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- 저자 : ( Keonvin Park ) (검색결과 1 건)
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( Jungsoo Chae ),( Geum Joon Cho ),( Min-jeong Oh ),( Keonvin Park ),( Sung Won Han ),( Mi Rang Seo ),( Yoo Min Kim ),( Suk-joo Choi ),( Soo-young Oh ),( Cheong-rae Roh ),( Jong-hwa Kim ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: In ACOG guidelines in 2012, it was noted that there have been reports of possible deleterious behavioral effects in offspring after in utero exposure to beta-adrenergic receptor agonists. Several recent studies from other countries also indicated that beta-adrenergic receptor agonist medication during pregnancy was associated with risk of autism and attention-deficit hyperactivity disorder in children. The purpose of this study was to examine the association between in utero exposure of ritodrine during pregnancy and risk of autism in their offsprings using data from the Korea National Health Insurance (KNHI) and national health screening program for infants and children. Methods: Study data was collected from the KNHI claims database and data from a national health screening program for infants and children. We enrolled women who delivered between 2007 and 2008 and examined the subsequent diagnosis of autism of their offspring until 2015. Clinical variables during pregnancy including age, parity, cesarean section, preterm birth, use of ritodrine, birth weight, gender, and preeclampsia were collected. Diagnosis of autism was based on ICD-10 code (F84). Results: Of the total 770,016 children born in 2007-2008, 5583(0.73%) were identified as autism until 8 years of age. By Cox proportional hazard analysis, use of ritodrine during pregnancy was associated with higher risk of autism [hazard ratio(HR): 1.273, 95% CI1.146-1.414] after adjustment for confounding variables including maternal age, primiparity, cesarean section, birth weight, male gender, preeclampsia and preterm birth. Compared to term delivery without ritodrine as a reference group, the risk of autism significantly increased in cases with term delivery with ritodrine [HR:1.289, 95% CI:1.125-1.478], preterm without ritodrine [HR:3.716, 95% CI:3.335-4.141] and preterm with ritodrine [HR:5.739, 95% CI:4.996-6.591]. Conclusion: In utero exposure of ritodrine during pregnancy was associated with an increased risk of autism in their offspring.
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