Rv and RA of NC were significantly higher than the ones of PD. That is, the k3/k4 Of NC was clearly separated from the one of PD. k3/k4 showed a good correlation with the ratio of (BG-OCC)/OCC. The results indicate that the noninvasive simplified quantitative methods may be useful to measure the transporter parameter k3/k4 and the specific binding ratio method can be used for quantitative studies of dopamine transporter with [I-123]IPT SPECT in humans brains.

A Review on the Application of Nanotechnology in Food Processing and Packaging

( Seong In Cho ),( Yong Rok Kim ),( Joon Woo Lee ),( Dae Sup So ),( Yong Jin Cho ),( Hyun Kwon Suh ),( Tu San Park ),( Seoung Im Oh ),( Ji Eun Im ) 한국산업식품공학회 2010 산업 식품공학 Vol.14 No.4

Currently, nanotechnology is widely applied in various industrial fields and is rapidly emerging as a promising future technology. In food industries, nanotechnology is used to enhance food quality and safety. Numerous cutting-edge studies on the advantages of nanotechnology have been conducted in the fields of food processing, food ingredients and additives, food packaging, and food engineering for optimal health. The market for these areas of research has grown steadily, and is expected to continue to do so. Because of this, R&D for nanotechnology that can be used effectively in food industries is being performed by several companies, as well as in academic research institutions around the world. This review describes the recent global R&D trends that have been in progress for two key areas: food processing and food packaging.

A Review on the Application of Nanotechnology in Food Processing and Packaging

Seong-In Cho,Yong-Rok Kim,Joon Woo Lee,Dae-Sup So,Yong-Jin Cho,Hyun Kwon Suh,Tu San Park,Seoung-Im Oh,Ji-Eun Im 한국산업식품공학회 2010 산업 식품공학 Vol.14 No.4

Currently, nanotechnology is widely applied in various industrial fields and is rapidly emerging as a promising future technology. In food industries, nanotechnology is used to enhance food quality and safety. Numerous cutting-edge studies on the advantages of nanotechnology have been conducted in the fields of food processing, food ingredients and additives, food packaging, and food engineering for optimal health. The market for these areas of research has grown steadily, and is expected to continue to do so. Because of this, R&D for nanotechnology that can be used effectively in food industries is being performed by several companies, as well as in academic research institutions around the world. This review describes the recent global R&D trends that have been in progress for two key areas: food processing and food packaging.