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다발성 대장암 간전이 환자의 간절제를 위한 새로운 시도
주종우,김형철,임철완,신응진,조규석,유기원,송옥평,홍대식,박성진,조준희,이혜경,김희경,권계원,고은석 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Multiple bilobar liver matastases (MBLM) are the main cause of low resectability in the colon cancer liver metastases. The authors experienced one case of initially non-resectable colon cancer liver metastases. He was curatively and safely treated with a two-stage hepatectomy using the new method of future remnant liver volume growing. A 54-year-old man was referred to our department with the sigmoid colon cancer combined with MBLM, which were checked in two small metastatic lesions in the left lobe and five large sized lesions in the right lobe in the computed tomogram (CT). A laparoscopic assisted anterior resection was primarily performed. We performed the 1^(st) stage hepatectomy 3 weeks after the colon resection. Intra-operative Ultrasonogram (US) found 9 small superficial metastatic lesions in the left lobe. All that lesions were completely removed by non-anatomical wedge resection. An occlusion ballon catheter was placed in the right portal vein through a small branch of the inferior mesenteric vein at that time. The future remnant liver volume was sufficiently increased 3 weeks after the 1^(st) hepatectomy. A right hepatectomy was safely performed 22 days after the 1^(st) hepatectomy. The patient received a regional chemotherapy (interleukin2 based immuno-chemotherapy through hepatic artery) for 4 months, then received 9 cycles of systemic chemotherapy (biweekly Oxaliplation, leucovorin, plus 5-fluorouracil) without any recurrence evidence.
Jang, Jung Eun,Ko, Myoung Seok,Yun, Ji-Young,Kim, Mi-Ok,Kim, Jin Hee,Park, Hye Sun,Kim, Ah-Ram,Kim, Hyuk-Joong,Kim, Bum Joong,Ahn, Young Eun,Oh, Jin Sun,Lee, Woo Je,Harris, Robert A.,Koh, Eun Hee,Lee, American Diabetes Association 2016 Diabetes Vol. No.
<P>Fibrosis of adipose tissue induces ectopic fat accumulation and insulin resistance by inhibiting adipose tissue expandability. Mechanisms responsible for the induction of adipose tissue fibrosis may provide therapeutic targets but are poorly understood. In this study, high-fat diet (HFD)-fed wild-type (WT) and iNOS(-/-) mice were used to examine the relationship between nitric oxide (NO) produced by macrophages and adipose tissue fibrosis. In contrast to WT mice, iNOS(-/-) mice fed an HFD were protected from infiltration of proinflammatory macrophages and adipose tissue fibrosis. Hypoxia-inducible factor 1 alpha (HIF-1 alpha) protein level was increased in adipose tissue of HFD-fed WT mice, but not iNOS(-/-) mice. In contrast, the expression of mitochondrial biogenesis factors was decreased in HFD-fed WT mice, but not iNOS(-)/(-) mice. In studies with cultured cells, macrophage-derived NO decreased the expression of mitochondrial biogenesis factors, and increased HIF-1 alpha protein level, DNA damage, and phosphorylated p53 in preadipocytes. By activating p53 signaling, NO suppressed peroxisome proliferator-activated receptor gamma coactivator is expression, which induced mitochondrial dysfunction and inhibited preadipocyte differentiation in adipocytes. The effects of NO were blocked by rosiglitazone. The findings suggest that NO produced by macrophages induces mitochondrial dysfunction in preadipocytes by activating p53 signaling, which in turn increases HIF-1 alpha protein level and promotes a profibrogenic response in preadipocytes that results in adipose tissue fibrosis.</P>
Gender Impact Assessment of the National Posting Project of Licensed Exercise Instructors
( Eun Ha Koh ),( Yong Sik Lee ),( Young Ok Park ),( Seong Sik Cho ),( Mi Kyung Hwang ) 체육과학연구원 2010 International Journal of Applied Sports Sciences Vol.22 No.2
This study aims to analyze the national posting project of licensed exercise instructors with gender-sensitive approach by conducting a gender impact assessment. This research explored gender issues that influenced immensely the planning, management and evaluation stages of the project, and suggested some recommendations. The gender impact assessment was drawn up by employing 8 evaluation indexes and 11 detailed questions. Major findings are as follows: First, in planning and decision-making stages, the national posting project did not reflect the current demands of instructors concerning gender perspectives. And the ratio of female members in charge of sports in all committees in local organizations was very low. Second, in the operating stage, there was no gender discrimination in the procedures of advertisement and engagement of instructors. However, there is a possibility that female instructors are restricted to a few sports such as aerobics, dancing and weight training. Third, in the evaluation stage, the participation ratio in this project and the satisfaction level of female instructors were high. However, further attention is needed to the fact that female instructors tend to work in poorer circumstances in the labor market and thus reveal less dissatisfaction than their male counterparts as well as to the possibility that male managers do not have such gender-sensitivity as to notice problems. Finally, government officers, administrators at sport organizations and local managers should have gender-sensitivity and consider gender equality as an important factor in posting exercise instructors. It is necessary to encourage female instructors` professional growth and development and enhance the position of women within all the service areas of public sports.
Effects of Buckwheat, Potato and Rice on Glycemic Indices in Healthy Subjects
Koh, Eun-Sook T.,Ju, Jin-Soon,Choi, Moon-Gi,Yoon, Tae-Heon,Ahn, Young-Sook,Lim, Kyung-Ja,Kim, Soon-Ok,Kim, Jong-Dai The Korean Society of Medicinal Crop Science 2002 韓國藥用作物學會誌 Vol.10 No.4
We compared the long-term metabolic effects of equal amounts of carbohydrate from potato, rice and buckwheat on glycemic indices and blood lipids in healthy subjects. Nine healthy volunteers-2 men and 7 women were studied. All subjects ate diets based on the same-7-day rotating menu differing only in that the major source of carbohydrate (about 50% of daily total calories) came either from buckwheat, rice or potato. The study was conducted with a triple crossover design over three 7 day periods. On the morning of the 8th day, fasting blood was drawn from each subject to determine serum glucose, insulin, triglycerides, total and HDL-cholesterol. Subjects were then asked to eat breakfast with their respective carbohydrate within a 20 min period. Blood samples were drawn at 30, 60, 120 and 180 min after the start of breakfast to determine glucose and insulin levels. At 30 min the glucose response to the rice meal(7.15mmol/L) and potato meal(6.71mmol/L) were greater than the response to the buckwheat meal(5.855mmol/L) (P < 0.05). The mean area under the glucose response to the curve following the rice meal was greater than that following the buckwheat meal(P < 0.05). The insulin responses to the potato and rice meals at 30 and 60 min were greater than those to the buckwheat meal (P < 0.05). The mean area under the serum insulin response curve after the rice meal was greater than of buckwheat. Blood lipids, uric acid and glycosylated hemoglobin were not affected by the three meals. The study shows that the buckwheat meal has more beneficial effects on glycemic indices than either the rice meal or potato meal in healthy subjects.
Koh, Eun Sil,Lee, Kyungsoo,Kim, Su Hyun,Kim, Young Ok,Jin, Dong Chan,Song, Ho Chul,Choi, Euy Jin,Kim, Yong Lim,Kim, Yon Su,Kang, Shin Wook,Kim, Nam Ho,Yang, Chul Woo,Kim, Yong Kyun S. Karger AG 2015 American journal of nephrology Vol.42 No.2
<P>Abstract</P><P><B><I>Background/Aims:</I></B> β<SUB>2</SUB>-Microglobulin (β<SUB>2</SUB>-M) is a surrogate marker of middle-molecule uremic toxins and is associated with mortality in chronic hemodialysis patients. However, the impact of serum β<SUB>2</SUB>-M levels on mortality in peritoneal dialysis (PD) patients is uncertain. The purpose of this study was to examine the association of serum β<SUB>2</SUB>-M levels with all-cause mortality in PD patients. <B><I>Methods:</I></B> A total of 771 PD patients were selected from the Clinical Research Center registry for end-stage renal disease cohort in Korea. Patients were categorized into 3 groups by tertiles of serum β<SUB>2</SUB>-M levels. The primary outcome was all-cause mortality. <B><I>Results:</I></B> The median value of serum β<SUB>2</SUB>-M was 23.6 mg/l (interquartile range 14.8-33.4 mg/l), and the median follow-up period was 39 months. The Kaplan-Meier analysis showed that the all-cause mortality rate was significantly different according to tertiles of serum β<SUB>2</SUB>-M in PD patients (p = 0.03, log-rank). Multivariate Cox proportional analysis showed that the hazards ratio for all-cause mortality was 1.02 (95% CI 1.01-1.04, p = 0.006) per 1 mg/l increase in β<SUB>2</SUB>-M after adjustment for multiple confounding factors that relate to malnutrition and inflammation marker. However, serum β<SUB>2</SUB>-M was not associated with all-cause mortality after adjustment for residual renal clearance. <B><I>Conclusions:</I></B> These results are supportive of the potential role of the serum β<SUB>2</SUB>-M level as a predictor of mortality in PD patients.</P><P>© 2015 S. Karger AG, Basel</P>
노년기 여성의 기성복 실태와 구입 태도에 관한 연구 : 서울시 거주지를 중심으로
고윤영,민현자,박은옥,방경혜,김회경,김진영,박소옥,손경미 연세대학교 생활과학대학 1986 婦學 Vol.19 No.-
노년기 여성의 기성복 실태와 구입태도에 관한 본 연구의 결과로 다음과 같은 결론을 내릴 수 있다. 1. 의복구입장소는 가격 때문에 주로 도매시장을 택하는 것으로 나타났고, 구입시 선택기준은 입어서 편한것, 색상, 가격의 순이었다. 2. 의복의 만족도와 관심도는 높게 나타났으며 양장착용이 일반화되었다. 앞으로 이에 관심있는 노인복 제작업체를 위한 참고자료로서 본 연구결과에 따른 디자인을 한 참고자료로서 본 연구결과에 따른 디자인을 한 참고자료로서 본 연구결과에 따른 디자인을 <그림 1>과 같이 제시하였다.