Pregnancy and delivery outcomes in the women who have received adenomyomectomy: performed by a single surgeon by a uniform surgical technique

( Minji Seo ),( Jae Young Kwack ),( Yong-soon Kwon ),( Soo Jeong Lee ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: Although adenomyomectomy for fertility-sparing is an expanding procedure worldwide, there is no guideline or consensus about how to manage the pregnant women who have previously received conservative surgery for adenomyosis. The aim of this study is to evaluate antenatal care and delivery outcomes in pregnant women after adenomyomectomy. Methods: Between May 2011 and May 2019, the medical record was reviewed in all delivery of pregnant women received adenomyomectomy performed by a single surgeon by a uniform surgical technique. The evaluating parameters consisted of antenatal care outcomes, delivery outcomes, intrapartum outcome, and neonatal outcomes. Results: Twenty-two patients were evaluated to monitor pregnancy and delivery outcomes after the adenomyomectomy. Mean age of delivery was 37.0 years old (SD=3.1, range 32-45, median 37). All were delivered by cesarean section. Mean gestational age was 36.2weeks (SD=3.6, range 27.4-39.4, median 37.3). The mean birth weight was 2560.9g (SD=771.8, range 1100-3920, median 2550) and the number of preterm births admitted for prematurity care was seven (31.8%, 7/22). Placental abnormality was found in the four cases, which included two placenta accreta and two previa. However, there were no cases of hysterectomy or intervention. We identified one case of uterine rupture during pregnancy (4.5 %, 1/22) at 27weeks of gestation. Except for preterm birth, adverse neonatal outcomes were not found in this study. Conclusion: Delivery of pregnant women who received adenomyomectomy can obtain safe perinatal outcomes under close monitoring of preterm labor and surveillance of catastrophic pregnancy related complications.

Letter : Relationship between sea ice concentration and sea ice albedo over Antarctica

( Minji Seo ),( Chang Suk Lee ),( Hyunji Kim ),( Morang Huh ),( Kyung Soo Han ) 대한원격탐사학회 2015 大韓遠隔探査學會誌 Vol.31 No.4

Sea ice is a key parameter for understanding the climate change in cryosphere. In this study, we investigated the correlation with the factors that influenced change of the sea ice extent. We used the Sea Ice Concentration (SIC) from Ocean and Sea Ice Satellite Application Facility (OSI-SAF), and surface albedo provided by The Satellite Application Facility on Climate Monitoring (CM SAF). We converted the same temporal and spatial resolution of the data and detected the sea ice using SIC data. We performed the relationship analysis between SIC and sea ice albedo. As a result, we found they have a strong positive correlation. We performed the linear regression between SIC and sea ice albedo, and found they have highlevel coefficient of determination. It shows using either SIC or sea ice albedo is possible to estimate the sea ice products.

Estimation of stream flow discharge using the satellite synthetic aperture radar images at the mid to small size streams

Seo Minji,Kim Dongkyun,Ahmad Waqas,Cha Jun-Ho 한국수자원학회 2018 한국수자원학회논문집 Vol.51 No.12

본 연구에서는 2015년에서 2017년 사이에 유럽항공우주국 Sentinel-1 위성이 촬영한 Synthetic Aperture Radar (SAR) 영상을 활용하여 한강 유역 내 하천의 유량을 추정하는 모형을 개발하였다. 한강 유역 내 15개 중소규모 하천을 연구지역으로 선정하였으며 SAR 인공위성 영상 자료와 수위 및 유량관측소에서 산정한 유량 자료를 모형 구축을 위하여 사용하였다. 우선, 오류 보정을 위해 다양한 전처리 과정을 거친 12장의 SAR 영상 을 히스토그램 매칭 기법을 적용하여 이미지의 밝기 분포를 동일하게 만들었다. 이후 임계치 분류방식을 사용하여 추출된 하천 수체의 면적과 지상 관측유량자료와의 관계식을 도출하여 유량추정모형을 구축하였다. 그 결과, 1개소를 제외한 14개 관측소에서 인공위성에서 추출한 하천 면적을 입력 자료로 하는 멱함수 형태의 유량추정모형을 구축할 수 있었다. 14개 관측소의 최소, 평균, 최대 결정 계수(R2)는 0.3, 0.8, 0.99로 나타났다. This study suggests a novel approach of estimating stream flow discharge using the Synthetic Aperture Radar (SAR) images taken from 2015 to 2017 by European Space Agency Sentinel-1 satellite. Fifteen small to medium sized rivers in the Han River basin were selected as study area, and the SAR satellite images and flow data from water level and flow observation system operated by the Korea Institute of Hydrological Survey were used for model construction. First, we apply the histogram matching technique to 12 SAR images that have undergone various preprocessing processes for error correction to make the brightness distribution of the images the same. Then, the flow estimation model was constructed by deriving the relationship between the area of the stream water body extracted using the threshold classification method and the in-situ flow data. As a result, we could construct a power function type flow estimation model at the fourteen study areas except for one station. The minimum, the mean, and the maximum coefficient of determination (R2) of the models of at fourteen study areas were 0.30, 0.80, and 0.99, respectively.

A Graph Embedding Technique for Weighted Graphs Based on LSTM Autoencoders

( Minji Seo ),( Ki Yong Lee ) 한국정보처리학회 2020 Journal of information processing systems Vol.16 No.6

A graph is a data structure consisting of nodes and edges between these nodes. Graph embedding is to generate a low dimensional vector for a given graph that best represents the characteristics of the graph. Recently, there have been studies on graph embedding, especially using deep learning techniques. However, until now, most deep learning-based graph embedding techniques have focused on unweighted graphs. Therefore, in this paper, we propose a graph embedding technique for weighted graphs based on long short-term memory (LSTM) autoencoders. Given weighted graphs, we traverse each graph to extract node-weight sequences from the graph. Each node-weight sequence represents a path in the graph consisting of nodes and the weights between these nodes. We then train an LSTM autoencoder on the extracted node-weight sequences and encode each nodeweight sequence into a fixed-length vector using the trained LSTM autoencoder. Finally, for each graph, we collect the encoding vectors obtained from the graph and combine them to generate the final embedding vector for the graph. These embedding vectors can be used to classify weighted graphs or to search for similar weighted graphs. The experiments on synthetic and real datasets show that the proposed method is effective in measuring the similarity between weighted graphs.

Combination effect of cilengitide derivatives with gefitinib on TGF-β1-induced epithelial-to-mesenchymal transition in human non-small cell lung cancer cells

Minji Seo,Jiyeon Kim 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.10

Cilengitide (cyclo[RGDf(NMe)V]), containing the arginine–glycine–aspartate motif,has been known to increase drug efficacy through coadministration with antican-cer agents in various cancers including non-small cell lung cancer (NSCLC), andcilengitide derivatives have also shown an epithelial-to-mesenchymal transition(EMT) inhibitory effect. In addition, we found that some cilengitide derivativesexert anti-EMT effects in NSCLC cells. Especially, cilengitide derivatives cRGDwVandcRGDyVwereshowntobethemosteffectiveinNSCLCcellproliferationandexerted an inhibitory effect against the transforming growth factor-β1(TGF-β1)-induced EMT phenotype changes and related signalings. In this study, we evalu-ated the combination effect of cRGDwVandcRGDyVwithanepidermalgrowthfactor receptor inhibitor gefitinib on the TGF-β1-induced EMT process in NSCLCcells. Cilengitide derivatives showed synergistic effects with gefitinib in the expres-sion of EMT markers. Based on these results, we can suggest the potential of thesepeptides as coadministered drugs in cancers undergoing an EMT process.

MAP4-regulated dynein-dependent trafficking of BTN3A1 controls the TBK1–IRF3 signaling axis

Seo, Minji,Lee, Seong-Ok,Kim, Ji-Hoon,Hong, Yujin,Kim, Seongchan,Kim, Yeumin,Min, Dal-Hee,Kong, Young-Yun,Shin, Jinwook,Ahn, Kwangseog National Academy of Sciences 2016 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.113 No.50

<P>The innate immune system detects viral nucleic acids and induces type I interferon (IFN) responses. The RNA-and DNA-sensing pathways converge on the protein kinase TANK-binding kinase 1 (TBK1) and the transcription factor IFN-regulatory factor 3 (IRF3). Activation of the IFN signaling pathway is known to trigger the redistribution of key signaling molecules to punctate perinuclear structures, but the mediators of this spatiotemporal regulation have yet to be defined. Here we identify butyrophilin 3A1 (BTN3A1) as a positive regulator of nucleic acid-mediated type I IFN signaling. Depletion of BTN3A1 inhibits the cytoplasmic nucleic acid-or virus-triggered activation of IFN-beta production. In the resting state, BTN3A1 is constitutively associated with TBK1. Stimulation with nucleic acids induces the redistribution of the BTN3A1-TBK1 complex to the perinuclear region, where BTN3A1 mediates the interaction between TBK1 and IRF3, leading to the phosphorylation of IRF3. Furthermore, we show that microtubule-associated protein 4 (MAP4) controls the dynein-dependent transport of BTN3A1 in response to nucleic acid stimulation, thereby identifying MAP4 as an upstream regulator of BTN3A1. Thus, the depletion of either MAP4 or BTN3A1 impairs cytosolic DNA- or RNA-mediated type I IFN responses. Our findings demonstrate a critical role for MAP4 and BTN3A1 in the spatiotemporal regulation of TBK1, a central player in the intracellular nucleic acid-sensing pathways involved in antiviral signaling.</P>

홀로닉 상관구조를 통한 공간표피의 분석

서민지 ( Minji Seo ),이종세 ( Jongse Yi ),김주연 ( Jooyun Kim ) 한국공간디자인학회 2015 한국공간디자인학회논문집 Vol.10 No.4

(연구배경 및 목적)환경의 다양한 변인들을 수용해나가는 공간표피는 인간과 가장 직접적으로 마주하는 매개적 역할로써, 끊임없는 형태적 변화를 보여주고 있다. 홀로닉 구조의 이론적 고찰을 통한 상관적이고 맥락적인 이해를 통해 공간과 표피의 관계및 동향 등 그 위치를 파악하는 것은 내외부의 경계를 구분 짓는 마감재라는 고정된 인식으로부터 탈피하고, 다양한 환경의 요구조건에 대해 대응할 수 있는 편재성(ubiquity)을 갖춘 표피로써 인식할 수 있는 기틀을 마련한다. 그에 따라 인간의 기대와 환경적 요구에 어떻게 부응하여 디자인될 수 있는지를 ‘상관관계의 흔적’이라는 요소로써 대상을 분석하고자 한다. (연구방법)홀론의 사상한적 특성을 이해함으로써, 표피는 다양한 요구가치에 부응한 물리적인 기능 뿐 아니라 사회문화적으로 연계된 가치를 촉발시킬 수 있는 확장된 역할언어를 가질 수 있다. 모든 존재의 홀론은 부분적 특성들이 필연적인 관계맺음으로써 파지되고 발현되기 때문에 사상한적으로 상관관계의 흔적을 파악해야 한다. 이처럼 표피는 인간의 필요에 의해 인위적으로 만들어진 외피기능의 인공시스템이지만 의식과 제도의 변화 등 서로의 관계에 깊이 맞물려 작용해왔기 때문에 현재는 자의적 해석에서도 즉각적으로 반응가능한 열린계로 진화할 수 있었다. 따라서 사상한적 이해의 결과로 표피를 ‘살아있는 시스템’인 유기체라 간주하였고, 그것은 철학가들의 존재생성방식에 대한 사유로 접근하여 풍부한 조망을 얻고자 한다. 살아있는 시스템인 표피의 가치적 특성은 가상적, 물리적으로 분류하여 파악하고자 하였고, 물리적 확장 가치에 대해 물질적 또는 행위적 문제를 이해하고 수반하며때로는 환기시킬 수 있는 지략적이고 지능적인 방법론인 모듈시스템은 가변적, 구조적, 표현적, 기능적인 접근으로 분석하여 파악하고자한다. 또한 사상한의 결과로 도출된 의지적, 행동적, 사회적, 문화적 측면에 대한 특징요소를 추출하여 표피가 갖는 상관적 특성을 이해하고자 한다. (결과)모듈시스템을 적용한 표피의 구축 사례를 6개로 선정하여 텍토닉의 ‘앎’과 ‘드러냄’, 홀론의 사상한적 ‘내면’과‘외면’을 중심으로 가상적 측면과 가상적 특성을 형(形)으로써 노출시킨 물리적 측면으로 나누어 분석한 결과 첫째, 표피는 상관적 특성을 수용한 연결고리의 역할을 하고 있다. 단일적인 기능만을 가지고 있었던 표피는 가상적, 물리적으로 확장된 역량을 갖추며 유기적인 매개체로 소통하고 있다. 둘째, 표피는 모듈시스템의 방법을 통해 재구성 및 변화의 촉진이 용이하여 지속적인 변화를 유도할 수 있는 감응체로 존재가치를 지닐 수 있다. (결론)서로가 서로에게 어떠한 영향을 미치고 있는지를 상관적·맥락적 이해를 통해 표피의 잠재적 가치를 기대해볼 수 있었다. 표피는 언제나 요구조건에 따라 물리적인 변화를 도모하고 있는 과정 중에 놓여있으며, 이것을 바탕으로 표피는 점차적으로 주변의 현상을 더욱 민감하게 읽어내는 열린 시스템의 변화를 가지게 될 것이라는 예측을 할 수 있다. 모듈시스템은 지속적으로 변모해나가는 시간성에 동참하기 어려운 공간구조에 설치함으로써, 가변성을 가질 수 있는 디자인 방법이 되기 때문에 모듈화를 통해 표피의 활성화를 기대해볼 수 있다. (Background and Purpose)Surface spaces that embrace a range of environmental variables play a mediating role that directly connects with humans and enables continuous morphological change. Understanding the context and relations between spaces and surfaces and trends by theoretically studying holonic structure will provide a framework. This framework does not adhere to the outdated conception that drawing boundaries is a finishing material, and lays a foundation for understanding a ubiquitous surface that can respond to all environmental conditions. In this regard, this study analyzes “elements of relations” in terms of how designs can be created according to human expectations and environmental conditions. (Method) By understanding the quadrant elements of holons, surfaces can be seen to have physical functions that adapt to the demands and expanded language of roles, which can trigger social and cultural value. All types of holons can be formed and destroyed by certain relations, so understanding quadrant traits within these relations is crucial. As such, although a surface is an artificial system of cortical functions established by human needs, since surfaces are closely related to concepts and institutional change, they can evolve into open systems that can immediately respond to surroundings. By understanding quadrants, thus, surfaces can be regarded as organisms, or “live systems;” therefore, this study examines surfaces from the perspective of philosophers who questioned existence. This study classifies the elements of surfaces as live systems and analyzes module systems using an intelligent methodology that incorporates a variable, structural, expressive, and functional approach. In addition, this study attempts to understand the relative traits of surfaces by using the characteristics of intentional, behavioral, social, and cultural aspects that arise within quadrants. (Results) Six surface construction cases are analyzed using a module approach in terms of the virtual side and physical side, which exposes the hypothetical nature of shapes, including tectonics “knowledge” and “demonstration,” and the “interior side” and “exterior side” of holon quadrants. The results show, first, that surfaces with correlative characteristics play a connecting role. Surfaces that used to have single function now play the role of organic media with hypothetical and physical capabilities. Second, surfaces can easily accelerate change or restructuring using module systems; thus, surfaces have existing values as sensitizers, which can lead to lasting change. (Conclusions) By correlatively and contextually understanding the influence on each other, the potential value of a surface can be estimated. Surfaces are continuously involved in a process of physical change according to conditions. Based on this understanding, it is predicted that surfaces can gradually transform to open systems that can sensitively read the environment. By setting up a module system within a space structure that is difficult to keep up with temporality, the system can be design methodology with variability. In this regard, vitalization of surfaces using the module system can be expected.

조직병리학 영상 분류를 위한 셀프-어텐션 기반 다중 인스턴스 학습 기법

서민지(Minji Seo),윤성로(Sungroh Yoon) 한국정보과학회 2020 한국정보과학회 학술발표논문집 Vol.2020 No.12

형산강의 지화학적 특성 및 하천 퇴적물 오염도 평가

서민지(Minji Seo),류종식(Jong-Sik Ryu),최영진(Young-Jin Choi),이지영(Jiyeong Lee),나공태(Kongtae Ra) 대한지질학회 2022 대한지질학회 학술대회 Vol.2022 No.10

클래스 불균형 문제가 있는 다중클래스 텍스트 분류에서의 특징 선택 방법

서민지(Minji Seo),안길승(Gilseung Ahn),허선(Sun Hur) 대한산업공학회 2019 대한산업공학회지 Vol.45 No.2