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Potential molecular mechanisms underlying the effect of arsenic on angiogenesis
Juan Zhang,Yue Zhang,Weiyan Wang,Zhiyi Zhang 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.11
Arsenic is a potent chemotherapeutic drug thatis applied as a treatment for cancer; it exerts its functionsthrough multiple pathways, including angiogenesis inhibition. As angiogenesis is a critical component of the progressionof many diseases, arsenic is a feasible treatmentoption for patients with other angiogenic diseases, includingrheumatoid arthritis and psoriasis, among others. However,arsenic is also a well-known carcinogen, demonstrating apro-angiogenesis effect. This review will focus on the dualeffects of arsenic on neovascularization and the relevantmechanisms underlying these effects, aiming to provide arational understanding of arsenic treatment. In particular, weexpect to provide a comprehensive overview of the currentknowledge of the mechanisms by which arsenic influencesangiogenesis.
Dissipative Analysis for Nonlinear Singular Systems with Time-delay
Juan Zhou,Qing-Ling Zhang,Yue Zhang,Bo Men 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.6
This paper is concerned with the dissipative control problem for a class of nonlinear singular systemswith time-delay. The quadratic supply rate with coefficient matrix Q > 0 and Q 0 are both discussed. Basedon the Lyapunov stability theory, sufficient conditions are given to guarantee that the system is strictly dissipativevia linear matrix inequality technique. Then congruent transformation method and Schur complement lemma arerespectively used to determine corresponding proportional and derivative feedback controller for Q > 0 andQ 0. At last, two examples involve a practical example are given to verify the effectiveness of the method proposed inthis paper.
The treatment effect of novel hGHRH homodimer to male infertility hamster
Zhang, Xu-Dong,Guo, Xiao-Yuan,Tang, Jing-Xuan,Yue, Lin-Na,Zhang, Juan-Hui,Liu, Tao,Dong, Yu-Xia,Tang, Song-Shan The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.6
Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important role in reproduction. To study the treatment effect of Grin (a novel hGHRH homodimer), the infertility models of 85 male Chinese hamsters were established by intraperitoneally injecting 20 mg/kg of cyclophosphamide once in a week for 5 weeks and the treatment with Grin or human menopausal gonadotropin (hMG) as positive control was evaluated by performing a 3-week mating experiment. 2-8 mg/kg of Grin and 200 U/kg of hMG showed similar effect and different pathological characteristics. Compared to the single cyclophosphamide group (0%), the pregnancy rates (H-, M-, L-Grin 26.7, 30.8, 31.3%, and hMG 31.3%) showed significant difference, but there was no difference between the hMG and Grin groups. The single cyclophosphamide group presented loose tubules with pathologic vacuoles and significant TUNEL positive cells. Grin induced less weight of body or testis, compactly aligned tubules with little intra-lumens, whereas hMG caused more weight of body or testis, enlarging tubules with annular clearance. Grin presented a dose-dependent manner or cell differentiation-dependentincrease in testicular GHRH receptor, and did not impact the levels of blood and testicular GH, testosterone. Grin promotes fertility by proliferating and differentiating primitive cells through up-regulating testicular GHRH receptor without triggering GH secretion, which might solve the etiology of oligoasthenozoospermia.
Juan Zhang,Shifeng Li 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.7
In the paper, we apply a structure-preserving doubling algorithm to solve the continuous coupled algebraic Riccati equation (CCARE). Using the existence and uniqueness of the CCARE, we show that the iteration solution of the CCARE are positive semi-definite, symmetric, and unique. Further, we discuss the convergent analysis of the structure-preserving doubling algorithm. Moreover, we present two modified structure-preserving doubling algorithms. Finally, we offer corresponding numerical examples to illustrate the effectiveness of the derived numerical algorithms.
Effect of Fermentation Conditions on L-Lactic Acid Production from Soybean Straw Hydrolysate
( Juan Wang ),( Qunhui Wang ),( Zhong Xu ),( Wenyu Zhang ),( Juan Xiang ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.1
Four types of straw, namely, soybean, wheat, corn, and rice, were investigated for use in lactic acid production. These straws were mainly composed of cellulose, hemicellulose, and lignin. After pretreatment with ammonia, the cellulose content increased, whereas the hemicellulose and lignin contents decreased. Analytical results also showed that the liquid enzymatic hydrolysates were primarily composed of glucose, xylose, and cellobiose. Preliminary experiments showed that a higher lactic acid concentration could be obtained from the wheat and soybean straw. However, soybean straw was chosen as the substrate for lactic acid production owing to its high protein content. The maximum lactic acid yield (0.8 g/g) and lactic acid productivity (0.61 g/(l/h)) were obtained with an initial reducing sugar concentration of 35 g/l at 30°C when using Lactobacillus casei (10% inoculum) for a 42 h fermentation period. Thus, the experimental results demonstrated the feasibility of using a soybean straw enzymatic hydrolysate as a substrate for lactic acid production.
RPSA Gene Mutants Associated with Risk of Colorectal Cancer among the Chinese Population
Zhang, Shan-Chun,Jin, Wen,Liu, Hui,Jin, Ming-Juan,Chen, Ze-Xin,Ding, Zhe-Yuan,Zheng, Shuang-Shuang,Wang, Li-Juan,Yu, Yun-Xian,Chen, Kun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
The primary aim of this study was to evaluate the relationship of single nucleotide polymorphisms (SNPs) in ribosomal protein SA (RPSA) gene with colorectal cancer (CRC). A case-control study including 388 controls and 387 patients with CRC was conducted in a Chinese population. Information about socio-demography and living behavior factors was collected by a structured questionnaire. Three SNPs (rs2133579, rs2269349, rs7641291) in RPSA gene were genotyped by Illumina SnapShot method. Multiple logistic regression models were used for assessing the joint effects between tea consumption and SNPs on CRC. The subjects with rs2269349 CC genotype had a decreased risk for CRC (OR=0.60; 95%CI = 0.37-0.99), compared with TT/CT genotype after adjustment for covariates. A similar association of rs2269349 with rectal cancer was observed (OR=0.49; 95%CI=0.24-1.00). Further analyses indicated that this SNP could modify the protective effect of tea drinking on CRC. Among the subjects with rs2269349 TT/CT or rs2133579 AA/GA, there was a marginal significantly lower risk of CRC (OR and 95%CI: 0.63 and 0.39-1.01 for rs2269349; 0.64 and 0.40-1.02 for rs2133579) in tea-drinking subjects in comparison to non-tea-drinking subjects. Mutants in the RPSA gene might be associated with genetic susceptibility to CRC and influence the protective effect of tea consumption in the Chinese population.
HIST1H2BN induced cell proliferation and EMT phenotype in prostate cancer via NF-κB signal pathway
Zhang Juan,Chang Yuhan,Xia Haiyan,Xu Luwei,Wei Xiaowei 한국유전학회 2021 Genes & Genomics Vol.43 No.11
Background The potential role of HIST1H2BN in prostate cancer remains unclear. Objective To evaluate the carcinogenic role of HIST1H2BN in prostate cancer. Methods The expression of HIST1H2BN in prostate cancer was analyzed using TCGA database and clinical samples. The roles and mechanisms of HIST1H2BN were investigated in DU145 and PC3 cells. Results HIST1H2BN was signifcantly upregulated in prostate cancer. HIST1H2BN knockdown inhibited cell proliferation, migration and EMT phenotype in prostate cancer cells. Downregulating HIST1H2BN diminished the expression and binding activity of NF-κB p65, then infuenced the expression of MMP2 and MMP9. Conclusion This is the frst study to elaborate a HIST1H2BN-NF-κB-EMT regulatory axis in oncogenesis, indicating that HIST1H2BN might be potential therapeutic target for prostate cancer.
Zhang Juan 한국식물학회 2021 Journal of Plant Biology Vol.64 No.4
Auxin is well recognized for its involvement in several developmental processes like floral and leaf development and shoot elongation. The transcriptional regulation of auxin-responsive genes is mediated via auxin response factors (ARF). In this study, we identified 46 ARF genes in Nicotiana tabacum, performed phylogenetic analysis and investigated their structure, conserved domains, and motifs. Our results demonstrate that some of NtARF genes are regulated by mi-RNAs and expression in multiple tobacco tissues. Additionally, the leaf NtARFs display a diverse expression pattern in vein and shoot apical meristem in response to exogenous auxin stimulus. Transgenic NtARF10-overexpressing Arabidopsis plants exhibit larger leave areas, cell area, and more numerous cell numbers compared to wild-type plants and include several upregulated genes involved in cell division and expansion, including AtCYCD3, AtTCP1, AtTCP20, AtXTH33, and AtARGOS. This suggests NtARF10 might play a role in the regulation of leaf size. Our study contributes to a better understanding of the characteristics of the ARF family in tobacco and provides a basis for further functional research into NtARFs.
Juan Xiao,Shuyi Li,Yong Sui,Xiaopeng Li,Qian Wu,Ruifen Zhang,Mingwei Zhang,Bijun Xie,Zhida Sun 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.4
The antioxidant activity of proanthocyanidins extracted from the lotus seedpods (LSPC) in vitro and ameliorative effects on memory impairment induced using scopolamine in mice were studied. 2,2-diphenyl-1- picrylhydrazyl (DPPH) radical scavenging ability, oxygen radical absorbance capacity, and cellular antioxidant activity assays revealed a potent LSPC antioxidant activity. Y-maze and step-down avoidance testing showed that LSPC administration at 30, 60, and 90 mg/kg ameliorated memory impairment. LSPC improved glutathione peroxidase and superoxide dismutase activities, inhibited activities of monoamine oxidase-B, total nitric oxide synthase, neuronal nitric oxide synthase, and acetylcholinesterase, and had no influence on inducible nitric oxide synthase and nitric oxide levels in the brain. LSPC ameliorated scopolamineinduced memory impairment based on improvement of the antioxidant system and cholinergic activity, which may be associated with potent antioxidant ability.