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( Jaekyung Bae ),( Ji-Hyung Yoon ),( Jung-hee Lee ),( Jong-ho Nam ),( Chan-hee Lee ),( Jang-won Son ),( Ung Kim ),( Jong-seon Park ),( Dong-gu Shin ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.6
Background/Aims: The clinical benefit of strict blood glucose-lowering therapy for patients with coronary artery disease (CAD) is still debated. We aimed to evaluate the long-term outcomes of patients with diabetes who under-went percutaneous coronary intervention (PCI), according to the mean hemoglobin A1c (HbA1c) level after PCI. Methods: We evaluated 675 diabetes patients with CAD treated with PCI. We categorized the study population into three groups based on the mean observed HbA1c levels during the follow-up duration, as follows: aggressive control (AC) group (HbA1c level < 6.5%, n = 148), moderate control (MC) group (HbA1c level ≥ 6.5% and < 7.0%, n = 138), and uncontrolled (UC) group (HbA1c level ≥ 7.0%, n = 389). The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCEs), defined as cardiac death, myocardial infarction, repeat target vessel revascularization, and stroke. Results: The mean HbA1c level of the AC group was significantly lower than that of the MC and UC groups (6.04% ± 0.36% vs. 6.74% ± 0.14% vs. 8.39% ± 1.20%, p < 0.001). The incidence of MACCEs was significantly lower in the AC group than in the MC and UC groups (16.0% vs. 24.3% vs. 26.3%, p = 0.010), mostly driven by the incidence of stroke (4.4% vs. 14.0% vs. 11.4%, p = 0.013). Multivariate Cox regression analysis showed that only the AC group was associated with a reduced rate of MACCEs (hazard ratio, 0.499; 95% confidence interval, 0.316 to 0.786; p = 0.004) com-pared with the UC group. Conclusions: Our study showed that intensive glycemic control (HbA1c level < 6.5%) is associated with improved clinical outcomes after PCI in patients with diabetes.
오픈 소스 기반 이상운동증 진단 보조 애플리케이션 개발
하재경(Jaekyung Ha),황보효정(Hyojeong Hwangbo),권효정(Hyojeong Gwon),장지현(Jihyun Jang),배수한(Suhan Bae),윤다은(Daeun Yun),김연수(Yeonsu Kim),윤현진(Hyunjin Yun),이예인(Yein Lee),김영구(Young Goo Kim),안민규(Minkyu Ahn) Korean Institute of Information Scientists and Eng 2021 정보과학회논문지 Vol.48 No.5
Movement disorders, such as Parkinsons disease and Essential tremor, are usually assessed using behavioral tests or clinical questionnaires. The assessment typically involves filling in questionnaires or observation by clinicians. Because of the nature of the process, data and records are not well organized and managed; consequently, accurate assessment may be difficult. In this study, we developed an open-source based application running on Tablet PC. Two clinical questionnaires (e.g. Unified Parkinson’s disease Rating Scale and Clinical rating scale of tremor) were implemented, and the application provides efficient management of assessment records. Two behavioral tests (e.g. line and spiral drawing) that are frequently used are also implemented for quick diagnosis. The source code for the application and user/developer manuals are currently open through the web repository (github), thus anyone can easily download and uses it or clinical or research purposes.
배수한(Suhan Bae),윤다은(Daeun Yun),하재경(JaeKyung Ha),황보효정(Hyojeong Hwangbo),권효정(Hyojeong Gwon),장지현(Jihyun Jang),권다은(Daeun Gwon),안민규(Minkyu Ahn) 한국HCI학회 2020 한국HCI학회 학술대회 Vol.2020 No.2
파킨슨 병과 본태성 진전은 이상운동증상을 일으키는 퇴행성 신경계 질환으로 전 세계적으로 증가하고 있다. 이 두 질병에 대한 정확한 기준이 없이 임상의의 의견만으로 진단이 되어진다면 임상의 마다 상이한 진단을 내릴 수도 있다. 본 연구에서는 파킨슨병 환자가 가지고 있는 손 떨림 혹은 서행을 정량적 판단 하기위해 설계된 5 가지 기준을 제시한다. 데이터들이 일정한 속도와 시간을 가진다고 가정하고 떨림의 정도에 따라 상, 중, 하로 나눈 30 개의 데이터와 서동 데이터 10 개, 총 40 개의 데이터를 분석하여 정량화 하였다. 결과로는 떨림, 강도, 빈도에 따라 상당한 차이를 보이고 떨림 성분이 운동 성분에 영향을 미칠 수 있음을 확인하였다.