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      • PGE_2와 DBcAMP가 골조직 세포의 생리적 활성에 미치는 영향

        이준기,채한정,강장숙,김형룡 원광대학교 생체재료·매식연구소 1998 원광생체재료·매식 Vol.7 No.2

        One of the primary functions for which bones have evolved is to act as structural support. To achieve this goal, bones are remodeling throughout life so that their structure remains optimal for the prevailing mechanical environment. Bone remodeling consists of an initial phase of osteoclastic bone resorption followed by a bone formation period. Prostaglandins are potent regulators of bone formation and bone resorption that can have both stimulatory and inhibitory effects. Elevation of intracellular cAMP is an important intracellular signaling mechanism involved in the regulation of the expression of many proteins. In this study, the author examined whether PGE_2 or DBcAMP affected osteoblastic activation or osteoclastic differentiation in mouse bone marrow cells and osteosarcoma ROS 17/2.8 cells. The effect of PGE_2 and DBcAMP on the cell proliferation was measured by the incorporation of [^3H]-thymidine into DNA. From the result, PGE_2( 0.5-1 ㎍/ml ) and DBcAMP(0.1-0.5 mM) inhibited the [^3H]-thymidine incorporation into DNA. The effect of PGE_2 and DBcAMP on the induction of alkaline phosphatase(ALP) was investigated in ROS 17/2.8 cells cultured in medium containing 0.4% fetal bovine serum. PGE_2 and DBcAMP stimulated ALP activity in the cells. PGE_2 also increased the intracellular cAMPs contents with a maximal effect at 0.5 ㎍/ml. ROS 17/2.8 cells released nitric oxide upon stimulation of PGE2 or DBcAMP with interferon-γ. PGE_2 and DBcAMP increase the phosphorylation level of CREB(cAMP response element binding protein) without any change on the amount of CREB protein. Also, PGE_2 (10^-6 M) and DBcAMP (10^-4 M) significantly increase the generation of osteoclast-like cell in mouse bone marrow cell culture system. In conclusion, the results of this study suggested that PGE_2 and cAMP should appear to be an important regulatory molecule in the processes of bone formation and resorption.

      • SCOPUSKCI등재

        졸 - 겔법에 의한 다공성 알루미나 미분체 제조에 관한 연구 : 2 . 물과 알콕시드의 비가 알루미나 미분체의 결정화 공정에 미치는 영향 2 . The Effect of [ H2O ] / [ Al - alkoxide ]on The Crystallization Mechanism of As - Prepared Particles

        이성원,박형상,윤호성,황운연,구기갑,유승준,김용렬,이정운 한국화학공학회 2001 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.39 No.2

        알루미늄 알콕시드의 반응속도를 제어하기 위한 혼합용매와 입자제조 과정에서의 응집을 방지하기 위한 분산제로 HPC를 첨가하는 방법에 의하여 구형의 다공성 알루미나 미분체를 제조하였으며, XRD, FT-IR 및 TG-DTA 분석을 통하여 공정변수로 선정한 물과 알루미늄 알콕시드의 비가 제조된 미분체의 결정화 공정에 미치는 영향에 대하여 고찰하였다. 축중합 반응에 첨가된 물과 Al-알콕시드의 비는 제조된 미분체 및 하소 공정을 거친 미분체의 결정구조에 영향을 미침을 알 수 있었다. [H₂O]/[ASB]의 비가 증가할수록 제조된 미분체는 비정질의 Al(OH)₃로부터 점진적으로 AlO(OH)의 화학조성을 갖는 의사-보헤마이트로 결정성이 바뀌었다. 그리고 건조 공정을 거친 미분체의 결정성이 좋을수록 δ와 θ-Al₂O₃는 저온에서 생성되었으나, α-Al₂O₃는 고온에서 생성되었다. 이와 같은 결과는 Al^(3+)이온의 결정 내에서의 배위체 변화와 관계됨을 알 수 있었다. 그리고 [H₂O]/[ASB]=2의 조건에서 제조된 입자는 다른 시료와 달리 600℃에서 η-Al₂O₃로 1,100℃에서 α-Al₂O₃2로 상전이 되었다. Spherical porous alumina particles were prepared by mixed solvent to control the reaction rate of Al-alkoxide and the particle shape with hydroxy-propyl cellulose(HPC). HPC was used as a dispersant to prevent aggregation during the formation of particles. The effect of [H₂O]/[ASB] ratio on the crystallization reactions of as-prepared particles was studied by XRD, FT-IR, and TG-DTA analysis. The mole ratio of water and Al-alkoxide added in the condensation reaction had an important effect on the crystal structure of as-prepared particles and the calcined particles. As the [H₂O]/[ASB] ratio increase, the crystal structure of as-prepared particles was continuously varied from amorphous Al(OH)₃ to pseudo-boehmite with chemical composition of AIO(OH). The samples which have higher crystallinite after drying process were transformed into the δ- and θ-Al₂O₃ at lower calcination temperature, but these sample were transformed into α-Al₂O₃ at higher calcination temperature. This result was thought to be the transformation of the coordination number of Al^(3+) ion in the crystal structure. The particles prepared by [H₂O]/[ASB]=2 condition crystallized to α-Al₂O₃at 600℃ and converted to η-Al₂O₃at 1,100℃ without intermediate phases.

      • 非線形 理論에 依한 채터 解析

        이형식,정준기,박태형 연세대학교 산업기술연구소 1983 논문집 Vol.15 No.2

        The chatter analysis has been studied by many authors using non-linear. In this study, the stability chart obtained from experimental work with a lathe was qualitatively compared with the result of chatter analysis by non-linear theory. Experimental results verify that the stability of the machining process is affected by the width of cut in the following manner. As the chip width is increased from zero with the rotational speed of the workpiece kept constant, three ranges are distinguished; (a) unconditionally stable range, (b) conditionally stable range, (c) unstable range. In the conditionally stable range the system is stable for small disturbances but unstable when these exceed a certain level. When the chatter occurs, the amplitude initially increases and stabilizes itself at a finite level. This phenomenon agrees well with the analysis of non-linear theory qualitatively.

      • Y₂O₃함량에 따른 Al₂O₃- ZrO₂계 세라믹스의 특성

        이형복,이홍림,홍기곤,김준태 연세대학교 산업기술연구소 1986 논문집 Vol.18 No.2

        In this work the effect of Y₂O₃ content on Al₂O₃-ZrO₂ ceramics was studied and compared for coprecipitation and powder methods. Al₂O₃-ZrO₂ ceramics prepared by coprecipitation method showed the maximum M.O.R. value at 15 mole% ZrO₂ content for both 1.5 and 3 mole% Y₂O₃ addition, on the other hand, the ceramics prepared by powder method showed the increasing strength with increase of ZrO₂ content over the range of this work.

      • 댐퍼붙이 거위목바이트를 使用하는 切削系의 動的 安定性에 關한 硏究

        李炯植,鄭準基,盧光春 연세대학교 산업기술연구소 1982 논문집 Vol.14 No.2

        The effect of the damped goose-neck tool upon the dynamic stability of machine tool was investigated. The dynamic stability of machine tool is directly related to the chatter in the metal cutting process. By the test of the dynamic characteristics for the damped goose-neck tool, theoretical approach of dynamic stability of machine tool is identified. It's results are compared with the results of actual cutting test. And the dynamic stability of machine tool is improved by the higher elasticity and the increase of damping coefficient for the damped goose-neck tool.

      • 「주체사상」의 이데올로기적 기능 : 단합 기능과 동원 기능을 중심으로

        李峻炯 경성대학교 1983 부산수산대학 논문집 Vol.4 No.4

        The analysis of the ideological functions of the "Idea of juche" is seen to be very significant becaus edefinitions of ideologies are dealt with as the central themes of recent political researches and ideologies play a crucial role in the analysis of politics. The aims of this study are: (1) to explore whether the "idea" functions mainly as pure ideology or practical ideology: (2) to investigate how the solidarity function is concretely manifested, and (3) to examine how the mobilization function is concretely manifested. To fulfill these purposes, we avail ourselves of an analytic frame of reference based on Frans Schurmann's pure and practical ideology and Anthoney F. C. Wallace's goal and transfer culture. In the analysis of the functions of the "idea", we chsre solidarity and mobilization alone among several functions of ideology. Four drives or movements, which have been imposed on the North korean inhabitants, are given for the concrete manifestations of the two functions of the "idea". The results of the study are as follous: The "idea of juche" prvned to be transfer culture rather than goal culture in that the North Korean theoreticians have asserted that "all the lines and policies of our party are from and are carried out by the idea of juche:. But they have sought to enhance the "idea" toward pure ideology. Though it is difficult to make explicit which function relate exactly to which component of the idea, the relations between them are to be said. "Juche in ideology" and "independence in politics" prove to be more concerned with solidarity function, while "self-sustenance in economy" and "selfdefence in national defence" have a lot to do with mobilization function. The North Korean Communists didn't build up their regime on their oven but by the help of Soviet Russia and China. It is natural that their regime should lack authority, which solidarity function of the "idea" legitimizes. In other words, the "idea" helps to support the North Korean elite and to justify the exercise of power. The solidarity function is concretely manifested in the use of myths, the rewriting of history and the search for a utopia, which serve to promote the ends of the North Korean communist system. Most Communist transfer-culture goals require sacrifices of the population; commonly such goals are unpopular or entail means that are not popularly supported. They are accordingly imposed by a "revolution from above," which is very like Amitai's "societal mobilization." This mobilization has brought about a considerable degree of indiffrence and inertia among the North Koreans. The North Korean authorities have consequently attempted to maximize the effects of mobilization policies through the "idea". They have taken advantage of "chulima" movement and four military lines for the concrete manifestations of mobilization. It is concluded that through the "idea" Kim Il-sung, leader of the North Korean regime, has intended to consolidate his monolithic power and to maintain the supreme position of the Korean Workers Party.

      • 전이성 골종양 환자 1례에 대한 증례보고

        이정현,정학수,이은용,김형준 세명대학교 한의학연구소 2001 韓醫學硏究所 論文集 Vol.3 No.-

        By process of treatment for a case which diagnosed as metastatic bone tumor and admitted from the 7th March, 2000 to the 7th April, 2000, the results are as follows. Method & Results : This patient was diagnosed as breast cancer metastasizes to bone, was treated with herb medication, acupuncture, moxibustion and kinesio taping. In treatment, cancer pain in lumbar, leg, shoulder, flank and chest portion of the patient was improving. Specially, by moxibustion therapy at pain points, cancer pain was improved remarkably. Conclusion : I consider that cancer pain diseases can be improved remarkably by Acupuncture, Moxibustion therapy.

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