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Structural and Luminescent Properties of Dy3+:YAP Nanophosphors
Ganji Seeta Rama Raju,Hong Chae Jung,박진영,Jong Won Chung,정중현,Se-Mo Son,Jung Hwan Kim,문병기 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.54 No.4
A series of dysprosium (Dy3+)-ion-activated YAlO3 nanophosphors were synthesized by using a solvothermal method. Thermogravimetric/differential thermal analyses (TG/DTA) and X-ray diffraction (XRD) measurements were used to investigate the phase transformations that occur during the preparation of these phosphors. The morphology of the powder after heating at 1600 ℃ was observed by scanning electron microscopy (SEM). Luminescent studies we carried out on these compounds by using measurements of their photoluminescence (PL) and photoluminescence excitation (PLE) spectra along with the decay curve. The PL spectra show two main groups of lines, one in the blue and the other in the yellow region, concentration quenching was observed at 1 mol% of Dy3+:YAP nanophosphors. The emission procedure in the system is also elucidated by using an energy level scheme.
Raju, Ganji Seeta Rama,Pavitra, Eluri,Lee, Hoomin,Nagaraju, Goli,Baskaran, Rengarajan,Yang, Su Geun,Kwak, Cheol Hwan,Nagaraju, Ganji Purnachandra,Huh, Yun Suk,Han, Young-Kyu Elsevier 2020 APPLIED SURFACE SCIENCE - Vol.505 No.-
<P><B>Abstract</B></P> <P>Rare-earth niobate compounds are excellent nonlinear optical materials. Unlike other niobate materials, gadolinium ortho-niobate (GdNbO<SUB>4</SUB>) is reported to be inert in the visible region. The synthesis of pure-phase GdNbO<SUB>4</SUB> with a definite morphology suitable for biomedical applications is still a great challenge. In this study, a novel strategy is introduced to successfully facilitate the bioavailability of GdNbO<SUB>4</SUB>:Eu<SUP>3+</SUP> luminescent material by harnessing the pre-ouzo effect during the synthesis of mesoporous GdNbO<SUB>4</SUB>:Eu<SUP>3+</SUP> nanospheroids. Because of the materialization of GdNbO<SUB>4</SUB> nanodomains, the mesoporous GdNbO<SUB>4</SUB> nanospheroids exhibit paramagnetic behaviour and allows the strong broadband excitation between 300 and 500 nm, which permits NbO<SUB>6</SUB> emissions to be obtained in the visible region, whereas Eu<SUP>3+</SUP> activated mesoporous GdNbO<SUB>4</SUB> nanospheroids produce an intense red emission under UV, near-UV and visible excitations. These mesoporous nanospheroids also demonstrate excellent cellular internalization for HCT116 and SW680 colon cancer cells and work in conjunction with optical and magnetic resonance imaging for the accurate diagnosis and prognosis of anatomical and physiological functions. The conjugation of chlorin e6 with mesoporous GdNbO<SUB>4</SUB>:Eu<SUP>3+</SUP> nanospheroids leads to efficient photodynamic therapy (PDT) in cancer treatment. Ultimately, our approach represents an advance in the use of mesoporous GdNbO<SUB>4</SUB>:Eu<SUP>3+</SUP> nanospheroids as multifunctional nanoprobes for multimodal imaging and PDT.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Mesoporous GdNbO<SUB>4</SUB>:Eu<SUP>3+</SUP> nanospheroids were synthesized by a hydrothermal reaction method<SUB>.</SUB> </LI> <LI> The formation mechanism of mesoporous GdNbO<SUB>4</SUB>:Eu<SUP>3+</SUP> nanospheroids was reported. </LI> <LI> The GdNbO<SUB>4</SUB> and GdNbO<SUB>4</SUB>:Eu<SUP>3+</SUP> nanodomains induced photoluminescence properties were investigated. </LI> <LI> The magnetic properties of GdNbO<SUB>4</SUB> and GdNbO<SUB>4</SUB>:Eu<SUP>3+</SUP> mesoporous nanospheroids were established. </LI> <LI> Multimodal bioimaging and photodynamic therapy of mesoporous GdNbO<SUB>4</SUB>:Eu<SUP>3+</SUP> nanospheroids were demonstrated. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Targeting autophagy in gastrointestinal malignancy by using nanomaterials as drug delivery systems
Raju, G. Seeta Rama,Pavitra, E.,Merchant, Neha,Lee, Hoomin,Prasad, Ganji Lakshmi Vara,Nagaraju, Ganji Purnachandra,Huh, Yun Suk,Han, Young-Kyu Elsevier 2018 Cancer letters Vol.419 No.-
<P><B>Abstract</B></P> <P>Autophagy is a conserved catabolic process involving large protein degradation by a ubiquitous autophagosomic signaling pathway, which is essential for cellular homeostasis. It is triggered by environmental factors such as stress, lack of nutrients, inflammation, and eliminating intracellular pathogens. Although the mechanisms underlying autophagy are still unclear, increasing evidence illuminates the magnitude of autophagy in a wide range of physiological processes and human diseases. Simultaneously, research community has focused on the triggering of autophagy by the internalization of engineered nanomaterials, which indicates a new line of revolution in cancer cure. However, most studies on nanoparticle-induced autophagy focus on brain, breast, and cervical cancers; limited reports are available on gastrointestinal (GI) cancers. Therefore, the aim of this mini review is to discuss in detail the role of autophagy in GI malignancy and the status of research on nanoparticle-induced autophagy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Role of autophagy in GI growth and metastasis. </LI> <LI> Autophagy as a new therapeutic target in GI malignancy. </LI> <LI> Use of nanoparticles as diagnostic and therapeutic agents in GI malignancy. </LI> <LI> Modulation of autophagy by nanoparticles as drug delivery carriers. </LI> </UL> </P>
Luminescence properties of Dy3+:GdAlO3 nanopowder phosphors
Ganji Seeta Rama Raju,박진영,Hong Chae Jung,Byung Kee Moon,정중현,Jung Hwan Kim 한국물리학회 2009 Current Applied Physics Vol.9 No.2
Different concentrations of dysprosium (Dy3+) doped gadolinium aluminates (GdAlO3) have been newly synthesized by the wet chemical route method. Very fine particles in the nanometer range could be prepared by this method, as evidenced by X-ray diffraction and SEM measurements. The XRD profile confirms their orthorhombic nature, which is well correlated with the reported results. Luminescence studies on these compounds have been carried out on the emission and excitation, along with lifetime measurements. Such luminescent powders are expected to find potential applications as new optical materials. The emission procedure in the system has also been elucidated by an energy level scheme
Seeta Rama Raju, G.,Pavitra, E.,Purnachandra Nagaraju, Ganji,Ramesh, Kandimalla,El-Rayes, Bassel F.,Yu, Jae Su The Royal Society of Chemistry 2014 Dalton Transactions Vol.43 No.8
<P>Mesoporous particles are emerging as multifunctional biomaterials for imaging and drug delivery in several disease models, including cancer. We developed PEGylated α-Gd<SUB>2</SUB>(MoO<SUB>4</SUB>)<SUB>3</SUB> marigold flower-like mesoporous particles for the purpose of drug delivery and, more specifically, evaluated their ability to deliver curcumin. The obtained mesoporous particles significantly conjugated the curcumin particles on their surfaces by inducing the formation of curcumin nanoparticles. <I>In vitro</I> studies of the PEGylated mesoporous particles filled with curcumin demonstrated that these particles could considerably facilitate the continuous and sustained release of curcumin into the cytoplasm and nucleus. As a result, the intracellular release of curcumin can inhibit proliferation in two human pancreatic cancer cell lines: MIA PaCa-2 and PANC-1. Additionally, the particles showed the increased inhibition of pIKKα, pIKKα/β and NF-κB–DNA binding activity as compared to pure curcumin. The curcumin conjugated mesoporous particles are concentrated in the cytoplasm and nucleus of the treated cancer cell lines. Consequently, these mesoporous particles are an effective method for drug delivery that can cross the biological barriers of the body targeting the cellular nucleoplasm.</P> <P>Graphic Abstract</P><P>The advantage of PEGylated α-Gd<SUB>2</SUB>(MoO<SUB>4</SUB>)<SUB>3</SUB> marigold-like mesoporous flowers with curcumin is to facilitate nuclear localization and release of the conjugated drug, triggering the signal within the nucleoplasm. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3dt52692e'> </P>
Light-extraction enhancement of white LEDs with different phases of TiO2:0.01Eu3+ spheres
문주영,Ganji Seeta Rama Raju,박진영,양현경 한국물리학회 2017 Current Applied Physics Vol.17 No.4
We report the synthesis of TiO2:0.01Eu3þ spheres by a solvothermal reaction method and their utilization in the enhancement of light-extraction efficiency. The light-extraction efficiency was enhanced by increasing the extraction probability of the internal and external reflected photons in the YAG:Ce3þ yellow phosphor based white light-emitting diodes (WLEDs). The crystalline structure of TiO2:0.01Eu3þ spheres was investigated by an X-ray diffraction analysis. The anatase phased TiO2:0.01Eu3þ spheres exhibited a typical red emission under 463.5 nm wavelength. The diffused reflectance spectra displayed higher reflectance for rutile phase and lower for anatase phase. However, compared to the typically, combination of YAG:Ce3þ yellow phosphor and blue LED chip, fabricated WLED, the light-extraction efficiency of WLED was improved to 80% when TiO2: 0.01Eu3þ spheres were mixed with YAG:Ce3þ phosphor in the fabrication process.
박진영,Hong Chae Jung,Ganji Seeta Rama Raju,정중현,Byung Kee Moon,김중환,Young Kuk Lee,유재수 한국물리학회 2013 Current Applied Physics Vol.13 No.3
The color rendering index (CRI) and structural stability of cerium doped yttrium aluminum garnet (YAG:Ce) based phosphors have been enhanced by replacing Y3+ ions by larger radius ions (Tb3þ, Gd3+, Eu3+, and Sm3+) at the dodecahedral site and replacing Al3+ ions by larger ones (Ga3+, Y3+, Tb3+, Gd3, and Sm3+) at the octahedral site. These aluminum garnet crystalline powders were prepared by solvothermal reaction method at 300 ℃ for 48 h. The lattice constant values of synthetic aluminum garnet crystalline powders are larger than that of YAG and the emissionwavelength of Ce3+ ion of these samples is longer than that of YAG:Ce. FESEM and TEM studies revealed that the Ln3Ga2Al3O12 and Ln3Al2Al3O12 crystalline powders have 3-dimensional star-like morphology with submicron size and good crystallinity, while, Ln3(LnAl)Al3O12 garnet crystalline powders were cubic crystalline phases and shaped as cubes with the round edge having an approximate diameter of about 200-400 nm. All the prepared powders were grown along (100) direction and crystallized into single crystal. Also, the effects of treatment time and reaction temperature on the structure of aluminum garnet crystalline powders have been investigated.
최남혁,( Seyed Majid Ghoreishian ),( Ganji Seeta Rama Raju ),( Kugalur Shanmugam Ranjith ),이후민,곽철환,박범준,한영규,허윤석 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
Well-designed heterostructure photocatalysts with effective interfacial contacts have attracted significant attention, owing to their enhanced visible-light absorption and optimal charge separation efficiency. Herein, novel visible-light-responsive heterostructure photocatalysts composed of reduced graphene oxide (rGO)/protonated g-C3N4 (p-CN)/ Cu3Mo2O9 (CMO) were constructed through a facile hydrothermal method. In particular, the ternary composite with 20 wt% of CMO content (rGO/p-CN/CMO-20) was optimized as an efficient catalyst for tetracycline (TC) degradation. The TC degradation rate of the rGO/ p-CN/CMO-20 catalyst was found to be ~41, 15, 22, 7, and 14 times higher than those of rGO, p-CN, CMO, p-CN/CMO-20, and rGO/ CMO-20, respectively.