In utero exposure of ritodrine during pregnancy and risk of autism until 8 years of age: Korea National Health Insurance (KNHI) data base analysis

( Jungsoo Chae ),( Geum Joon Cho ),( Min-jeong Oh ),( Keonvin Park ),( Sung Won Han ),( Mi Rang Seo ),( Yoo Min Kim ),( Suk-joo Choi ),( Soo-young Oh ),( Cheong-rae Roh ),( Jong-hwa Kim ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: In ACOG guidelines in 2012, it was noted that there have been reports of possible deleterious behavioral effects in offspring after in utero exposure to beta-adrenergic receptor agonists. Several recent studies from other countries also indicated that beta-adrenergic receptor agonist medication during pregnancy was associated with risk of autism and attention-deficit hyperactivity disorder in children. The purpose of this study was to examine the association between in utero exposure of ritodrine during pregnancy and risk of autism in their offsprings using data from the Korea National Health Insurance (KNHI) and national health screening program for infants and children. Methods: Study data was collected from the KNHI claims database and data from a national health screening program for infants and children. We enrolled women who delivered between 2007 and 2008 and examined the subsequent diagnosis of autism of their offspring until 2015. Clinical variables during pregnancy including age, parity, cesarean section, preterm birth, use of ritodrine, birth weight, gender, and preeclampsia were collected. Diagnosis of autism was based on ICD-10 code (F84). Results: Of the total 770,016 children born in 2007-2008, 5583(0.73%) were identified as autism until 8 years of age. By Cox proportional hazard analysis, use of ritodrine during pregnancy was associated with higher risk of autism [hazard ratio(HR): 1.273, 95% CI1.146-1.414] after adjustment for confounding variables including maternal age, primiparity, cesarean section, birth weight, male gender, preeclampsia and preterm birth. Compared to term delivery without ritodrine as a reference group, the risk of autism significantly increased in cases with term delivery with ritodrine [HR:1.289, 95% CI:1.125-1.478], preterm without ritodrine [HR:3.716, 95% CI:3.335-4.141] and preterm with ritodrine [HR:5.739, 95% CI:4.996-6.591]. Conclusion: In utero exposure of ritodrine during pregnancy was associated with an increased risk of autism in their offspring.

Risk factors and factors affecting the severity of overactive bladder symptoms in Korean women who use public health centers

( Jungsoo Chae ),( Eun-hee Yoo ),( Yeonseong Jeong ),( Seungyeon Pyeon ),( Donguk Kim ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.3

Objective To investigate the prevalence, risk factors of overactive bladder (OAB) and the factors affecting the severity of OAB symptoms. Methods A total 822 interviews with women aged 18-80 years who visited public health centers were conducted between April 2014 and April 2015. The questionnaire was composed of 16 questions about urinary symptoms, 14 questions about self-treatment and the use of complementary and alternative medicine, and 21 questions about socio-demographic characteristics. The diagnostic criterion for OAB is a total OAB symptom score of 3 and more, with an urgency score of 2 or more. To know the risk factors and factors affecting the severity of OAB, the multivariate logistic regression analysis was performed. Results One hundred fifty-seven participants (19.3%) were diagnosed with OAB, of whom 10.7%, 8.1%, and 0.7% had mild, moderate, and severe OAB symptoms, respectively. In addition, the prevalence of OAB increased with age. Among all the participants, 39.1% had stress incontinence, among them 32.7% had OAB as well. The significant risk factors of OAB were identified as age, current smoking, hyperlipidemia, cardiovascular and renal disease, whereas, the factors affecting the severity of OAB were age, current smoking, and hyperlipidemia. Conclusion Those who have risk factors and factors affecting severity of OAB should be educated to increase OAB awareness and act of urinary health promotion.

네트워크 분석 기반 도로 유실에 따른 고립위험지역 탐색

함정수(Jungsoo Ham),김민준(Minjun Kim),채한성(Hansung Chae),최진무(Jinmu Choi) 대한공간정보학회 2021 한국공간정보학회 학술대회 Vol.2021 No.6

재난 · 재해 상황시 교량 붕괴 또는 산사태 등으로 도로 유실이 발생할 수 있으며 그에 따른 고립위험지역이 발생할 수 있다. 본 연구에서는 python 3.6.10의 networkx 모듈을 이용하여 네트워크를 이용하여 도로 유실이 발생할 경우 그에 따른 고립위험지역을 탐색할 수 있는 알고리즘을 개발하고자 하였다. 데이터로 2020년 8월 9일 폭우에 의해 창녕보가 유실되면서 침수되었던 경상남도 창녕군 구학마을 인근의 도로 유실에 따른 마을 고립을 사례로 적용하였다. 결과적으로 폭우에 의한 침수로 장천우회길, 곱자골길, 구학길 인근 지역이 고립위험지역으로 분석되었다. 향후 분류된 고립위험지역 내에 있는 개별 주택으로부터 대피소로의 대피경로 분석 알고리즘도 개발되면 침수피해 대피를 위한 효율적인 도구로 활용될 수 있을 것이다.

퍼지 PI+D 제어기의 절계변수와 제어가 이득 자기동조에 관한연구

장철수,전정수,황준석,채석 금오공과대학교 2005 論文集 Vol.26 No.-

This paper describes the design of the Proportional-Integral(PI) plus a Derivative(D) controller using self-tuning of the design variables and controller gains. First, the fuzzy PI+D controller is derived from the conventional continuous time linear PI+D controller. Then, the fuzzification, control-rule base, and defuzzification in the the fuzzy controller are discussed in detail. The resulting controller .is a discrete time fuzzy version of the conventional PI+D controller, which has the same linear structure, but is nonlinear functions of the input signals. The proposed controller enhances the self-tuning control capability, particularly when the process to be controlled is nonlinear. When the fuzzy PI+D controller is applied. First, the fuzzy inference results can be calculated with splitting fuzzy variables into each action component and are determined as the functional form of corresponding design variables and adjust controller gains. So the proposed method has the capability of the high speed inference and can be adapted to increasing the number of the fuzzy input variables easilly and has the advantage to reduce a reconstruction(digital sampling reconstruction) error. This controller has better efficiency and improvement by using a design variables and controller gains. 이 논문에서는 설계변수와 제어기 이득의 자기 동조를 사용하는 PI+D 제어기 설계에 대하여 기술한다. 사용된 퍼지 PI+D 제어기는 일반적인 연속 시간 선형 PI+D 제어기를 근사화하여 사용하였고 퍼지화는 퍼지싱글톤으로, 비퍼지화는 간략화된 무게중심법을 사용하였다. 제안된 제어기는 제어대상이 비선형일 때 자기 동조 성능이 개선된다. 퍼지 PI+D 제어기가 적용되면 퍼지추정 결과는 분리된 퍼지 변수로서 다른 작용 성분으로 계산되고, 그 결과는 설계변수에 해당히는 함수의 형태로 결정되어 제어이득을 결정한다. 따라서 제안된 방법은 빠른 속도 추정의 성능을 가지며, 퍼지 입력변수의 증가에도 쉽게 적용될 수 있고, 재생 오차를 줄이는 이점을 가진다. 이 제어기는 설계변수와 제어기 이득의 사용으로 보다 높은 효율성과 개선점을 가지고 있다.

Predictive value for adverse pregnancy outcome of quad serum markers in antiphospholipid antibody syndrome

( Sir-yeon Hong ),( Jungsoo Chae ),( Mi Rang Seo ),( Yoo Min Kim ),( Suk-joo Choi ),( Soo-young Oh ),( Cheong-rae Roh ),( Jong-hwa Kim ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: We investigated the validity of quad serum markers for the prediction of the adverse pregnancy outcome(APO) in women with antiphospholipid antibody syndrome(APAS). Methods: We included 62 women with APAS who delivered in our institution between 2005 and 2017. APO was defined as fetal death in utero(FDIU), small for gestation age(SGA), preeclampsia or preterm delivery(<34weeks). First, we compared clinical characteristics between patients with or without APO. Second, we compared APO according to abnormal level of quad serum markers, which was defined as above 2.0MoM for -fetoprotein(AFP), human chorionic gonadotropin(hCG), inhibin A and below 0.5MoM for unconjugated estriol(uE3). Lastly, receiver operating characteristic(ROC) curve analysis was performed to determine the cutoff of quad serum markers for prediction of each and composite APO. Results: 1) APAS mothers with composite APO showed higher median AFP(1.331 vs. 0.990MoM, p=0.020) and inhibin A(1.568 vs. 0.814MoM, p<0.001) compared to those without APO and was also associated with higher rates of positive risk of Down syndrome(18.8% vs. 0%, p=0.07) and neural tube defect(29.0% vs. 5.3%, p=0.067). 2) Elevated AFP level was associated with higher rates of FDIU(36.4% vs. 5.4%, p=0.019), and SGA(90.9% vs. 51.4%, p=0.032). Elevated inhibin A level was associated with higher rates of FDIU(50.0% vs. 2.9%, p=0.001), SGA(100.0% vs. 55.9%, p=0.009), and preterm delivery(60.0% vs. 15.2%, p=0.053). hCG and uE3 levels were not associated with any of APO and composite APO. 3) ROC curve for prediction of FDIU revealed area under the curve of 0.816 for AFP and 0.930 for inhibin A. With the cut-off value of above 1.28 MoM of AFP, the sensitivity, specificity, positive and negative predictive value for prediction of FDIU was 100%, 63.2%, 28.6% and 100%, respectively. And those of inhibin A above 1.84 MoM were 100%, 86.8%. 54.5% and 100%. Conclusion: Elevated AFP and inhibin A levels in women with APAS have high predictive value for APO, especially FDIU.

한방 입욕제 처방이 피부 병변 모델에 미치는 영향

한승헌(Seungheon Han),김정수(Jungsoo Kim),정보경(Bokyoung Jung),박소정(Sojung Park),김형우(Hyungwoo Kim),채한(Han Chae),권영규(Youngkyu Kwon),김병주(Byungjoo Kim) 한국한의학연구원 2010 한국한의학연구원논문집 Vol.16 No.3

Objective : Active treatment for a skin condition has produced a substantial change in the history of allergic contact or wound induced dermatitis. The frequency of opportunistic contacts and allergen-related dermatitis has increased, though new skin treatments have developed. Especially, there has been a interest in the korean herbal bathing. This study was performed to investigate the effects of the korean herbal bathing candidates on skin lesions in mice model. These candidates are Korea's representative herbs on skin lesions. Method : ICR mice were divided into five groups : naive, control, experimental group A and B and C. Control and experimental groups induced skin lesions by DNFB and TMA. Each experimental group was pasted with corresponding korean herbal bathing candidates on skin lesions. Result : Significant improvements in skin wound index, epidermal thickness associated with skin lesions were seen with the korean herbal bathing candidates. Conclusion : These results suggest that the korean herbal bathing candidates could be at least as effective as steroid, anti-histamine for the treatment of skin lesions.

The reduction of the rate of uterine fundal pressure maneuvers by an inflatable obstetric belt in nulliparous women: A preliminary study

( Eunwook Joo ),( Ji Young Park ),( Gwan Hee Han ),( Do Youn Kwon ),( Jungsoo Chae ),( Eunjoo Son ),( Yeonseong Jeong ),( Hyun-joo Seol ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

목적: Uterine fundal pressure maneuver has been frequently used in laboring women to help pushing the baby with doubtful efficacy and safety. The inflatable obstetric belt is synchronized to adapt consistent fundal pressure during a uterine contraction. Its efficacy of decreasing the duration of the second stage of labor without remarkable complications in nulliparous women has been proven. The aim of this study was to determine whether or not the inflatable obstetric belt reduces the rate of uterine fundal pressure in the management of the second stage of labor in nulliparous women. 방법: Thirteen nulliparous women with a singleton cephalic pregnancy above 37+0 weeks gestation in the second stage of labor were enrolled. The control cohort group was 29 primiparous women who underwent the same criteria with standard care. All participants in the active group wore the belt (Baidy M-600/Curexo, Inc., Seoul, Korea) at the end of the first stage of labor and the inflatable belt was started at the beginning of the second stage and maintained until delivery of a baby. The primary outcome was the rate of fundal pressure maneuvers in the second stage of labor. The secondary outcomes were the duration of labor, rates of cesarean section, perineal laceration, and perinatal outcomes. 결과: There were no significant differences between the active group and the control group according to the maternal and fetal demographic variables. The active group showed a significantly decreased the rate of fundal pressure maneuvers as compared to the control group (23.07% vs. 100.00%, p=0.02). Duration of the second stage of labor was shorter in the active group than in the control group (43.23±19.02 min vs. 67.51±32.80 min, p=0.008). There was no difference in the rates of cesarean section, perineal laceration, and perinatal outcomes between the two groups. 결론: The results of the preliminary study demonstrate that the use of the inflatable obstetric belt significantly decreases the rate of fundal pressure maneuvers during the second stage of labor in nulliparous women.

가상물리 기반 수소 충전소 핵심 기자재의 신뢰성중심유지보수 방법론 개발을 위한 프레임워크

류경하(Kyungha Ryu),이태현(Taehyun Lee),박종원(Jongwon Park),강보식(Bosik Kang),서정수(Jungsoo Suh),이기봉(Gibong Lee),오성룡(Soungryong Oh),채충근(Chungkeun Chae) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.3